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ALLANTOINE

CAS NUMBER; 97-ALLANTOINE (ALLANTOIN) CAS NUMBER; 97-59-6 

Glyoxyldiureide, 5-Ureidohydantoin; Allantoin; allantoin; 97-59-6; 5-Ureidohydantoin; Glyoxyldiureide; 1-(2,5-dio yl)urea; Glyoxyldiureid; Allantol; Cordianine; Sebical; Alantan; AVC/Dienestrolcream; Urea, (2,5-dioxo-4-imidazolidinyl)-; Hydan Cutemol emollient; Uniderm A; Glyoxylic diureide; (2,5-Dioxo-4-imidazolidinyl)urea; Psoralon; Septalan; Caswell No. 024; (2,5-d 4-yl)urea; Glyoxylic(acid) diureide; 5-Ureido-2,4-imidazolidindion; NSC 7606; Ureidohydantoin; CCRIS 1958; Allantoin [USAN:BA 5-Ureidohydrantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; EPA Pesticide Chemical Code 085701; AI3-15281; NSC7606; 2,5-Dioxo urea; Allantoin (JAN/USP); EINECS 202-592-8; BRN 0102364; urea, N-(2,5-dioxo-4-imidazolidinyl)- MLS000737882; C4H6N4O3; C ureido-2,5-Imidazolidinedione; POJWUDADGALRAB-UHFFFAOYSA-N; MFCD00005260; N-(2,5-dioxoimidazolidin-4-yl)urea; DSSTox_CID_43Herpecin L; D00121; DSSTox_RID_75334; DSSTox_GSID_20043; (S)-Allantoin; N-[2,5-dioxoimidazolidin-4-yl]urea amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))amideSR-01000766252; allantion; Allantoinum; Allantoi; Hemocane; DL-Allantoin; HSDB [USAN:USP:BAN:JAN]; CAS-97-59-6; Prestwick_11; NCGC00016358-01; 5-ureido-Hydantoin; Allantoin (8CI); 5-eaAoAOEO; (+/-)-A Spectrum_001078; ACMC-209twn; Prestwick0_000002; Prestwick1_000002; Prestwick2_000002; Prestwick3_000002; Spectrum Spectrum3_000876; Spectrum4_000716; Spectrum5_001526; bmse000437; D01HNL; AC1L18PM; AC1Q2AJ8; SCHEMBL3208; O Allantoin, 98% 250g; BSPBio_000003; BSPBio_002551; KBioGR_001271; KBioSS_001558; 5-25-15-00338 (Beilstein Handbook Re KSC679I2B; MLS002473300; Allantoin, analytical standard; Bio-0219; DivK1c_000281; SPECTRUM1500801; SPBio_000237; SPBi BPBio1_000005; CHEMBL593429; 5-Ureido-2,4-imidazolidindione; DTXSID3020043CTK5H9420; HMS500O03; KBio1_000281; K KBio2_004126; KBio2_006694; KBio3_002051; Allantoin, >=98.0% (N); MolPort-001-779-876; NINDS_000281; Urea,5-dioxo-4-im HMS1568A05; HMS1921I10; HMS2092K16; HMS2095A05; HMS2268N08; Pharmakon1600-01500801; component of Skin-balm N0543; NSC-7606; 2,5-Imidazolidinedione, 4-ureido-; Tox21_110395; Tox21_202087; Tox21_302912; ANW-43029; BBL027508; NSC757792; SBB003997; STL373778; AKOS000120642; AKOS016038547Tox21_110395_1; CS-7741; LS-7181; MCULE-10083262 RL06095; RTR-038622; SDCCGMLS-0066595.P001; 1-(2,5-Dioxoimidazolidin-4-yl);urea;IDI1_000281; KS-0000005S; Allantoin, p.a (2,5-Dioxo-4-imidazolidinyl)urea #; NCGC00094854-01; NCGC00094854-02; NCGC00094854-03; NCGC00094854-04; NCGC0009 NCGC00094854-07; NCGC00256403-01; NCGC00259636-01; (RS)-(2,5-dioxoimidazolidin-4-yl)urea; 4CN-0784; 5377-33-3; AC-11 AN-24454; AS-13865; H736; NCI60_041675; SC-18051; N-(2,5-Dioxo-4(1h)-imidazolidinyl)urea; SBI-0051759.P002; KB-212681; S 038622; A0211; AB00052307; BG01500390; FT-0604592; ST50308144; C01551; J10470; M-5668; Urea, (2,5-dioxo-4-imidazolidin