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CAS Number: 94-26-8
European Community (EC) Number: 202-318-7
Molecular Formula: C11-H14-O3
IUPAC name: Butyl 4-hydroxybenzoate
DESCRIPTION:
Butyl Paraben is a long-chained paraben in the form of a white, crystalline powder.
Butyl Paraben is highly effective in preventing the growth of fungi and bacteria and is non-irritating and has low toxicity levels.
Butyl Paraben can be used alone or combined with other parabens in a blend, and is used in toothpaste, mascara, lipstick, and eyeshadow.
Butyl parabens are a group of preservatives that are commonly used in cosmetics, pharmaceuticals, and food products to protect against microbial growth.
Butyl Paraben have been shown to have anti-inflammatory activity in humans and animals.
Butyl parabens may also be produced during the treatment of wastewater by benzalkonium chloride. Butyl Paraben concentrations were higher in the treated wastewater than in the untreated wastewater.
Butylparaben is toxic to 3T3-L1 preadipocytes, which may be due to its ability to inhibit protein synthesis and cell division.
The matrix effect caused by butylparaben on the substrate film has been studied extensively.
The reaction solution between p-hydroxybenzoic acid and butylparaben was investigated by applying it as a preservative onto a film of poly(vinyl acetate) at different rates of concentration.
Parabens are an uncommon cause of allergic contact dermatitis
Butyl Paraben is a skin irritant
Butyl Paraben Causes liver injury in feeding studies of mice
Butyl Paraben is a potential skin sensitizer
An eye and mild skin irritant
Butyl Paraben may cause skin sensitization
Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.
Butyl Paraben belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters.
These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group.
Butyl paraben, or butyl p-hydroxybenzoate, is an organic compound with the formula C4H9O2CC6H4OH.
Butyl paraben is a white solid that is soluble in organic solvents.
Butyl paraben has proven to be a highly successful antimicrobial preservative in cosmetics.
Butyl paraben is also used in medication suspensions, and as a flavoring additive in food.
Butylparaben is an organic molecular entity.
Butylparaben is a Standardized Chemical Allergen.
The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
Butyl paraben is a natural product found in Strychnos cathayensis with data available.
N-butyl-p-hydroxybenzoate appears as odorless white crystals or crystalline powder.
Butyl paraben is Tasteless, but numbs the tongue.
Butyl paraben is colorless solid; Insoluble in water (207 mg/L at 20 deg C)
Butyl paraben is Very hygroscopic.
Butyl paraben is white odorless solid
Butyl paraben is insoluble in water
Butyl paraben is Powder.
Butyl paraben is slightly soluble in water.
Butyl paraben, with the chemical formula of C11H14O3 is an antimicrobial preservative used in many cosmetics, as a food flavoring agent and as a suspending agent for medications.
Butyl paraben used in industry is synthetically created, but natural parabens also exist in nature.
All parabens have similar structure to estrogen.
Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%
CAS Number: 94-26-8
European Community (EC) Number: 202-318-7
Molecular Formula: C11-H14-O3
IUPAC name: Butyl 4-hydroxybenzoate
NATURAL OCCURRENCE OF BUTYL PARABEN:
Members of the paraben family are found in fruit and vegetable products, such as barley, flax seed, and grapes.
Butylparaben has also been found to be produced in some microorganisms including Microbulbifer.
PREPARATION OF BUTYL PARABEN:
Butyl paraben is prepared by the esterification of 4-hydroxybenzoic acid with 1-butanol in the presence of an acid catalyst such as sulfuric acid.
Butyl paraben is produced industrially.
MECHANISM OF ACTION:
The exact mechanism of how parabens work is unknown but they are proposed to act by inhibiting DNA and RNA synthesis, and enzymes like ATPase and phosphotransferase in some bacterial species. It has also been suggested that they interfere with membrane transport processes by disrupting the lipid bylayer and possibly causing the leakage of intracellular constituents
CAS Number: 94-26-8
European Community (EC) Number: 202-318-7
Molecular Formula: C11-H14-O3
IUPAC name: Butyl 4-hydroxybenzoate
CHEMICAL AND PHYSICAL PROPERTIES OF BUTYL PARABEN:
Category: Preservatives
Chemical formula: C11H14O3
Molar mass: 194.230 g•mol−1
Appearance: Colorless, odorless, crystalline powder
Melting point: 68 to 69 °C (154 to 156 °F; 341 to 342 K)
Solubility in water: Slightly soluble
Solubility in acetone, ethanol, chloroform, glycerin, propylene glycol: Soluble
Molecular Weight: 194.23
XLogP3: 3.6
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 5
Exact Mass: 194.094294304
Monoisotopic Mass: 194.094294304
Topological Polar Surface Area: 46.5 Ų
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 171
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Color/Form: Small, colorless crystals or powder
Odor: Odorless
Melting Point: 68-69°C
Flash Point: 181 °C
Solubility: less than 1 mg/mL at 63° F
Vapor Pressure: 0.000186 [mmHg]
LogP: 3.57
Henry's Law constant = 6.0X10-9 atm-cu m/mol at 25 °C (est)
Stability/Shelf Life:
Stable under recommended storage conditions.
