PRODUCTS

1,2-BENZISOTHIAZOL-3(2H)-ONE (BIT)

1,2-benzisothiazol-3(2H)-one (BIT) is an organic compound with the formula C6H4SN(H)CO.
A white solid, 1,2-benzisothiazol-3(2H)-one (BIT) is structurally related to isothiazole, and is part of a class of molecules called isothiazolinones.
1,2-benzisothiazol-3(2H)-one (BIT) is widely used as a preservative and antimicrobial.

CAS Number : 2634-33-5
EC Number : 220-120-9
Molecular Formula : C7H5NOS
Molecular Weight : 151.19

Usage of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) has a microbicide and a fungicide mode of action.
1,2-benzisothiazol-3(2H)-one (BIT) is widely used as a preservative, for example in:

emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions
home cleaning and car care products; laundry detergents, stain removers and fabric softeners;
industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
agriculture in pesticide formulations
gas and oil drilling in muds and packer fluids preservation.

In paints, 1,2-benzisothiazol-3(2H)-one (BIT) is commonly used alone or as a mixture with methylisothiazolinone.
Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides.
According to a study in Switzerland, 19% of the paints, varnishes and coatings contained 1,2-benzisothiazol-3(2H)-one (BIT) in 2000.
The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%.
A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.

Home cleaning and other care products that are high in water are easily contaminated by microorganisms, so isothiazolinones are often used as a preservatives in these products because they are good at combatting a broad array of bacteria, fungi, and yeasts.
A Swiss investigation found that 1,2-benzisothiazol-3(2H)-one (BIT) is used in concentrations between 50 and 500 ppm in tattooing ink.
According to regulations in the EU and Switzerland, 1,2-benzisothiazol-3(2H)-one (BIT) cannot be used in cosmetics.
However, it is allowed in the United States and Canada.

1,2-benzisothiazol-3(2H)-one (BIT) is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
1,2-benzisothiazol-3(2H)-one (BIT) has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser.
1,2-benzisothiazol-3(2H)-one (BIT) is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

1,2-benzisothiazol-3(2H)-one (BIT) is present in can-end cements 1,2-Benzisothiazol-3(2H)-one belongs to the family of Benzothiazoles.
These are organic compounds containing a benzene fused to a thiazole ring (a five-member ring with four carbon atoms, one nitrogen atom and one sulfur atom).

Usage of 1,2-benzisothiazol-3(2H)-one (BIT)

1,2-benzisothiazol-3(2H)-one (BIT) is widely used biocide that inhibits bacterial growth and spoilage.
1,2-benzisothiazol-3(2H)-one (BIT) is toxic to both microbes and fungus.
1,2-benzisothiazol-3(2H)-one (BIT) is also marketed as a mixture with other isothiazolinone-based biocides.
Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides.

1,2-benzisothiazol-3(2H)-one (BIT) also is active against bacteria and fungi, especially in highly alkaline environments.
1,2-benzisothiazol-3(2H)-one (BIT) is used as a preservative in emulsion paints, varnishes, adhesives, washing agents, fuels and in the papermaking process.
In paints, 1,2-benzisothiazol-3(2H)-one (BIT) is commonly used as a mixture with methylisothiazolinone.
1,2-benzisothiazol-3(2H)-one (BIT) is also used to preserve a variety of water-based process liquids, including metal-working fluids, oil-field fluids and injection water, textile solutions, pesticide emulsions, and mineral slurries and coatings used in paper mills.

1,2-benzisothiazol-3(2H)-one (BIT) is a broad spectrum microbicide for the preservation of industrial water-based products against the attack of microorganisms.
1,2-benzisothiazol-3(2H)-one (BIT) is 20% solution of 1,2-Benzisothiazolin-3-one in dipropylene glycol and water.
1,2-benzisothiazol-3(2H)-one (BIT) is specifically recommended for the preservation of polymer emulsions, paints and coatings, adhesives, and printing inks.

Substance identity

EC / List no.: 220-120-9
CAS no.: 2634-33-5
Mol. formula: C7H5NOS

Hazard classification & labelling of 1,2-benzisothiazol-3(2H)-one (BIT)
Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is very toxic to aquatic life, is harmful if swallowed, causes serious eye damage, causes skin irritation and may cause an allergic skin reaction.
Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects.