AB00052307_11; I05-0376; J-522839; SR-01000766252-2; SR-01000766252-3; SR-01000766252-4W-100104; I14-13401; Allantoi Pharmacopoeia (EP) Reference Standard; A999F0D6-0285-41D9-A6BA-B705987B663C; Allantoin, United States Pharmacopeia Standard; Allantoin, Pharmaceutical Secondary Standard; Certied Reference Material; Ao>>u(1/4)a paragraph signthorn-micr 2,4- paragraph signthornI feminine; 37305-69-4; 5-Ureidohydantoin; Glyoxyldiureide; Glyoxylic diureide; Cordianine; Glyoxyldi 4-imidazolidinyl)urea; 58308-55-7; Allantoin; Herpecin L; Herpecin-L; HerpecinL; Sebical; Woun`dres; 5-Ureidohydantoin, Glyo diureide; (2,5-DIOXO-4-IMIDAZOLIDINYL) - UREA; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; GLYOXYLDIUR GLYOXYLDIUREIDE; GLYOXYLIC DIUREIDE; UREA, (2,5-DIOXO-4-IMIDAZOLIDINYL) -; UREA, (2,5DIOXO4IMIDAZOLIDINYL) ; (2,5-D IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; AI3-15281; (±)-Allantoin; (±)-Allantoin; 1-(2,5-Dioxo-4-imidazolidinyl)harnsto [ [ACD/IUPAC Name]; 1-(2,5-Dioxo-4-imidazolidinyl)urea [ACD/IUPAC Name]; 1-(2,5-Dioxo-4-imidazolidinyl)urée [French] [ACD/IU (2,5-Dioxoimidazolidin-4-yl)harnsto; 1-(2,5-dioxoimidazolidin-4-yl)urea; 2,5-Dioxo-4-imidazolidinyl-urea; 202-592-8 [EINECS]; 39669-95-9 [RN]; 4H-imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]- 4-ureido-2,5-Imidazolidinedione; 5-Ureido-2,4-imidazolidindion; 5-ureido-Hydantoin; 97-59-6 [RN]; Allantoin [BAN] [JAN] [USAN Allantoin (8CI); DL-Allantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; UNII:344S277G0Z; Urea, (2,5-dioxo-4-imidazolidinyl)-; Urea, (2 imidazolidinyl)- (9CI); Urea, N-(2,5-dioxo-4-imidazolidinyl)- [ACD/Index Name]; 5-Ureidohydrantoin; Fancol TOIN; (2,5-diketoim yl)urea; (2,5-dioxo-4-imidazolidinyl)-urea; (2,5-Dioxo-4-imidazolidinyl)urea; (2,5-dioxoimidazolidin-4-yl)urea; (2,5-Dioxo-imidazo (RS)-(2,5-dioxoimidazolidin-4-yl)urea; [97-59-6]; 2,5-dioxoimidazolidin-4-ylurea; 2,5-Imidazolidinedione, 4-ureido-; 5-Ureido-2,4 imidazolidindione; 5-Ureido-2,4-imidazolidinedione; Actinac; Alantan; Allantoi; allantoin 98%; Allantoin CTFA allantoin standar allantoin, 98%; allantoin, powder; Allantoinum; Allantol; Alloxantin [Wiki]; Alphosyl; amino-N-(2,5-dioxo(1,3-diazolidin-4-yl))ami AVC/Dienestrolcream; c4h6n4o3; Cordianin; Cutemol emollient; Dermalex; DL-ALLANTOIN-5-13C,1-15N; Glyoxyldiureid; Glyox Glyoxylic(acid) diureide; Hemocane; Hydantoin, 5-ureido-; MFCD00005260 [MDL number]; N-(2,5-dioxoimidazolidin-4-yl)urea; Pharmakon1600-01500801; ProClin 300; Psoralon S-allantoin; Sebical; Septalan; Uniderm A; Urea, (2, 5-dioxo-4-imidazolidinyl)-; Ureidohydantoin.; YT1600000; ??? [Chinese]; (2,5 imidazolidinyl)urea 2,5-Dioxo-4-imidazolidinyl-urea; 4-ureido-2,5-imidazolidinedione; 5-Ureido-2,4-imidazolidindione; 5-Ureidohydantoin; 5-ureido glyoxyldiureide; N-(2,5-Dioxo-4-imidazolidinyl)urea; InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,1 POJWUDADGALRAB-UHFFFAOYSA-N; Urea, (2,5-dioxo-4-imidazolidinyl)-; 