PRODUCTS

THIAMINE-HYDROCHLORIDE

Thiamine Hydrochloride (CAS: 67-03-8), commonly referred to as Vitamin B1, is an essential nutrient used widely in medicine and food applications.
Thiamine Hydrochloride plays a crucial role in cellular energy production as it helps in the conversion of carbohydrates into glucose, which cells use for energy.

CAS: 67-03-8
European Community (EC) Number: 200-641-8

IUPAC Name: 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

Molecular Formula: HC12H17ON4SCl2
C12H18Cl2N4OS
Molecular Weight: 337.3 g/mol

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THIAMINE CHLORIDE HYDROCHLORIDE [JAN], THIAMINI HYDROCHLORIDUM [WHO-IP LATIN], D02094, EN300-258109, Thiamine Hydrochloride (B1), analytical standard, THIAMINE CHLORIDE, HYDROCHLORIDE [WHO-IP], Q-201928, Thiamine hydrochloride, tested according to Ph.Eur., Q27121486, Thiamine hydrochloride, reagent grade, >=99% (HPLC), Thiamine hydrochloride, SAJ special grade, >=98.5%, F0001-2415, F2173-0852, Thiamine hydrochloride, meets USP testing specifications, Z1954805523, WLN: T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &G &GH, Thiamine hydrochloride, 99% (dry wt.), may cont. up to 5% water, Thiamine Hydrochloride (Vitamin B1) 1.0 mg/ml in Methanol (as free base), Thiamine hydrochloride, European Pharmacopoeia (EP) Reference Standard, Thiamine hydrochloride, United States Pharmacopeia (USP) Reference Standard, 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-chloridethiazolium, Thiamine for system suitability, European Pharmacopoeia (EP) Reference Standard, Thiamine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material, THIAZOLIUM,3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-5-(2-HYDROXYETHYL)-4-METHYL-, 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethylthiazolium chloride, monohydrochloride, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium hydrochloride chloride, Thiamine hydrochloride, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethyl, chloride, monohydrochloride, Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, hydrochloride (1:1:1), Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, monohydrochloride

Thiamine hydrochloride is a hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.
Thiamine Hydrochloride has a role as an insect repellent.
Thiamine Hydrochloride is a vitamin B1 and a hydrochloride.
Thiamine Hydrochloride contains a thiamine(2+).

Thiamine Hydrochloride is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.
Upon hydrolysis, thiamine hydrochloride is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase.
TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

Thiamine hydrochloride, a water-soluble vitamin belonging to the B vitamin group, exhibits several noteworthy properties.
Thiamine Hydrochloride serves as a model system for studying the phase transition temperature of fatty acids in biological membranes.
Furthermore, thiamine hydrochloride has demonstrated the ability to enhance thermal expansion and improve chronic exposure in fetal bovine brain cells.
Thiamine Hydrochlorides insecticidal activity has been observed against various insect species, such as the tobacco budworm and the Indianmeal moth.
Thiamine hydrochloride actively participates in cellular metabolism by facilitating the conversion of l-lysine into succinic acid through an intermediate called anthranilate.
Moreover, Thiamine Hydrochloride plays a vital role in pyridoxal phosphate synthesis, a crucial component for protein synthesis and tissue growth.
Thiamine Hydrochloride is a cofactor required for oxidation of carbohydrates and for the synthesis of ribose.

Thiamine hydrochloride, or vitamin B1, occurs as white crystals or crystalline powder that usually has a slight characteristic odor.
Thiamine Hydrochloride is freely soluble in water; soluble in glycerin; slightly soluble in alcohol; insoluble in ether and benzene.
Thiamine is rapidly destroyed in neutral or alkaline solutions but is stable in the dry state.
Thiamine Hydrochloride is reasonably stable to heat in acid solution.

The chemical name of thiamine hydrochloride is thiazolium,3-[(4-amino-2-methyl-5- pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylchloride, monohydrochloride and it has the following structural formula:
C12H17CIN4OS • HCl M.W. 337.27

Thiamine hydrochloride belongs to the group of vitamins.
The active substance is an important cofactor and plays a role in metabolism.
Thiamine Hydrochloride is used for the treatment of vitamin B1 deficiency and nerve cell diseases.

