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1,4-DIMETHYLPIPERAZINE

Chemical Identifiers
CAS: 106-58-1
Molecular Formula: C6H14N2
Molecular Weight (g/mol): 114.192

Description of 1,4-Dimethylpiperazine
Catalogue Number: 803580
Product Information
CAS number: 106-58-1
EC number: 203-412-0
Hill Formula: C₆H₁₄N₂
Molar Mass: 114.19 g/mol
HS Code: 2933 59 95

Uses of 1,4-Dimethylpiperazine
As an anthelmintic
1,4-Dimethylpiperazine was marketed by Bayer as an anthelmintic in the early 20th century, and was featured in print ads alongside other popular Bayer products at the time, including heroin.
In fact, a large number of piperazine compounds have an anthelmintic action.
Their mode of action is generally by paralysing parasites, which allows the host body to easily expel the invasive organism.
The neuromuscular effects are thought to be caused by blocking acetylcholine at the myoneural junction.
This action is mediated by its agonist effects upon the inhibitory GABA (γ-aminobutyric acid) receptor.
1,4-Dimethylpiperazine's selectivity for helminths is because vertebrates use GABA only in the CNS, and the GABA receptor of helminths is of a different isoform from that of vertebrates.

Piperazine hydrate, piperazine adipate and piperazine citrate (used to treat ascariasis and enterobiasis) are the most common anthelmintic piperazine compounds.
These drugs are often referred to simply as "piperazine" which may cause confusion between the specific anthelmintic drugs, the entire class of piperazine-containing compounds, and the compound itself.
Diethylcarbamazine, a derivative of piperazine, is used to treat some types of filariasis.

Other uses of 1,4-Dimethylpiperazine
1,4-Dimethylpiperazine are also used in the manufacture of plastics, resins, pesticides, brake fluid and other industrial materials.
1,4-Dimethylpiperazine, especially BZP and TFMPP were extremely common adulterants in the club and rave scene, often being passed off as MDMA, although they do not share many similarities in their effects.
1,4-Dimethylpiperazine is also a fluid used for CO2 and H2S scrubbing in association with methyl diethanolamine (MDEA).

Carbon capture and storage
Simplified absorption column.
Typical operating range: 35-50 °C and 5-205 atm of absolute pressure
Amine blends that are activated by concentrated piperazine are used extensively in commercial CO2 removal for carbon capture and storage (CCS) because piperazine advantageously allows for protection from significant thermal and oxidative degradation at typical coal flue gas conditions.
The thermal degradation rates for methyl diethanolamine (MDEA) and piperazine (PZ) are negligible, and PZ, unlike other metals, protect MDEA from oxidative degradation.
This increased stability of the MDEA/PZ solvent blend over MDEA and other amine solvents provides for greater capacity for and requires less work to capture a given amount of CO2.

Applications of 1,4-Dimethylpiperazine
1,4-Dimethylpiperazine can be analyzed by this reverse phase (RP) HPLC method with simple conditions.
The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid.
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid.
Smaller 3 µm particles columns available for fast UPLC applications.
This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation.
1,4-Dimethylpiperazine also suitable for pharmacokinetics.

Applications of 1,4-Dimethylpiperazine:
Used in polyurethane resin curing agent
Used for pharmaceutical intermediates
Used for intermediates for surfactants

Physicochemical Information of 1,4-Dimethylpiperazine:
Density: 0.85 g/cm3 (20 °C)
Explosion limit: 1.8 - 9.6 %(V)
Flash point: 20 °C
Ignition temperature: 180 °C
Melting Point: -1 °C
pH value: 11.4 (H₂O)
Vapor pressure: 13.06 hPa (20 °C)

MDL Number: MFCD00006156
InChI Key: RXYPXQSKLGGKOL-UHFFFAOYSA-N
PubChem CID: 7818
IUPAC Name:1,4-dimethylpiperazine

Chemical Properties of 1,4-Dimethylpiperazine:
clear colorless to yellow liquid

Uses of 1,4-Dimethylpiperazine:
Catalyst for polyurethane foams and intermediate for cationic surfactants.

