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CAS NUMBER: 661-19-8
EC NUMBER: 211-546-6
MOLECULAR FORMULA: C22H46O
MOLECULAR WEIGHT: 326.6
IUPAC NAME: docosan-1-ol
1-Docosanol is known as behenyl alcohol
1-Docosanol is a saturated fatty alcohol containing 22 carbon atoms
1-Docosanol is used traditionally as:
-an emollient
-emulsifier
-thickener in cosmetics
-nutritional supplement (as an individual entity and also as a constituent of policosanol).
More recently, docosanol has been approved by the Food and Drug Administration (FDA) as a pharmaceutical antiviral agent for reducing the duration of cold sores caused by the herpes simplex virus in the OTC medication Abreva.
In Europe, 1-Docosanol is available as Erazaban
Mechanism of Action:
1-Docosanol is thought to act by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication.
This mechanism has not been demonstrated empirically.
1-Docosanol is a saturated 22-carbon aliphatic alcohol with antiviral activity.
1-Docosanol has a distinct mechanism of action and inhibits fusion between the plasma membrane and the herpes simplex virus envelope, thereby preventing viral entry into cells and subsequent viral activity and replication.
1-Docosanol is used as a Thickener
1-Docosanol is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help heal sores faster.
1-Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters).
A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV).
1-Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
1-Docosanol is used as an Emulsifier.
1-Docosanol is a natural product found in Populus tremula, Hypericum laricifolium, and other organisms
1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro.
1-Docosanol has been isolated from Clematis brevicaudata.
1-Docosanol was used in the synthesis of series of amphiphilic dendrimers with hydrophilic aliphatic polyether-type dendritic core and hydrophobic docosyl peripheries.
1-Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.
1-Docosanol is used as an anti Viral Agent in Topical Applications such as Cold Sore Treatment.
1-Docosanol is also used as an Emollient.
1-Docosanol contains 80% behenyl alcohol
1-Docosanol is very safe
1-Docosanol's viscosity does not change much with temperature and thus forms a stable emulsion.
APPLICATIONS:
-Raw material for surfactants
-for conditioners
-for disinfectants
-for plasticizers
-Oil base for lubricants of synthetic resin
-for emulsifiers of emulsion polymerization
-Raw material for creams
-ointment
-metal rolling oil
-Adhesives
-Lubricants
-Industrial Uses
1-Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope
1-Docosanol is soluble in:
-methanol
-diethyl ether
-n-octanol
1-Docosanol is very slightly soluble in cold water.
1-Docosanol is white powder
1-Docosanol is a binder and an emulsion stabilizer.
1-Docosanol is also used to increase a formulation’s viscosity.
1-Docosanol is a mixture of fatty alcohols.
1-Docosanol may be used for any number of purposes in a cosmetic formulation, including as:
-an emollient
-a binder
-an emulsion stabilizer
-or to increase a product’s viscosity
1-Docosanol may be derived either synthetically or from plants.
1-Docosanol works as a surfactant in cosmetics.
1-Docosanol cream has also been approved as a safe and effective topical treatment for herpes labialis
1-Docosanol is a long-chain, saturated fatty alcohol.
1-Docosanol is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis.
1-Docosanol is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking.
The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
1-Docosanol is approved for the over-the-counter treatment of herpes labialis.
1-Docosanol shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
1-Docosanol is used as a raw material in the production of surfactants.
1-Docosanol is used for cleaning air conditioners.
1-Docosanol is a substance used in the manufacture of disinfectants.
1-Docosanol is used as an oil base for synthetic resin lubricants.
1-Docosanol takes part in emulsion polymerization.
1-Docosanol is a substance often used in the cosmetic industry.
1-Docosanol is especially found in the structure of creams.
1-Docosanol is used in the manufacture of adhesives due to its good holding properties.
1-Docosanol has many uses in the industrial field.
PHYSICAL PROPERTIES:
-Molecular Weight: 326.6
-XLogP3: 10.5
-Exact Mass: 326.354866087
-Monoisotopic Mass: 326.354866087
-Topological Polar Surface Area: 20.2 Ų
-Physical Description: Pellets Large Crystals,Liquid
-Color: Colorless waxy solid
-Form: Waxy solid
-Boiling Point: 180 °C
-Melting Point: 65-72 °C
-Solubility: Slightly soluble in ether; very soluble in ethanol, methanol, petroleum ether; soluble in chloroform
-Solubility in water: Insoluble in water
-Density: 0.8063 g/ml
-Vapor Pressure: 6.1X10-8 mm Hg
-LogP: 9
-Henrys Law Constant: 1.6X10-3 atm-cu m/mol
-Surface Tension: 21.82 dyne/cm
-Refractive Index: 1.4360 at 75 °C/D
1-Docosanol is also known as behenyl alcohol
1-Docosanol is a saturated fatty alcohol containing 22 carbon atoms
1-Docosanol is a saturated 22-carbon aliphatic alcohol with antiviral activity.
