1,7-HEPTANEDICARBOXYLIC ACID

1,7-Heptanedicarboxylic acid is a naturally occurring dicarboxylic acid found in whole grains, animal products, and produced by Malassezia furfur, possessing antibacterial, keratolytic, comedolytic, and antioxidant properties.
1,7-Heptanedicarboxylic acid is effective in treating mild to moderate acne and rosacea by inhibiting microbial protein synthesis, reducing stratum corneum thickness, and exerting anti-inflammatory effects through free radical scavenging.
Beyond dermatological applications, 1,7-Heptanedicarboxylic acid serves as a precursor in industrial processes, contributing to the production of polymers, plasticizers, and skin and hair conditioning products.

CAS Number: 123-99-9
EC Number: 204-669-1
Molecular formula: C9H16O4
Molar mass: 188.22 g/mol

Synonyms: 1,7-dicarboxyheptane, 1,7-Heptanedicarboxylic acid, 1,9-nonanedioic acid, acide azélaïque, acidum azelaicum, anchoic acid, Azelaic acid, AZELAIC ACID, azelaic acid, Azelainsäure Deutsch, lepargylic acid, n-nonanedioic acid, Nonandisäure Deutsch, Nonanedioic acid, 1,7-Heptanedicarboxylic acid, 1101094 [Beilstein], 123-99-9 [RN], 204-669-1 [EINECS], Acide azélaïque [French] [ACD/IUPAC Name], acide nonanedioïque [French], Acido azelaico [Spanish], anchoic acid, Azalaic Acid, Azelaate [ACD/IUPAC Name], Azelaic acid [ACD/IUPAC Name] [USAN] [Wiki], Azelainic acid, Azelainsäure [German] [ACD/IUPAC Name], Azelex [Trade name], Finaceae [Trade name], lepargylic acid, MFCD00004432 [MDL number], Nonandisäure [German], Nonanedioic acid [ACD/Index Name], Skinoren [Trade name], 1,7-dicarboxyheptane, 1,9-NONANEDIOIC ACID, 119176-67-9 [RN], acide azelaique [French], Acido azelaico [Spanish], Acidum acelaicum, Acidum azelaicum [Latin], AHI, AZ1, Azelaic acid,, azelaicacid, Azelainsäure [ACD/IUPAC Name], Azelate, DB00548, Emery's L-110, Finacea [Wiki], Heptanedicarboxylic acid, n-nonanedioic acid, Nonandisäure, Nonanedioate, Nonanedioic-D14 Acid, Nonanedionic acid, Skinorem, Water-soluble azelaic acid, Zumilin, азелаиновая кислота, حمض أزيلائيك, 壬二酸, azelaic acid, NONANEDIOIC ACID, 123-99-9, Finacea, Anchoic acid, Azelex, 1,7-Heptanedicarboxylic acid, Lepargylic acid, Skinoren, 1,9-Nonanedioic acid, Heptanedicarboxylic acid, n-Nonanedioic acid, Emerox 1110, Emerox 1144, acide azelaique, Finevin, Azelainic acid, acidum azelaicum, azelate, Polyazelaic anhydride, Skinorem, 1,7-Dicarboxyheptane, Azelaic acid, technical grade, Emery's L-110, azelaate, Poly(azelaic anhydride), ZK 62498, ZK-62498, UNII-F2VW3D43YT, NSC 19493, Azelaic acid 99%, Azelaic acid, 98%, CHEBI:48131, MFCD00004432, F2VW3D43YT, MLS000069659, 26776-28-3, NSC19493, NSC-19493, NCGC00014993-07, SMR000059164, Acido azelaico, Azalaic Acid, DSSTox_CID_1640, Acide azelaique [French], Acido azelaico [Spanish], Acidum azelaicum [Latin], DSSTox_RID_76254, DSSTox_GSID_21640, heptane-1,7-dicarboxylic acid, Azelaic acid [USAN:INN], Azelaic polyanhydride, Nonanedioic acid, homopolymer, Azelaic, Azelaic acid polyanhydride, CAS-123-99-9, Finacea (TN), Azelex (TN), SR-01000075671, EINECS 204-669-1, Azelaic acid (USAN/INN), BRN 1101094, Azelaicacidtech, Azelainsaeure, Lepargylate, Nonandisaeure, Anchoate, Nonanedioic acid, sodium salt, n-Nonanedioate, AI3-06299, nonanedionic acid, HSDB 7659, 1tuf, azelaic acid group, 1,9-Nonanedioate, SH-441, AGN-191861, Spectrum_000057, ACMC-1BTAP, Opera_ID_740, Polyazelaic Polyanhydride, 1,7-Heptanedicarboxylate, Spectrum2_000995, Spectrum3_000278, Spectrum4_000401, Spectrum5_001304, C9-120-alpha-polymorph, C9-140-alpha-polymorph, C9-180-alpha-polymorph, C9-220-alpha-polymorph, C9-260-alpha-polymorph, C9-298-alpha-polymorph, Epitope ID:187039, A-9800, EC 204-669-1, Nonanedioic acid homopolymer, Lopac-246379, SCHEMBL3887, CHEMBL1238, Lopac0_000051, BSPBio_001756, KBioGR_000662, KBioSS_000437, Nonanedioic acid Azelaic acid, 4-02-00-02055 (Beilstein Handbook Reference), 1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, 1-azelaoyl-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, 2-azelaoyl-sn-glycero-3-phosphocholine has functional parent nonanedioic acid, nonanedioic acid monoglycoside has functional parent nonanedioic acid, azelaate is conjugate base of nonanedioic acid, azelaate(2−) is conjugate base of nonanedioic acid

1,7-Heptanedicarboxylic acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. 
1,7-Heptanedicarboxylic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. 

1,7-Heptanedicarboxylic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to 1,7-Heptanedicarboxylic acid inhibitory effect on the synthesis of microbial cellular proteins. 
1,7-Heptanedicarboxylic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. 

