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Nipagin™ M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries, and topical pharmaceuticals.
CAS-99-76-3
EC Number 243-171-5
Synonyms:
Methyl 4-hydroxybenzoate; METHYLPARABEN; 99-76-3; Methyl paraben; Methyl p-hydroxybenzoate; Nipagin; Methyl parahydroxybenzoate; Maseptol; p-Hydroxybenzoic acid methyl ester; p-Methoxycarbonylphenol; 4-Hydroxybenzoic acid methyl ester; Benzoic acid, 4-hydroxy-, methyl ester; p-Carbomethoxyphenol; Tegosept M; Methaben; Metoxyde; Preserval; Metaben; Moldex; Paridol; Septos; Solbrol; Methyl parasept; Methyl butex; Methyl chemosept; Nipagin M; Aseptoform; Methylben; Abiol; Methyl-p-hydroxybenzoate; Preserval M; Solbrol M; 4-(Methoxycarbonyl)phenol; Methyl p-oxybenzoate; 4-Hydroxybenzoic acid, methyl ester; Methyl ester of p-hydroxybenzoic acid; p-Oxybenzoesauremethylester; MFCD00002352; FEMA No. 2710; Benzoic acid, p-hydroxy-, methyl ester; UNII-A2I8C7HI9T; NSC 3827; p-Hydroxybenzoic acid, methyl ester; p-Hydroxybenzoic methyl ester; 4-HYDROXY-BENZOIC ACID METHYL ESTER; Methylester kyseliny p-hydroxybenzoove; A2I8C7HI9T; CHEMBL325372; CHEBI:31835; NCGC00159376-02; NCGC00159376-04; E218; DSSTox_CID_2529; WLN: QR DVO1; DSSTox_RID_76616; DSSTox_GSID_22529; Methyl 4-hydroxybenzoate, 99%; Caswell No. 573PP; FEMA Number 2710; CAS-99-76-3; SMR000036660; CCRIS 3946
Nipagin™ M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries, and topical pharmaceuticals. It is suitable to preserve both rinse-off and leave-on formulations. This product is highly soluble in cold water for ease of addition.Sodium Methylparaben. Nipagin® M Sodium is a water-soluble preservative. It is a short-chain paraben in sodium salt form. It offers a broad spectrum of activity against bacteria & fungi and stability over a broad pH-range. It exhibits effectiveness at low concentrations. It shows high solubility in cold water, low order of toxicity and good biodegradability at environmental concentrations. Nipagin® M Sodium is used in all kinds of personal care products.Nipagin‚ M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries, and topical pharmaceuticals. It is suitable to preserve both rinse-off and leave-on formulations. This product is highly soluble in cold water for ease of addition.Nipagin M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals. Nipagin M Sodium is suitable to preserve both rinse- off and leaveon formulations. Nipagin M Sodium is effective against bacteria, molds and yeast. The recommended use level of Nipagin M Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product. The Paraben esters have many advantages as preservatives, like broad spectrum antimicrobial activity, effective at low use concentrations, compatible with awide range of cosmetic ingredients, colourless, odourless, well documented toxicological and dermatological acceptability based on human experience (used in cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acid and a number of its esters occur naturally in a variety of plants and animals, stable and effective over a wide pH- range, etc. The Sodium Parabens, like Nipagin M Sodium have several additional advantages: Nipagin M sodium is highly soluble in cold water for ease of addition. No heating stage required for incorporation, thus saving energy and plant occupancy. Increased antimicrobial activity at alkaline pH. Nipagin M Sodium is designed for preservation of a wide range of cosmetics and toiletries. Nipagin M Sodium is suitable to preserve both rinse- off and leave- on formulations. Formulations which are prone to bacteria contamination an additional antibacterial preservative, like Nipaguard DMDMH might be necessary to add as Nipagin M Sodium provides a higher efficacy against fungi than against bacteria. Nipagin M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations. It is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained.
Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. The major benefit offered by the sodium salts is their high solubility in cold water, thereby enabling the introduction of parabens without heating or pre-dissolving in solvents.
Benefits
High solubility in cold water
Broad spectrum of activity against bacteria and fungi
Low order of toxicity
Effectiveness at low concentrations
Stability over a broad pH-range
Water-soluble
Biodegradability at environmental concentrations
Global acceptance in personal care applications
Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. The major benefit offered by the sodium salts is their high solubility in cold water, thereby enabling the introduction of parabens without heating or pre-dissolving in solvents.
Benefits
High solubility in cold water
Broad spectrum of activity against bacteria and fungi
Low order of toxicity
Effectiveness at low concentrations
Stability over a broad pH-range
Water-soluble
Biodegradability at environmental concentrations
Global acceptance in personal care applications
Nipagin M Sodium remains fully stable over a wide pH range from 3.0- 11.0. Aqueous solutions of Nipagin M Sodium are not long- term stable at alkaline pH.
The recommended maximum handling temperature is 80°C.
Nipagin M Sodium can be used up to a maximum
concentration of 0.4 % in cosmetic products, no further restrictions.
Annex VI, 76/768/EEC (Europe).
