PRODUCTS

1,2-BENZISOTHIAZOL-3(2H)-ONE (BIT)

1,2-benzisothiazol-3(2H)-one (BIT) is an organic compound with the formula C6H4SN(H)CO.
A white solid, 1,2-benzisothiazol-3(2H)-one (BIT) is structurally related to isothiazole, and is part of a class of molecules called isothiazolinones.
1,2-benzisothiazol-3(2H)-one (BIT) is widely used as a preservative and antimicrobial.

CAS Number: 2634-33-5
EC Number: 220-120-9
IUPAC Name: 1,2-Benzothiazol-3(2H)-one
Chemical Formula: C7H5NOS

Other names: 2634-33-5, 1,2-Benzisothiazolin-3-one, benzisothiazolone, 1,2-benzothiazol-3-one, benzisothiazolinone, Benzo[d]isothiazol-3(2H)-one, benzoisothiazol-3-one, Proxel, 1,2-Benzisothiazoline-3-one, Proxel PL, Benzo[d]isothiazol-3-one, Benzo[d]isothiazol-3-ol, Nipacide BIT, Benzisothiazolin-3-one, Proxel AB, 2,3-dihydro-1,2-benzothiazol-3-one, 1,2-benzoisothiazolin-3-one, 1,2-BENZISOTHIAZOL-3-ONE, 3-Hydroxy-1,2-benzisothiazole, C7H5NOS, Proxel XL 2, Benzocil, 1,2-Benzisothiazolone, Caswell No. 079A, Caswell No. 513A, 1,2-benzisothiazolinone, Acticide BIT, Canguard BIT, Denicide BIT, Proxel BD, Proxel CF, Proxel TN, Proxel XL, Proxel BDN, Proxel GXL, San-aibac AP, Proxel Ultra 5, Apizas AP-DS, Proxel LV-S, Proxel Press Paste, Acticide BW 20, Bestcide 200K, Parmetol B 70, Parmetol D 11, Nipacide BIT 20, Proxel GXL(S), Proxel HL 2, 1,2-Benzoisothiazol-3-one, Nuosept 485, Nuosept 491, Nuosept 495, Topcide 600, XBINX, Denicide BIT 20N, Koralone B 119, Nipacide BIT 10W, Preventol BIT 20D, Proxel BD 20, Proxel Press Paste D, Troysan 1050, Bioban BIT 20DPG, benzisothiazoline-3-one, Canguard BIT 20DPG, CCRIS 6369, 2-Thiobenzimide, SD 202 (bactericide), UNII-HRA0F1A4R3, Canguard Ultra BIT 20LE, EINECS 220-120-9, HRA0F1A4R3, BIT 10W, EPA Pesticide Chemical Code 098901, BIT 20, DTXSID5032523, IPX, ORISTAR BIT, 2,3-Dihydrobenzisothiazol-3-one, CHEBI:167099, Benzisothiazolone (BIT), SD 202, 1,2-Benzoisothiazoline-3-one, DTXCID3012523, HSDB 8271, 1, 2-BENZISOTHIAZOLIN-3-ONE, 2,3-dihydro-3-oxo-1,2-benzisothiazole, BENZISOTHIAZOL-3(2H)-ONE, 1,2-, MLS-0254244.0001, Benzo(d)isothiazol-3(2H)-one, 1329616-16-1, Benzoisothiazol-3-one-13C6, 40991-37-5, 1,2-BENZISOTHAZOL-3(2H)-ONE, 1,2-Benzothiazolinone, 1,2Benzisothiazolin3one, Epitope ID:115004, Benzisothiazol-3(2H)-one, Benzo(D) Isothiazol-3-one, 1,2Benzisothiazol3(2H)one, SCHEMBL26078, cid_17520, MLS000771034, REGID_for_CID_17520, CHEMBL297304, SCHEMBL5586024, BDBM46658, BENZISOTHIAZOLINONE [INCI], HMS1755P21, HMS2706H20, Tox21_300489, MFCD00044001, AKOS001062434, AKOS030227972, AC-2653, CS-W018117, FB18220, FS-3163, HY-W017401, 1,2-Benzisothiazol-3(2H)-one, 97%, NCGC00164206-01, NCGC00248077-01, NCGC00254467-01, PD168615, SMR000344133, US9011882, Table 1, Compound 20, CAS-2634-33-5, DB-027306, B2430, NS00000271, EN300-17679, B66088, A818398, AE-562/40151878, Q411746, 1,2-Benzisothiazol-3(2H)-one, analytical standard, Z56983154, F0288-0100, Benzoisothiazol-3-one;3-Hydroxy-1,2-benzisothiazole;Acticide BIT, 1,2-Benzisothiazol-3(2H)-one; Benzisothiazolin-3-one; Proxan; Proxel; Proxel XL; Proxil, 220-120-9

Usage of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) has a microbicide and a fungicide mode of action.
1,2-benzisothiazol-3(2H)-one (BIT) is widely used as a preservative, for example in:

emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions
home cleaning and car care products; laundry detergents, stain removers and fabric softeners;
industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
agriculture in pesticide formulations
gas and oil drilling in muds and packer fluids preservation.