1,7-Heptanedicarboxylic acid also possesses a direct anti-inflammatory effect due to 1,7-Heptanedicarboxylic acid scavenger activity of free oxygen radical. 
This drug is used topically to reduce inflammation associated with acne and rosacea.

1,7-Heptanedicarboxylic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. 
1,7-Heptanedicarboxylic acid  is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin. 

1,7-Heptanedicarboxylic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. 
1,7-Heptanedicarboxylic acid  works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. 
1,7-Heptanedicarboxylic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.

1,7-Heptanedicarboxylic acid is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH). 
1,7-Heptanedicarboxylic acid possesses a variety of biological actions both in vitro and in vivo. 

Interest in the biological activity of 1,7-Heptanedicarboxylic acid arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection. 
Later, 1,7-Heptanedicarboxylic acid was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro. 

1,7-Heptanedicarboxylic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: 1,7-Heptanedicarboxylic acid possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base cream than other dicarboxylic acids. 
1,7-Heptanedicarboxylic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris. 

1,7-Heptanedicarboxylic acid offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin. 
1,7-Heptanedicarboxylic acid is less expensive than certain other prescription acne preparations, but 1,7-Heptanedicarboxylic acid is much more expensive than nonprescription benzoyl peroxide preparations. 
Whether 1,7-Heptanedicarboxylic acid is safe and effective when used in combination with other agents is not known.

1,7-Heptanedicarboxylic acid is an organic compound with the formula HOOC(CH2)7COOH.
This saturated dicarboxylic acid exists as a white powder. 

1,7-Heptanedicarboxylic acid is found in wheat, rye, and barley. 
1,7-Heptanedicarboxylic acid is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners

1,7-Heptanedicarboxylic acid has role antibacterial agent.
1,7-Heptanedicarboxylic acid has role antineoplastic agent.

1,7-Heptanedicarboxylic acid has role dermatologic drug.
1,7-Heptanedicarboxylic acid has role plant metabolite.

1,7-Heptanedicarboxylic acid is a α,ω-dicarboxylic acid.
1,7-Heptanedicarboxylic acid is conjugate acid of azelaate.
1,7-Heptanedicarboxylic acid is conjugate acid of azelaate(2−).

1,7-Heptanedicarboxylic acid is a dicarboxylic acid and is a white crystalline powder available in various purity grades depending on the final application.
The innovative production process achieves 1,7-Heptanedicarboxylic acid with very high purity and low monocarboxylic content, fundamental features for 1,7-Heptanedicarboxylic acid use as an intermediate in polymerization processes, typically as an alternative to sebacic acid and adipic acid.

The physiologic effect of 1,7-Heptanedicarboxylic acid is by means of Decreased Protein Synthesis, and Decreased Sebaceous Gland Activity.

1,7-Heptanedicarboxylic acid is an ingredient with antibacterial, skin cell regulating, anti-inflammatory and skin-lightening magic properties.
1,7-Heptanedicarboxylic acid is especially useful for acne-prone or rosacea-prone skin types (in concentration 10% and up)
1,7-Heptanedicarboxylic acid is a prescription drug in the US but can be freely purchased in the EU in an up to 10% concentration.

1,7-Heptanedicarboxylic acid is a compound found in wheat, rye and barley that can help treat acne and rosacea because 1,7-Heptanedicarboxylic acid soothes inflammation.
1,7-Heptanedicarboxylic acid treats sunspots and melasma because 1,7-Heptanedicarboxylic acid blocks the production of abnormal pigmentation

1,7-Heptanedicarboxylic acid is also a tyrosinase inhibitor, meaning 1,7-Heptanedicarboxylic acid can prevent hyperpigmentation because it interferes with melanin production. 
1,7-Heptanedicarboxylic acid is anti-inflammatory for the acne and 1,7-Heptanedicarboxylic acid is anti-pigment because it blocks tyrosinase.

1,7-Heptanedicarboxylic acid is a more gentle exfoliant than other alpha hydroxy acids (AHAs), including glycolic, lactic and mandelic acids

Chemically, 1,7-Heptanedicarboxylic acid is a dicarboxylic acid. 
1,7-Heptanedicarboxylic acid works on skin as a gentle leave-on exfoliant which helps unclog pores and refine skin's surface. 

1,7-Heptanedicarboxylic acid also significantly lessens factors in skin that lead to sensitivity and bumps and delivers antioxidant benefits. 
1,7-Heptanedicarboxylic acid can be derived from grains like barley, wheat, and rye, but it’s the lab-engineered form that is typically used in skincare products because of 1,7-Heptanedicarboxylic acid stability and effectiveness.

Much of the research on this ingredient has looked at prescription-only topical products with concentrations between 15% and 20%, but there are incredible benefits to be seen even at lower concentrations.

1,7-Heptanedicarboxylic acid is a naturally occurring acid found in grains like barley, wheat, and rye.
Today's 1,7-Heptanedicarboxylic acid is synthesized in a lab, though, to ensure 1,7-Heptanedicarboxylic acid is uniform and stable.

1,7-Heptanedicarboxylic acid is an exfoliant that unclogs pores and also reduces pigmentation and the effects of scarring. 
1,7-Heptanedicarboxylic acid manipulates the most upper layers in the cells which leaves you with a smooth and visibly healthier skin tone. 
If you’re looking for a brighter skin tone with visibly improved evenness, skincare including 1,7-Heptanedicarboxylic acid is a great choice.

1,7-Heptanedicarboxylic acid isn't an incredibly common skin care ingredient, but 1,7-Heptanedicarboxylic acid can be found in some over-the-counter anti-aging and skin brightening products in strengths up to 10%.
For treating acne or rosacea, though, a prescription strength of at least 15% is needed.

1,7-Heptanedicarboxylic acid is relatively obscure when compared to some of the more trendy and well-known skin care acids like glycolic, lactic, salicylic, and even hyaluronic acid.
But 1,7-Heptanedicarboxylic acid works slightly differently than other skin care acids.

Over-the-counter 1,7-Heptanedicarboxylic acid can help improve minor blackheads, refine the pores, even out skin tone, and brighten the complexion. 
Stronger, prescription 1,7-Heptanedicarboxylic acid has even more benefits for the skin.