Technical Information of 1,4-Dimethylpiperazine:
Physical State :Liquid
Storage :Store at room temperature
Boiling Point :131-132° C (lit.) at 750 mmHg
Density :0.84 g/cm3 at 25° C

Computed Properties of 1,4-Dimethylpiperazine:
Molecular Weight: 114.19
XLogP3: -0.4
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count : 0
Exact Mass: 114.115698455
Monoisotopic Mass: 114.115698455
Topological Polar Surface Area: 6.5 Å²
Heavy Atom Count: 8
Formal Charge: 0
Complexity: 54.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count   0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of 1,4-Dimethylpiperazine:
Chemical Name or Material
1,4-Dimethylpiperazine
pH: 10
Boiling Point: 131°C to 132°C
Molecular Formula: C6H14N2
Odor: Amine-like
Molecular Weight (g/mol): 114.192
Formula Weight: 114.19
CAS: 106-58-1
Melting Point: -1°C
Flash Point: 21°C (69°F)
MDL Number: MFCD00006156
UN Number
UN number : 2733
IUPAC Name:1,4-dimethylpiperazine
PubChem CID:7818
Percent Purity: 98%

TECHNICAL DATA of 1,4-Dimethylpiperazine:
CAS No:   106-58-1
Product Code:   FD34698
MDL No:   MFCD00006156
Chemical Formula: C6H14N2
Molecular Weight: 114.19 g/mol

Properties of 1,4-Dimethylpiperazine:
Melting Point: -1°C
Boiling Point: 131-132°C @ 750 mmHg
Density: 0.84 g/mL @ 20 °C

Compound number:
MolPort-001-768-832
CAS number:   106-58-1
IUPAC:   1,4-dimethylpiperazine
IUPAC traditional: piperazine, 1,4-dimethyl-
Molecular formula: C6H14N2
Molecular weight: 114.192
Solubility:   not available

Identificators of 1,4-Dimethylpiperazine:
InChI: InChI=1S/C6H14N2/c1-7-3-5-8(2)6-4-7/h3-6H2,1-2H3
InChI Key: RXYPXQSKLGGKOL-UHFFFAOYSA-N
Canonical SMILES: CN1CCN(CC1)C
CAS: 106581

Structure of 1,4-Dimethylpiperazine:
Stereochemistry: ACHIRAL
Molecular Formula: C6H14N2
Molecular Weight: 114.189
Optical Activity: NONE
Defined Stereocenters: 0 / 0
E/Z Centers: 0
Charge: 0

DESCRIPTION of 1,4-Dimethylpiperazine:
1,4-Dimethylpiperazine by Research Lab Fine Chem Industries is a high grade reagent.
1,4-Dimethylpiperazine is a derivative of piperazine.
1,4-Dimethylpiperazine is available as a powder. It has a melting point of -1 C and a boiling point of 131 132 C.
While 1,4-Dimethylpiperazine is stable under general conditions, this reagent is incompatible with strong oxidizing agents.
CAS No.: 106-58-1
Quantity Provided: 50 gm per bottle
Molecular formula: C6H14N2
Molecular weight: 114.19
Assay: 98
%1,4-Dimethylpiperazine has a variety of applications in chemical and biological sectors.
This compound finds several applications in the synthesis of various organic derivatives.
1,4-Dimethylpiperazine finds use as a catalyst for polyurethane foams and also as an intermediate for cationic surfactants.
1,4-Dimethylpiperazine is suitable for the industrial synthesis of products and research applications.