Thiamine hydrochloride plays an important role as a nutrient for carbohydrate metabolism and in nerve function.
Thiamine Hydrochloride finds application as a food-additive to add a brothy/meaty flavor to gravies or soups.
Thiamine Hydrochloride is involved in the preparation of 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium chloride.
In addition, Thiamine Hydrochloride finds use in amino acid synthesis in cultured cells, which is present in many classical and serum-free formulations.

Vitamin B1, also known as Thiamine, named "thio-vitamine" (sulphur-containing vitamins).
Molecular formula C12H17N4OS+.
Vitamin B1 is one of the 13 essential vitamins for the human body.
Vitamin B1 is a water-soluble vitamin and belongs to the vitamin B family.
Vitamin B1 was eventually designated the generic denomination vitamin B1.
Vitamin B1's phosphate derivatives participate in many cellular processes.
The best form is thiamine pyrophosphate (TPP), a coenzyme for the catabolism of sugars and amino acids.

Experimental Properties

Physical Description: Solid with a mild thiazole odor; White to light yellow crystalline powder; Hygroscopic
Color / Form: Crystals from water
Odor: SLIGHT, CHARACTERISTIC
Melting Point: 164 °C
Solubility: SLIGHTLY SOL IN ALC & CHLOROFORM /MONONITRATE/
Stability / Shelf Life: Stable under normal storage conditions; it is degraded in neutral and alkaline solutions (even at room temp)
Decomposition: When heated to decomposition it emits very toxic fumes of /nitric oxide/, /sulfur oxide/, and /chlorine/.
Other Experimental Properties: Monoclinic plates in rosette-like clusters.
Slight thiazole odor; bitter taste; decomposes at 248 °C.
One gram dissolves in approximately 1 mL water, 18 mL glycerol, 100 mL 95% alcohol, 315 mL absolute alcohol; more soluble in methanol.
Soluble in propylene glycol. Practically insoluble in ether, benzene, hexane, chloroform.
pH of 1% wt/vol solution in water 3.13; pH of 0.1% wt/vol solution in water 3.58.
On exposure to air of average humidity, the vitamin absorbs an amount of water corresponding to nearly one mole, forming a hydrate.

Thiamine hydrochloride is used as a food-additive to add a brothy/meaty flavor to gravies or soups.
Thiamine hydrochloride is also used as food supplement. Used in fluorometric determination of mercury.

Thiamine hydrochloride is used to prevent or treat low levels of vitamin B1 in people who do not get enough of the vitamin from their diets.
Most people who eat a normal diet do not need extra vitamin B1.
However, some conditions (such as alcoholism, cirrhosis, stomach/intestinal problems) can cause low levels of vitamin B1.
Vitamin B1 plays an important role in the body.
It is needed to maintain the health of the nerves and the heart.
Low levels of vitamin B1 may cause heart failure and mental/nerve problems.

Thiamine hydrochloride injection is a form of vitamin B1 effective for the treatment of thiamine deficiency or beriberi whether of the dry (major symptoms related to the nervous system) or wet (major symptoms related to the cardiovascular system) variety.
Thiamine hydrochloride injection should be used where rapid restoration of thiamine is necessary, as in Wernicke’s encephalopathy, infantile beriberi with acute collapse, cardiovascular disease due to thiamine deficiency, or neuritis of pregnancy if vomiting is severe.
Thiamine hydrochloride is also indicated when giving intravenous (IV) dextrose to individuals with marginal thiamine status to avoid precipitation of heart failure.

Thiamine hydrochloride injection is also indicated in patients with established thiamine deficiency who cannot take thiamine orally due to coexisting severe anorexia, nausea, vomiting, or malabsorption.

Thiamine hydrochloride is a water-soluble vitamin generally used as a nutrient supplement.
Thiamine hydrochloride undergoes heat-degradation, it may form volatile flavor compounds such as hydrogen sulfide, 2-methylthiopehene, 2-methylfuran, and 4,5-dihydro-2-methylthiophene.

