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CAS Number: 55965-84-9
NIPACIDE CFX 3 is a low toxicity biocide specifically developed for the complete microbiological protection of water based products against bacterial and fungal spoilage in the wet state, particularly where NIPACIDE CFX 3 is to be used at high ambient temperatures.
NIPACIDE CFX 3 is a water based liquid.
NIPACIDE CFX 3 is described chemically as a blend of chlorinated and non-chlorinated isothiazolinones plus ethyl glycol bis hemiformal.
A unique stabilisation system has been developed and incorporated into NIPACIDE CFX 3.
NIPACIDE CFX 3 is recommended for a wide range of applications including adhesives, polymer emulsions, fountain solutions, MWF and paint where protection against fungi and bacteria is required in the wet state.
NIPACIDE CFX 3 is In-can biocide based on CMIT/MIT + EDDM.
NIPACIDE CFX 3 is a mixture of isothiazolinones andformaldehyde releaser and provides also head-space protection.
NIPACIDE CFX 3 is a water based, liquid biocide specifically developed for the complete in-can microbiological protection of industrial water based products against bacterial and fungal spoilage in the wet state.
NIPACIDE CFX 3 is a water-based low toxicity isothiazolinone/ formaldehyde donor biocide, developed for the complete in-can and head space protection of water-based products.
NIPACIDE CFX 3 is a low toxicity, in-can biocide based on formaldehyde, chloromethyl and methylisothiazolinone.
NIPACIDE CFX 3 is a water-based isothiazolinone/ formaldehyde donor biocide developed for complete head space protection of water-based products.
NIPACIDE CFX 3 is effective against gram positive and gram negative bacteria, yeast and fungi over a wide pH and temperature range.
NIPACIDE CFX 3 complies with FDA regulation.
NIPACIDE CFX 3 is an in-can biocide based on formaldehyde + chloromethyl and methylisothiazolinone.
NIPACIDE CFX 3 is a water-based low toxicity isothiazolinone/ formaldehyde donor biocide, developed for the complete in-can and head space protection of water-based products.
NIPACIDE CFX 3 is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi.
When products are prone to surface contamination by fungi and head space protection is required, NIPACIDE CFX 3 should be the biocide of choice.
NIPACIDE CFX 3 is effective against a wide range of spoilage organisms effective over a wide pH and temperature range.
NIPACIDE CFX 3 utilizes a two-step mechanism involving rapid growth inhibition leading to a loss of cell viability.
Growth inhibition is the result of rapid disruption of the central metabolic pathways of the cell by inhibition of several specific enzymes, including dehydrogenases.
The critical enzymes which are affected are associated with the Krebs cycle, nutrient metabolism and energy generation.
The key physiological activities that are rapidly inhibited in microbial cells are respiration (oxygen consumption), energy generation (ATP synthesis), and growth (assimilation).
Many of these key enzymes are present in both aerobic and anaerobic microorganisms, which explains why NIPACIDE CFX 3 is such a broad spectrum biocide.
Inhibition of cellular activity and growth is rapid (within minutes), whereas cell death (cidal activity) is observed after several hours’ contact.
In general, the higher the concentration of biocide, the shorter the contact time required for more complete kill.
Cell death results from the progressive loss of protein thiols in the cell from one of multiple pathways.
As cell metabolism is disrupted, free radicals are produced which also results in cell death.
This unique mechanism results in the broad spectrum of activity of NIPACIDE CFX 3, low use levels for microbial control, and difficulty in attaining resistance by mutation.
Within minutes after addition of NIPACIDE CFX 3 to a metalworking fluid sump, the metabolic activity of the microorganisms in the system shuts down.
This includes cellular respiration (oxygen uptake), growth, energy generation, and nutrient uptake.
The microorganisms, although still alive, are no longer able to reproduce or metabolize metalworking fluid components.
After 24 to 48 hours of contact with a lethal dose of the biocide, most of the microorganisms have been killed.
NIPACIDE CFX 3 has excellent in-use stability and generally retains NIPACIDE CFX 3 antimicrobial efficacy in metalworking fluid systems for 2 to 4 weeks.
Variables such as degree of fluid contamination, effectiveness of the filtration system, system turnover time, compatibility between the microbicide and the metalworking fluid components, and other system additives involved, can affect the life of the microbicide in a system.
NIPACIDE CFX 3 has been shown to reduce microbial fouling and prevent biofilm development in metalworking fluid systems.
The benefits of reduced fungal biofouling include improved system performance, reduced filter plugging, reduced biocorrosion, and improved microbial control.
NIPACIDE CFX 3 may be used in certain fluid concentrates to provide efficacy in the final use dilutions.
Although NIPACIDE CFX 3 stability may not be suitable for all concentrates, we have had success with the biocide alone or in combination with one of our recommended stabilizers.
