Quick Search
Allantoin is a chemical compound with formula C4H6N4O3.
Allantoin is also called 5-ureidohydantoin or glyoxyldiureide.
Allantoin is a diureide of glyoxylic acid.
CAS Number: 97-59-6
EC Number: 202-592-8
IUPAC Name: N-(2,5-Dioxoimidazolidin-4-yl)urea
Chemical Formula: C4H6N4O3
Other names: allantoin, 97-59-6, 5-Ureidohydantoin, Glyoxyldiureide, 1-(2,5-dioxoimidazolidin-4-yl)urea, Glyoxyldiureid, Allantol, Cordianine, Sebical, Alantan, AVC/Dienestrolcream, Urea, (2,5-dioxo-4-imidazolidinyl)-, Hydantoin, 5-ureido-, Cutemol emollient, Uniderm A, (2,5-Dioxo-4-imidazolidinyl)urea, Glyoxylic diureide, Glyoxylic(acid) diureide, NSC 7606, Psoralon, Septalan, Caswell No. 024, (2,5-dioxoimidazolidin-4-yl)urea, 5-Ureido-2,4-imidazolidindion, N-(2,5-Dioxo-4-imidazolidinyl)urea, CCRIS 1958, 2,5-Dioxo-4-imidazolidinyl-urea, Fancol TOIN, 5-Ureidohydrantoin, MFCD00005260, EPA Pesticide Chemical Code 085701, C4H6N4O3, 4-ureido-2,5-Imidazolidinedione, AI3-15281, NSC7606, Allantoin (JAN/USP), N-(2,5-Dioxo-4-imidazolidinyl)urea, 97-59-6 (racemic), urea, N-(2,5-Dioxo-4-imidazolidinyl)-, MLS000737882, 5-Ureido-2,4-imidazolidindione, CHEBI:15676, Allantoin, 98%, DSSTox_CID_43, Herpecin L, D00121, DSSTox_RID_75334, DSSTox_GSID_20043, Allantoin [USAN], SMR000528073, amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amide, SR-01000766252, EINECS 202-592-8, BRN 0102364, Allantoi, DL-Allantoin, HSDB 7490, Allantoin [USAN:USP:BAN], CAS-97-59-6, Prestwick_11, NCGC00016358-01, Allation,(S), 5-ureido-Hydantoin, Allantoin (8CI), (+/-)-Allantoin, Spectrum_001078, EC 202-592-8, SCHEMBL3208, 5-25-15-00338 (Beilstein Handbook Reference), MLS002473300, Allantoin, analytical standard, 5-Ureidohydantoin;Glyoxyldiureide, component of Skin-balm (Salt/Mix), HY-N0543, NSC-7606, 2,5-Imidazolidinedione, 4-ureido-, 1-(2,5-Dioxoimidazolidin-4-yl);urea, IDI1_000281, Allantoin, p.a., 98.5-101.0%, N-(2,5-Dioxo-4-imidazolidinyl)urea #, (RS)-(2,5-dioxoimidazolidin-4-yl)urea, AC-11040, AS-13865, H736, NCI60_041675, N-(2,5-Dioxo-4(1h)-imidazolidinyl)urea, SBI-0051759.P002, Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI), Allantoin, European Pharmacopoeia (EP) Reference Standard, A999F0D6-0285-41D9-A6BA-B705987B663C, Allantoin, United States Pharmacopeia (USP) Reference Standard, Allantoin, Pharmaceutical Secondary Standard; Certified Reference Material, 5-Ureidohydantoin;Glyoxyldiureide; Glyoxylic diureide; Cordianine; Glyoxyldiureid; (2,5-Dioxo-4-imidazolidinyl)urea, (2,5-dioxo-4-imidazolidinyl)urea, ALLANTOIN, ALL, 5-UREIDOHYDANTOIN, Alphosyl, Alyonyldiurened, Egopsoryl, Allantin, CORDIANINE, Allantoin,98%, 1-(2,5-Dioxoimidazolidin-4-yl)-urea, Allantoin (200 mg), Allantoin, USP, EP, 5-Ureidohydantoin, Glyoxylic(acid) diureide, [(4R)-2,5-dioxoiMidazolidin-4-yl]urea, Allantoin, 98% 100GR, Allantoin skin curative, Allantoi, glyoxylic diureide, GLYOXYLIDIUREIDE, GLYOXYLIC ACID