Functions and Applications

Thiamine hydrochloride plays an important role as a nutrient for carbohydrate metabolism and in nerve function.
Thiamine hydrochloride finds application as a food-additive to add a brothy/meaty flavor to gravies or soups.
Thiamine hydrochloride is involved in the preparation of 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium chloride.
In addition, Thiamine hydrochloride finds use in amino acid synthesis in cultured cells, which is present in many classical and serum-free formulations.

1. Thiamine hydrochloride can protect the nervous system and promote gastrointestinal motility and increase appetite.

2. Thiamine hydrochloride mainly plays the role of sugar and sugar (starch) in the process of digestion in the food, and finally produces energy; at the same time, it is necessary for muscle coordination and maintenance of nerve conduction.

3. Thiamine hydrochloride also has a moderate diuretic effect.

Thiamine hydrochloride is a type of Vitamin B, also known as Vitamin B1.
Thiamine hydrochloride helps the body to use carbohydrates for energy and is mostly found in heart, muscles and nervous system.

Signs and symptoms for thiamine deficiency includes loss of appetite, fatigue, tingling sensation in arms and legs or muscle weakness.

This medication is used to treat or prevent a lack of thiamine.
Most people are able to obtain thiamine from their diet but certain medical or health conditions (eg poor nutrition may lead to beri-beri, prolonged vomiting, alcoholism, stomach/intestinal diseases, etc) can cause a deficiency in thiamine.

Effective for...

Metabolic disorders:
Taking thiamine by mouth helps correct certain inherited metabolic disorders, including Leigh's disease, maple syrup urine disease, and others.

Thiamine deficiency:
Taking thiamine by mouth helps prevent and treat thiamine deficiency.
Brain disorder due to thiamine deficiency (Wernicke-Korsakoff syndrome).
Thiamine helps decrease the risk and symptoms of a specific brain disorder called Wernicke-Korsakoff syndrome (WKS).

This brain disorder is related to low levels of thiamine:
It is often seen in alcoholics.
Giving thiamine shots seems to help decrease the risk of developing WKS and decrease symptoms of WKS during alcohol withdrawal.

Thiamine hydrochloride (vitamin B1) is used as a dietary supplement when the amount of thiamine in the diet is not enough.
People most at risk for thiamine deficiency are older adults, those who are dependent on alcohol, or who have HIV/AIDS, diabetes, malabsorption syndrome (problems absorbing food), or have had bariatric surgery (an operation that helps you lose weight by making changes to your digestive system).
Thiamine hydrochloride is used to treat beriberi (tingling and numbness in feet and hands, muscle loss, and poor reflexes caused by a lack of thiamine in the diet) and to treat and prevent Wernicke-Korsakoff syndrome (tingling and numbness in hands and feet, memory loss, confusion caused by a lack of thiamine in the diet).
Thiamine hydrochloride is in a class of medications called vitamins.
Thiamine is needed by the body to turn foods into energy, which is important for the growth, development, and function of cells.

Thiamine is a water-soluble vitamin-B complex.
Structurally, it possesses a five-membered thiazolium ring and a six-membered amino-pyrimidine ring connected by a methyl group.
Thiamine is naturally available in fruits, vegetables, poultry, eggs.

Thiamine hydrochloride (vitamin B1) is found in many foods and is used to treat low thiamine, beriberi, certain nerve diseases, and Wernicke-Korsakoff syndrome (WKS).

Thiamine is required by our bodies to properly use carbohydrates.
Thiamine hydrochloride helps maintain proper nerve function.
Thiamine hydrochloride's found in foods such as yeast, cereal grains, beans, nuts, and meat.
Thiamine hydrochloride's often used in combination with other B vitamins, and is found in many vitamin B complex products.

People take Thiamine hydrochloride for conditions related to low levels of thiamine, including beriberi and inflammation of the nerves (neuritis).
Thiamine hydrochloride's also used for digestive problems, diabetic nerve pain, heart disease, and other conditions, but there is no good scientific evidence to support these other uses.

WHAT DOES Thiamine hydrochloride DO?
Thiamine hydrochloride contributes to normal energy yielding metabolism.
Thiamine Hydrochloride is required as a coenzyme for a few but important enzymes that enable pyruvate to form Acetyl Co A (see Acetyl Co A Support), and alpha ketoglutarate to form Succinyl-Co A products in the cells that make energy from food.

