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NIPASOL M SODIUM

CAS Number: 35285-69-9
EC Number: 252-488-1
Molecular Formula: C10H11NaO3
Molecular Weight: 202.182

Nipasol M Sodium is a single long-chain paraben preservative for personal care products.          

Nipasol M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations.
Nipasol M Sodium is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained.

Benefit of Nipasol M Sodium:
Water soluble

Uses of Nipasol M Sodium:
Nipasol M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals. 
Nipasol M Sodium is suitable to preserve both rinse- off and leave-on formulations.

Nipasol M Sodium is effective against bacteria, molds and yeast. 
The recommended use level of Nipasol M Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.

The Paraben esters have many advantages as preservatives, like broad spectrum antimicrobial activity, effective at low use concentrations, compatible with a wide range of cosmetic ingredients, colourless, odourless, well documented toxicological and dermatological acceptability based on human experience (used in cosmetics, food and pharmaceuticals since 1930ies),p-Hydroxybenzoic Acid and a number of Nipasol M Sodium estersoccur naturally in a variety of plants and animals, stable and effective over a wide pH- range, etc.

The Sodium Parabens, like Nipasol M Sodium have several additional advantages:
Nipasol M sodium is highly soluble in cold water for ease of addition.
No heating stage required for incorporation, thus saving energy and plant occupancy.
Increased antimicrobial activity at alkaline pH.

Applications of Nipasol M Sodium:
Nipasol M Sodium is designed for preservation of a wide range of cosmetics and toiletries. 
Nipasol M Sodium is suitable to preserve both rinse- off and leave- on formulations. 
Formulations which are prone to bacteria contamination an additional antibacterial preservative, like DMDMH might be necessary to add as Nipasol M Sodium provides a higher efficacy against fungi than against bacteria.  

Nipasol M Sodium is suitable for the following products:
Antiperspirants & Deodorants,
Wet Wipes,
Decorative Cosmetics,
Creams, Lotions,
Shampoos, Shower Gels, Liquid Soap,
Hair Conditioner,
Hair Styling,
Syndet, Bar Soap.

Solubility of Nipasol M Sodium:
Water max. 50 %

pH stability of Nipasol M Sodium:
Nipasol M Sodium remains fully stable over a wide pH range from 3.0- 11.0.
Aqueous solutions of Nipasol M Sodium are not longterm table at alkaline pH.

Temperature stability of Nipasol M Sodium:
The recommended maximum handling temperature is 80°C.

Microbial activity of Nipasol M Sodium:
Nipasol M Sodium has a broad spectrum of activity
which includes the following common spoilage organisms.

Microorganisms MIC level (%)

Bacteria
Pseudomonas aeruginosa - 0.019
Staphylococcus aureus - 0.045

Microorganisms MIC level (%)

Yeasts
Candida albicans - 0.015

Molds
Aspergillus niger - 0.022

Storage instructions of Nipasol M Sodium:
Nipasol M Sodium is stable in sealed original containers.
Further information on handling, storage and dispatch is given in the EC safety data sheet.

Identifiers of Nipasol M Sodium:
Appearance: Powder
Active substance (ca.): 100%
INCI-Name: Sodium Propylparaben
Applications: Nipasol M Sodium is a long chain paraben preservative for personal care products.

Properties of Nipasol M Sodium:
Appearance: White powder
Chemical and physical data
pH: 9.5- 10.5
Water content: max. 5.0 %
Assay by non aqueous titration: 99 - 104 %
Molecular Formula: C₁₀H₁₁NaO₃
Appearance: White to Off-White Solid
Melting Point: >170°C (dec.)
Molecular Weight: 202.18
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: Hygroscopic

Names of Nipasol M Sodium:

CAS names of Nipasol M Sodium:
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt (1:1)

IUPAC names of Nipasol M Sodium:
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt
p-Hydroxybenzoesäure-n-propylester Natriumsalz
propyl 4-hydroxybenzoate
Propyl-4-hydroxybenzoat natrium
sodium 4-(propoxycarbonyl)benzen-1-olate
sodium 4-(propoxycarbonyl)phenolate
Sodium 4-propoxycarbonylphenoxide
sodium 4-propoxycarbonylphenoxide
Sodium Propyl 4-Hydroxybenzoate
Sodium propylparaben
Sodium propylparabenSodium 4-propoxycarbonylphenoxide
sodium;4-propoxycarbonylphenolate
Sodium propyl hydroxybenzoate
Cosmetic Products Regulation, Annex V - Allowed Preservatives, Other

Synonyms of Nipasol M Sodium:    
Paradept
Sodium propyl paraben
Solbrol P, Natriumsalz
4-Hydroxybenzoic acid propyl ester sodium salt
sodium 4-(propoxycarbonyl)phenolate
Propyl 4-hydroxybenzoate sodium
Propyl Paraben Sodium
4-Hydroxybenzoic acid, propyl ester, sodium salt
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt
Benzoic acid, p-hydroxy-, propyl ester, sodium deriv.
E217
Natrium propyl 4-hydroxybenzoat
Parasept
Propyl 4-hydroxybenzoate sodium salt
Propyl p-hydroxybenzoate, sodium salt
Propyl-4-hydroxybenzoat natriumsalz
Propylparaben sodium
Propylparaben, sodium salt
Sodium 4-propoxycarbonylphenoxide
35285-69-9
Propylparaben sodium
Sodium propylparaben
Sodium 4-(propoxycarbonyl)phenolate
Propylparaben sodium salt
Parasept
Propyl 4-hydroxybenzoate sodium salt
UNII-625NNB0G9N
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt
625NNB0G9N
sodium;4-propoxycarbonylphenolate
Sodium Propyl Parahydroxybenzoate
Caswell No. 714A
Sodium 4-propoxycarbonylphenoxide
Natrium propyl 4-hydroxybenzoat
Propyl-4-hydroxybenzoat natriumsalz
EINECS 252-488-1
Propyl p-hydroxybenzoate, sodium salt
Propylparaben, sodium salt
EPA Pesticide Chemical Code 061204
Sodium propyl hydroxybenzoate
C10H11NaO3
Propylparaben sodium [USAN:NF]
4-Hydroxybenzoic acid propyl ester sodium salt
E217
PROPYLPARABENSODIUM
Propylparaben sodium (NF)
4-Hydroxybenzoic acid, propyl ester, sodium salt
SCHEMBL48862
CHEMBL2107021
DTXSID3042348
sodium,4-propoxycarbonylphenolate
KS-00000GZL
MFCD00016477
4-(Sodiooxy)benzoic acid propyl ester
AKOS015961951
4-Hydroxybenzoic acid-propyl ester sodium
AC-15528
AK121813
AS-14864
M920
DB-048766
FT-0639250
D02459
Q3963919
W-106681
UNII-F57SQP06GK component IXMINYBUNCWGER-UHFFFAOYSA-M
BENZOIC ACID, p-HYDROXY-, PROPYL ESTER, SODIUM DERIV.
Propyl 4-hydroxybenzoate sodium salt, tested according to Ph.Eur.
 

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