DIUREIDE, glyoxyldiureid, GLYOXYLDIUREIDE, LABOTEST-BB LT02085084, TIMTEC-BB SBB003997, UREA, (2,5-DIOXO-4-IMIDAZOLIDINYL), Hydantoin, 5-ureido-, N-(2,5-Dioxo-4-imidazolidinyl)urea, nsc7606, Psoralon, Sebical, Septalan, toin, uniderma, (2,5-Dioxo-imidazolidin-4-yl)-urea, AllantoinPowder, ALLANTOIN POWDER ( Glyoxylic acid Diureide), Allantoin Joyce, Allantoin >=98.0% (N), AllantoinuM, Alantan、Allegron、Alphosyl、Alyonyldiurened、Cordianine、Egopsoryl、Sebical, Urea, N-(2,5-dioxo-4-imidazolidinyl)-, AllantoinUSP, 98.5-101.0% (Assay), (2,5-Dioxo-4-imidazolidinyl)urea 5-Ureidohydantoin Glyoxyldiureide Cordianine, ALLANTOIN (5-UREIDOHYDANTOIN), Allantoine ( 2,5-Dioxo-4-imidazoidinyl urea), 5-ureido-hydantoi, 5-Ureidohydrantoin, ai3-15281, Alantan, Allantol, AVC/Dienestrolcream, component of Skin-balm, Fancol TOIN, 5-ureidohydantoin (2,5-dioxoimidazolidin-4-yl)urea, ALLANTOIN(RG), 2,5-DIOXO-4-IMIDAZOLIDINYLUREA(ALLANTOIN), ALANTOIN
Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria.
Allantoin is produced from uric acid, which itself is a degradation product of nucleic acids, by action of urate oxidase (uricase).
History
Allantoin was first isolated in 1800 by the Italian physician Michele Francesco Buniva (1761–1834) and the French chemist Louis Nicolas Vauquelin, who mistakenly believed it to be present in the amniotic fluid.
In 1821, the French chemist Jean Louis Lassaigne found it in the fluid of the allantois; he called it "l'acide allantoique".
In 1837, the German chemists Friedrich Wöhler and Justus Liebig synthesized it from uric acid and renamed it "allantoïn".
Bacteria
In bacteria, purines and their derivatives (such as allantoin) are used as secondary sources of nitrogen under nutrient-limiting conditions.
Their degradation yields ammonia, which can then be utilized.
For instance, Bacillus subtilis is able to utilize allantoin as its sole nitrogen source.
Mutants in the B. subtilis pucI gene were unable to grow on allantoin, indicating that it encodes an allantoin transporter.
In Streptomyces coelicolor, allantoinase (EC 3.5.2.5) and allantoicase (EC 3.5.3.4) are essential for allantoin metabolism.
In this species the catabolism of allantoin, and the subsequent release of ammonium, inhibits antibiotic production (Streptomyces species synthesize about half of all known antibiotics of microbial origin).
Applications
Allantoin is present in botanical extracts of the comfrey plant and in the urine of most mammals. Chemically synthesized bulk allantoin, which is chemically equivalent to natural allantoin, is safe, non-toxic, compatible with cosmetic raw materials and meets CTFA and JSCI requirements.
Over 10,000 patents reference allantoin.
Cosmetics and toiletries
Manufacturers cite several beneficial effects for allantoin as an active ingredient in over-the-counter cosmetics, including: a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents.