Benefits of NIPACIDE CFX 3:
Provides heat-space protection
Bactericide
Fungicide
pH stable 4-9
Temperature stable up to 40° C
FDA approved for various applications
Applications of NIPACIDE CFX 3:
NIPACIDE CFX 3 is recommended for the preservation of a wide range of applications including water based adhesives, polymer emulsions, water based decorative paints, metal working fluids, sealants and tile grouts, household detergent cleaners, car care products and construction chemicals where protection against fungi and bacteria is required in the wet state.
NIPACIDE CFX 3 is effective against a wide range of common spoilage organisms including gram positive and gram negative bacteria, yeast and fungi.
NIPACIDE CFX 3 can be used over a pH range 4 - 9 and temperature range up to 40°C.
NIPACIDE CFX 3 is particularly effective at providing head space protection, in-can, by the slow release of formaldehyde.
Use Levels of NIPACIDE CFX 3:
NIPACIDE CFX 3 should be evaluated in finished products at levels between 0.1% and 0.3%.
Please note that NIPACIDE CFX 3 above 0.16% requires R43 (causes sensitization by skin contact) hazard labeling.
The level of protection required will depend on many factors including the degree of contamination of raw materials and the susceptibility of the final product.
Chemical Compatibility of NIPACIDE CFX 3:
NIPACIDE CFX 3 is compatible with most raw materials used in the manufacture of industrial and decorative coatings.
However NIPACIDE CFX 3 is recommended that the compatibility of NIPACIDE CFX 3 with the application should always be checked and evaluated before use.
Microbiological Data of NIPACIDE CFX 3:
NIPACIDE CFX 3 exhibits a broad spectrum of activity which is demonstrated by the following.
MIC data against some common microorganisms associated with wet-state spoilage:
Organism MIC (ppm)
Bacteria:
Pseudomonas aeruginosa - 400
Aspergillus niger - 150
Pseudomonas putida - 400
Penicillium mineoluteum - 75
Proteus vulgaris - 125
Fusarium solani - 125
Escherichia coli - 500
Geotrichum candidum - 200
Staphylococcus aureus - 550
Yeast:
Candida albicans - 150
Stability of NIPACIDE CFX 3:
In-Use Stability:
NIPACIDE CFX 3 has excellent stability in end use dilutions of metalworking fluids.
NIPACIDE CFX 3 is stable over a wide pH range (4-10) in water and in metalworking fluid systems.
Concentrate Stability:
NIPACIDE CFX 3 stability, in metalworking fluid concentrates, is variable.
We recommend checking stability and performance before commercialization of products.
Storage Stability:
In general, the storage stability of the NIPACIDE CFX 3 product is excellent.
The shelf life of NIPACIDE CFX 3 is nominally twelve years at 25°C.
NIPACIDE CFX 3 is strongly recommended, however, that both the stability and compatibility of NIPACIDE CFX 3 in metalworking fluid formulations or systems be thoroughly examined before commercialization.
Method of Addition of NIPACIDE CFX 3:
NIPACIDE CFX 3 should be directly dispensed into metalworking fluid concentrates or use-dilution metalworking fluids using a metering pump or other point-of-use device where possible and uniformLy dispersed throughout the fluid.
Fluid Concentrate of NIPACIDE CFX 3:
NIPACIDE CFX 3 should be added to metalworking fluid concentrates at a level that ensures the final use-dilution fluid will contain 55 to 167 ppm of product (25 to 75 ppm active ingredient).
NIPACIDE CFX 3 stability in a given concentrate should be determined prior to commercialization.
Contact local representative for assistance in selecting one of several recommended stabilizers to enhance the performance and compatibility of NIPACIDE CFX 3 in your metalworking fluid concentrate.
Use-Dilution Fluid:
We highly recommend grossly contaminated systems be cleaned before treatment is begun.
Initial Dose:
For a noticeably fouled system, add 0.47 to 1.44 lbs (7 to 21 fl oz) of NIPACIDE CFX 3 per 1,000 gallons of fluid.
This will provide 25 to 75 ppm active ingredient.
Repeat until control is achieved.
Subsequent Dose:
For maintenance of a non-fouled system, add 0.09 to 0.58 lbs (1.3 to 8.6 fl oz) of NIPACIDE CFX 3 per 1,000 gallons of fluid every four weeks.
This will provide 5 to 30 ppm active ingredient.
A higher dose range and/or increased frequency of treatment may be required, depending upon the rate of dilution of the preservative with the makeup fluid, the nature and severity of contamination, level of control required, filtration effectiveness, system design, etc.
Technical Service of NIPACIDE CFX 3:
Technical service staff is available to assist customers in the determination of the optimum use level of biocide required to fully protect their product.
