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2-(morpholinothio)-benzothiazole) induces mainly delayedtype hypersensitivity, but a case of immediatetype hypersensitivity was reported in a dental assistant.
2-(morpholinothio)-benzothiazole), synonymous with NOBS (MBS) is faint yellow or orange granules that are at least 95% pure.
2-(morpholinothio)-benzothiazole) vulcanization accelerator is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles.
CAS Number: 102-77-2
Molecular Formula: C11H12N2OS2
Molecular Weight: 252.36
EINECS Number: 203-052-4
Synonyms: 102-77-2, 2-(Morpholinothio)benzothiazole, 4-(Benzo[d]thiazol-2-ylthio)morpholine, Sulfenamide M, Morpholinylmercaptobenzothiazole, Santocure MOR, Sulfenax MOR, Vulcafor BSM, Vulkacit MOZ, NOBS Special, Usaf cy-7, AMAX, Accel NS, 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine, Meramide M, 2-(4-Morpholinothio)benzothiazole, Delac MOR, Morpholine, 4-(2-benzothiazolylthio)-, 2-(4-Morpholinylthio)benzothiazole, N-Oxydiethylenebenzothiazole-2-sulfenamide, 2-(4-Morpholinylmercapto)benzothiazole, N-Oxydiethylene-2-benzothiazylsulfenamide, 4-(2-Benzothiazolylthio)morpholine, 2-Benzothiazolesulfenemorpholide, N-(Oxydiethylene)benzothiazole-2-sulfenamide, Benzothiazolyl-2-sulfenmorpholide, Benzothiazole, 2-(4-morpholinylthio)-, 2-(4-Morpholino)thiobenzothiazole, 2-Benzothiazolylsulfenyl morpholine, 2-Morpholinothiobenzothiazole, BENZOTHIAZOLE, 2-(MORPHOLINOTHIO)-, 2-Benzothiazolyl N-morpholino sulfide, N-(Oxydiethylene)benzothiazylsulfenamide, 2-Benzothiazolylsulfenylmorpholine, 2-Benzothiazolesulfenamide, N-morpholinyl-, N-Oxydiethylene-2-benzothiazole sulfenamide, N-(Oxodiethylene)-2-benzothiazolesulfenamide, N,N-(Oxydiethylene)-2-benzothiazylsulfenamide, NSC 70078, N,N-(Oxydiethylene)benzothiazole-2-sulfenamide, 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole, NSC-70078, VCD7623F3K, (2-Morpholinothio)benzothiazole, DTXSID0021096, Morpholinylmercapto-benzo-thiazole, NSC70078, NCGC00042523-02, NCGC00042523-03, 2-(morpholin-4-ylthio)-1,3-benzothiazole, N-(Oxydiethylene)-2-benzothiazolesulfenamide, Vulcafor SSM, N,N-(Oxydiethylene)-2-benzothiazolesulfenamide, Cure-rite OBTS, DTXCID201096, Meramid M, CAS-102-77-2, CCRIS 4911, HSDB 2867, EINECS 203-052-4, BRN 0191684, UNII-VCD7623F3K, AI3-27134, Accelerator NC, 2-(Morpholinthio)-benzothiazole, 4-(2-Benzothiazolylthio)-morpholine, NOBS, OBTS, 2-(4-Morpholino)thiobenzothiazole [HSDB], EC 203-052-4, NCIOpen2_003384, SCHEMBL79658, 4-27-00-01868 (Beilstein Handbook Reference), MLS000055410, CHEMBL1530581, MHKLKWCYGIBEQF-UHFFFAOYSA-, 2-morpholinosulphenyl-benzothiazole, HMS1760H22, HMS2163A20, HMS3323A19, 2-(4-morpholinothio)-benzothiazole, 4-(2-benzothiazolylthio)-morpholin, Tox21_110976, 2-morpholin-4-ylsulfanylbenzothiazole, MFCD00022870, 2-Benzothiazolesulfenamide, N-morphol, AKOS001025507, Tox21_110976_1, DB14202, 2-(MORPHOLINOTHIO)-BENZOTHIAZOLE, WLN: T56 BN DSJ CS-AT6N DOTJ, BS-42257, N-Oxydiethylene-2-benzothiazolesulfenamide, SMR000066103, 2-(4-Morpholinylthio)-1,3-benzothiazole, CS-0201154, FT-0608683, M0532, NS00004147, E78169, 2-(4-Morpholinylsulfanyl)-1,3-benzothiazole #, EN300-1726082, A896704, Q-200146, BRD-K97360717-001-07-6, Q27291760, Z56821717, InChI=1/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2
This rubber vulcanization accelerator is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles.
As a corrosion inhibitor, it can be found in cutting fluids or in releasing fluids in the pottery industry.
2-(morpholinothio)-benzothiazole) induces mainly delayedtype hypersensitivity, but a case of immediatetype hypersensitivity was reported in a dental assistant.
This rubber vulcanization accelerator belongs to the mercaptobenzothiazolesulfenamide group.
2-(morpholinothio)-benzothiazole) is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles.
