CMIT/MIT 14%

CMIT/MIT 14%

CAS NO : 55965-84-9

SYNONYM : 5-chloro-2-methyl-2h-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one; EXOCIDE CC;  CMIT (5-Chloro-2-methylisothiazolin-3-one ) + MIT (2-Methylisothiazolin-3-one ); 55965-84-9; Kathon 886; Kathon biocide; Kathon CG; Bio-Perge; Kathon LX; Kathon WT; ProClin 300; Microcide III; Legend MK; Kathon 886MW; Kathon CG/ICP II; Slaoff 360; Kathon 886 W; Kathon RH 886; MBC 215; Tret-O-Lite XC 215; 2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(14%in H2O); 3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone; 5-Chloro-2-methyl-3(2H)-isothiazolone mixt. with 2-methyl-3(2H)-isothiazolone; 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one; 3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with2-methyl-3(2H)-isothiazoloneOTHER CA INDEX NAMES:3(2H)-Isothiazolone, 2-methyl-, mixt. contg.; Isothiazolinone chloride; 2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1); C8H9ClN2O2S2; 2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one (1:1); 2-Methylisothiazol-3(2H)-one 5-chloro-2-Methylisothiazol-3(2H)-one; 2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1) 14% in water; 2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(14%in H2O) 55965-84-9; Isothiazolinone chloride; Kathon 886; Kathon CG; CMIT/MIT mixture; 5-Chloro-2-methyl-3(2H)-isothiazolone mixt. with 2-methyl-3(2H)-isothiazolone; Chloromethylisothiazolione/Methylisothiazolinone (75%/25%); CMI/MI; MCI/MI; CIT/MIT; Microcare IT; Microcare ITL; Acticide 14; Acticide LGMicrocide III; ProClin 300; Slaoff 360; Somacide RS; Tret-O-Lite XC 215; Zonen F; Other RN: 229619-22-1, 70294-89-2, 72980-78-0, 96118-96-6

Appearance: Light yellow liquid
PH (Not Diluted): <4
Specific gravity (25 degrees):> 1,25 g / cm3
CMIT Content (HPLC): 10.1-11.5%
MIT Content (HPLC): 2.6-3.5%
Applications: Industrial cooling water, filling water and paper production lines of oil fields, coating, paint, latex and so on. It is widely used for.
Description: The characters are as follows:
1. Wide spectrum disinfectant function: It effectively disinfects algae bacteria and fungi.
2. No environmental pollution: After dilution to use the concentration, it is readily reduced to non-toxic and non-polluting materials by the microorganism.
3. Good solubility in water: Good compatibility with various formulations and suitable for wide pH values.
Application Method: CMIT/MIT 14% is in a liquid state, can be added directly to the consumables and then evenly mixed under normal temperature. Add 500-1000 g material per ton. The above data are declared to be based on our knowledge and experience; Due to many different factors, this data should not be independent of the controls and tests when processing and using the product.
CMIT/MIT 14% is an isothiazolinone and preservative agent with antimicrobial and antifungal properties.
Methylchloroisothiazolinone (CMIT) is an isothiazolinone(MIT) commonly used as a preservative with antibacterial and antifungal properties. CMIT/MIT 14% is found within many commercially available cosmetics, lotions, and makeup removers. CMIT/MIT 14% is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013. Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.

CMIT/MIT 14% is microbiocide.
5-Chloro-2-methyl-4-isothiazolinone (CMIT) is a crystalline solid. CMIT has a pungent odor when it is mixed with 2-methyl-3(2H)-isothiazolinone (methylisothiazolinone; MIT) at a 3:1 ratio. CMIT/MIT 14% is very soluble in water. USE: CMIT is used an antimicrobial preservative in household cleaners, paints, human and pet shampoos, car maintenance products, and water storage units. It is commonly found in biocide products that also contain MIT at a 3:1 ratio. CMIT/MIT 14% is a component of cutting fluid. CMIT is an ingredient in over 101 pesticide formulations. EXPOSURE: Workers who use or produce CMIT may be breathe in mists or have direct skin contact. The general population is exposed through skin contact when using shampoos. Exposure can occur from breathing in vapors from cleaning and paint products containing CMIT. If CMIT is released to air, CMIT/MIT 14% will be broken down by reaction with other chemicals and light. If released to water or soil, CMIT/MIT 14% is not expected to bind to soil particles or suspended particles. CMIT/MIT 14% is expected to move through soil. CMIT/MIT 14% is not expected to move into air from wet soils or water surfaces. CMIT is expected to be broken down by microorganisms. However CMIT/MIT 14% is not biodegradable at high concentrations. CMIT/MIT 14% is not expected to build up in tissues of aquatic organisms. RISK: No information on toxic effects in humans following exposure to CMIT was identified. Potential health effects following exposure to CMIT in laboratory animals have only been assessed using CMIT/MIT 14%. Severe skin irritation, allergic skin reactions, and eye corrosion were observed in laboratory animals exposed to CMIT/MIT 14%. The U.S. EPA's Office of Pesticide Program considers the MIT and MIT mixtures are highly toxic. However, mixtures are not expected to cause adverse health effects if used according to directions. Death occurred in some laboratory animals exposed once to moderate doses of CMIT/MIT 14% by the oral, dermal and inhalation routes. Decreased body weight and erosion of the lining of the stomach were observed in laboratory animals fed low doses of CMIT/MIT 14% in their diet over time. Decreased body weight and minor damage to the lining of the nose were observed in laboratory animals that breathed low levels of CMIT/MIT 14% vapors over time. No evidence of infertility, abortions or birth defects was observed in laboratory animals orally exposed to CMIT/MIT 14% before or during pregnancy. Tumors were not increased in laboratory animals following lifetime exposure to CMIT/MIT 14% in their drinking water. The U.S. EPA's Office of Pesticide Program determined that CMIT/MIT 14% is not classifiable as to human carcinogenicity. The potential for CMIT to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 13th Report on Carcinogens. (SRC)