An animal study in 2010 found that based on the results from histological analyses, a soft lotion with 5% allantoin ameliorates the wound healing process, by modulating the inflammatory response.
The study also suggests that quantitative analysis lends support to the idea that allantoin also promotes fibroblast proliferation and synthesis of the extracellular matrix.
A study published in 2009 reported the treatment of pruritus in mild-to-moderate atopic dermatitis with a topical nonsteroidal agent containing allantoin.
Pharmaceuticals
Allantoin is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products.
Biomarker of oxidative stress
Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with reactive oxygen species will give rise to allantoin, which is thus a suitable biomarker to measure oxidative stress in chronic illnesses and senescence.
Molar mass: 158.117 g·mol−1
Appearance: colourless crystalline powder
Odor: odorless
Density: 1.45 g/cm3
Melting point: 230 °C (decomposes)
Boiling point: 478 °C
Solubility in water: 0.57 g/100 mL (25 °C) 4.0 g/100 mL (75 °C)
Solubility: soluble in alcohol, pyridine, NaOH insoluble in ethyl ether
log P: −3.14
Acidity (pKa): 8.48
XLogP3-AA: -2.2
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 1
Exact Mass: 158.04399007 g/mol
Monoisotopic Mass: 158.04399007 g/mol
Topological Polar Surface Area: 113Ų
Heavy Atom Count: 11
Complexity: 225
Undefined Atom Stereocenter Count: 1
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Allantoin is an imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.
Allantoin has a role as a vulnerary, a human metabolite, a Saccharomyces cerevisiae metabolite and an Escherichia coli metabolite.
Allantoin is a member of ureas and an imidazolidine-2,4-dione.
Allantoin derives from a hydantoin. Allantoin is a tautomer of a 1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea.
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets.
In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l.
During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated.
In human muscle, urate is oxidized to allantoin during such exercise.
The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediately after short-term exhaustive cycling exercise.
More specifically, allantoin is a diureide of glyoxylic acid that is produced from uric acid.
Allantoin is a major metabolic intermediate in most organisms.
Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions.
Allantoin has also demonstrated to ameliorate the wound healing process in some studies.
Use and Manufacturing
Allantoin is listed on the FDA OTC Ingredient List as used for or having reviews pending for use as a wound healing agent, skin protectant and external analgesic, a dandruff/seborrheic dermatitis/psoriasis product, a grower for hair loss, a corn/callus remover, and a sunscreen ingredient.
Industry Uses: stabilizers
Consumer Uses: Personal care products
Household & Commercial/Institutional Products
Personal Care
Pet Care
Anti-inflammatory analgesic effects
Allantoin has anti-inflammatory analgesic effects, but it also has a weak partial paralysis effect, can effectively reduce stimuli of stimulus, can be used as a skin protectant and anti-irritant, can reduce skin irritation of cosmetic ingredients, China food and Drug Administration rank it as the first kind efficient active ingredient of skin care agent, now has been widely used in many products such as shampoo, sunscreen products, creams and lotions, shaving creams and oral care products.
Chemical properties
Colorless crystalline powder.
Melting point is 238-240 ℃ (decomposition).
Can be dissolved in hot water, hot alcohol and dilute sodium hydroxide solution, slightly soluble in water and alcohol, almost insoluble in ether and chloroform.
Odorless, tasteless.
In dry air is stable, prolonged boiling in the water or strong base will be destroyed. pH of saturated aqueous solution is 5.5.
The above information is edited by the chemicalbook of Liu Yujie.
Uses:
Allantoin can promote skin cell growth and rapid wound healing.
Used as anti-ulcer drug, mixed with dry aluminum hydroxide gel, for gastrointestinal ulcers and inflammation.
The product can soften keratin, making the skin retain moisture, moist and soft, is special effects of additive in cosmetic.
Allantoin and its derivatives are the quality improver and additive of many household chemical products.