2-(morpholinothio)-benzothiazole) is contained in “mercapto mix.”
As a corrosion inhibitor, it can be found in cutting fluids or in releasing fluids in the pottery industry.
2-(morpholinothio)-benzothiazole) iIs contained in the "mercapto mix".
As a corrosion inhibitor, it can be found in cutting fluids or in releasing fluids in the pottery industry.
2-(morpholinothio)-benzothiazole) induces mainly delayed-type hypersensitivity, but a case of immediate-type hypersensitivity was reported in a dental assistant.
2-(morpholinothio)-benzothiazole) and 2-(4-morpholinodithio)benzothiazole (MDB) were heated with sulfur and ZnO in a DSC.
The products formed at various temperatures were identified and analyzed by HPLC.
At temperatures below 200°C, decomposition of the accelerator in the absence of other curatives was slow, degradation products being mainly 2-bisbenzothiazole-2,2′-disulfide (MBTS) and 2-mercaptobenzothiazole (MBT).
2-(morpholinothio)-benzothiazole) is a Standardized Chemical Allergen.
The physiologic effect of morpholinylmercaptobenzothiazole is by means of Increased Histamine Release, and Cell-mediated Immunity.
2-(morpholinothio)-benzothiazole) is a well-known rubber accelerator used in the vulcanization process of rubber.
2-(morpholinothio)-benzothiazole) helps form cross-links between rubber chains, strengthening the final product.
2-(morpholinothio)-benzothiazole) is a well-known rubber accelerator, meaning it speeds up the vulcanization process of rubber.
This process strengthens the rubber and improves its elasticity and durability.
Studies have shown that 2-(morpholinothio)-benzothiazole) can effectively enhance the vulcanization rate and improve the mechanical properties of rubber compounds.
Research suggests that 2-(morpholinothio)-benzothiazole) exhibits antimicrobial activity against various bacteria and fungi.
Studies have found that it can inhibit the growth of some pathogenic bacteria, including Staphylococcus aureus and Escherichia coli.
2-(morpholinothio)-benzothiazole) has been investigated for its potential as a corrosion inhibitor for metals.
Studies have shown that it can effectively inhibit the corrosion of mild steel in acidic media.
2-(morpholinothio)-benzothiazole), also known as Morpholinylmercaptobenzothiazole, is a chemical compound with the molecular formula C11H12N2OS2 .
2-(morpholinothio)-benzothiazole) is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles .
2-(morpholinothio)-benzothiazole) is a Standardized Chemical Allergen and its physiologic effect is by means of Increased Histamine Release, and Cell-mediated Immunity .
2-(morpholinothio)-benzothiazole) is a chemical compound used as an accelerator in the rubber industry.
2-(morpholinothio)-benzothiazole) promotes vulcanization of rubber to improve its mechanical properties, such as elasticity and durability.
2-(morpholinothio)-benzothiazole) comes in a 25g package and must be handled with care due to its toxic nature.
Safety measures include wearing gloves, protective clothing, and eye protection when handling the compound.
Proper storage guidelines for this product suggest keeping it in a cool, dry place away from sources of heat or ignition.
Environmental impact data is not available for this specific 2-(morpholinothio)-benzothiazole); however, care should be taken to dispose of it properly according to local regulations.
2-(morpholinothio)-benzothiazole), also known by various other names such as Santocure MOR, Vulcafor BSM, and NOBS Special, is an organic compound used primarily as a rubber accelerator in the vulcanization process.
The vulcanization process involves forming cross-links between polymer chains in rubber to enhance its mechanical properties, durability, and elasticity.
2-(morpholinothio)-benzothiazole) is used as a delayed-action accelerator in the rubber vulcanization process.
2-(morpholinothio)-benzothiazole) improves the mechanical properties of tires, making them more resistant to wear and tear.
2-(morpholinothio)-benzothiazole) is used in the production of various rubber products like belts, hoses, and seals.
2-(morpholinothio)-benzothiazole) should be handled with care, as it may pose health hazards if not managed properly.
2-(morpholinothio)-benzothiazole) is advisable to follow safety data sheet (SDS) guidelines for handling, storage, and disposal.
2-(morpholinothio)-benzothiazole) is an after-effect quick accelerator which can increase scorching time and improve processing safety.
2-(morpholinothio)-benzothiazole) is primarily used as an accelerator in the production rubbers and adhesives.
2-(morpholinothio)-benzothiazole) is a primary accelerator for natural and synthetic rubber.
2-(morpholinothio)-benzothiazole) oers more processing safety than MBT, MBTS, BBTS or CBTS.
2-(morpholinothio)-benzothiazole) is a masterbatch and can be used in combination with a secondary accelerator.
2-(morpholinothio)-benzothiazole) is designed for thick crosssection articles where delayed scorch and rapid cure is required.
Accelerator2-(morpholinothio)-benzothiazole) is suitable for injection molding.
2-(morpholinothio)-benzothiazole) is easy to handle polymerbound dispersion providing better uniformity of mix at low temperature, upgrade plant safety and quality.