Topical 1,7-Heptanedicarboxylic acid formulations have been used to address a wide range of physiological maladies including acne, hyperpigmentary dermatoses, hair loss, wrinkling, hyperhidrosis, non-acne inflammatory dermatoses, infectious cutaneous diseases and ichthyosis.
However, the only topical formulations of 1,7-Heptanedicarboxylic acid presently known are dispersions. 

Dispersions deliver 1,7-Heptanedicarboxylic acid in an undissolved state. 
When applied to the skin, undissolved 1,7-Heptanedicarboxylic acid is not readily absorbed and as a result an excess of 1,7-Heptanedicarboxylic acid must be present to be effective. 

The higher the concentration of 1,7-Heptanedicarboxylic acid, the more likely irritation (burning, stinging and redness) to the skin will occur.
What is needed is a completely solubilized topical 1,7-Heptanedicarboxylic acid composition. 

Solubilized 1,7-Heptanedicarboxylic acid is much less likely to irritate the skin because 1,7-Heptanedicarboxylic acid in a dissolved state is much more readily absorbed by the need be present in the formulation to be effective thereby lowering the risk of irritation to the skin.
While 1,7-Heptanedicarboxylic acid is somewhat soluble in water, cosmetic oils and alcohols, each of these solvents has serious limitations. 

Thus, water only marginally dissolves 1,7-Heptanedicarboxylic acid so that a water and 1,7-Heptanedicarboxylic acid solution would contain a maximum of about .24% by weight (w/w) 1,7-Heptanedicarboxylic acid, not likely enough to be effective. 
1,7-Heptanedicarboxylic acid has little or no solubility in cosmetic oils. 

Alcohols are good solvents but are unsatisfactory because large amounts of alcohol e.g., isopropyl alcohol, in a topical composition has the undesirable side effect of drying the skin. 
Indeed, some alcohols e.g., ethyl alcohol, render 1,7-Heptanedicarboxylic acid unstable at normal temperatures and atmospheric pressures resulting in a totally ineffective composition

1,7-Heptanedicarboxylic acid is produced by a yeast (Malassezia fur fur, also known as Pityrosporum ovale) that is part of normal skin flora. 
1,7-Heptanedicarboxylic acid can help in both acne vulgaris and acne rosacea as an antimicrobial, antiinflammatory, and comedolytic. 

1,7-Heptanedicarboxylic acid can also be used for postinflammatory hyperpigmentation.
One study that compared results of European clinical trials showed 1,7-Heptanedicarboxylic acid 20% cream is as effective as tretinoin 0.05%, benzoyl peroxide 5%, and topical erythromycin 2%.
1,7-Heptanedicarboxylic acid is similar to benzoyl peroxide, but there is less evidence of 1,7-Heptanedicarboxylic acid usefulness.

Dosage:
Recommended dosage is 20% cream for acne vulgaris and 15% gel for acne rosacea, both applied one to two times a day.

Precautions:
Can cause hypopigmentation and some skin irritation but is usually well tolerated.

Topical 1,7-Heptanedicarboxylic acid:
The topical application of 1,7-Heptanedicarboxylic acid appears to be extremely effective in papulopustular rosacea. 
Initially, 1,7-Heptanedicarboxylic acid was released in a 20% cream formulation and was shown in this vehicle to be effective in the treatment of mild to moderate rosacea. 

A 15% gel formulation of 1,7-Heptanedicarboxylic acid vastly improved the delivery of 1,7-Heptanedicarboxylic acid and has been shown to be superior in head-to-head studies to the 20% 1,7-Heptanedicarboxylic acid cream. 
1,7-Heptanedicarboxylic acid is equally as effective as metronidazole cream or gel.

In a meta-analysis of five double-blind trials involving topical 1,7-Heptanedicarboxylic acid (cream or gel) for the treatment of rosacea compared with placebo or other topical treatments, four of five studies demonstrated significant decreases in mean inflammatory lesion count and erythema severity after treatment with 1,7-Heptanedicarboxylic acid compared with placebo, and 1,7-Heptanedicarboxylic acid was found to be equal to metronidazole in papulopustular rosacea. 
However, no significant decrease in the severity of telangiectasia occurred in any treatment group.

Overexpression of cathelicidin peptide LL-37 has been implicated in the pathophysiology of rosacea, and 1,7-Heptanedicarboxylic acid has been found to inhibit the pathological expression of cathelicidin, as well as the hyperactive protease activity that cleaves cathelicidin into LL-37. 
A small, prospective, open-label, interventional study was performed to assess the effects of 1,7-Heptanedicarboxylic acid 15% gel on inflammatory lesions of papulopustular rosacea.
1,7-Heptanedicarboxylic acid use was associated with a significant reduction in inflammatory lesions, and these results persisted beyond the active treatment phase.

Chemical peels:

Bleaching agents:
Hydroquinones are the most commonly used bleaching agents; other products include 1,7-Heptanedicarboxylic acid, aloesin, vitamin C, arbutin, licorice extract, glabridin, mequinol (4-hydroxyanisol), melatonin, niacinamide, paper mulberry, soy, vitamin E, kojic acid, α- and β-hydroxy acids, and retinoids and retinoid combination therapy.

1,7-Heptanedicarboxylic acid is a prescription medication used to treat mild to moderate acne vulgaris, as well as rosacea. 

1,7-Heptanedicarboxylic acid comes in a gel, lotion, and cream. 
1,7-Heptanedicarboxylic acid is sold under the brand names Azelex, Finacea, and Finevin, as well as generic 1,7-Heptanedicarboxylic acid.

Uses of 1,7-Heptanedicarboxylic Acid:
1,7-Heptanedicarboxylic acid is used in many pharmaceutical preparations as an active ingredient in acne rosacea, due to 1,7-Heptanedicarboxylic acid therapeutic effectiveness.
The vegetable origin of 1,7-Heptanedicarboxylic acid makes it particularly suitable also for other important applications such as the synthesis of complex esters.

