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NIPACIDE BIT

NIPACIDE BIT


Nipacide BIT is a glycol based solution; low toxicity biocide developed for the complete in-can protection of water based products. Nipacide BIT is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi. 
Nipacide BIT can be used over a wide pH and temperature range. Nipacide BIT should be the biocide of choice for products with pH >8 and production temperatures of >40 C.

CAS No. : 2634-33-5
EC No. : 220-120-9


Synonyms:
Nipacid; nipacid bit; BIT; nipasit; nipasid bit; nipasit bit; NIPACID BIT; Benzisothiazolinone (BIT); BIOCIDE FOR IN-CAN PRESERVATION; Nipacide CI 15; Nipacide CFX 3; NIPACIDE BIT 20; NIPACIDE BIT AS 20; NIPACIDE BIT; NIPACIDE PC; NIPACIDE PX; NIPACIDE OPP; NIPACIDE SOPP; NIPACIDE FC; NIPACIDE CI; nipacide bit 20; nipacide bit as 20; nipacide bit; nipacide pc; nipacide px; nipacide opp; nipacide sopp; nipacide fc; nipacide ci; nipacide; bit; Denicide BIT; Proxel BD; Proxel CF; Proxel TN; Proxel XL; Proxel BDN; Proxel GXL; Proxel Ultra 5; San-aibac AP; Proxel LV-S; Proxel Press Paste; Apizas AP-DS; Acticide BW 20; Bestcide 200K; Nipacide BIT 20; Parmetol B 70; Parmetol D 11; Proxel GXL(S); Proxel HL 2; Nuosept 485; Nuosept 491; Nuosept 495; Topcide 600; BIT; XBINX; Denicide BIT 20N; Koralone B 119; Nipacide BIT 10W; Preventol BIT 20D; Proxel BD 20; Nipacide BIT ; Proxel Press Paste D; Troysan 1050; Bioban BIT 20DPG; 1,2-benzisothiazole-3(2h)-one; benzisothiazoline-3-one; Canguard BIT 20DPG; SD 202 (bactericide); Canguard Ultra BIT 20LE; 1,2-Benzoisothiazol-3-one; BIT 10W; BIT 20; 2-Thiobenzimide; 1,2-BENZISOTHIAZOL-3-ONE; 1,2-benzisothiazolinone; Nipacide BIT; Proxel AB; Benzo[d]isothiazol-3-ol; 2,3-dihydro-1,2-benzothiazol-3-one; Proxel XL 2; benzoisothiazol-3-one; 1,2-benzoisothiazolin-3-one; 1,2-Benzisothiazolone; Caswell No. 079A; Caswell No. 513A; C7H5NOS; UNII-HRA0F1A4R3; NIPACIDE BIT; CCRIS 6369; 3-Hydroxy-1,2-benzisothiazole; IPX; CHEBI:167099; EINECS 220-120-9; EPA Pesticide Chemical Code 098901; HRA0F1A4R3; 1,2-Benzoisothiazoline-3-one; 2,3-dihydro-3-oxo-1,2-benzisothiazole; MLS-0254244.0001; Benzo(d)isothiazol-3(2H)-one; Benzisothiazolin-3-one; Nipacide BIT  Benzocil; Acticide BIT; Canguard BIT; Nipacide BIT; 2,3-Dihydrobenzisothiazol-3-one; SD 202; 1,2-Benzothiazolinone; PubChem15685; Benzisothiazolone (BIT); ACMC-209u7v; Epitope ID:115004; Benzisothiazol-3(2H)-one; 1,2-BENZISOTHAZOL-3(2H)-ONE; 1,2-Benzisothiazol-3(2H)-one, 97%; 1,2-benzisothiazol-3(2H)-one; Benzisothiazolinone; Benzisothiazolin-3-one; Benzisothiazolone; 1,2-Benzisothiazol-3(2H)-one; 2634-33-5; 1,2-Benzisothiazolin-3-one; 1,2-benzothiazol-3-one; benzisothiazolone; Benzo[d]isothiazol-3(2H)-one; benzisothiazolinone; Benzo[d]isothiazol-3-one; Proxel; 1,2-Benzisothiazoline-3-one; Proxel PL


Nipacide BIT 

Nipacide BIT is an in-can biocide based on BIT.