General Information of 1,4-Dimethylpiperazine:
Product Number D0787
Purity / Analysis Method: >98.0%(GC)(T)
Molecular Formula / Molecular Weight: C6H14N2 = 114.19
Physical State (20 deg.C): Liquid
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Air Sensitive
Reaxys Registry Number: 103022
PubChem Substance ID: 87567414
SDBS (AIST Spectral DB): 2167
MDL Number: MFCD00006156

Specifications of 1,4-Dimethylpiperazine:
Appearance: Colorless to Light yellow clear liquid
Purity(GC): min. 98.0 %
Purity(Nonaqueous Titration): min. 98.0 %
Properties (reference)
Melting Point: -1 °C
Boiling Point: 133 °C
Flash point: 25 °C
Specific Gravity (20/20): 0.85
Refractive Index: 1.45
Solubility in water: Completely miscible

CHEMICAL DATA of 1,4-Dimethylpiperazine:
Formula Weight: 114.19 g/mol
Density: 0.844 g/cm³
Melting Point: -1 °C
Boiling Point: 131-132/750mm °C
Flash Point: 18 °C

Basic Info of 1,4-Dimethylpiperazine:
Chemical Name
1,4-dimethylpiperazine-2,3-dione
CAS No.: 59417-06-0
Molecular Formula: C6H10N2O2
Molecular Weight: 142.15600
PSA: 40.62000
LogP: -1.20740

Properties of 1,4-Dimethylpiperazine:
Density: 1.169g/cm3
Boiling Point: 206.5ºC at 760 mmHg
Flash Point: 81.2ºC
Refractive Index: 1.491

Strong and weakly acidic ion exchange resins and polymeric adsorbents are used for recovery of 1,4‐dimethyl piperazine (DMP) from aqueous solutions.
Sorption of the amine in undissociated form is the primary mechanism of uptake of DMP on the ion‐exchange resins.
Equilibrium adsorption data for DMP on the resins, at various temperatures, are fitted in Langmuir adsorption isotherm.
Kinetic studies show that intraparticle diffusional resistance controls the sorption of DMP into the resin matrix.
A mathematical model based on intraparticle diffusion and external mass transfer is used for simulating breakthrough profiles and compared with the experimental results for a fixed bed of weakly acidic Indion‐652 resin.
The DMP loaded bed of the resin was effectively regenerated with methanol.

STORAGE of 1,4-Dimethylpiperazine:
It should be stored at ambient Temperature in dry area in tightly closed container and away from direct sun light.

PACKAGING of 1,4-Dimethylpiperazine:
Packed in 180 Kgs. Nett HM-HDPE Drums.

HANDLING & SAFETY of 1,4-Dimethylpiperazine:
Wear protecting clothing, goggles and gloves.
Absorb material spilled on the floor with absorbent granules.
Fight fire with chemical Carbon dioxide or DCP extinguisher.

FIRST AID
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid.
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Those who take it by mistake, take milk, soy milk or egg white orally to induce vomiting.
Seek medical attention.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Get medical aid.

Synonyms of 1,4-Dimethylpiperazine
1,4-Dimethylpiperazine
N,N'-dimethylpiperazine
106-58-1
Lupetazine
PIPERAZINE, 1,4-DIMETHYL-
Texacat DMP
1,4-dimethyl-piperazine
UNII-TF146U602L
MFCD00006156
1,4-dimethyl-2,3,5,6-tetrahydropyrazine
TF146U602L
CCRIS 6690
EINECS 203-412-0
NSC 41177
Piperazine,4-dimethyl-
N,N'-Dimethyipiperazine
N,N'-di-methylpiperazine
N,N/'-Dimethylpiperazine
EC 203-412-0
SCHEMBL1069
DSSTox_CID_30096
DSSTox_GSID_51544
N,N-DIMETHYLPIPERAZINE
1,4-Dimethylpiperazine, 98%
SCHEMBL7539180
CHEMBL3560545
DTXSID8051544
NSC41177
Tox21_303778
7550AF
NSC-41177
ZINC19366060
AKOS005206832
NCGC00357070-01
CAS-106-58-1
PS-11956