Thiamine hydrochloride contributes to normal functioning of the nervous system.
In the brain Thiamine is required by nerve cells and supporting nervous system cells (or "glial cells"), it's also needed to create neurotransmitters.

Thiamine hydrochloride contributes to normal psychological function – Thiamine Hydrochloride is necessary to create some neurotransmitters (brain chemicals) that are essential for normal psychological function.

Thiamine hydrochloride contributes to the normal function of the heart -Thiamine is found in high concentration in the heart as well as the brain, liver and kidney.
The heart is particularly sensitive to Thiamine deficiency, and impairment of the Thiamine Hydrochloride dependent enzymes primarily affects the heart and nervous system.

Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.
Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase.
TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

Thiamine hydrochloride is specifically used in the treatment of the various manifestations of thiamine deficiency such as Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.
Supplementary Thiamine may be indicated prophylactically in conditions where there is low dietary intake or impaired gastro intestinal absorption of thiamine (e.g. alcohol) or where requirements are increased (pregnancy, carbohydrate rich diet).

DEFICIENCY OF VITAMIN B1
Deficiency is rare as foods and cereals are fortified but symptoms of deficiency might include tiredness, confusion and irritability, apathy, decrease in short term memory, depression and abdominal discomfort.
There is a specific deficiency disorder called Wernicke-Korsakoff syndrome (a neurological disorder), which can occur commonly in malnourished chronic alcoholics, which is a result of Thiamine deficiency.
The active transport of thiamine in the small intestine is inhibited by alcohol and folic acid deficiency.

Thiamine hydrochloride is a hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.
Thiamine hydrochloride has a role as an insect repellent.
Thiamine hydrochloride is a vitamin B1 and a hydrochloride.
Thiamine hydrochloride contains a thiamine(2+).

Thiamine hydrochloride, a water-soluble vitamin belonging to the B vitamin group, exhibits several noteworthy properties.
Thiamine hydrochloride serves as a model system for studying the phase transition temperature of fatty acids in biological membranes.
Furthermore, thiamine hydrochloride has demonstrated the ability to enhance thermal expansion and improve chronic exposure in fetal bovine brain cells.
Thiamine hydrochloride's insecticidal activity has been observed against various insect species, such as the tobacco budworm and the Indianmeal moth.
Thiamine hydrochloride actively participates in cellular metabolism by facilitating the conversion of l-lysine into succinic acid through an intermediate called anthranilate.
Moreover, Thiamine hydrochloride plays a vital role in pyridoxal phosphate synthesis, a crucial component for protein synthesis and tissue growth.
Thiamine Hydrochloride is a cofactor required for oxidation of carbohydrates and for the synthesis of ribose.

Thiamine is important in maintaining overall good health.
A deficiency of thiamine, or vitamin B1, may go undiagnosed and is associated with poor health outcomes, including death.3 The body uses thiamine to get the energy to grow cells and support body functions.
Thiamine helps some of the enzymes in the body that are used in the metabolism of glucose.
This makes thiamine levels important in diseases of the metabolic and gastrointestinal systems.
For that reason, a deficiency may lead to a lack of certain enzymes.
A severe deficiency could lead to decreased production of some enzymes and go on to cause problems in brain function.

Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider.
No supplement is intended to treat, cure, or prevent disease.

Thiamine hydrochloride may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by high-performance liquid chromatography and spectrophotometric methods.

Thiamine hydrochloride has been used as a component:
of the vitamin-concentrated stock solution for the preparation of Hv-Ca medium for culturing Haloferax volcanii
of the tris-acetate-phosphate (TAP) medium for culturing Chlamydomonas nivalis
of modified Bold 3N medium for culturing Chlorella minutissima

Solubility
Soluble in water, glycerol, ethanol, dimethyl sulfoxide and methanol.
Insoluble in benzene, hexane, chloroform and ether.

Notes
Light sensitive and hygroscopic.
Keep the container tightly closed in a dry and well-ventilated place.
Incompatible with strong oxidizing agents.