Benefits of Nipacide BIT 
formaldehyde-free
pH stable from 2-12
temperature stable up to 100°C
FDA approved for various applications
bactericide
fungicide

Technical data of Nipacide BIT 
Product class    
Benzisothiazolinone (BIT)
Physical form    Solution
Active content (ca.)     %
pH stability    2 - 12
Temperature stability     100°C
Recommended use level     0.1 - 0.25%

Regulations and approvals
FDA 21 CFR 175.105 Adhesives
FDA 21 CFR 176.170 Components of paperboard in contact with aqueous and fatty foods
FDA 21 CFR 176.180 Components of paper and paperboard in contact with dry food.
BfR XIV Plastic dispersions
BfR XXXVI Preservative for Paper and Board

Application of Nipacide BIT 
Nipacide BIT is recommended for preservation of a wide range of applications including:

Water-based, casein, animal bone based and PVA adhesives
Polymer emulsions including, SBR latex, Polyvinyl acetate and acrylic
Water-based decorative paints
Metal working fluids
Calcium Carbonate and Kaolin mineral slurries 
Concrete add-mixtures


Nipacide BIT is a formaldehyde-free, in-can biocide based on benzisothiazolinone (BIT). It is an FDA approved, glycol-based solution exhibiting low toxicity. Effective against a wide range of microorganisms including gram positive & gram negative bacteria, yeast and fungi. It can be used over a wide pH and temperature range. Developed for the complete in-can protection of water-based decorative paints. Recommended usage level of Nipacide BIT is 0.1 - 0.25%.

Nipacide BIT 
Producer: 
Clariant
Brand: 
Nipacide
Nipacide BIT is an in-can biocide based on BIT. Nipacide BIT is a glycol based solution; low toxicity biocide developed for the complete in-can protection of water based products. Nipacide BIT is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi. Nipacide BIT can be used over a wide pH and temperature range. Nipacide BIT should be the biocide of choice for products with pH >8 and production temperatures of >40 C.


Nipacide BIT (BIT) is a organic compound with the formula C6H4SN(H)CO. A white solid, it is structurally related to isothiazole. BIT is widely used as a preservative and antimicrobial.

Usage of Nipacide BIT
Nipacide BIT has a microbicide and a fungicide mode of action. It is widely used as a preservative, for example in:

emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions
home cleaning and car care products; laundry detergents, stain removers and fabric softeners;
industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
agriculture in pesticide formulations
gas and oil drilling in muds and packer fluids preservation.
In paints, it is commonly used alone or as a mixture with methylisothiazolinone. Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides. According to a study in Switzerland, 19% of the paints, varnishes and coatings contained BIT in 2000. The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%. A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.

Health hazards of Nipacide BIT
Given sufficient dose and duration, dermal exposure can produce skin sensitization and allergic contact dermatitis, and is classified as an irritant for skin and eyes. Nipacide BIT has also been linked with Systemic Contact Dermatitis via airborne contact.

In 2012, the Scientific Committee on Consumer Safety in Europe found BIT's "sensitising potential is of concern...Sensitisation from related isothiazolinones is an important problem in consumers. This has occurred because there has been consumer exposure before safe levels of exposure relevant to sensitisation have been established. Nipacide BIT is a skin sensitiser in animal models with potency similar to methylisothiazolinone. Methylisothiazolinone, at 100 ppm (0.01%) in cosmetic products is causing contact allergy and allergic contact dermatitis in the consumer. Nipacide BIT is known to be a sensitiser in man and has induced sensitisation at circa 20 ppm in gloves."

The opinion further states: "There is no information on what may be safe levels of exposure to Nipacide BIT in cosmetic products from the point of view of sensitisation. Until safe levels of exposure have been established, the use of Nipacide BIT in cosmetic products as a preservative or for other functions cannot be considered safe in relation to sensitisation."

Later, in 2013, researchers published a study that set out to derive the highest concentration of Nipacide BIT in certain consumer products that would result in exposures below the No Expected Sensitization Induction Level (NESIL); that is, where normal use would yield a dose below the level at which skin sensitization might occur. The products under consideration were sunscreen, laundry detergent, dish soap, and spray cleaner; by way of calculation they derived Nipacide BIT NESILs of 0.0075%, 0.035%, 0.035%, 0.021%, respectively. They then performed a pilot examination via bulk sample analysis of one representative product from each category labelled as containing Nipacide BIT. Their findings showed all Nipacide BIT concentrations well below the derived NESIL, with 0.0009% and 0.0027% for sunscreen and dish soap, respectively, and no detection in the laundry detergent and spray cleaner products, meaning the concentration was at or below the limit of detection of 0.0006%.