1-(2,5-dioxoimidazolidin-4-yl)urea; Urea, (2,5-dioxo-4- Allantol; AVC/Dienestrolcream; Cordianine; Glyoxyldiureid; Glyoxyldiureide; Hydantoin, 5-ureido-; Sebical; 5-Ureidohydantoin; imidazolidinyl-urea; Alantan; Glyoxylic diureide; 5-Ureidohydrantoin; Fancol TOIN; Psoralon; Septalan; 2,5-Imidazolidinedione, 7606; Urea, N-(2,5-dioxo-4-imidazolidinyl)-; Glyoxyldiureide, 5-Ureidohydantoin; Allantoin; allantoin; 97-59-6; 5-Ureidohydanto Glyoxyldiureide; 1-(2,5-dioxoimidazolidin-4-yl)urea; Glyoxyldiureid; Allantol; Cordianine; Sebical; Alantan; AVC/Dienestrolcream 4-imidazolidinyl)-; Hydantoin, 5-ureido-; Cutemol emollient; Uniderm A; Glyoxylic diureide; (2,5-Dioxo-4-imidazolidinyl)urea; Ps Caswell No. 024; (2,5-dioxoimidazolidin-4-yl)urea; Glyoxylic(acid) diureide; 5-Ureido-2,4-imidazolidindion; NSC 7606; Ureidohyd 1958; Allantoin [USAN:BAN]; Fancol TOIN; 5-Ureidohydrantoin; N-(2,5-Dioxo-4-imidazolidinyl)urea; EPA Pesticide Chemical Cod 15281; NSC7606; 2,5-Dioxo-4-imidazolidinyl-urea; Allantoin.

The skin is a natural actor proven to be refreshing and protective. The US Food and Drug Administration (FDA) classied Allantoin as Category 1 (safe and eective) as a skin protector. Although the working mechanism of Allantoin as a cosmetic raw material is still unclear, value and ecacy have been support vitro and in-vivo tests Even when allantoin is used at 0.3%, it is a highly eective anti-inammatory. Because it is both eective and economical, it is over-the-counter topical formulations and cosmetic products. Allantoin is used to promote natural renewal of the skin, to prevent irritation, to improve moisture retention capacity and to s Description Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA L human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin conce increases about two fold and remains elevated [FDA Label]. In human muscle, urate is oxidized to allantoin during such exerc The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediate term exhaustive cycling exercise [FDA Label]. More specically, allantoin is a diureide of glyoxylic acid that is produced from uric acid. It is a major metabolic intermediate i Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipst products, sun care products, and clarifying lotions . Allantoin has also demonstrated to ameliorate the wound healing process What it is ? Allantoin is a white powder. It can be found in plants, like comfrey and horse chestnut, and in the urine of most mammals. Th commonly used in cosmetics and skincare products though derives from urea and glyoxylic acid. What it does ? Allantoin has anti-irritant, soothing and healing properties: it calms down irritations, helps shed the upper layers of dead skin promotes the growth of healthy tissue. That`s why it`s eective at treating wounds,eczema, psoriasis, burns and other skin c Uses Allantoin is useful for the treatment of wound, carbuncles, burns and sunburns, scalds, acne and skin eruptions, impetigo.