Autoignition Temperature: 495 °C
Decomposition : When heated to decomposition it emits acrid smoke and irritating fumes.
Dissociation Constants: pKa = 8.47
CAS Number: 94-26-8
European Community (EC) Number: 202-318-7
Molecular Formula: C11-H14-O3
IUPAC name: Butyl 4-hydroxybenzoate
TAXONOMY OF BUTYL PARABEN:
Kingdom: Organic compounds
Super Class: Benzenoids
Class: Benzene and substituted derivatives
Sub Class: Benzoic acids and derivatives
Direct Parent: p-Hydroxybenzoic acid alkyl esters
Alternative: Parents
• Benzoyl derivatives
• 1-hydroxy-2-unsubstituted benzenoids
• Carboxylic acid esters
• Monocarboxylic acids and derivatives
• Organooxygen compounds
• Organic oxides
• Hydrocarbon derivatives
USES OF BUTYL PARABEN:
Butyl paraben is a Butyl Parahydroxybenzoate mainly used as an antiseptic in cosmetics.
Many cosmetic products make use of parabens.
Butyl paraben can be found in shaving creams, moisturizers, shampoos, lubricants, and other cosmetic products where they serve as fungicidal and bacteriocidal agents.
Commercially used parabens are synthetically produced, though many are similar, if not identical, to parabens appearing in nature.
Butylparaben is also used as a suspension fluid in many medications.
Butyl paraben is Used as an antifungal agent, preservative in antiseptic creams, food preservative, and pharyngeal antiseptic
The parabens (methyl, ethyl, propyl, and butyl) were the most widely used preservatives in cosmetics (0.1% to 0.8%) until their sensitizing potential was recognized
Butyl paraben is one of the most common bactericidal/fungicidal additives in cosmetics.
Butyl paraben has been used in cosmetic products since the 1940s and in pharmaceutical products since 1924.
The popularity of butylparaben in these products is due to its low toxicity in humans and its effective antimicrobial properties, in particular those against mold and yeast.
Butyl paraben is now found in more than 20,000 cosmetic products including eye shadow, facial moisturizer/treatment, anti-aging cream, foundation, and sunscreen.
Butyl paraben is also used as low-ionic strength solutions as a preservative in some foods and drugs.
In most cosmetics paraben is used at low levels, ranging from 0.01 to 0.3%.
Butyl paraben is used in low concentrations in liquid and solid medication suspensions, such as Tylenol (acetaminophen) and ibuprofen.
CAS Number: 94-26-8
European Community (EC) Number: 202-318-7
Molecular Formula: C11-H14-O3
IUPAC name: Butyl 4-hydroxybenzoate
SAFETY INFORMATION ABOUT BUTYL PARABEN:
First aid measures:
Description of first aid measures:
General advice:
Show this material safety data sheet to the doctor in attendance.
If inhaled:
After inhalation: fresh air.
In case of skin contact:
In case of skin contact: Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
In case of eye contact:
After eye contact: rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed:
After swallowing: immediately make victim drink water (two glasses at most).
Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling
Indication of any immediate medical attention and special treatment needed
Firefighting measures:
Extinguishing media
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
Special hazards arising from the substance or mixture
Nature of decomposition products not known.
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters:
Stay in danger area only with self-contained breathing apparatus.
Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts.
Avoid substance contact.
Ensure adequate ventilation.
Evacuate the danger area, observe emergency procedures, consult an expert.
Environmental precautions:
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7 and 10).
Take up dry. Dispose of properly.
Clean up affected area.
Avoid generation of dusts.
Reference to other sections
Handling and storage:
Precautions for safe handling
Conditions for safe storage, including any incompatibilities
Storage conditions:
Tightly closed.
Dry.
Exposure controls/personal protection:
control parameter
Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.
Exposure controls
Personal protective equipment:
Eye/face protection:
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin protection:
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use.
When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
Body Protection:
protective clothing
Respiratory protection:
required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type: Filter type P2
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.
