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CAS NO:813-94-5
EC NO:212-391-7
E number: E333
Calcium citrate is the calcium salt of citric acid.
Calcium citrate is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate.
Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass. The tetrahydrate occurs in nature as the mineral Earlandite.
Chemical properties
Calcium citrate is sparingly soluble in water. Needle-shaped crystals of tricalcium dicitrate tetrahydrate [Ca3(C6H5O7)2(H2O)2]·2H2O were obtained by hydrothermal synthesis. The crystal structure comprises a three-dimensional network in which eightfold coordinated Ca2+ cations are linked by citrate anions and hydrogen bonds between two non-coordinating crystal water molecules and two coordinating water molecules.
Production
Calcium citrate is an intermediate in the isolation of citric acid from the fungal fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by limewater, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
3 Ca(OH)2(s) + 2 C6H8O7(l) → Ca3(C6H5O7)2(s) + 6 H2O(l)
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.
Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent.
Uses
*In the production of citric acid amd other citrates; improvement of baking properties of flour
*Dietary supplement; sequestrant, buffer and firming agent in foods; medicine
*Acidity regulator (flour, jams, soft drinks, confectionery)
General description
Thermal decomposition of calcium citrate tetrahydrate in dynamic air or dry nitrogen has been investigated by by TG, DTA and DSC.
Application
Calcium citrate tetrahydrate may be used as raw material in the preparation of nanoparticle with the nominal composition Ca0.8 Ba0.2 Ti03 :Pr3+, via sol-gel process.
Calcium citrate may be employed as carbon source in a simple and effective carbonization method to prepare porous carbon without any activation process.
Calcium citrate is suitable for use in the preparation of bovine serum albumin (BSA) nanoparticles.
Description
Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid.
Calcium citrate is present in foods which have naturally occurring citric acid.
Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
Calcium citrate may be chemopreventive for colon and other cancers.
Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt.
Calcium citrate is also used to improve the baking properties of flours and as a stabilizer.
Description
Calcium citrate is the calcium salt of citric acid.
Calcium citrate is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate.
Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions.
Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal).
Calcium makes up 21% of calcium citrate by weight.
Chemical Properties
white powder or white to colourless crystals
Production Methods
Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.
Calcium Citrate can be used as a dietary ingredient and as a nutrient.
Calcium Citrate is known to be used in pharmaceutical applications.
UseNutrient; Dietary Ingredient; Pharmaceuticals
DescriptionFine, white powder with characteristic odor
Appearance: white fine powder (est)
Assay: 97.50 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 309.00 to 310.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.000057 mmHg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.00 °C. )
logP (o/w): -1.721 (est)
Odor: characteristic
Use:
Calcium Citrate is mainly used as a food additive as a preserver, flavor enhancer, or firming agent.
Calcium Citrate can also be used in dietary supplements, as a chemical buffer, water softener, and a sequestrating agent.
Appearance:
white powder or white to colourless crystals
Act as chelant, buffer, coagulant and calcareous intensifying agent in food industry.
Calcium Citrate is chiefly used in bakery, dairy and beverages industries.
Properties: Odorless powder. Loses most of its water at 100° and all at 120°. Sol in 1050 parts cold water; somewhat more sol in hot water. Insol in alcohol.
Use: In foods as calcium fortifier; as anticaking agent in dry mixes.
GROUPS / USES
*Buffering Agents
*Food & Beverage
*Food Additives
*Preservatives
1. As a food calcium fortifier, calcium citrate has a better absorption effect than inorganic calcium.
2. Calcium citrate can be used as chelating agent, buffer, tissue coagulant, calcium fortifier, emulsifying salt, etc.
3. Calcium citrate is a calcium salt derived from citric acid.
Calcium citrate is used as a nutritional supplement for the prevention and treatment of calcium deficiency.
Calcium citrate can promote tooth and bone health and help lose weight.
About this substance
Helpful information
Calcium citrate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.
Calcium citrate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
Calcium citrate is used in the following products: adhesives and sealants, adsorbents, air care products, biocides (e.g. disinfectants, pest control products), coating products, fillers, putties, plasters, modelling clay, fertilisers, inks and toners, pH regulators and water treatment products, laboratory chemicals, perfumes and fragrances, photo-chemicals, polishes and waxes, textile treatment products and dyes, washing & cleaning products, water softeners, water treatment chemicals and cosmetics and personal care products.
Other release to the environment of Calcium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).
Article service life
Release to the environment of Calcium citrate can occur from industrial use: in the production of articles.
Other release to the environment of Calcium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).
Calcium citrate can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and wood (e.g. floors, furniture, toys).
Calcium citrate is intended to be released from scented: paper products.