Uses in Practice:
Topical 1,7-Heptanedicarboxylic acid is Food and Drug Administration (FDA) approved for mild-moderate inflammatory acne vulgaris under the brand name Azelex as 20% cream.
1,7-Heptanedicarboxylic acid is also FDA approved for mild-to-moderate papulopustular rosacea under the brand name Finacea as 15% gel and 15% foam.
At this time, 1,7-Heptanedicarboxylic acid is not approved for any other subtype of rosacea.

In clinical studies for 1,7-Heptanedicarboxylic acid gel 15% (Finacea), there was some reduction of erythema noted in patients treated for papulopustular rosacea, but no specific clinical trials were performed to study erythema in rosacea in the absence of papules and pustules.
1,7-Heptanedicarboxylic acid is also used off-label for the treatment of hyperpigmentation disorders, including melasma, due to 1,7-Heptanedicarboxylic acid inhibition of tyrosinase.

Pharmacokinetics:
Topical 1,7-Heptanedicarboxylic acid has a bioavailability of up to 10% in the epidermis and dermis.
Approximately 4% of 1,7-Heptanedicarboxylic acid cream or gel is absorbed systemically after topical application.

1,7-Heptanedicarboxylic acid is a saturated dicarboxylic acid (HOOC-(CH2)7-COOH) found in many foods, including animal products and whole grains.
1,7-Heptanedicarboxylic acid may undergo some beta-oxidation to shorter-chain dicarboxylic acids, but 1,7-Heptanedicarboxylic acid is predominately excreted in its original form in urine.

The half-life of topical 1,7-Heptanedicarboxylic acid is approximately 12 hours, and the patient should apply 1,7-Heptanedicarboxylic acid to the area of concern twice daily.
Favorable results are typically seen within 4 weeks in patients with acne vulgaris and within 12 weeks in patients with papulopustular rosacea.

Uses of 1,7-Heptanedicarboxylic acid for acne:

1,7-Heptanedicarboxylic acid works by:
Clearing your pores of bacteria that may be causing irritation or breakouts.
Reducing inflammation so acne becomes less visible, less red, and less irritated.
Gently encouraging cell turnover so your skin heals more quickly and scarring is minimized.

1,7-Heptanedicarboxylic acid can be used in gel, foam, or cream form.

All forms have the same basic instructions for use:
Wash the affected area thoroughly with warm water and pat dry.
Use a cleanser or mild soap to make sure the area is clean.

Wash your hands before applying the medication.
Apply a small amount of medication to the affected area, rub 1,7-Heptanedicarboxylic acid in, and let it dry completely.

Once the medication has dried, you can apply cosmetics.
There’s no need to cover or bandage your skin.
Keep in mind that you should avoid using astringents or “deep-cleansing” cleansers while you use 1,7-Heptanedicarboxylic acid.

Some people will need to apply the medication twice per day, but this will vary according to a doctor’s instructions.

1,7-Heptanedicarboxylic acid for acne scars:
Some people use azelaic to treat acne scarring in addition to active outbreaks.
1,7-Heptanedicarboxylic acid encourages cell turnover, which is a way to reduce how severe scarring appears.

1,7-Heptanedicarboxylic acid also prevents what’s known as melanin synthesis, the ability of your skin to produce pigments that can vary your skin’s tone.

If you’ve tried other topical medications to help with scarring or blemishes that’re slow to heal, 1,7-Heptanedicarboxylic acid might help. 
More research is needed to understand who this treatment works best for and how effective 1,7-Heptanedicarboxylic acid can be.

Other uses:
1,7-Heptanedicarboxylic acid is also used for other skin conditions, such as hyperpigmentation, rosacea, and skin lightening.

1,7-Heptanedicarboxylic acid for hyperpigmentation:
After a breakout, inflammation can result in hyperpigmentation on some areas of your skin.
1,7-Heptanedicarboxylic acid stops discolored skin cells from populating.

A pilot study from 2011 showed 1,7-Heptanedicarboxylic acid can treat acne while evening out hyperpigmentation triggered by acne. 
Further research on skin of color has also shown that 1,7-Heptanedicarboxylic acid is safe and beneficial for this use.

1,7-Heptanedicarboxylic acid for skin lightening:
The same property that makes 1,7-Heptanedicarboxylic acid effective for the treatment of inflammatory hyperpigmentation also enables 1,7-Heptanedicarboxylic acid to lighten skin that’s discolored by melanin.

Using 1,7-Heptanedicarboxylic acid for skin lightening in patchy or blotchy areas of your skin due to melanin has been found effective, according to an older study.

1,7-Heptanedicarboxylic acid for rosacea:
1,7-Heptanedicarboxylic acid can reduce inflammation, making it an effective treatment for symptoms of rosacea. 
Clinical studies demonstrate that 1,7-Heptanedicarboxylic acid gel can continually improve the appearance of swelling and visible blood vessels caused by rosacea.

According to older research, 1,7-Heptanedicarboxylic acid cream may be as effective as benzoyl peroxide and tretinoin (Retin-A) for the treatment of acne. 
While 1,7-Heptanedicarboxylic acid results are similar to those of benzoyl peroxide, it’s also more expensive.

1,7-Heptanedicarboxylic acid also works more gently than alpha hydroxy acid, glycolic acid, and salicylic acid.
While these other acids are strong enough to be used on their own in chemical peels, 1,7-Heptanedicarboxylic acid isn’t. 

This means that while 1,7-Heptanedicarboxylic acid is less likely to irritate your skin, 1,7-Heptanedicarboxylic acid also has to be used consistently and given time to take effect.

Takeaway:
1,7-Heptanedicarboxylic acid is a naturally occurring acid that’s milder than some more popular acids used to treat acne.
While the results of treatment with 1,7-Heptanedicarboxylic acid might not be obvious right away, there is research that points to this ingredient as effective.

Acne, uneven skin tone, rosacea, and inflammatory skin conditions have all been shown to be effectively treated with 1,7-Heptanedicarboxylic acid. 
As with any medication, follow the dosing and application directions from your doctor closely.