Allantoin protein may be formulated anti-irritant, anti-dandruff, cleaning and wound healing scalp preparations, making hair soft, shiny and elastic.
The product is an amphoteric compound, can bind to a variety of material form double salts, with dark, antiseptic, analgesic, deodorant, anti-oxidation effect, and therefore is household chemical products, additives of cosmetics such as freckle cream, acne solution, shampoo , soap, toothpaste, shaving lotion, convergence liquid and antiperspirant deodorant detergent. Allantoin also is a biochemical reagents.
For the roles such as skin care, oral products, anti-allergy, the treatment of skin ulcers promote wound healing.
Widely used in treatment of a variety of skin ulcers and trauma and additives of nutritional cosmetics.
Production methods
Allantoin presents in the sheath cyst fluid, fetal urine and some of the plants.
However, the cost extracted Allantoin from these substances is too high.
Currently synthesis methods of Allantoin are: potassium permanganate oxidation uric acid method: dichloroacetic acid and urea heated to synthesize Allantoin; direct condensation method of glyoxylic acid and urea.
Technological process of dichloroacetic acid and urea as raw materials is as follows: The sodium methoxide solution and methanol were added into the reaction tank, and heated to 40-50 ℃, slowly dropwise added dichloroacetic acid, after added and reflux reaction for 2 h. Cooled to room temperature, filtered, washed with methanol and the filtrate was combined, washed, added methanol solution of sodium dimethoxyethane.
The solution was reduced to dryness under reduced pressure , 2.8 portion of hydrochloric acid was added,heated and stirred into a paste in a water bath.
Then heated to 90 ℃, and then cooled to about 10 ℃, filtered, 0.25 portion of hydrochloric acid and urea was added into , dissolved by heated, reacted at 80 ℃ for 2 h.
Cooled and crystallization, and then maintained at 0 ℃ for above 3 h, centrifugation, washed ,spin-dried, dried to crude product.
After The crude product was used 15 times of the water to recrystallize, Allantoin was obtained.
As for the dichloroacetic acid, the total yield was 30.3%.
The direct condensation of glyoxylic acid and urea (glyoxylate derived by oxidation of glyoxal) operation example: oxidation was in 500 ml four-hole boiling flask equipped with mechanical stirrer, condenser, thermometer and dropping funnel, added 193 g (1 mol) 30% glyoxal aqueous solution, controlled the internal temperature at 40 ± 2 ℃ and stirred to dropwise add 135.5 g ( 1 mol) 45% nitric acid, After addition, continued to stir at this temperature and reacted for 2-3 h, until reddish brown oxidation no longer escaped, the reaction solution was blue-green and immediately disappeared.
Replaced by simple distillation apparatus, at about 2.76 kPa, the outside temperature did not exceed 60 ℃ and about 125 g water was evaporated, concentrate solution was standing overnight at room temperature, oxalic acid crystals were precipitated (dried to get 19 g, together 0.21 mol), concentration was 39% ).
Continue to stir and react for about 8h at an internal temperature of 40 ± 2 ℃, the oxidation reaction was completed.
Condensation In 500 ml three-hole boiling flask equipped with mechanical stirrer, condenser and thermomete, above 150 g glyoxylic acid aqueous solution was added, added 170 g (2.83 mol) urea and 23.3 g of concentrated hydrochloric acid, heated to an internal temperature of 80 ℃ under stirring.
After about 15min urea was dissolved, the reaction solution was transparent, approximately another 30-45 min, the reactant appeared white cloudy, white precipitate was gradually increased, stirred at an inner temperature of 80 ℃ for 1 h, heating was stopped and the reactant was cooled to room temperature, The white precipitate was collected on a Buchner funnel, precipitated with cold water several times, obtained crude product of Allantoin.
Used 1000 ml distilled water to recrystallize. 60-63% white fine crystalline Allantoin was obtained, melting point was 236 ℃ (decomposition).
