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CALCIUM ACETATE

CAS NUMBER: 62-54-4

EC NUMBER: 200-540-9

MOLECULAR FORMULA: (CH3CO2)2Ca

MOLECULAR WEIGHT: 158.17

 

Calcium acetate is a chemical compound which is a calcium salt of acetic acid. 
Calcium acetate has the formula Ca(C2H3O2)2. 
Calcium acetates standard name is calcium acetate, while calcium ethanoate is the systematic name. 
An older name is acetate of lime. 
The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2•H2O) is the common form.

Calcium Acetate is a calcium salt of acetic acid. 
Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. 
Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.

Calcium acetate is the calcium salt of acetic acid. 
Calcium acetate is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces. 
Calcium acetate has a role as a chelator. 

Calcium acetate contains an acetate.
The chemical compound calcium acetate is the calcium salt of acetic acid. 
Calcium acetate has been commonly referred to as the acetate of lime. 
The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.

 

PRODUCTION:

Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as limestone or marble) or hydrated lime in vinegar:

CaCO3(s) + 2CH3COOH(aq) → Ca(CH3COO)2(aq) + H2O(l) + CO2(g)
Ca(OH)2(s) + 2CH3COOH(aq) → Ca(CH3COO)2(aq) + 2H2O(l)

Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

 


USES:

Calcium acetate is used to control high blood levels of phosphorus in people with kidney disease who are on dialysis (medical treatment to clean the blood when the kidneys are not working properly). 
Calcium acetate is in a class of medications called phosphate binders. 
Calcium acetate binds phosphorus that you get from foods in your diet and prevents it from being absorbed into your blood stream.

-In kidney disease, blood levels of phosphate may rise (called hyperphosphatemia) leading to bone problems. 

-Calcium acetate binds phosphate in the diet to lower blood phosphate levels.

-Calcium acetate is used as a food additive, as a stabilizer, buffer and sequestrant, mainly in candy products under the number E263.

-Calcium acetate has been found to be a better alternative; being soluble, it requires less skill and a smaller amount.

-Because Calcium acetate is inexpensive, calcium acetate was once a common starting material for the synthesis of acetone before the development of the cumene process: Ca(CH3COO)2 → CaCO3(s) + (CH3)2CO

-A saturated solution of calcium acetate in alcohol forms a semisolid, flammable gel that is much like "canned heat" products such as Sterno.

-Chemistry teachers often prepare "California Snowballs", a mixture of calcium acetate solution and ethanol.

-The resulting gel is whitish in color, and can be formed to resemble a snowball.

 

HOW SHOULD CALCIUM ACETATE BE USED:

Calcium acetate comes as a capsule, tablet, and a solution (liquid) to take by mouth. 
Calcium acetate is usually taken along with each meal (e.g., 3 times a day if you eat 3 meals a day) as directed by your doctor. 
Take calcium acetate at around the same times every day. 
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. 
Take calcium acetate exactly as directed. 

Do not take more or less of it or take it more often than prescribed by your doctor.
If you are using the solution, do not use a household spoon to measure your dose. 
Use the dosing cup that comes with the medication to measure your dose. 
Ask your pharmacist if you have any question about how much medication you should take or how to use the dosing cup.
Your doctor will probably adjust your dose based on your phosphorus blood levels, not more often than once every 2 to 3 weeks.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

 

STORAGE:

Keep this medication in the container it came in, tightly closed, and out of reach of children. 
Store Calcium acetate at room temperature and away from excess heat and moisture (not in the bathroom).
Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. 
Calcium acetate decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.

 

NATURAL OCCURENCE:

Pure calcium acetate is yet unknown among minerals. 
Calcium acetate is listed as a known mineral, but its genesis is likely anthropogenic (human-generated, as opposed to naturally occurring) and it may soon be discredited.

 

SYNONYM:

62-54-4
Calcium diacetate
Acetic acid, calcium salt
Lime acetate
Lime pyrolignite
Acetate of limeacetic acid calcium salt
Gray Acetate of Lime
Brown Acetate of Lime
calcium;diacetate
calcium ethanoate
FEMA No. 2228
UNII-Y882YXF34X
calcium(II) acetate
PhosLo
CHEBI:3310
Y882YXF34X
Teltozan
Brown acetate
Sorbo-calcion
Vinegar salts
Gray acetate
Phoslo Gelcaps
Acetic acid, calcium salt (2:1)
Calcium di(acetate)
Phoslyra
Ca(OAc)2
SanopanCCRIS 4921
HSDB 928
EINECS 200-540-9
Calcium acetate 
AI3-02903
Calcarea acetica
calcium acetate salt
Phoslo (TN)
Calcium Acetate, FCC
Calcium acetate (USP)
Calcium acetate anhydrous
Calcium acetate, anhydrous
EC 200-540-9
Calcium Acetate 23% 10M
SCHEMBL23872
INS NO.263
CHEMBL1200800
DTXSID0020234
INS-263
Calcium Acetate 
AMY23411
MFCD00012448
AKOS015904560
DB00258
E263
E-263
FT-0623376
FT-062337
D00931CIS,CIS-1,3,5-CYCLOHEXANETRICARBOXYLICACID
Q409251
calcium diacetate, CAc - acetic acid, calcium salt
J-519530