The staff is on hand at all times to assist customers with all technical enquiries relating to product protection.
Full microbiological efficacy testing is available at the Microbiology Laboratory.
Handling and Storage of NIPACIDE CFX 3:
The procedures used for handling concentrated biocide solutions are similar to those used for handling concentrated acids and alkalis.
The purpose is to prevent all eye and skin contact, including inhalation of mists, and thereby prevent possible injury and sensitization.
Personnel handling NIPACIDE CFX 3 as supplied should always wear protective clothing, which includes chemical splash goggles, an impervious apron or rain suit, and impervious rubber gloves.
We recommend that employees working with NIPACIDE CFX 3 as supplied thoroughly wash with soap and water at the end of a shift or prior to eating, drinking, smoking, or applying cosmetics.
Special care should be taken to avoid contamination of surfaces or materials that may later be handled by unprotected personnel, for example, door and tap handles.
NIPACIDE CFX 3 is packaged in polyethylene or polyethylene-lined containers.
NIPACIDE CFX 3 should not be stored in unlined metal containers since NIPACIDE CFX 3 is a corrosive material.
Normal recommended storage temperatures are in the range of 10° to 25°C (50° to 80°F).
Shelf life ~12 years (packaging should be evaluated and replaced as needed for transport compliance over the duration of product shelf life).
Storage at >120°F for extended periods of time can result in degradation of the active ingredient.
Decontamination Solutions of NIPACIDE CFX 3:
NIPACIDE CFX 3 can be decontaminated with a 5% solution of sodium hypochlorite (NaOCl) containing 2-5% sodium bicarbonate (NaHCO3 ).
Solutions should be freshly prepared.
Employees preparing or handling decontamination solutions should wear chemical splash goggles, an impervious apron or rain suit, and impervious rubber gloves.
Note: Do not use decontamination solution to treat skin, eyes or clothing which have come in contact with NIPACIDE CFX 3.
Decontamination of Equipment of NIPACIDE CFX 3:
Equipment used in the handling of NIPACIDE CFX 3, such as mix tanks, lines, pumps, etc., must be decontaminated before carrying out maintenance or used for other service.
To decontaminate this equipment, estimate the volume of NIPACIDE CFX 3 remaining in the well-drained system.
Prepare 10 volumes of decontamination solution per volume of NIPACIDE CFX 3 (45%) and circulate the mixture throughout the equipment.
Be certain that the NIPACIDE CFX 3 and decontamination solution mix well.
Wait at least 30 minutes to ensure complete reaction.
Drain and rinse with clean water or detergent solution.
Decontamination solution runoffs should be drained to a chemical sewer unless prohibited by state or local regulations.
Drips, minor spills and exposed wet areas should be cleaned up promptly with the hypochlorite/bicarbonate mixture.
Contaminated surfaces should be swabbed with decontamination solution and allowed to stand for 30 minutes before rinsing thoroughly with water.
Decontaminated solutions should be drained to a chemical sewer unless prohibited by state or local regulations.
Properties of NIPACIDE CFX 3:
CIT / MIT: 0.8 - 1.0%.
1,6–dihydroxy-2,5–dioxahexane: 9.0 – 12.0%
Appearance: Colourless to Yellow, clear liquid
pH (neat): 2.0 – 4.0
Specific Gravity at 20⁰C: 1.020 – 1.100
Solubility in water: Soluble
Product class: Formaldehyde + chloromethyl and methylisothiazolinone
Physical Form: Solution
Active content (ca.): 23%
pH stability: 4 - 9
Temperature stability: 40°C
Recommended Use Level: 0.075 - 0.2%
Synonyms of NIPACIDE CFX 3:
formaldehyde + chloromethyl and methylisothiazolinone
formaldehyde-chloromethyl-methylisothiazolinone
NIPACIDE-CFX-3
Con WT
Kathon 886
kathon biocide
CMIT/MIT 1.5CG
CMIT/MIT B/PLUS
CMI/MI Kathon 886
(96118-96-6) kathon 886
CIT/MIT14 Kathon Biocide
Mixture with methylchloroisothiazolinone
5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone
2-Octyl-4-isothiazolin-3-one
3(2H)-Isothiazolone, 2-octyl-
Kathon LP Preservative
Octhilinone
Ultrafresh DM 25
Vinyzene IT 3000DIDP
Octhilinone
26530-20-1
2-n-Octyl-4-isothiazolin-3-one
2-Octyl-4-isothiazolin-3-one
2-octylisothiazol-3(2H)-one
2-Octyl-3-isothiazolone
3(2H)-Isothiazolone, 2-octyl-
Kathon 893
Skane 8
Skane M-8
Kathon 893F