Your patch testing results indicate that you have a contact allergy to Nipacide BIT. It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it.

What is Nipacide BIT and where is it found?
This is a chemical preservative used in cooling fluids, adhesives, paper, leather, fur, cutting oils, water systems, cosmetics, household goods and antiseptic agents. It is also found in bactericides and fungicides and widely used in the paint industry. Further research may identify additional product or industrial usages of this chemical.

What is it?
Benzisothiazolinone is a chemical preservative used in a wide variety of industries and households.

How can I avoid it?
Avoidance requires reading the product labels, package inserts, Material Safety Data Sheets (MSDS), and on occasion, direct communication with the manufacturer.

USES of Nipacide BIT:
Adhesives
Antiseptic agents
Bactericides
Care care products
Cooling fluids
Cosmetics
Cutting oil
Dyes
Fabric softener
Fungicides
Fur
Gloves
Household goods
Inks
Laundry detergents
Leather
Paints
Paper
Photographic processing solutions
Stain removers
Textile industry
Varnishes
Water systems

Other names for Nipacide BIT:
Tinuvim 928
BIT
Proxel PL
Proxan
1,2-Benzisothiazolin-3-one
1,2-Benzisothiazol-3(2H)-one
Benzisothiazol-3(2H)-one
Benzisothiazolin-2-one
Benzisothiazolin-3-one
Benzisothiazolin

Nipacide BIT is a glycol based solution; low toxicity biocide developed for the complete in-can protection of water based products. Nipacide BIT is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi.

Nipacide BIT can be used over a wide pH and temperature range. Nipacide BIT should be the biocide of choice for products with pH >8 and production temperatures of >40 C.

Nipacide BIT DPG is a formaldehyde-free, in-can biocide based on BIT (benzisothiazolinone). It is an FDA approved, glycol-based solution exhibiting low toxicity. Effective against a wide range of microorganisms including gram positive & gram negative bacteria, yeast and fungi. It can be used over a wide pH and temperature range. Developed for the complete in-can protection of water-based decorative paints. Recommended use level of Nipacide BIT DPG is 0.1 - 0.25%.

Nipacide BIT is not expected to move into air from wet soils or water surfaces. Nipacide BIT is expected to be broken down by microorganisms but this depends on the amount of the chemical. It may not build up in tissues of aquatic organisms. RISK: Skin irritation has been reported in humans following direct skin contact with industrial or consumer products containing Nipacide BIT. Allergic skin reactions have been reported in some individuals that use powder-free polyvinyl gloves containing Nipacide BIT. No other information about potential health effects in humans exposed to Nipacide BIT was located. Severe eye irritation was observed in laboratory animals with direct eye exposure. Decreased body weight, vomiting, damage to the lining of the stomach, and changes in blood chemistry were observed in laboratory animals exposed to a moderate oral doses of Nipacide BIT over time. No evidence of infertility, abortions or birth defects was observed in laboratory animals orally exposed to Nipacide BIT or during pregnancy. Slight delays in bone development were observed in offspring, but only at high doses that caused toxic effects in the pregnant animals (decreased body weight gain, labored breathing, stomach effects). The potential for Nipacide BIT to cause cancer has not been examined in laboratory animals. The potential for Nipacide BIT to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 13th Report on Carcinogens.


Nipacide BIT is an in-can biocide based on BIT. Nipacide BIT is a glycol based solution; low toxicity biocide developed for the complete in-can protection of water based products. Nipacide BIT is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi. Nipacide BIT can be used over a wide pH and temperature range. Nipacide BIT should be the biocide of choice for products with pH >8 and production temperatures of >40 C.

Nipacide BIT is a glycol based solution; low toxicity biocide developed for the complete in-can protection of water based products. Nipacide BIT is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi. Microorganisms grow at a rapid rate and without use of the correct biocide, numbers can increase dramatically. 

Applications of Nipacide BIT:
Nipacide BIT is recommended for preservation of a wide range of applications including water based, casein, animal bone based and PVA adhesives. Polymer emulsions including, SBR latex, Polyvinyl acetate and acrylic. Water based decorative paints, metal working fluids, Calcium Carbonate and Kaolin mineral slurries and concrete add-mixtures. Nipacide BIT is effective against a wide range of spoilage organisms and effective over a wide pH and temperature range. Nipacide BIT should be the biocide of choice for products with pH >8 and production temperatures of >40 C. 

Use level of Nipacide BIT:
Nipacide BIT should be evaluated in finished products at levels between 0.1% and 0.25%. Please note that Nipacide BIT above 0.25% requires R43 (causes sensitization by skin contact) hazard labeling. 