 

PHYSICAL AND CHEMICAL INFORMATION:

-Density: 1.5 g/cm3 (20 °C)

-Ignition temperature: 680 - 730 °C

-pH value: 7.2 - 7.8 (50 g/l, H₂O, 20 °C)

-Bulk density: 400 kg/m3

-Solubility: 400 g/l

 

SPECIFICATION:

-Appearance of solution (100 g/l, water): clear and colorless

-pH (50 g/l; water): 7.2 - 7.8

-Total nitrogen (N): ≤ 0.002 %

-Chloride (Cl): ≤ 100 ppm

-Sulphate (SO₄): ≤ 1000 ppm

-Heavy metals (as Pb): ≤ 10 ppm

-Fe (Iron) ≤ 10 ppm

-K (Potassium): ≤ 0.02 %

-Na (Sodium): ≤ 0.02 %

 

DESCRIPTION:

Calcium acetate is used to treat hyperphosphatemia (too much phosphate in the blood) in patients with end stage kidney disease who are on dialysis.
Calcium acetate works by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.

Calcium acetate is a phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.
This medicine is available only with your doctor's prescription.
Calcium acetate is available in the following dosage forms:

-Solution

-Tablet

-Capsule

 


BACKGROUND:

The chemical compound calcium acetate is the calcium salt of acetic acid. 
Calcium acetate has been commonly referred to as the acetate of lime. 
The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.
Calcium acetate is used to prevent high blood phosphate levels in patients who are on dialysis due to severe kidney disease. 
Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced. 
Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and possibly decrease the risk of heart disease and strokes that can result from high phosphate levels. 

Calcium acetate is a natural mineral that works by holding onto phosphate from the diet so that it can pass out of your body.
Calcium acetate, on the other hand, is more soluble at a higher pH.
Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure who are on dialysis.

Calcium Acetate is available as white powder or agglomerate. 
These two versions are chemically identical and differ only in physical form. 
The agglomerate offers the properties on non-dustiness, improved wettability, higher reactivity, higher bulk density, and improved free-flow ability.
Calcium acetate may also be used for purposes not listed in this medication guide.

 

HOW TO USE CALCIUM ACETATE:

If you are taking the over-the-counter product to self-treat, read and follow all directions on the product package before taking this medication. 
If you have any questions, consult your pharmacist. 
If your doctor has prescribed this medication, take it as directed.
This medication is usually taken by mouth with each meal. 

The dosage is based on your medical condition and response to treatment.
If you are using the liquid form, use a medication-measuring device or spoon to carefully measure the prescribed dose. 
Do not use a household spoon because you may not get the correct dose.
Use this medication regularly in order to get the most benefit from it. 
Remember to take Calcium acetate with each meal every day or on the schedule given to you by your doctor.

 


PROPERTIES:

-Compound Formula: C4H6CaO4

-Molecular Weight: 158.17

-Appearance: White powder

-Melting Point: 160°C

-Density: 1.509 g/cm3

-Exact Mass: 157.9892

-Monoisotopic Mass: 157.9892

 


CHEMICAL IDENTIFIERS:

-Linear Formula: Ca(C2H3O2)2

-Beilstein/Reaxys No.: 3692527

-Pubchem CID: 6116

-IUPAC Name: calcium; diacetate

 


WHAT IS CALCIUM ACETATE:

Calcium acetate is a medication used to bind excess phosphate. 
Calcium acetate is primarily used in patients with chronic kidney disease, as abnormally high phosphate levels occur with this disease.

 

HOW IS CALCIUM ACETATE GIVEN:

Calcium acetate is given by mouth and with food in the form of a tablet, a capsule, or a liquid solution. 
Your veterinarian may prescribe additional doses between meals, but it should primarily be given with meals. 
Measure liquids carefully.
Calcium acetate should take effect within 1 to 2 hours; however, its effects may not be visibly noticeable and therefore laboratory tests may need to be done to evaluate this medication’s effectiveness.

 

APPLICATION:

Calcium acetate hydrate is used as a precursor to produce calcium ions in the development of calcium oxide based mesoporous carbon dioxide sorbent. 
Calcium acetate is an active component of pyroligneous acid-modified limestone. 
Calcium acetate is employed in the preparation of magnetite-calcium phosphate core-shell nanoparticles. 
Calcium acetate serves as a raw material in the preparation of hydroxyapatite-wollastonite composites. 
Calcium acetate acts as a crosslinking agent in the microfluidic production of alginate hydrogel microbeads. 
In addition to this, Calcium acetate is used to induce crystallization of proteins.

 

GENERAL INFORMATION:

Calcium Acetate formula, also known as Calcium Diacetate formula or Acetate Of Lime formula is explained in this article. 
Calcium acetate is the calcium salt of acetic acid. 
Calcium acetate consists of four carbon atoms, six hydrogen atoms, one calcium atom, and four oxygen atoms. 
The chemical or molecular formula of Calcium Acetate is C4H6CaO4.