Face acids, or skin acids, work by exfoliating, or shedding, the top layer of your skin. 
Whenever you exfoliate your skin, new skin cells emerge to take the place of the old ones. 
The process helps even out your skin tone and makes 1,7-Heptanedicarboxylic acid smoother overall.

Many face acids are available OTC at beauty stores and drugstores. 

Popular options include:
Alpha hydroxy acids, such as glycolic, lactic, citric, malic, or tartaric acid
1,7-Heptanedicarboxylic acid
Kojic acid
Salicylic acid
Vitamin C (in the form of l-ascorbic acid)

Main uses:
Fibres (E.g. Nylon 6,9 - Nylon 5,9 - Nylon 6,69)
Polyester Polyols (Polyurethanes and PUR Hotmelt)
Bioplastics (Polyesters)
Hot Melt Adhesives (Polyamides, Polyester)
Polyamide Hardeners (Epoxy Resins)
Low Temperature Plasticisers (Dioctyl Azelate DOZ)

1,7-Heptanedicarboxylic acid can also be used directly in other formulations such as:
Electrolytes for Capacitors
Lithium Complex Greases
Metalworking Fluids, Corrosion Inhibitors
Coating - Powder Resins (GMA)
Engine cooling fluids

Applications of 1,7-Heptanedicarboxylic Acid:
1,7-Heptanedicarboxylic acid is a naturally occurring acid found in grains such as barley, wheat, and rye.
1,7-Heptanedicarboxylic acid has antimicrobial and anti-inflammatory properties, which make 1,7-Heptanedicarboxylic acid effective in the treatment of skin conditions like acne and rosacea. 

1,7-Heptanedicarboxylic acid can prevent future outbreaks and clean bacteria from your pores that causes acne.
1,7-Heptanedicarboxylic acid is applied to your skin and is available in gel, foam, and cream form. 

Azelex and Finacea are two brand names for prescription topical preparations. 
They contain 15 percent or more of 1,7-Heptanedicarboxylic acid. Some over-the-counter products contain smaller amounts.

Because 1,7-Heptanedicarboxylic acid takes some time to take effect, 1,7-Heptanedicarboxylic acid by itself isn’t typically a dermatologist’s first choice for treating acne. 
1,7-Heptanedicarboxylic acid also has some side effects, such as skin burning, dryness, and peeling. 

The antibacterial, antiphlogistic and keratolytic 1,7-Heptanedicarboxylic acid is used in acne therapy. 
1,7-Heptanedicarboxylic acid is also used for treatment of skin pigmentation including melasma and post-inflammatory hyperpigmentation, particularly in individuals with darker skin types. 

1,7-Heptanedicarboxylic acid has been recommended as an alternative to hydroquinone.
As a tyrosinase inhibitor, 1,7-Heptanedicarboxylic acid reduces synthesis of melanin. 

About 4–8% of the topically applied substance is absorbed systemically. 
In animal experiments 1,7-Heptanedicarboxylic acid, even in high doses, is not teratogenic. 
However, systematic studies on 1,7-Heptanedicarboxylic acid use in humans are lacking.

Recommendation:
During pregnancy, 1,7-Heptanedicarboxylic acid should only be used for strict indications on small skin surfaces, e.g. facial acne, preferably not in the first trimester.

Esters of this dicarboxylic acid find applications in lubrication and plasticizers.
In lubricant industries 1,7-Heptanedicarboxylic acid is used as a thickening agent in lithium complex grease.
With hexamethylenediamine, 1,7-Heptanedicarboxylic acid forms Nylon-6,9, which finds specialized uses as a plastic

Medical:
1,7-Heptanedicarboxylic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne.
1,7-Heptanedicarboxylic acid belongs to a class of medication called dicarboxylic acids.

1,7-Heptanedicarboxylic acid works by killing acne bacteria that infect skin pores. 
1,7-Heptanedicarboxylic acid also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria.

1,7-Heptanedicarboxylic acid is also used as a topical gel treatment for rosacea, due to 1,7-Heptanedicarboxylic acid ability to reduce inflammation.
1,7-Heptanedicarboxylic acid clears the bumps and swelling caused by rosacea.
The mechanism of action is thought to be through the inhibition of hyperactive protease activity that converts cathelicidin into the antimicrobial skin peptide LL-37.

Acne treatment:
In patients with moderate acne twice daily over 3 month topical 20% 1,7-Heptanedicarboxylic acid reduced numbers of comedones, papules and pustules.
Along with retinoids 1,7-Heptanedicarboxylic acid is considered to be effective in improving acne-treatment results.

The studies of latter though were admittedly limited.
In comparative review of effects of topical 1,7-Heptanedicarboxylic acid, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid 1,7-Heptanedicarboxylic acid enjoyed more high-quality evidence of effectiveness than the rest.

Whitening agent:
1,7-Heptanedicarboxylic acid has been used for treatment of skin pigmentation including melasma and postinflammatory hyperpigmentation, particularly in those with darker skin types. 
1,7-Heptanedicarboxylic acid has been recommended as an alternative to hydroquinone.

As a tyrosinase inhibitor, 1,7-Heptanedicarboxylic acid reduces synthesis of melanin.
According to one report of 1988 1,7-Heptanedicarboxylic acid (in combination with zinc sulfate) in vitro showed to be a potent (90% inhibition) 5α-Reductase inhibitor, similar to the hair loss drugs finasteride and dutasteride.
Middle 80s in vitro research evaluating acid's depigmenting (whitening) capability concluded 1,7-Heptanedicarboxylic acid is effective (cytotoxic to melanocytes) only at high concentrations.

More recent review claimed 20% 1,7-Heptanedicarboxylic acid being more potent than 4% hydroquinon after period of application for three months without latter's adverse effects and even more effective if applied along with tretinoin for the same period of time.