1-Docosanol is used as a Thickener
1-Docosanol is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help heal sores faster.
1-Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters).
1-Docosanol is used as an Emulsifier.
1-Docosanol is a natural product found in Populus tremula, Hypericum laricifolium, and other organisms
CHEMICAL PROPERTIES:
-Hydrogen Bond Donor Count: 1
-Hydrogen Bond Acceptor Count: 1
-Rotatable Bond Count: 20
-Heavy Atom Count: 23
-Formal Charge: 0
-Complexity: 190
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 0
-Undefined Atom Stereocenter Count: 0
-Defined Bond Stereocenter Count: 0
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 1
-Compound Is Canonicalized: Yes
1-Docosanol is also known as behenyl alcohol
1-Docosanol is a saturated fatty alcohol containing 22 carbon atoms
1-Docosanol is a saturated 22-carbon aliphatic alcohol with antiviral activity.
1-Docosanol is used as a Thickener
1-Docosanol is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help heal sores faster.
1-Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters).
1-Docosanol is used as an Emulsifier.
1-Docosanol is a natural product found in Populus tremula, Hypericum laricifolium, and other organisms
1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro.
1-Docosanol has been isolated from Clematis brevicaudata.
1-Docosanol was used in the synthesis of series of amphiphilic dendrimers with hydrophilic aliphatic polyether-type dendritic core and hydrophobic docosyl peripheries.
1-Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.
1-Docosanol is used as an anti Viral Agent in Topical Applications such as Cold Sore Treatment.
1-Docosanol is also used as an Emollient.ol
1-Docosanol is very safe
1-Docosanol's viscosity does not change much with temperature and thus forms a stable emulsion.
1-Docosanol is very slightly soluble in cold water.1-Docosanol is white powder
1-Docosanol is a binder and an emulsion stabilizer.
1-Docosanol is also used to increase a formulation’s viscosity.
1-Docosanol is a mixture of fatty alcohols.
1-Docosanol cream has also been approved as a safe and effective topical treatment for herpes labialis
1-Docosanol is a long-chain, saturated fatty alcohol.
1-Docosanol is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking.
1-Docosanol is approved for the over-the-counter treatment of herpes labialis.
1-Docosanol shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
1-Docosanol is used as a raw material in the production of surfactants.
1-Docosanol is used for cleaning air conditioners.
1-Docosanol is a substance used in the manufacture of disinfectants.
1-Docosanol is used as an oil base for synthetic resin lubricants.
1-Docosanol takes part in emulsion polymerization.
1-Docosanol is a substance often used in the cosmetic industry.
1-Docosanol is especially found in the structure of creams.
1-Docosanol is used in the manufacture of adhesives due to its good holding properties.
1-Docosanol has many uses in the industrial field.
STORAGE OF 1-DOCOSANOL:
1-Docosanol should be under good storage conditions.
1-Docosanol should be kept away from immediate reactive substances.
1-Docosanol should be kept away from very high pressure or flammable materials.
1-Docosanol should be stored below 25 °C (77 °F).
1-Docosanol should not be present at very low temperatures.
1-Docosanol must be protected from freezing.
1-Docosanol should be stored in a clean and dry environment.
1-Docosanol should be kept in containers suitable for its chemical structure.
1-Docosanol should be stored in ventilated and cool place.
1-Docosanol should be in a damp environment.
SYNONYMS:
1-DOCOSANOL
docosan-1-ol
Docosanol
Behenyl alcohol
661-19-8
Behenic alcohol
n-Docosanol
Abreva
Docosyl alcohol
Tadenan
Lidavol
Stenol 1822
Lanette 22
Lidakol
Stenol 1822A
Nacol 22-97
IK 2
30303-65-2
Docosanol
Erazaban
Herepair
IK.2
Healip
C22H46O
Cachalot BE-22
Abreva (TN)
HSDB 5739
Loxiol VPG 1451
EINECS 211-546-6
BRN 1770470
AI3-36489
CCRIS 8943
1-Bromoderivative
n-Docosan-1-ol
C22 Alcohol
Docosanol-(1)
1-Docosanol, 98%
EC 211-546-6
4-01-00-01906 (Beilstein Handbook Reference)
Pharmakon1600-01505729
MCULE-3239333381
NSC-759235
Behenyl alcohol
AI3-36489
Behenic alcohol
1-Docosanol
Docosyl alcohol
IK-2
Tadenan