About 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
1,2-benzisothiazol-3(2H)-one (BIT) is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

Biocidal Uses of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is being reviewed for use as a biocide in the EEA and/or Switzerland, for: disinfection, product preservation, preservation of fibres, leather, rubber, or polymers, preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.

Consumer Uses of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following products: plant protection products and cosmetics and personal care products.
Other release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) is likely to occur from: outdoor use as processing aid and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Article service life of 1,2-benzisothiazol-3(2H)-one (BIT)
ECHA has no public registered data on the routes by which 1,2-benzisothiazol-3(2H)-one (BIT) is most likely to be released to the environment.
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following products: plant protection products and fertilisers.
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following areas: agriculture, forestry and fishing.
Other release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) is likely to occur from: outdoor use as processing aid and indoor use as processing aid.

Formulation or re-packing of 1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following products: plant protection products, biocides (e.g. disinfectants, pest control products), fertilisers and laboratory chemicals.
Release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industrial sites of 1,2-benzisothiazol-3(2H)-one (BIT)
ECHA has no public registered data indicating whether or in which chemical products the substance might be used.
1,2-benzisothiazol-3(2H)-one (BIT) is used in the following areas: scientific research and development.
Release to the environment of 1,2-benzisothiazol-3(2H)-one (BIT) can occur from industrial use: in processing aids at industrial sites.

Manufacture of 1,2-benzisothiazol-3(2H)-one (BIT)
ECHA has no public registered data on the routes by which 1,2-benzisothiazol-3(2H)-one (BIT) is most likely to be released to the environment.