Calculated by glyoxal, the theoretical yield of Allantoin was 38-40% (weight yield was 103-108%).
Uses:
Allantoin is a botanical extract said to be healing, calming, and soothing, it can also help protect the skin from harmful external factors (e.g., wind burn).
Allantoin is considered an excellent temporary anti-irritant and is believed to stimulate new tissue growth, helping heal damaged skin.
Allantoin is appropriate for sensitive, irritated, and acne skins. Derived from the comfrey root, it is considered non-allergenic.
This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy).
Emollients are substances that soften and moisturize the skin and decrease itching and flaking.
Some products (e.g., zinc oxide, white petrolatum) are used mostly to protect the skin against irritation (e.g., from wetness).
Dry skin is caused by a loss of water in the upper layer of the skin.
Emollients/moisturizers work by forming an oily layer on the top of the skin that traps water in the skin.
Petrolatum, lanolin, mineral oil and dimethicone are common emollients.
Humectants, including glycerin, lecithin, and propylene glycol, draw water into the outer layer of skin.
Many products also have ingredients that soften the horny substance (keratin) that holds the top layer of skin cells together (including urea, alpha hydroxy acids such as lactic/citric/glycolic acid, and allantoin).
This helps the dead skin cells fall off, helps the skin keep in more water, and leaves the skin feeling smoother and softer.
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets Label.
In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l.
During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated Label.
In human muscle, urate is oxidized to allantoin during such exercise Label.
The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediately after short-term exhaustive cycling exercise Label.
More specifically, allantoin is a diureide of glyoxylic acid that is produced from uric acid.
Allantoin is a major metabolic intermediate in most organisms.
Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions 4.
Allantoin has also demonstrated to ameliorate the wound healing process in some studies 1.
Consumer Uses
Allantoin is used in the following products: pharmaceuticals and cosmetics and personal care products.
Other release to the environment of Allantoin is likely to occur from: indoor use as processing aid.
Article service life
Widespread uses by professional workers
Allantoin is used in the following products: pharmaceuticals and cosmetics and personal care products.
Allantoin is used in the following areas: health services and formulation of mixtures and/or re-packaging.
Other release to the environment of Allantoin is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Formulation
Allantoin is used in the following products: pharmaceuticals and cosmetics and personal care products.
Release to the environment of Allantoin can occur from industrial use: formulation of mixtures.
Uses at industrial sites
Allantoin has an industrial use resulting in manufacture of another substance (use of intermediates).
Allantoin is used for the manufacture of: chemicals.
Release to the environment of Allantoin can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).
Manufacture
Release to the environment of Allantoin can occur from industrial use: manufacturing of the substance.
Extracted from the root of the comfrey plant, Allantoin is a non-irritating ingredient that soothes and protects the skin.
With the ability to help heal the skin and stimulate the growth of new tissue, it’s a great all-rounder for keeping skin at the top of its game.
Allantoin effectively softens the skin and helps to protect it, making it suitable for sensitive skin in need of a little extra TLC.
Allantoin, a white colorless crystalline powder, is well known skin and oral mucosa protectant.
Allantoin usp meets current US Pharmacopeia (USP) and European Pharmacpeia (EP) monographs.
The United States (U.S.) Food and Drug Administration (FDA) lists Allantoin as a skin protectant at 0.5% to 2.%.
Applications:
toothpaste
mouthwash
denture adhesives
Allantoin Description
Allantoin is a byproduct of uric acid that can be extracted from urea and is the result of metabolic processes that occur in most organisms – among them animals (including humans) and bacteria.
Allantoin can also be extracted from comfrey (taken from the roots and leaves) and is proven safe and effective because it does not contain the potentially irritating alkaloid compounds that occur in the comfrey plant.
Despite the natural source of allantoin being safe, the type of allantoin used in skin care products is generally produced synthetically as this guarantees no impurities while sacrificing none of allantoin’s effectiveness.