Calcium acetate is colourless to white crystalline solid which has a slight odour of acetic acid. 
Calcium acetate dissolves in water and alcohol and is insoluble in benzene and acetone. 
In its anhydrous form is strongly hygroscopic and therefore occurs as monohydrate in its common form. 
Calcium acetate can be obtained by soaking calcium carbonate or hydrated lime in vinegar. 

Calcium acetate is widely used in food products as a food additive, buffer, sequestrant, and as a stabilizer.
Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure who are on dialysis.
Calcium acetate is colorless and white crystalline solid having a slight odor of acetic acid. 
Calcium acetate can be dissolved in water and alcohol and but it is insoluble in benzene and acetone. 

In Calcium acetates anhydrous form, it is strongly hygroscopic and therefore occurs as monohydrate in its common form.
Calcium acetate can be obtained by soaking the calcium carbonate or hydrated lime in the vinegar solution. 
Calcium acetate is widely in use in a variety of food products as a food additive, buffer, sequestrate, and as a stabilizer.
Calcium acetate is useful for medical treatment to patients with kidney disease. 

Calcium acetate is also a food additive and largely in use as a chelator. 
In the past, it was in use as a precursor in the synthesis of acetone.
Calcium acetate is also useful to prevent high blood phosphate levels in patients who are on dialysis. 
Calcium acetate is a natural mineral that works by holding onto phosphate from the diet so that it can pass out of the human body.

 

PROPERTIES:

-Chemical formula: C4H6CaO4

-Molecular weight: 158.166 g/mol

-Density: 1.509 g/cm3

-Refractive index: 1.55

-Melting point: 160°C

 

CHARACTERISTICS:

Calcium acetate is a white, hygroscopic, acetic acid-like odor solid. 
Calcium acetates density is 1.509 g m L−1. 
Calcium acetate melting point is 160 degrees C and it is soluble in water. 
Calcium acetate is slightly soluble in methanol and insoluble in ethanol and acetone.

Calcium acetate is a chelator, it means this molecule can form a different type of coordinated bond name “chelation”. 
This is because it has a metallic atom that can bond with other chemical ions.
Calcium atom available in the molecule is very useful to treat the excess of phosphate in the blood. 
This is because it can react to form calcium phosphate, which is insoluble and can be easily excreted.

Calcium acetate may be used to make an aluminum acetate mordant. 
Calcium acetate is an alternative to sodium acetate. 
Calcium acetate is a prescription medication used to treat elevated blood phosphate levels in end stage kidney failure. 
Calcium acetate belongs to a group of drugs called phosphate binders, which work by binding  phosphorous in the gut and preventing its absorption in the body.

 

DESCRIPTION:

Calcium acetate is a water-soluble compound that has been used for aqueous and nonaqueous neutralization and alkalization of paper. 
However, during the neutralization process, calcium acetate is converted to calcium carbonate with the release of acetic acid. 
Any residual calcium acetate will continue to release acetic acid. 
Calcium acetate has also been used to reintroduce calcium ions into weathered glass.
Calcium acetate is used commercially as a mordant in dyeing and printing textiles, for liming rosin, for curing and tanning skins, and as a metallic soap.

 

PHYSICAL AND CHEMICAL PROPERTIES:

-Rod-shaped crystals.

-Soluble in water (pH = 7.6 for 0.2M solution).

-Slightly soluble in methanol. Insoluble in ethanol, acetone, benzene.

 


APPLICATION:

Calcium acetate monohydrate is used to precipitate oxalates in solution. 
Calcium acetate is used to control the phosphate levels in blood, thereby controlling the bone problems. 
Calcium acetate is also involved in the neutralization of fluoride in water. 
Further, Calcium acetate is used as a food additive mainly in candy products. 
In addition to this, Calcium acetate serves as a stabilizer, buffer and sequestrant.

Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. 
Calcium acetate is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life.
Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. 
Calcium acetate contains approximately 25% calcium. 
Calcium acetate is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. 

Calcium acetates solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.
Calcium Acetate is a salt of acetic acid (A167640), a common chemical reagent used in a multitude of organic reactions. 
Calcium acetate is the primary constituent of vinegar, contributing to its distinct taste and odor. 
Calcium acetate is used in the synthesis of dye-sensitized solar cells.

 

GENERAL DESCRIPTION:

Calcium Acetate belongs to the group of calcium salts, widely used as phosphorus binders in patients with chronic renal failure.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

 


IUPAC NAME:

Acetic acid, calcium salt
calcium (di)stearate
Calcium Acetate
Calcium acetate
Calcium acetate
Calcium acetate monohydrate
calcium bis(acetate)
calcium di(acetate
Calcium di(acetate)
calcium di(acetate)
Calcium di(acetate)
calcium di(acetate)
Calcium diacetate
calcium diacetate
Calcium diacetate
calcium ethanoate
calcium;diacetate

 

 

 

 

 

 

 

 

 

 

 

 

 

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