Type of Pesticide CMIT/MIT 14%: Microbiocide/Microbiostat (slime-forming bacteria, fungi, and algae), Fungicide (mold and mildew, sapstain) ... Use sites: Wood Protection Treatment To Forest Products (Seasoned), Wood Pressure Treatment To Forest Products, Oil Recovery Drilling Muds/Packer Fluids ... Commercial/Industrial Water Cooling Systems, Oil Recovery Drilling Muds/Packer Fluids, Pulp/Paper Mill Water Systems, Secondary Oil Recovery Injection Water, Wood Protection Treatment, Adhesives, Industrial Coatings, Industrial Emulsions, Resin/Latex/Polymer ... Microbiocide for oil recovery drilling muds and packer fluids - 0.34 to 34 ppm active ingredient.

Composition: A concentrated formulation of 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and
2-methyl-4-isothiazolin-3-one (MIT)
Appearance: Colourless to pale yellow liquid
Odour: Mild
MIT: 3.40 – 3.60 %
CIT: 10.50 - 10.70 %
DCIT: <100 ppm
Total Active: 13.90 – 14.30 %
Density (20°C): 1.230 - 1.260 g/cm³
pH (20°C): 2.5 - 3.0
Colour (Gardner): 1 – 4
Mg-chloride: 4.0 – 8.0 %
Mg-nitrate: 14.0 – 18.0 %
Solubility: Fully soluble in water and most lower alcohols and glycols
Stability in application*: Stable in the presence of light, over the pH range 2 - 9 and up to 60°C

CMIT/MIT 14% has a very broad spectrum of activity against bacteria, moulds and yeasts including the following typical spoilage organisms.
Typical Spoilage Organisms
Bacteria :Corynebacterium sp., Escherichia coli, Klebsiella sp.,Proteus penneri, Pseudomonas aeruginosa 
Moulds :Aspergillus niger,  Aureobasidium pullulans, Penicillium funiculosum, Trichoderma viride
Yeasts :Saccharomyces cerevisiae
CMIT/MIT 14% is suitable for the wet-state preservation of a wide range of aqueous products including paints, polymer emulsions, adhesives, ceramic glazes, fillers and sealants. CMIT/MIT 14% may be used as a tankside additive for ready-diluted metalworking fluids, for industrial water treatment, including cooling systems and papermaking and for the production of preservative formulations including those for the prevention of surface mould growth on timber, applied by vacuum impregnation CMIT/MIT 14%.
CMIT/MIT 14% can be added at any time during manufacturing. However, CMIT/MIT 14% is advised to incorporate CMIT/MIT 14% as early as possible to give protection throughout the production process. Care should be taken to ensure that temperature, pH and redox potential at the point of addition are suitable for stability of the product CMIT/MIT 14%.
CMIT/MIT 14% is compatible with most formulations in which CMIT/MIT 14%'s application is recommended and CMIT/MIT 14% may be used in formaldehyde sensitive systems. Reducing agents, amines and other strong nucleophiles can cause degradation of the active ingredients CMIT/MIT 14%.
 
CMIT/MIT 14% is a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-Methyl-4-isothiazolin-3-one. Acts as an industrial microbiocide. CMIT/MIT 14% controls the growth of bacteria and fungi. CMIT/MIT 14% is used in water-soluble and water dispersed adhesives such as animal glues, vegetable glues, natural rubber latices, polyvinyl acetate, styrene-butadiene and acrylic latices. The recommended dosage is 0.06 to 0.22 lb.