Japan: maximum concentration 1 % in cosmetic product, no restrictions.
USA: considered safe as used by Cosmetic Ingredient
Review (1984).
Nipagin M Sodium is stable in sealed original containers. Further information on handling, storage and dispatch is given in the EC safety data sheet.
Chemical name: Sodium Methyl p-Hydroxybenzoate.
INCI designation
Sodium Methylparaben.
Product properties
Appearance: White powder
Chemical and physical data
pH: 9.5- 10.5
Water content: max. 5.0 %
Assay by non aqueous titration: 99 - 102 %
Uses
Nipagin M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals.
Nipagin M Sodium is suitable to preserve both rinse- off and leave-on formulations.
Nipagin M Sodium is effective against bacteria, molds and yeast.
The recommended use level of Nipagin M Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.
The Paraben esters have many advantages as preservatives,like broad spectrum antimicrobial activity, effective at low use concentrations, compatible with a wide range of cosmetic ingredients, colourless, odourless, well documented toxicological and dermatological acceptability based on human experience (used in cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acid and a number of its esters occur naturally in a variety of plants and animals, stable and effective over a wide pH- range, etc.
The Sodium Parabens, like Nipagin M Sodium have several additional advantages:
Nipagin M sodium is highly soluble in cold water for ease of addition.
No heating stage required for incorporation, thus saving energy and plant occupancy.
Increased antimicrobial activity at alkaline pH.
Applications
Nipagin M Sodium is designed for preservation of a wide range of cosmetics and toiletries.
Nipagin M Sodium is suitable to preserve both rinse- off and leave- on formulations.
Formulations which are prone to bacteria contamination an additional antibacterial preservative, like DMDMH might be necessary to add as Nipagin M Sodium provides a higher efficacy against fungi than against bacteria.
Solubility
Water up to 33 %
Incorporation
Nipagin M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations.
It is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained.
pH stability
Nipagin M Sodium remains fully stable over a wide pH range from 3.0- 11.0.
Aqueous solutions of Nipagin M Sodium are not long- term stable at alkaline pH.
Temperature stability
The recommended maximum handling temperature is 80°C.
Microbial activity
Nipagin M Sodium has a broad spectrum of activity which includes the following common spoilage organisms.
Microorganisms MIC level (%)
Bacteria
Pseudomonas aeruginosa 0.228
Staphylococcus aureus 0.17
Microorganisms MIC level (%)
Yeasts
Candida albicans 0.114
Molds
Aspergillus niger 0.114
Regulatory Status
Nipagin M Sodium can be used up to a maximum concentration of 0.4 % in cosmetic products, no further restrictions.
Storage instructions
Nipagin M Sodium is stable in sealed original containers.
Further information on handling, storage and dispatch is given in the EC safety data sheet.
Nipagin‚ M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries, and topical pharmaceuticals.
It is suitable to preserve both rinse-off and leave-on formulations.
This product is highly soluble in cold water for ease of addition.
Nipagin M Sodium is designed for preservation of a wide range of cosmetics and toiletries.
Nipagin M Sodium is suitable to preserve both rinse- off and leave- on formulations.
Nipagin M Sodium is a broad spectrum antimicrobial agent designed forpreservation of a wide range of cosmetics, toiletries pharmaceuticals.
Nipagin M Sodium is suitable to preserve both rinse- off and leave- onformulations.Nipagin M Sodium is effective against bacteria, molds and yeast.
The recommended use level of Nipagin M Sodium to preserve most product types is normally in the range of 0.1 - 0.3 % based on the total weight of the finished product.
The Paraben esters have many advantages as preservatives, like broad spectrumantimicrobial activity, effective at low use concentrations, compatible with awide range of cosmetic ingredients, colourless, odourless, well documentedtoxicological and dermatological acceptability based on human experience (usedin cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acidand a number of its esters occur naturally in a variety of plants and animals,stable and effective over a wide pH- range, etc.
The Sodium Parabens, like Nipagin M Sodium have several additional advantages:
Nipagin M sodium is highly soluble in cold water for ease of addition.
No heating stage required for incorporation, thus saving energy and plant occupancy.
Increased antimicrobial activity at alkaline pH.
Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. The major benefit offered by the sodium salts is their high solubility in cold water, thereby enabling the introduction of parabens without heating or pre-dissolving in solvents.
Benefits
High solubility in cold water
Broad spectrum of activity against bacteria and fungi
Low order of toxicity
Effectiveness at low concentrations
Stability over a broad pH-range
Water-soluble
Biodegradability at environmental concentrations
Global acceptance in personal care applications
Sodium Methylparaben.
Nipagin M Sodium by Clariant is a water-soluble preservative.
Nipagin M Sodium is a short-chain paraben in sodium salt form.
Nipagin M Sodium offers a broad spectrum of activity against bacteria & fungi and stability over a broad pH-range.
Nipagin M Sodium exhibits effectiveness at low concentrations.
Nipagin M Sodium shows high solubility in cold water, low order of toxicity and good biodegradability at environmental concentrations.
Nipagin M Sodium is used in all kinds of personal care products.