Nipacide BIT is a low toxicity biocide specifically developed for the complete microbiological protection of water based products against bacterial and fungal spoilage in the wet state. Nipacide BIT is a glycol based solution product.

Nipacide BIT is recommended for a wide range of applications including adhesives, polymer emulsions, fountain solutions, MWF and paint where protection against fungi and bacteria is required in the wet state.


Nipacide BIT is an antimicrobial and preservative chemical used in a wide variety of applications, such as cleaning and building products. It may be in the form of a white to yellow powder or liquid. While many uses of the chemical are approved by the federal government, it can cause allergic reactions in some individuals and is considered an ingredient of concern by many healthy products sources.

Other Names for Nipacide BIT
As noted in PubChem, the National Library of Medicine's ChemIDPlusLite, and documentation from the Environmental Protection Agency (EPA), Nipacide BIT can go by several different names:

Synonyms: BIT; 1,2-Benzisothiazol-3(2H)-one, 1,2-Benzoisothiazolin-3-one, Benzoisothiazolin-3-one
Trade names: IPX, Proxan, Proxel, Proxel PL, Nipacide BIT, Mergal BIT
Chemical formula: C7H5NOS (See the Chemistry Structures Index for more information.)
Cleaning Uses
Nipacide BIT is used in many types of cleaning products, including laundry detergents, air fresheners, fabric softeners, stain removers, dish detergents, stainless steel cleaners, and more. It is used at a rate of 0.10 percent to 0.30 percent (by weight) when added to laundry and household cleaning products, according to the EPA document, "Registration Eligibility Decision (RED) for Benzisothiazoline-3-one." Also, it is important to point out that Nipacide BIT is often used in many cleaning products in conjunction with methylisothiazolinone, a synthetic preservative that has raised some health concerns.


Other Uses
In addition to cleaning products, Nipacide BIT has a wide range of other applications. It can be found in flea and tick treatments, paints, stains, car care products, textile solutions, metalworking fluids, oil recovery fluids, leather processing chemicals, pesticides, and paper mill systems. It is also used in building products, such as adhesives, caulks, sealants, grouts, spackle, and wallboard. In addition, Nipacide BIT is commonly used in personal care products, like sunscreen and liquid hand soap, and as an inert ingredient on crops, such as blueberries, strawberries, tomatoes, spinach, lettuce, and more.


Product Brands Containing Nipacide BIT
There are three public sources for updated lists of products containing Nipacide BIT:

U.S. Department of Health and Human Services Household Products Database
Environmental Working Group's (EWG) Guide to Healthy Cleaning
Skin Deep Cosmetic Database (EWG)
Regulation
When Nipacide BIT is used in personal care preparations or applications that come into contact with food, it is monitored by the U.S. Food and Drug Administration (FDA). For other uses, such as pesticides and cleaning products, it is monitored by the EPA.

Health and Safety
In 2005, Nipacide BIT underwent a review process by the EPA to determine its reregistration eligibility for use in a range of products and applications. After considering the overall information on its toxicity, uses, and environmental effects, the EPA concluded that it posed no harm to the population. However, that doesn't mean no health effects were found at all.

Also, the EPA found that the amount of Nipacide BIT being used in flea and tick products was a concern for children, so it specified a limited allowable amount in those products.

Environmental Effects
This chemical quickly biodegrades and there is "minimal environmental exposure" according to the EPA in its 2005 review of the chemical. However, the EPA also notes that there is evidence for Nipacide BIT being toxic to aquatic life when it is used in oil-recovery fluids. This indicates that some applications for this chemical should be restricted or prohibited.

Green Alternatives
There are plenty of green products that don't use Nipacide BIT as a preservative or antimicrobial. This may be the best option if you are concerned about the potential for allergy interactions or other health or environmental effects. Good Guide is one source for identifying green products that do not contain Nipacide BIT or other potentially harmful chemicals. Carefully read ingredient labels and product reviews to ensure you know what you're getting.

Nipacide BIT is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Nipacide BIT is reported to readily biodegrade in soil. Results of an aerobic study found a half-life of less than 24 hours in a sandy loam soil. Nipacide BIT is a biocide, and a 0% theoretical BOD in the Japanese MITI suggests that the compound may be toxic to microorganisms at high concentrations. If released into water, Nipacide BIT is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. 1,2-Benzisothiazolin-3-one has been shown to be hydrolytically stable with a hydrolysis half life of >30 days. Occupational exposure to Nipacide BIT may occur through inhalation and dermal contact with this compound at workplaces where Nipacide BIT is produced or used. Monitoring and use data indicate that the general population may be exposed to Nipacide BIT via inhalation of air near consumer products and dermal contact with consumer products, such as cosmetics and paints, containing Nipacide BIT.