Isothiazolines are used as preservatives in the paint industry, where they serve to protect the product from fungal and mould attacks. One of the more common products of this kind used to be CMIT/MIT 14%, a 1.5%-aqueous solution consisting of 1 part methylisothiazolinone (CAS No 2682-20-4), and 3 parts of chloromethylisothiazolinone (CAS No 26172-55-4). This mixture can also be identified with a specific CAS No, 55965-84-9. To avoid risk of allergy the much weaker 1,2-benzisothiazolinone (commonly called BIT) is used. CMIT/MIT 14% is above all used as a preservative in latex paints. CMIT/MIT 14% substances are used in paint, adhesives, jointing compounds, cutting fluids and detergents. Paint, adhesive and detergents are products sold for both professional and consumer use.
CMIT/MIT 14% Biocide (current process) is defined as a combination of the two active ingredients produced by an integrated production process, resulting in an approximate total of 14% active ingredients, 16% magnesium nitrate, 10% magnesium chloride and 62% water.
The "mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate" is currently regulated as a preservative in the cosmetic directive (76/768/EEC) in annex VI, part 1, entry 39 with the maximum authorized concentration 0.0015% (15 ppm) of the mixture. The submission describes CMIT/MIT 14% as cosmetic grade at 1.5% active ingredient stabilized with magnesium nitrate. It is the formulated product sold to customers for cosmetic applications. CMIT/MIT 14% is a cosmetic preservative. The main uses are rinse-off products, such as shampoos, conditioners, gels and surfactants. The EU use concentration is a maximum of 15 ppm a.i. for rinse-off and leave-on products. However, the manufacturers recommend a maximum level of 7.5 ppm a.i. (0.05% by weight of product as supplied) for leave-on products. The manufacturers recommend CMI/MI as a preservative in shower gels, body washes, bubble baths, liquid soaps, shampoos, hair conditioners and wipes. The CMI/MI mixtures have wide applications in household (domestic) and industrial products.
Isothiazolinones  containing sulfur atom (S),  nitrogen (N), oxygen (O) at 3 position and  hydrogen (H) can find application for making broad-spectrum biocides and preservatives  such as  antiseptic agents,  bactericides, slimicides, and   fungicides CMIT/MIT 14%. The biggest application is in paint industry especially marine antifouling agent. They are also used in adhesives, cutting oils, water systems, cosmetics, household goods and wound protectant for pruning cuts. They are also used as pulp and wood impregnating agents as well as in leather, fur and polymer process. It is known to cause allergy and chemical burn if high concentration is used in personal care products and cosmetics.

GENERAL DESCRIPTION OF ANTISEPTIC AGENT: Antiseptic agent is a substance which kills or inhibits the growth of disease-causing bacteria and other microorganisms. CMIT/MIT 14% is essentially nontoxic to to be applied to the skin or mucous membranes. (Disinfectant including cresol, bleaching powder, and phenol is in general toxic to cells of the body). Common antiseptic agents are Benzalkonium Chloride, Cetrimide, Chlorhexidine, Hexachlorophene, Iodine Compounds, Mercury Compounds (Thimerosol), Alcohol and Hydrogen Peroxide, Hexamine Hippurate, Triclosan, Cetylpyridinium Chloride, And Dequalinium. Other substances which can be used for antiseptic purpose include Boric acid and volatile oils such as Methyl Salicylate. Hexachlorophene and Benzalkonium Chloride are used primarily in hand or face washes. Benzalkonium Chloride must not be applied to areas which have not been fully rinsed as it is inactivated by organic compounds. Benzalkonium application many include disinfecting instruments and preservativing drugs in low concentration form. Iodine compounds have the widest spectrum of antiinfectives against bacteria, fungi, spores, protozoa, viruses, and yeasts. Aqueous iodine are less effective than alcoholic solutions, but alcoholic component is drying and irritating to abraided skin. Povidone iodine is convenient to use as it is less irritating, but not as effective. Chlorhexidine is used as a safe antiseptic or disinfectant to apply to prevent body infection and in oral rinses for treating sore gums and mouth ulcers and preventing plaque on teeth. It is used in the form of acetate, gluconate or hydrochloride, either alone or in combination with others such as cetrimide. Cetrimide is an antiseptic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treating seborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums. Hippuric Acid, an amino acid glycine, is excreted from the body and is used in urinary system drugs. Hexamine hippurates is helpful for preventing and treating infections of the urinary system; it acts by being transformed to formaldehyde. Triclosan is a very popular antibacterial agent. It is used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics and textiles for antibacterial activity purpose. Cetylpyridinium chloride is used in oral rinses for cleaning mouth and treating minor throat or mouth infections and teething problems. Dequalinium chloride is antiinfectives against bacteria and fungi. It is used in treating bacterial or fungal infections of mouth and throat.