Stability and reactivity:
Reactivity:
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
Incompatible materials:
Strong oxidizing agents
CAS Number: 94-26-8
European Community (EC) Number: 202-318-7
Molecular Formula: C11-H14-O3
IUPAC name: Butyl 4-hydroxybenzoate
SYNONYMS
MeSH Entry Terms:
butyl-p-hydroxybenzoate
butylparaben
Depositor-Supplied Synonyms:
Butyl 4-hydroxybenzoate
BUTYLPARABEN
94-26-8
Butyl paraben
Butyl p-hydroxybenzoate
Nipabutyl
Butoben
Butyl chemosept
Butyl parasept
Tegosept B
Butyl tegosept
Butyl butex
Tegosept Butyl
Aseptoform butyl
Preserval B
Butyl parahydroxybenzoate
Solbrol B
n-Butyl p-hydroxybenzoate
Butyl-Parasept
4-(Butoxycarbonyl)phenol
Benzoic acid, 4-hydroxy-, butyl ester
n-butyl 4-hydroxybenzoate
n-Butyl parahydroxybenzoate
n-Butyl hydroxybenzoate
n-Butyl-p-hydroxybenzoate
4-Hydroxybenzoic acid butyl ester
FEMA No. 2203
Benzoic acid, p-hydroxy-, butyl ester
butyl p-hydroxy benzoate
n-Butyl-paraben
p-Hydroxybenzoic acid butyl ester
Lexgard B
n-Butyl-4-hydroxybenzoate
UNII-3QPI1U3FV8
NSC 8475
Butylparaben (NF)
Butylparaben (TN)
Butylparaben [NF]
SPF
p-Hydroxybenzoic acid, butyl ester
4-Hydroxybenzoic acid, butyl ester
p-Hydroxybenzoic butyl ester
3QPI1U3FV8
Butyl parahydroxybenzoate (TN)
CHEBI:88542
CAS-94-26-8
NCGC00016354-03
DSSTox_CID_209
DSSTox_RID_75434
DSSTox_GSID_20209
Butylparaben [USAN]
butyl-p-hydroxybenzoate
Caswell No. 130A
FEMA Number 2203
n-Butyl paraben
Butyl Par asept
SMR000462402
CCRIS 2462
HSDB 286
NSC-13164
p-Hydroxy butyl benzoate
SR-01000389296
p-Hydroxybenzoic acid n-butyl ester
EINECS 202-318-7
EPA Pesticide Chemical Code 061205
BRN 1103741
butyl-paraben
AI3-02930
27K
MFCD00016478
Butyl Paraben-[d9]
4mg9
Prestwick0_000894
Prestwick1_000894
Prestwick2_000894
Prestwick3_000894
WLN: QR DVO4
cid_7184
SCHEMBL3647
BSPBio_000708
Butyl //p//-Hydroxybenzoate
MLS000575004
MLS002154054
MLS002303045
BIDD:ER0231
SPBio_002917
BPBio1_000780
CHEMBL459008
F0266-0124
N-Butyl-P-Hydroxybenzoate,(S)
DTXSID3020209
BDBM23448
FEMA 2203
NSC8475
Butyl parahydroxybenzoate (JP15)
Butyl parahydroxybenzoate (JP17)
Butyl 4-hydroxybenzoate, >=99%
BUTYL PARA HYDROXY BENZOATE
HMS1570D10
HMS2094A21
HMS2097D10
HMS2220G15
HMS3327P04
HMS3714D10
Pharmakon1600-01505995
HY-B1431
NSC-8475
ZINC1586769
4-Hydroxybenzoic acid-n-butyl ester
Tox21_110393
Tox21_201785
Tox21_300332
NSC759303
p-Hydroxybenzoic acid, n-butyl ester
s4584
AKOS000121421
Tox21_110393_1
CCG-213596
CS-4783
DB14084
MCULE-3352613586
NSC-759303
Butyl 4-?Hydroxybenzoate(Butyl Paraben)
NCGC00016354-01
NCGC00016354-02
NCGC00016354-04
NCGC00016354-05
NCGC00016354-06
NCGC00016354-07
NCGC00016354-11
NCGC00091142-01
NCGC00091142-02
NCGC00254294-01
NCGC00259334-01
AC-34535
AS-14309
K716
SBI-0206946.P001
Butyl 4-hydroxybenzoate, >=99.0% (GC)
DS-010619
AB00513951
B3771
FT-0623315
H0210
A16382
D01420
AB00513951_09
A844895
Q3302873
SR-01000389296-1
SR-01000389296-3
W-100204
BRD-K08287586-001-03-6
BRD-K08287586-001-08-5
Butyl 4-hydroxybenzoate, SAJ first grade, >=99.0%
Z291799028
4-Hydroxybenzoic acid-n-butyl ester 1000 microg/mL in Acetonitrile