What Is Nipacide BIT?
Nipacide BIT, also called BIT, is an off-white to yellowish liquid antimicrobial substance.

What Does Nipacide BIT Do in Our products?
Nipacide BIT is a preservative, but it is also a disinfectant used in the film, fiber, leather, masonry, metalworking, and embalming industries. However, it is also found in liquid hand soap and sunscreen. It dissolves in water and is used in water-based solutions, such as pastes, paints, and oils. 

Why Puracy Uses Nipacide BIT
We use Nipacide BIT in several of our products as a biodegradable preservative that is a better alternative to formaldehyde, methylisothiazolinone, and medium-chain triglycerides. The Scientific Committee on Consumer Safety considers the ingredient safe when used as a preservative up to 0.01% in cosmetics. Whole Foods has deemed the ingredient acceptable in its body care and cleaning product quality standards. In addition, research shows the ingredient is not a strong skin irritant in skin cream up to 100ppm.

How Nipacide BIT Is Made
There are three common methods for making Nipacide BIT. The first involves reacting 2-halogenothiobenzoyl halide with a primary amine to obtain an N-substituted BIT. The 2-halogenothiobenzoyl halide is typically made by cleaving the disulphide bond of 2,2'-dithio-bis-benzoic acid with halogen and simultaneously or sequentially converting the carboxylic acid groups to acid halides. A second method involves cyclising 2-halogenothiobenzamide in the presence of acid or alkali. The 2-halogenothiobenzamide typically comes from converting 2,2'-dithio-bis- benzoic acid to bisamide and then cleaving the disulphide bond with halogen. The third method is to heat 2,2'-dithio-bis-benzamides in the presence of a sodium hydroxide solution. Another method is to disproportion bisamide in alkali in the presence of oxygen or an oxygen-release agent.


Nipacide BIT is an off-white to yellowish solid or a white to off-white fine, crystalline powder. It can also be an off-white to brown paste. It is moderately soluble in water. 

USE: Nipacide BIT is used as a preservative and antimicrobial agent in industrial and consumer products such as cosmetics and paints. It is also an ingredient in some fungicides, microbiocides, disinfectants and pesticides. Benzisothiazolinone is used as a slimicide in the manufacture of powder-free polyvinyl gloves. It is a component of air fresheners, printer inks, household cleaners and laundry products. EXPOSURE: Workers can be exposed to Nipacide BIT from breathing in vapors and mists or by skin contact when producing or using this chemical. The general population may be exposed by breathing in vapors or mists and by dermal contact with consumer products such as cosmetics. If Nipacide BIT is released to air, it will be broken down slowly by reaction with other chemicals and light. Nipacide BIT released to air will also be in the form of particles that eventually fall to the ground. If released to water or soil, it is not expected to bind to soil particles or suspended particles. Nipacide BIT is expected to move through soil. 


What is Nipacide BIT?

Nipacide BIT is used in cosmetic items as a preservative. It is used on an industrial level as a biocide on buildings (to kill fungus on roofs and buildings) as well as a preservative in paints and cleaning products. 

What type of products is it found in?

Hand wash, sunblock, air freshener

What are Nipacide BITs risks?

Has been found that when used in air freshener products, Nipacide BIT is cytotoxic to lung cells, creating free radical damage to these cells. (Source)
Exposure can lead to allergic contact dermatitis and skin sensitization. (Source)
The Scientific Committee on Consumer Safety (EU) has advised that it not be used in personal care items due to lack of data as well as its potential for skin sensitization. (Source)
Animal studies have observed reproductive effects when administered orally at high doses. (Concentrations in household/personal care products are thought not to be high enough to have an effect on human reproduction, however.)

Nipacide BIT is a widely used biocide and belongs to the group of isothiazolinones.

A biocide of the isothiazolinone group, used as a preservative in paints, varnishes and fuels and in paper-making. What are some products that may contain Nipacide BIT?
Household Products
• Detergents
• Glues
• Paints
• Plasters
• Sealants

Where is Nipacide BIT found?
Nipacide BIT is a preservative found in paints, varnishes, adhesives, washing agents, plasters, and sealants.

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