Allantoin serves as an effective soothing agent and has moisturizing properties, giving it value especially in products designed to treat sensitive or compromised skin.
Allantoin can also help mitigate skin’s response to stronger active ingredients and is often included in formulas to help buffer any potential adverse effects.
In cosmetics, it is used in concentrations up to 2%, but in clinical settings it can be used in greater amounts, where research has shown it can have an impact on healing.
In the United States, it is FDA-approved as an over the counter (OTC) skin protectant in concentrations of 0.5–2%.
Allantoin is extracted from the comfrey root and is often synthetically derived.
Allantoin is added to many products to treat burns, dermatitis, wounds, acne, and impetigo.
Allantoin is also added to sensitive skin moisturizers and hand sanitizers, and in topical formulations for the treatment of scars and keloids.
Allantoin is carcinogenic and thus contraindicated in pregnancy and lactation, and can be fatal when orally consumed.
The growing consumer demand for all-natural ingredients in foods and over-the-counter products has increased interest in botanicals for skin care (Table 2-8).
There is little evidence from human trials to support their efficacy, and the rigorous processing prior to their inclusion in cosmeceuticals often depletes the beneficial properties of the extract.
Despite this, the use of botanicals is widespread and will continue to expand as the demand for natural products increases.
Allantoin is a multi-functional skin care ingredient which:
Increases moisture retention
Skin is particularly sensitive to life’s daily stress factors, which may result in skin dryness and tightness.
By increasing the capacity of corneocytes to bind water, Allantoin reinforces the skin’s natural protective barrier and improves its moisture retention, providing a smoothing effect to the skin.
Softens the skin
Allantoin exfoliates dry and damaged cells and boosts the radiant appearance of the skin. Due to its keratolytic activity, it removes corneocytes by loosening the intercellular kit or the desmosomes (protein bridges) that maintain the adhesion of corneocytes to each other.
Thus the surface of the skin is smoother, softer and becomes more supple.
Prevents skin irritation
Allantoin has been demonstrated as an anti-irritant.
When Allantoin is added to rinse-off products (shower gels, shampoos, wash lotions or shaving creams) it protects the skin by minimizing irritation caused e.g. by surfactants.
Allantoin also helps avoid the feeling of tightness, and volunteers have experienced a better skin feeling after showering or washing.
The use of Allantoin in antiperspirant products can help counter the irritation caused by some of the more aggressive actives.
Supports the natural regeneration of the skin
Allantoin aids to protect skin against environmental and mechanical stresses such as shaving by helping the skin to maintain its integrity.
What is Allantoin?
Allantoin can be found in several plants, like Comfrey, Horse Chestnut and Sugar Beet.
The most popular source of Allantoin is from the Comfrey plant, originally from Europe.
Allantoin is water-based meaning it can be easily added to haircare products and then applied to hair and scalp!
Allantoin benefits
As a natural ingredient, Allantoin is very gentle so can be used on all skin types, perfect for those with sensitive skin.
Allantoin is thought to moisturise and soothe skin as it removes dead skin cells, leaving nourished smooth skin underneath.
Allantoin for hair
One of the main benefits of Allantoin for hair is that it’s keratolytic action can treat or prevent a dry and itchy scalp by conditioning and nourishing the scalp.
It’s anti-irritant properties also reduce redness and leave the scalp feeling soothed and refreshed.
Allantoin also helps improve the softness and elasticity of hair, whilst improving shine.
All-round Allantoin is a hair saviour!
Allantoin is a white crystalline powder.
Allantoin is a nitrogenous compound that is found both in the plant environment (Comfrey Root for example) or animal (in the urine of calves).
Allantoin can also be obtained synthetically from uric acid.
In cosmetics, allantoin is used for its astringent, anti-irritant, anti-inflammatory, healing and moisturizing properties.
Allantoin is also used in the treatment of dentine hypersensitivity.
Allantoin is not authorized in organic in France.