Brand names:
Brand names for 1,7-Heptanedicarboxylic acid include Dermaz 99, Crema Pella Perfetta (micronized 1,7-Heptanedicarboxylic acid, kojic dipalmitate, and liquorice extract), Azepur99, Azetec99, Azaclear (1,7-Heptanedicarboxylic acid and niacinamide), AzClear Action, Azelex, White Action cream, Finacea, Finevin, Melazepam, Skinoren, Ezanic, Azelac, Azaderm, (Acnegen, Eziderm, Acnicam, Azelexin in Pakistan)

Topical Antibacterial Agents:

Disorders of Pigmentation:
1,7-Heptanedicarboxylic acid has no depigmenting activity on normal skin, solar freckles, senile freckles, lentigines, pigmented seborrheic keratoses, or nevi.
1,7-Heptanedicarboxylic acid has some activity against hypermelanosis caused by physical and chemical agents, postinflammatory hyperpigmentation, melasma, lentigo maligna, and lentigo maligna melanoma.
In melasma, treatment for 24 weeks with 1,7-Heptanedicarboxylic acid 20% cream alone showed similar efficacy to treatment for 8 weeks with clobetasol 0.05% cream followed by 16 weeks with 1,7-Heptanedicarboxylic acid 20% cream (90% vs. 96.7% improvement).

Benefits of 1,7-Heptanedicarboxylic acid in Skin Care Products:
1,7-Heptanedicarboxylic acid products in concentrations of 10% or less aren’t easy to find, as very few brands have discovered 1,7-Heptanedicarboxylic acid powerful skincare benefits, perhaps because it’s just such a tricky ingredient to formulate properly. 
If not formulated properly, the texture may be grainy, which could be problematic for skin.

If you’re wondering whether to choose a cosmetic 1,7-Heptanedicarboxylic acid skin care product or a prescription version, research has shown that a 10% concentration can still improve many of the visible imperfections some of us struggle with, from bumps to dull, uneven skin tone and various concerns related to aging.

But, there are some stubborn or advanced skin concerns where it’s best to consider one of the prescription products with 1,7-Heptanedicarboxylic acid. 
You and your dermatologist can discuss whether a prescription 1,7-Heptanedicarboxylic acid product is right for you, and how to work 1,7-Heptanedicarboxylic acid into your skincare routine.

The Science Behind 1,7-Heptanedicarboxylic acid Skin Care Products:
Researchers have a theory on how 1,7-Heptanedicarboxylic acid works its skin-improving magic. 
What's suspected is that 1,7-Heptanedicarboxylic acid works by inhibiting misbehaving elements on and within skin's uppermost layers. 

Left unchecked, these troublemakers lead to persistent, visible skin imperfections (like brown patches and post-blemish marks), dull skin tone, and signs of sensitivities.
1,7-Heptanedicarboxylic acid seems 1,7-Heptanedicarboxylic acid has a radar-like ability to interrupt or inhibit what's causing skin to act up.
Skin "hears" the message 1,7-Heptanedicarboxylic acid sends and responds favorably, which leads to skin that looks remarkably better, no matter your age, skin type, or concerns.

The ongoing research on 1,7-Heptanedicarboxylic acid led us to formulate our 10% 1,7-Heptanedicarboxylic acid Booster. 
The 1,7-Heptanedicarboxylic acid within targets a wide range of skin imperfections and is formulated with 0.5% salicylic acid for a bit of a pore-refining nudge. 

The 10% 1,7-Heptanedicarboxylic acid Booster also contains a soothing complex of brightening plant extracts plus skin-restoring adenosine, an energizing ingredients that visibly reduces signs of aging.
Adding the 10% 1,7-Heptanedicarboxylic acid Booster to your routine is easy: 1,7-Heptanedicarboxylic acid can be applied once or twice daily after cleansing, toning, and exfoliating. 

Apply on 1,7-Heptanedicarboxylic acid own or mix with your favorite serum or moisturizer. 
1,7-Heptanedicarboxylic acid is fine to apply it to the entire face, or you can target blemished areas as needed.
During the day, finish with a broad-spectrum sunscreen rated SPF 30 or greater. 

The booster isn't an 1,7-Heptanedicarboxylic acid cream or 1,7-Heptanedicarboxylic acid gel; instead 1,7-Heptanedicarboxylic acid is a gel-cream hybrid that's compatible with all skin types and can be used with any of our other products, including our exfoliants, which might lead you to wonder how 1,7-Heptanedicarboxylic acid compares to AHA and BHA exfoliants.

Benefits of 1,7-Heptanedicarboxylic acid for Skin:
1,7-Heptanedicarboxylic acid is a multifunctional skincare ingredient that tackles a multitude of concerns related to breakouts and inflammation.

Exfoliates gently:
1,7-Heptanedicarboxylic acid goes deep within the pores and removes dead skin cells that cause dull skin tone and clogged pores.

Fights acne:
1,7-Heptanedicarboxylic acid has antibacterial properties, and according to Fusco, 1,7-Heptanedicarboxylic acid is reported to be bactericidal to P. acnes, which leads to acne.

Reduces inflammation:
1,7-Heptanedicarboxylic acid soothes irritation and helps to improve red bumps caused by inflammation.

Evens skin tone:
1,7-Heptanedicarboxylic acid inhibits tyrosinase, which is an enzyme that leads to hyperpigmentation. 
1,7-Heptanedicarboxylic acid is effective on post-inflammatory hyperpigmentation from acne breakouts and can possibly have an effect on melasma as well.

Treats rosacea:
1,7-Heptanedicarboxylic acid could help with pore-clogging, inflammation, and secondary infections caused by rosacea.

1,7-Heptanedicarboxylic acid is a so-called carboxylic acid.
1,7-Heptanedicarboxylic acid is not an AHA or BHA but a distant relative to them (all being carboxylic acids).
1,7-Heptanedicarboxylic acid can be found naturally in wheat, rye, and barley. 

Antibacterial effect → Anti-Acne:
1,7-Heptanedicarboxylic acid has a great antibacterial effect.
1,7-Heptanedicarboxylic acid works against multiple bacteriaS, acne-causing Propionibacterium acnes (P. acnes).
Very few ingredient are proven to work against P. acnes, so this alone makes 1,7-Heptanedicarboxylic acid an awesome choice for acne-prone skin. 