Synonyms:
1,2-benzisothiazol-3(2H)-one
1,2-benzisothiazol-3(2H)-one
1,2-benzisothiazol-3(2H)-one (BIT)
1,2-benzisothiazol-3(2H)-one;1,2-benzisothiazolin-3-one
1,2-benzisothiazolin-3-one
1,2-Benzisothiazoline-3-one
2-benzisothiazolin-3-one
Benzisothiazol-3(2h)one
1,2,bencisotiazol-3-ona (es)
1,2-bencisotiazol-3(2H)-ona (es)
1,2-Bencisotiazol-3(2H)-ona (BIT) (es)
1,2-bensisotiasool-3(2H)-oon (et)
1,2-bensisotiasool-3(2H)-oon (BIT) (et)
Biocidal active substances
1,2-bensisotiasool-3-oon (et)
1,2-bensisotiazol-3(2H)-on (BIT) (sv)
1,2-bentsisotiatsol-3(2H)-oni (fi)
1,2-bentsisotiatsol-3(2H)-oni (BIT) (fi)
1,2-bentsisotiatsolin-3-oni (fi)
1,2-benzisothiazol-3(2H)-on (da)
1,2-Benzisothiazol-3(2H)-on (de)
1,2-benzisothiazol-3(2H)-one (BIT) (no)
1,2-benzisothiazol-3(2H)-one;1,2-benzisothiazolin-3-one (fr)
1,2-benzisothiazole-3(2H)-one (BIT) (fr)
Biocidal active substances
1,2-Benzisothiazolin-3-on (de)
1,2-benzisothiazool-3(2H)-on (nl)
1,2-Benzisothiazool-3(2H)-on (BIT) (nl)
Biocidal active substances
1,2-benzisotiazol-3(2<I>H</I>)-on (hr)
1,2-benzisotiazol-3(2H)-on (no)
1,2-benzisotiazol-3(2H)-on (sv)
1,2-benzisotiazol-3(2H)-ona (pt)
1,2-benzisotiazol-3(2H)-ona (ro)
1,2-benzisotiazol-3(2H)-ona (BIT) (pt)
Biocidal active substances
1,2-benzisotiazol-3(2H)-one (it)
1,2-benzisotiazol-3(2H)-one (BIT) (it)
Biocidal active substances
1,2-benzisotiazol-3(2H)-onă (BIT) (ro)
Biocidal active substances
1,2-benzisotiazolin-3-on (hr)
1,2-benzisotiazolin-3-ona (ro)
1,2-benzizotiazol-3(2H)-on (hu)
1,2-benzizotiazol-3(2H)-on (sl)
1,2-benzizotiazol-3(2H)-on (BIT) (hr)
Biocidal active substances
1,2-benzizotiazol-3(2H)-on (BIT) (hu)
Biocidal active substances
1,2-benzizotiazol-3(2H)-on (BIT) (pl)
Biocidal active substances
1,2-benzizotiazol-3(2H)-on (BIT) (sl)
Biocidal active substances
1,2-benzizotiazol-3(2H)-on 1,2-benzizotiazol-3(2H)-on (sl)
C&L Inventory
1,2-benzizotiazol-3(2H)-on 1,2-benzizotiazolin-3-on (hu)
C&L Inventory
1,2-benzizotiazol-3(2H)-onas (lt)
1,2-benzizotiazol-3(2H)-onas (BIT) (lt)
Biocidal active substances
1,2-benzizotiazol-3(2H)-onas 1,2-benzizotiazolin-3-onas (lt)
C&L Inventory
1,2-benzizotiazol-3(2H)-ons (lv)
1,2-Benzizotiazol-3(2H)-ons (BIT) (lv)
Biocidal active substances
1,2-benzizotiazol-3(2H)-ón (sk)
1,2-benzizotiazol-3(2H)-ón (BIT) (sk)
Biocidal active substances
1,2-benzizotiazolin-3-on (hu)
1,2-benzizotiazolin-3-onas (lt)
1,2-benzizotiazolin-3-ons (lv)
1,2-benzizotiazolín-3-ón (sk)
1,2-benzoisothiazol-3(2H)-on (BIT) (cs)
Biocidal active substances
1,2-benzoisothiazol-3(2H)-on+ (cs)
1,2-benzoisothiazolin-3-on (cs)
1,2-benzoizotiazol-3(2H)-on (pl)
1,2-benzoizotiazolin-3-on (pl)
1,2-Benżisotijażol-3(2H)-on (BIT) (mt)
Biocidal active substances
1,2-βενζισοθειαζολ-3(2H)-όνη (el)
1,2-βενζισοθειαζολ-3(2H)-όνη (BIT) (el)
Biocidal active substances
1,2-бензизотиазол-3(2H)-oн (bg)
1,2-бензизотиазол-3(2H)-он (BIT) (bg)
Biocidal active substances
1,2-бензизотиазолин-3-oн (bg)
1,2-Benzisothiazol-3(2H)-one
2634-33-5
1,2-Benzisothiazolin-3-one
1,2-benzothiazol-3-one
benzisothiazolone
Benzo[d]isothiazol-3(2H)-one
Benzo[d]isothiazol-3-one
1,2-Benzisothiazoline-3-one
Proxel
Proxel PL
benzoisothiazol-3-one
1,2-BENZISOTHIAZOL-3-ONE
Benzo[d]isothiazol-3-ol
2,3-dihydro-1,2-benzothiazol-3-one
Benzisothiazolin-3-one
1,2-benzoisothiazolin-3-one
Nipacide BIT
Proxel AB