Allantoin is an anti-aging ingredient used in facial rejuvenation products. It is a common ingredient of skin care products. It is soothing irritated skin, stimulates cell regeneration and moisturizes dry skin. In harnessing the eectiveness and benets of allantoin, it is used in various facial cleaners, acne products, toners, sunscreen and other specialty skin care products. The derivatives of allantoin brought about personal care products such as follows: • Deodorants and antiperspirants • Shaving products • Skin-astringent lotions • Anti-Acne • Foot preparations products • Veterinary preparations products • Dusting powder and cream • Hair care products • Anti-inammatory products Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide.[1][2] It is a d glyoxylic acid. Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria. It is prod acid, which itself is a degradation product of nucleic acids, by action of urate oxidase (uricase). History Allantoin was rst isolated in 1800 by the Italian physician Michele Francesco Buniva (1761-1834) and the French chemist Lou Vauquelin, who mistakenly believed it to be present in the amniotic uid.[6] In 1821, the French chemist Jean Louis Lassaigne uid of the allantois; he called it "l`acide allantoique".[7] In 1837, the German chemists Friedrich Wöhler and Justus Liebig syn uric acid and renamed it "allantoïn". Animals Named after the allantois (an amniote embryonic excretory organ in which it concentrates during development in most mam humans and other higher apes), it is a product of oxidation of uric acid by purine catabolism. After birth, it is the predominant nitrogenous waste is excreted in the urine of these animals.[9] In humans and other higher apes, the metabolic pathway for c acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes used as a drug to catalyze th conversion in patients. In sh, allantoin is broken down further (into ammonia) before excretion. Allantoin has been shown to improve insulin resistance when administered to rats and increased lifespan when administered worm Caenorhabditis elegans. Bacteria In bacteria, purines and their derivatives (such as allantoin) are used as secondary sources of nitrogen under nutrient-limiting degradation yields ammonia, which can then be utilized.[13] For instance, Bacillus subtilis is able to utilize allantoin as its sole Mutants in the B. subtilis pucI gene were unable to grow on allantoin, indicating that it encodes an allantoin transporter. In Streptomyces coelicolor, allantoinase (EC 3.5.2.5) and allantoicase (EC 3.5.3.4) are essential for allantoin metabolism. In this catabolism of allantoin, and the subsequent release of ammonium, inhibits antibiotic production (Streptomyces species synth all known antibiotics of microbial origin). Applications Allantoin is present in botanical extracts of the comfrey plant and in the urine of most mammals. Chemically synthesized bulk chemically equivalent to natural allantoin, is safe, non-toxic, compatible with cosmetic raw materials and meets CTFA and JSCI Over 10,000 patents reference allantoin. Cosmetics and toiletries Manufacturers cite several benecial eects for allantoin as an active ingredient in over-the-counter cosmetics, including: a m keratolytic eect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin by forming complexes with irritant and sensitizing agents. An animal study in 2010 found that based on the results from histological analyses, a soft lotion with 5% allantoin ameliorates healing process, by modulating the inammatory response. The study also suggests that quantitative analysis lends support t allantoin also promotes broblast proliferation and synthesis of the extracellular matrix. A study published in 2009 reported the treatment of pruritus in mild-to-moderate atopic dermatitis with a topical nonsteroida allantoin. Pharmaceuticals It is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products. Well recognized skin protectant agent with keratolytic, moisturizing, soothing and healing properties. Natural-identical to the comfrey (Symphytum ocinale), it is an extremely safe ingredient with no reports of adverse reactions over a long use history cosmetic raw materials, it meets requirements. Allantoin enhances the performance of personal care formulations also at low levels, giving a smooth and healthy appearance Used on injuried skin it helps relief from pain and promotes cell-proliferation. Useful in all cosmetic and dermopharmaceutica adults, children and infants, also as only active ingredient. Uses This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper from radiation therapy). Emollients are substances that soften and moisturize the skin and decrease itching and aking. Some zinc oxide, white petrolatum) are used mostly to protect the skin against irritation (e.g., from wetness). Dry skin is caused by a loss of water in the upper layer of the skin. Emollients/moisturizers work by forming an oily layer on th that traps water in the skin. Petrolatum, lanolin, mineral oil and dimethicone are common emollients. Humectants, including g and propylene glycol, draw water into the outer layer of skin. Many products also have ingredients that soften the horny subs that holds the top layer of skin cells together (including urea, alpha hydroxy acids such as lactic/citric/glycolic acid, and allanto dead skin cells fall o, helps the skin keep in more water, and leaves the skin feeling smoother and softer. How to use Allantoin Cream Use this product as directed. Some products require priming before use. Follow all directions on the product package. If you h questions, ask your doctor or pharmacist. Some products need to be shaken before use. Check the label to see if you should shake the bottle well before using. Apply to areas of the skin as needed or as directed on the label or by your doctor. How often you apply the medication will depend on your skin condition. To treat dry hands, you may need to use the product every time you wash your hands, applying it throug If you are using this product to help treat diaper rash, clean the diaper area well before use and allow the area to dry before a product. If you are using this product to help treat radiation skin burns, check with radiation personnel to see if your brand can be app radiation therapy. Follow all the directions on the label for proper use. Apply to the skin only. Avoid sensitive areas such as your eyes, inside you and the vaginal/groin area, unless the label or your doctor directs you otherwise. Check the label for directions about any are where you should not apply the product (e.g., on the face, any areas of broken/chapped/cut/irritated/scraped skin, or on a rec of the skin). Consult your doctor or pharmacist for more details. Use this medication regularly to get the most benet from it. Most moisturizers need water to work well. Apply the product af bathing/showering while the skin is still damp. For very dry skin, your doctor may instruct you to soak the area before using th hot, or frequent bathing/washing can worsen dry skin.

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