For acne treatment, 20% is the standard prescription strength choice. 
Comparing 20% 1,7-Heptanedicarboxylic acid to other acne treatments like 0.05% retinoic acid cream, 5% benzoyl peroxide cream or 2% erythromycin ointment 1,7-Heptanedicarboxylic acid had nothing to be ashamed for as 1,7-Heptanedicarboxylic acid showed similar effectiveness.  

There is also a study that showed that 5% 1,7-Heptanedicarboxylic acid is also somewhat effective (about 32% improvement) and 1,7-Heptanedicarboxylic acid can be made much more effective by combining 1,7-Heptanedicarboxylic acid with 2% clindamycin (about 64% improvement.)

Regulate the production of skin cells → Anti-Acne:
1,7-Heptanedicarboxylic acid also works on the cells that line hair follicles by changing the way they mature and proliferate, which decreases follicular ‘plugging’ and helps prevent blackheads, whiteheads, and inflamed acne lesions.
1,7-Heptanedicarboxylic acid helps with healthy skin cell production in the pores that is often problematic in acne and blackhead prone skin, which is nice!

Anti-inflammatory effect → Anti-rosacea, anti-acne:
The third magic property of 1,7-Heptanedicarboxylic acid is that it is proven to ha an e anti-inflammatory effect.
This is cool not only for treating acne, but also for treating rosacea. 
15% is the standard prescription strength dose for rosacea treatment. 

Skin lightening effect → Anti-PIH, anti-melasma:
Last but not least 1,7-Heptanedicarboxylic acid also shows skin lightening properties.
1,7-Heptanedicarboxylic acid seems to be especially effective for post-inflammatory hyperpigmentation (that often comes with acne) and melasma.

Studies have compared 20% 1,7-Heptanedicarboxylic acid to 2% and 4% Hydroquinone and here again, 1,7-Heptanedicarboxylic acid has nothing to be ashamed of, 1,7-Heptanedicarboxylic acid showed similar skin lightening properties. (Though interestingly 1,7-Heptanedicarboxylic acid did not seem to be effective for lightening age spots that are called solar lentigines.)

So the bottom line is that 1,7-Heptanedicarboxylic acid can be a game changer (or rather skin changer) especially for acne-prone or rosacea skin types. 
1,7-Heptanedicarboxylic acid is antibacterial, can regulate problematic skin cell production in pores, it’s anti-inflammatory and even helps with PIH and melasma.
1,7-Heptanedicarboxylic acid really can do a lot.

1,7-Heptanedicarboxylic acid keeps pores clear:
1,7-Heptanedicarboxylic acid is a comedolytic.
This means 1,7-Heptanedicarboxylic acid helps break down existing pore blockages (AKA comedones) and keeps new ones from forming.
Clear pores and fewer pore blockages ultimately lead to fewer pimples.

1,7-Heptanedicarboxylic acid gently exfoliates:
1,7-Heptanedicarboxylic acid is also a keratolytic.
Keratolytics help your skin exfoliate by dissolving old, flaky skin cells.
1,7-Heptanedicarboxylic acid is a fairly gentle exfoliant, especially when compared to other acne treatments like topical retinoids.

1,7-Heptanedicarboxylic acid reduces acne-causing bacteria:
1,7-Heptanedicarboxylic acid kills Propionibacteria acnes, the bacteria that are responsible for inflamed acne breakouts.
This, in turn, reduces redness and inflammation.

1,7-Heptanedicarboxylic acid evens out your skin tone:
Another benefit of 1,7-Heptanedicarboxylic acid 1,7-Heptanedicarboxylic acid is ability to improve post-inflammatory hyperpigmentation, or those discolored spots pimples leave behind.
Complexions that are prone to hyperpigmentation will especially benefit from 1,7-Heptanedicarboxylic acid.

Production of 1,7-Heptanedicarboxylic Acid:
1,7-Heptanedicarboxylic acid is industrially produced by the ozonolysis of oleic acid.
The side product is nonanoic acid.

1,7-Heptanedicarboxylic acid is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
The bacterial degradation of nonanoic acid gives 1,7-Heptanedicarboxylic acid.

Biological function of 1,7-Heptanedicarboxylic Acid:
In plants, 1,7-Heptanedicarboxylic acid serves as a "distress flare" involved in defense responses after infection.
1,7-Heptanedicarboxylic acid serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.

Action Mechanism of 1,7-Heptanedicarboxylic Acid:
The mechanism of action of 1,7-Heptanedicarboxylic acid is not well understood. 
However, in vitro, 1,7-Heptanedicarboxylic acid possesses antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, most likely through microbial cellular protein synthesis inhibition.

Microcomedones and comedones can arise because of hyperkeratinization. 
1,7-Heptanedicarboxylic acid produces an anticomedonal effect by decreasing the amount of hyperkeratinization. 

Biopsies have shown a decrease in stratum corneum thickness, keratohyalin granules, and filaggrin in patients treated with 1,7-Heptanedicarboxylic acid cream. 
1,7-Heptanedicarboxylic acid also competitively inhibits tyrosinase, an enzyme involved in the conversion of tyrosine to melanin. 

Last, 1,7-Heptanedicarboxylic acid mechanism of action also includes the inhibition of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects on the melanocyte. 
Therefore, 1,7-Heptanedicarboxylic acid is thought to decrease postinflammatory hyperpigmentation.

Alternatives:
Currently, there are no other known drugs with the same mechanism of action as 1,7-Heptanedicarboxylic acid.
On the other hand, there are many other drugs that can be used in the treatment of acne vulgaris, such as topical and oral retinoids, oral and topical antibiotics, benzoyl peroxide, topical dapsone, salicylic acid, photodynamic therapy, lasers, and peels.

Antibiotics develop resistance when not used in combination with benzoyl peroxide and therefore should not be used as monotherapy.
1,7-Heptanedicarboxylic acid is an effective monotherapy for acne vulgaris in pregnant women.