3-Hydroxy-1,2-benzisothiazole
C7H5NOS
Proxel XL 2
1,2-Benzisothiazolone
1,2-benzisothiazolinone
1,2-Benzoisothiazol-3-one
IPX
CHEBI:167099
HRA0F1A4R3
1,2-Benzoisothiazoline-3-one
DTXSID5032523
2,3-dihydro-3-oxo-1,2-benzisothiazole
MLS-0254244.0001
Benzo(d)isothiazol-3(2H)-one
Caswell No. 079A
Caswell No. 513A
Benzocil
Acticide BIT
Canguard BIT
Denicide BIT
Proxel BD
Proxel CF
Proxel TN
Proxel XL
Proxel BDN
Proxel GXL
Proxel Ultra 5
San-aibac AP
Proxel LV-S
Proxel Press Paste
Apizas AP-DS
Acticide BW 20
Bestcide 200K
Nipacide BIT 20
Parmetol B 70
Parmetol D 11
Proxel GXL(S)
Proxel HL 2
Nuosept 485
Nuosept 491
Nuosept 495
Topcide 600
XBINX
CCRIS 6369
Denicide BIT 20N
Koralone B 119
Nipacide BIT 10W
Preventol BIT 20D
Proxel BD 20
Proxel Press Paste D
Troysan 1050
Bioban BIT 20DPG
benzisothiazoline-3-one
Canguard BIT 20DPG
EINECS 220-120-9
SD 202 (bactericide)
UNII-HRA0F1A4R3
Canguard Ultra BIT 20LE
EPA Pesticide Chemical Code 098901
BIT 10W
BIT 20
2-Thiobenzimide
2,3-Dihydrobenzisothiazol-3-one
SD 202
ORISTAR BIT
1,2-BENZISOTHAZOL-3(2H)-ONE
1,2-Benzothiazolinone
Benzisothiazolone (BIT)
Epitope ID:115004
Benzisothiazol-3(2H)-one
Benzo(D) Isothiazol-3-one
SCHEMBL26078
40991-37-5
cid_17520
MLS000771034
REGID_for_CID_17520
CHEMBL297304
SCHEMBL5586024
DTXCID3012523
BDBM46658
HSDB 8271
BENZISOTHIAZOLINONE [INCI]
HMS1755P21
HMS2706H20
ZINC2581983
Tox21_300489
MFCD00044001
1, 2-BENZISOTHIAZOLIN-3-ONE
AKOS001062434
AKOS030227972
AC-2653
CS-W018117
FS-3163
1,2-Benzisothiazol-3(2H)-one, 97%
NCGC00164206-01
NCGC00248077-01
NCGC00254467-01
SMR000344133
US9011882, Table 1, Compound 20
CAS-2634-33-5
BENZISOTHIAZOL-3(2H)-ONE, 1,2-
DB-027306
AM20060449
B2430
FT-0606282
EN300-17679
A818398
AE-562/40151878
Q411746
1,2-Benzisothiazol-3(2H)-one, analytical standard
W-107178
Z56983154
F0288-0100
1,2-Benzisothiazol-3(2H)-one [ACD/Index Name]
1,2-Benzisothiazol-3-ol [ACD/Index Name]
1,2-Benzothiazol-3(2H)-on [German] [ACD/IUPAC Name]
1,2-Benzothiazol-3(2H)-one [ACD/IUPAC Name]
1,2-Benzothiazol-3(2H)-one [French] [ACD/IUPAC Name]
1,2-Benzothiazol-3-ol [German] [ACD/IUPAC Name]
1,2-Benzothiazol-3-ol [ACD/IUPAC Name]
1,2-Benzothiazol-3-ol [French] [ACD/IUPAC Name]
2,3-dihydro-1,2-benzothiazol-3-one
220-120-9 [EINECS]
2634-33-5 [RN]
BENZISOTHIAZOLINONE
Benzisothiazolone [Wiki]
Benzisothiazolone (BIT)
benzo[d]isothiazol-3-one
DE4620000
HRA0F1A4R3
MFCD00127753 [MDL number]
T56 BSMVJ [WLN]
T56 BSNJ DQ [WLN]
[2634-33-5] [RN]
1,2-BENZISOTHAZOL-3(2H)-ONE
1,2-Benzisothiazol-3-one
1,2-Benzisothiazolin-3-one
1,2-Benzisothiazolinone
1,2-Benzisothiazolone
1,2-benzoisothiazolin-3-one
1,2-Benzoisothiazoline-3-one
1,2-Benzothiazol-3-one
1,2-Benzothiazolinone
2,3-dihydro-3-oxo-1,2-benzisothiazole
2-hydrobenzo[d]isothiazol-3-one
2-Thiobenzimide
3-Hydroxy-1,2-benzisothiazole
54392-15-3 [RN]
75037-67-1 [RN]
9015-68-3 [RN]
Acticide BIT
Benzisothiazol-3(2H)-one
BENZISOTHIAZOLINONE|"1,2-BENZOTHIAZOL-3-OL"
Benzo(D) Isothiazol-3-one
benzo[d]isothiazol-3(2H)-one
Benzo[d]isothiazol-3-ol
Benzoisothiazol-3-one
Benzoisothiazol-3-one|1,2-Benzisothiazol-3(2H)-one|3-Hydroxy-1,2-benzisothiazole
BIT
BR-46705
EINECS 220-120-9
FS-3163
IPX
MFCD00044001 [MDL number]
MLS000771034
NCGC00164206-01
Nipacide BIT
proxan
Proxel
Proxel AB
Proxel PL
Proxel XL 2
PROXELCRL
SMR000344133
ST-8237
T5241073
UNII:HRA0F1A4R3
UNII-HRA0F1A4R3