Widespread uses by professional workers
Calcium citrate is used in the following products: biocides (e.g. disinfectants, pest control products), fertilisers, laboratory chemicals, adsorbents, air care products, coating products, fillers, putties, plasters, modelling clay, inks and toners, perfumes and fragrances, photo-chemicals, polishes and waxes, textile treatment products and dyes, washing & cleaning products, water softeners, water treatment chemicals and cosmetics and personal care products.
Calcium citrate is used in the following areas: building & construction work, health services, mining, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging.
Calcium citrate is used for the manufacture of: machinery and vehicles and furniture.
Release to the environment of Calcium citrate can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles.
Other release to the environment of Calcium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).
Formulation or re-packing
Calcium citrate is used in the following products: air care products, fertilisers, polishes and waxes, washing & cleaning products, laboratory chemicals and perfumes and fragrances.
Release to the environment of Calcium citrate can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and formulation in materials.
Other release to the environment of Calcium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.
Uses at industrial sites
Calcium citrate is used in the following products: pH regulators and water treatment products, polishes and waxes, washing & cleaning products and water treatment chemicals.
Calcium citrate is used in the following areas: mining, health services, formulation of mixtures and/or re-packaging and building & construction work.
Calcium citrate is used for the manufacture of: machinery and vehicles, metals, fabricated metal products, electrical, electronic and optical equipment, textile, leather or fur and chemicals.
Release to the environment of Calcium citrate can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, formulation of mixtures and as processing aid.
Other release to the environment of Calcium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Manufacture
Release to the environment of Calcium citrate can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials and in processing aids at industrial sites.
Appearance
White powder
Usage
Food additive, Industrial emulsifier
Calcium citrate is the calcium salt of citric acid.
Calcium citrate is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate.
Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions.
Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass.
Calcium citrate is used to prevent and to treat calcium deficiencies.
Calcium citrate may also be used for other purposes not listed in this medication guide.
Calcium citrate is commonly used as a food additive, as a preservative, but sometimes for flavour.
Calcium citrate is also found in some dietary calcium supplements.
Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions.
IUPAC names
2-hydroxy-1,2,3-propane- tricarboxylic acid calcium salt (2:3)
2-hydroxypropane-1,2,3-tricarboxylate
calcium citrates
tri-Calcio di-Citrato 4-hidrato
Tricalcium 2-hydroxypropane-1,2,3-tricarboxylate
tricalcium bis(2-hydroxypropane-1,2,3-tricarboxylate)
Tricalcium Citrate
Tricalcium dicitrate
tricalcium dicitrate
tricalcium;2-hydroxypropane-1,2,3-tricarboxylate
SYNONYMS:
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt (2:3) [ACD/Index Name]
Calcium 2-hydroxy-1,2,3-propanetricarboxylate (3:2) [ACD/IUPAC Name]
Calcium 2-hydroxypropane-1,2,3-tricarboxylate (3:2)
Calcium citrate [USP] [Wiki]
Calcium-2-hydroxy-1,2,3-propantricarboxylat (3:2) [German] [ACD/IUPAC Name]
Citrate de calcium (2:3) [French] [ACD/IUPAC Name]
12405-04-8 [RN]
212-391-7 [EINECS]
2-Hydroxy-1,2,3-propanetricarboxylic acid calcium salt
2-Hydroxy-1,2,3-propanetricarboxylic acid calcium salt (2:3)
5785-44-4 [RN]
7693-13-2 [RN]
813-94-5 [RN]
86117BWO7P
Acicontral
Calcium 2-hydroxypropane-1,2,3-tricarboxylate
Calcium citrate [USAN] [USAN]
CALCIUM CITRATE ANHYDROUS
1,2,3-Propanetricarboxylicacid,2-hydroxy-,calciumsalt(2:3)
2,3-propanetricarboxylicacid,2-hydroxy-calciumsalt(2:3)
acicontral
citricacid,calciumsalt(2:3)
citrical
tribasiccalciumcitrate
citric acid sesquicalcium tetrahydrate
Tricalcium Citrate anhydrous
CalciumCitrate/TriCalciumCitrateCalciumCitrateUsp/Fcc
(tri)Calcium(di)citrate,tribasic,anhydrous
Calciumcitrateanhydrous
CALCIUM CITRATE, PHARMA
CALCIUM CITRATE TRIBASIC 4-HYDRATE, PHARMA
Tricalcium dicitrate (anhydrous)
CALCIUM CITRATE USP
DICALCIUMCITRATE
CALCIUMSALTSOFCITRICACID
2-Hydroxy-1,2,3-propanetricarboxylic acid calcium salt (2:3)