Handling and storage of 1,7-Heptanedicarboxylic Acid:

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage class:
Storage class (TRGS 510): 11: Combustible Solids

Stability and reactivity of 1,7-Heptanedicarboxylic Acid:

Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability:
1,7-Heptanedicarboxylic acid is chemically stable under standard ambient conditions (room temperature).

Possibility of hazardous reactions:
No data available

Conditions to avoid:
Strong heating.

Incompatible materials:
Bases, Reducing agents, Oxidizing agents

Warnings And Precautions
Hypersensitivity reactions have been reported with the use of 1,7-Heptanedicarboxylic acid.
1,7-Heptanedicarboxylic acid should be avoided in patients with known hypersensitivity reactions to 1,7-Heptanedicarboxylic acid or its components.

Hypopigmentation has been reported with the use of 1,7-Heptanedicarboxylic acid as well.
Skin should be monitored for signs of hypopigmentation, especially in patients with dark complexions.
In addition, contact with the eyes, mouth, and other mucous membranes should be avoided.

First aid measures of 1,7-Heptanedicarboxylic Acid:

General advice:
Show this material safety data sheet to the doctor in attendance.

If inhaled:

After inhalation:
Fresh air.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.

In case of eye contact:

After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.

If swallowed:

After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.

Indication of any immediate medical attention and special treatment needed:
No data available

Firefighting measures of 1,7-Heptanedicarboxylic Acid:

Suitable extinguishing media:
Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture:
Carbon oxides
Combustible.

Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters:
Stay in danger area only with self-contained breathing apparatus.
Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

Accidental release measures of 1,7-Heptanedicarboxylic Acid:

Personal precautions, protective equipment and emergency procedures:

Advice for non-emergency personnel:
Avoid inhalation of dusts.
Avoid substance contact.

Ensure adequate ventilation.
Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions.

Take up dry.
Dispose of properly.

Clean up affected area.
Avoidgeneration of dusts.

Identifiers of 1,7-Heptanedicarboxylic Acid:
CAS Number: 123-99-9
Beilstein Reference: 1101094
ChEBI: CHEBI:48131
ChEMBL: ChEMBL1238
ChemSpider: 2179
DrugBank: DB00548
ECHA InfoCard: 100.004.246
EC Number: 204-669-1
Gmelin Reference: 261342
IUPHAR/BPS: 7484
KEGG: D03034
PubChem CID: 2266
UNII: F2VW3D43YT
CompTox Dashboard (EPA): DTXSID8021640
InChI: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N
InChI=1/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
Key: BDJRBEYXGGNYIS-UHFFFAOYAK
SMILES: O=C(O)CCCCCCCC(=O)O

CAS Number: 123-99-9 
EC Number: 204-669-1

Chemical formula: C9H16O4
Molar mass: 188.22 g/mol
Appearance: white solid
Density: 1.443 g/mL
Melting point: 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point: 286 °C (547 °F; 559 K) at 100 mmHg
Solubility in water: 2.14 g/L
Acidity (pKa): 4.550, 5.498

Display Name: 1,7-Heptanedicarboxylic acid
EC Number: 204-669-1
EC Name: 1,7-Heptanedicarboxylic acid
CAS Number: 123-99-9
Molecular formula: C9H16O4

CAS number: 123-99-9
EC number: 204-669-1
Hill Formula: C₉H₁₆O₄
Chemical formula: HOOC(CH₂)₇COOH
Molar Mass: 188.22 g/mol
HS Code: 2917 13 90

Properties of 1,7-Heptanedicarboxylic Acid:
Chemical formula: C9H16O4
Molar mass: 188.22 g/mol
Appearance: white solid
Density: 1.443 g/mL
Melting point: 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point: 286 °C (547 °F; 559 K) at 100 mmHg
Solubility in water: 2.14 g/L
Acidity (pKa): 4.550, 5.498

vapor density: 6.5 (vs air)
Quality Level: 200
vapor pressure: <1 mmHg ( 20 °C)
Assay: 98%
form: powder
bp: 286 °C/100 mmHg (lit.)
mp: 109-111 °C (lit.)
SMILES string: OC(=O)CCCCCCCC(O)=O
InChI: 1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI key: BDJRBEYXGGNYIS-UHFFFAOYSA-N

Boiling point: 237 °C (20 hPa)
Density: 1.029 g/cm3 (20 °C)
Flash point: 215 °C
Melting Point: 107 °C
pH value: 3.5 (1 g/l, H₂O)
Vapor pressure: <1 hPa (20 °C)
Solubility: 2.4 g/l

Specifications of 1,7-Heptanedicarboxylic Acid:
Assay (GC, area%): ≥ 90.0 % (a/a)
Identity (IR): passes test

Pharmacology of 1,7-Heptanedicarboxylic Acid:
ATC code: D10AX03 (WHO)
Routes of
administration: Topical
Pharmacokinetics:
Bioavailability: Very low
Biological half-life: 12 h
Legal status: 
AU: S2 (Pharmacy Only)
US: ℞-only

Names of 1,7-Heptanedicarboxylic Acid:

Preferred IUPAC name:
Nonanedioic acid
1,7-Heptanedicarboxylic acid
1,9-Nonanedioic acid
Acide azelaique
Acido azelaico
Acidum azelaicum
Anchoic acid
Azelaic acid
Azelaic acid
azelaic acid
Azelaic acid, technical grade
Azelex
Emerox 1110
Emerox 1144
Finacea
Heptanedicarboxylic acid
Lepargylic acid
Skinoren

CAS name:
Nonanedioic acid

IUPAC names:
1,7-Heptanedicarboxylic acid
AZELAIC ACID
Azelaic Acid
Azelaic acid
azelaic acid
Azelaic acid
azelaic acid
Azelainsäure
Azeleic Acid
Nonanedioic acid
nonanedioic acid
Nonanedioic acid
Nonanedionic acid

Trade names:
Crodacid DC1195
Ácido Azelaico