In paints, 1,2-benzisothiazol-3(2H)-one (BIT) is commonly used alone or as a mixture with methylisothiazolinone.
Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides.
According to a study in Switzerland, 19% of the paints, varnishes and coatings contained 1,2-benzisothiazol-3(2H)-one (BIT) in 2000.
The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%.
A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.

Home cleaning and other care products that are high in water are easily contaminated by microorganisms, so isothiazolinones are often used as a preservatives in these products because they are good at combatting a broad array of bacteria, fungi, and yeasts.
A Swiss investigation found that 1,2-benzisothiazol-3(2H)-one (BIT) is used in concentrations between 50 and 500 ppm in tattooing ink.
According to regulations in the EU and Switzerland, 1,2-benzisothiazol-3(2H)-one (BIT) cannot be used in cosmetics.
However, it is allowed in the United States and Canada.

1,2-benzisothiazol-3(2H)-one (BIT) is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
1,2-benzisothiazol-3(2H)-one (BIT) has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser.
1,2-benzisothiazol-3(2H)-one (BIT) is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

1,2-benzisothiazol-3(2H)-one (BIT) is present in can-end cements 1,2-Benzisothiazol-3(2H)-one belongs to the family of Benzothiazoles.
These are organic compounds containing a benzene fused to a thiazole ring (a five-member ring with four carbon atoms, one nitrogen atom and one sulfur atom).

Usage of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is widely used biocide that inhibits bacterial growth and spoilage.
1,2-benzisothiazol-3(2H)-one (BIT) is toxic to both microbes and fungus.
1,2-benzisothiazol-3(2H)-one (BIT) is also marketed as a mixture with other isothiazolinone-based biocides.
Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides.

1,2-benzisothiazol-3(2H)-one (BIT) also is active against bacteria and fungi, especially in highly alkaline environments.
1,2-benzisothiazol-3(2H)-one (BIT) is used as a preservative in emulsion paints, varnishes, adhesives, washing agents, fuels and in the papermaking process.

In paints, 1,2-benzisothiazol-3(2H)-one (BIT) is commonly used as a mixture with methylisothiazolinone.
1,2-benzisothiazol-3(2H)-one (BIT) is also used to preserve a variety of water-based process liquids, including metal-working fluids, oil-field fluids and injection water, textile solutions, pesticide emulsions, and mineral slurries and coatings used in paper mills.

1,2-benzisothiazol-3(2H)-one (BIT) is a broad spectrum microbicide for the preservation of industrial water-based products against the attack of microorganisms.
1,2-benzisothiazol-3(2H)-one (BIT) is 20% solution of 1,2-Benzisothiazolin-3-one in dipropylene glycol and water.
1,2-benzisothiazol-3(2H)-one (BIT) is specifically recommended for the preservation of polymer emulsions, paints and coatings, adhesives, and printing inks.

Hazard classification & labelling of 1,2-benzisothiazol-3(2H)-one (BIT)
Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, 1,2-benzisothiazol-3(2H)-one (BIT) is very toxic to aquatic life, is harmful if swallowed, causes serious eye damage, causes skin irritation and may cause an allergic skin reaction.
Additionally, the classification provided by companies to ECHA in REACH registrations identifies that 1,2-benzisothiazol-3(2H)-one (BIT) is toxic to aquatic life with long lasting effects.

1,2-benzisothiazol-3(2H)-one (BIT) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
1,2-benzisothiazol-3(2H)-one (BIT) is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

Biocidal Uses of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is being reviewed for use as a biocide in the EEA and/or Switzerland, for: disinfection, product preservation, preservation of fibres, leather, rubber, or polymers, preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.

Consumer Uses
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following products: plant protection products and cosmetics and personal care products.
Other release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) is likely to occur from: outdoor use as processing aid and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Widespread uses by professional workers
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following products: plant protection products and fertilisers.
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following areas: agriculture, forestry and fishing.
Other release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) is likely to occur from: outdoor use as processing aid and indoor use as processing aid.

Formulation
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following products: plant protection products, biocides (e.g. disinfectants, pest control products), fertilisers and laboratory chemicals.
Release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industry
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following areas: scientific research and development.
Release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) can occur from industrial use: in processing aids at industrial sites.