BENZILIC ACID

EC / List no.: 200-993-2
CAS no.: 76-93-7
Mol. formula: C14H12O3

Benzilic acid is an organic compound with formula C14H12O3 or (C6H5)2(HO)C(COOH). 
It is a white crystalline aromatic acid, soluble in many primary alcohols.

Preparation
Benzilic acid can be prepared by a heating mixture of benzil, ethanol ,and potassium hydroxide.

Another preparation, performed by Liebig in 1838, is the dimerization of benzaldehyde, to benzil, which is transformed to the product by the benzilic acid rearrangement reaction.

Uses
Benzilic acid is used in the manufacture of glycollate pharmaceuticals including clidinium, dilantin, flutropium, and mepenzolate which are antagonists of the muscarinic acetylcholine receptors.

It is used in manufacture of the incapacitating agent 3-quinuclidinyl benzilate (BZ) and is regulated by the Chemical Weapons Convention. 
It is also monitored by law enforcement agencies of many countries, because of its use in the manufacture in hallucinogenic drugs.

Moderately toxic by subcutaneousroute. Slightly toxic by ingestion. 
When heated todecomposition it emits acrid smoke and irritating vapors.

Uses
Agents of chemical warfare
Used in the synthesis of the anticholinergic drug clidinium bromide
Precursor in the synthesis of the chemical warfare agent 3-quinuclidinyl benzilate

Benzilic acid is a white crystalline aromatic acid soluble in many primary alcohols. It can be prepared by heating mixture of benzil, alcohol and potassium hydroxide. The other preparation way is through benzaldehyde, which dimerizates to benzil and it is further transformed by benzilic acid rearrangement to benzilic acid. This reaction was also the first example of benzilic acid rearrangement preformed by Liebig in 1838.

Odor: characteristic
Use: Benzilic Acid is an impurity of Trospium. Trospium is a derivative of tropine with anticholinergic property, which is used in the treatment of urinary incontinence as an antispasmodic.

benzilic acid
: a white crystalline acid (C6H5)2C(OH)COOH obtained by warming benzil with alcohol and alkali; diphenyl-glycolic aci

Benzilic acid is a white crystalline aromatic acid soluble in many primary alcohols. 
It can be prepared by heating mixture of benzil, alcohol and potassium hydroxide. 
The other preparation way is through benzaldehyde, which dimerizates to benzil and it is further transformed by benzilic acid rearrangement to benzilic acid. 
This reaction was also the first example of benzilic acid rearrangement performed by Liebig in 1838
Benzilic acid is used in organic synthesis, as a base point for preparation of glycollate pharmaceuticals and some hallucinogenic drugs.

IUPAC NAMES
2,2-diphenyl-2-hydroxyacetic acidα,α-diphenylglycolic acidα-hydroxy-α-phenylbenzeneacetic acidα-hydroxy-α,α-diphenylacetic acid
2,2-diphenylglycolic acid
2-hydroxy-2,2-di(phenyl)acetic acid
2-hydroxy-2,2-diphenylacetic acid
Benzilic acid
hydroxy(diphenyl)acetic acid

SYNONYMS
BENZILIC ACID extrapure
Benzilic acidDiphenylglycolic acid
TrospiuM Chloride Related CoMpound A
Trospium Chloride Related Compound A (20 mg) (Benzilic Acid) (Internationally Restricted Sales Item)
BENZILIC ACID FOR SYNTHESIS 1 KG
BENZILIC ACID FOR SYNTHESIS 250 G
Benzeneacetic acid,a-hydroxy-a-phenyl-
Trospium Chloride Related Compound A (20 mg) (Benzilic Acid) (International Restricted Sales Item)
HYDROXY-DIPHENYL-ACETIC ACID
DIPHENYLGLYCOLIC ACID
BENZILIC ACID
2,2-DIPHENYL-2-HYDROXY ACETATE
.alpha.-hydroxy-.alpha.-phenyl-Benzeneaceticacid
TIMTEC-BB SBB003299
2,2-Diphenyl-2-hydroxyacetic acid
2-Hydroxy-2,2-diphenylacetic acid
2-Hydroxy-2,2-diphenylaceticacid
Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-
BENZILIC ACID, 99+%
BenzilicAcidForSynthesis
BENZILIC ACID (controlled chemical)
BENZILLIC ACID
Benzeneacetic acid, α-hydroxy-α-phenyl-
a,a-Diphenyl-a-hydroxyacetic acid
a,a-Diphenylglycolic acid
Acide diphenylhydroxyacetique
acidediphenylhydroxyacetique
a-Hydroxy-2,2-diphenylacetic acid
a-Hydroxy-a-phenylbenzeneacetic acid
a-Hydroxydiphenylacetic acid
alpha,alpha-Diphenyl-alpha-hydroxyacetic acid
alpha,alpha-Diphenylglycolic acid
alpha,alpha-diphenylglycolicacid
alpha-Hydroxy-2,2-diphenylacetic acid
alpha-Hydroxy-alpha-phenylbenzeneacetic acid
alpha-hydroxy-alpha-phenyl-benzeneaceticaci
alpha-hydroxy-alpha-phenylbenzeneaceticacid
benzilic
Benzylic acid
Diphenylglycollicacid
Diphenylhydroxyacetic acid
diphenylhydroxyaceticacid
Glycolic acid, diphenyl-
-Hydroxy-phenylbenzeneaceticacid
Mandelic acid, alpha-phenyl-
Pipenzolate Impurity 1(Benzilic Acid)
Trospium Impurity 1（Trospium EP Impurity A）
2,2-dicyclohexyl-2-hydroxyacetate
Trospium EP Impurity A
Trospium impurity A CRS