Melting point: 78-80°C
Boiling point: 413.1±55.0 °C(Predicted)
Density: 1.34-1.40
vapor pressure: 0.001Pa at 25℃
refractive index: 1.5650 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly)
form: Solid
pka: 1.05±0.10(Predicted)
color: White to Pale Yellow
Odor: buff to brn. flakes, sweet odor
LogP: 3.4 at 25℃ and pH7
Dissociation constant: -6.82-2.65 at 25℃
2-(morpholinothio)-benzothiazole) is used as a chemical in the rubber industry, especially in the production of synthetic rubber articles.
2-(morpholinothio)-benzothiazole) is contained in “mercapto mix.”
As a corrosion inhibitor, 2-(morpholinothio)-benzothiazole) can be found in cutting fluids or in releasing fluids in the pottery industry.
2-(morpholinothio)-benzothiazole) induces mainly delayed-type hypersensitivity, but a case of immediate-type hypersensitivity was reported in a dental assistant.
2-(morpholinothio)-benzothiazole) is recommended as a primary accelerator for natural and synthetic rubbers.
2-(morpholinothio)-benzothiazole) oers more processing safety than MBT, MBTS, BBTS, or CBTS.
2-(morpholinothio)-benzothiazole) (sometimes referred to as MBS) can be compounded alone or in conjunction with many secondary accelerators.
2-(morpholinothio)-benzothiazole) is recommended for applications where extended processing safety is required.
2-(morpholinothio)-benzothiazole) is particularly useful for thick cross section articles where delayed scorch and rapid cure completion are a must.
Typical dosages range from 0.5 to 3.5 PHR depending on the length of timed needed to prevent onset of cure.
2-(morpholinothio)-benzothiazole) provides an eective compounding tool to improve bin stability.
2-(morpholinothio)-benzothiazole)'s long scorch delay is also advantageous in injection molding allowing the safe use of high injection temperatures.
The synthesis of2-(morpholinothio)-benzothiazole) typically involves the oxidative condensation of 2mercaptobenzothiazole with morpholine.
This reaction is often mediated by sodium hypochlorite (NaOCl) as the oxidizing agent.
One route involves the direct reaction of these two starting materials in the presence of NaOCl.
Alternatively, labeled versions of2-(morpholinothio)-benzothiazole), incorporating either carbon14 (¹⁴C) or sulfur35 (³⁵S) isotopes, can be synthesized using the same method.
This involves starting with either 2mercaptobenzothiazole2¹⁴C or 2mercaptobenzothiazole2³⁵S, respectively.
A third approach utilizes morpholineU¹⁴C as the starting material, leading to the formation of 2(morpholinoU¹⁴Cthio) benzothiazole.
Techniques such as HPLC (High-Performance Liquid Chromatography) and GC (Gas Chromatography) are commonly used to analyze the presence and concentration of 2-(Morpholinothio benzothiazole in industrial products.
2-(morpholinothio)-benzothiazole) and NMR (Nuclear Magnetic Resonance) are utilized for structural analysis and verification.
Should be disposed of according to local environmental regulations to prevent contamination of soil and water.
Potential for recycling in specialized facilities equipped to handle chemical recycling processes.
Research continues on improving the efficiency and environmental safety of rubber accelerators.
Studies focus on finding alternatives or modifications to reduce toxicity and enhance biodegradability.
2-(morpholinothio)-benzothiazole) is typically synthesized through the reaction of 2-mercaptobenzothiazole with morpholine.
This process involves a nucleophilic substitution reaction where the thiol group of 2-(morpholinothio)-benzothiazole) reacts with morpholine to form the thioether linkage.
In the vulcanization process, 2-(morpholinothio)-benzothiazole) reacts with sulfur to form cross-links between polymer chains, enhancing the physical properties of rubber.
2-(morpholinothio)-benzothiazole) can undergo oxidation reactions, which might alter its effectiveness as an accelerator and change its chemical properties.
Exposure to moisture can lead to hydrolysis, resulting in the breakdown of the compound and potential release of morpholine and benzothiazole derivatives.
Companies manufacturing or importing 2-(morpholinothio)-benzothiazole) in quantities over one tonne per year must register the substance with the European Chemicals Agency (ECHA).
Regulates workplace exposure levels and mandates the use of personal protective equipment (PPE) when handling the compound.
Lists 2-(morpholinothio)-benzothiazole) under the Toxic Substances Control Act (TSCA), requiring reporting and review of the compound's environmental and health effects.
Classified as hazardous, with specific labeling requirements to indicate potential health and environmental hazards.
Can cause skin and eye irritation upon contact.
2-(morpholinothio)-benzothiazole) inhalation of dust or fumes may lead to respiratory tract irritation.
Symptoms of exposure might include coughing, shortness of breath, and skin rashes.
Prolonged or repeated exposure may cause dermatitis and respiratory issues.
There is limited data on its carcinogenicity, mutagenicity, and reproductive toxicity, but precautionary measures should be taken to minimize exposure.
Potentially harmful to aquatic life with long-lasting effects.
2-(morpholinothio)-benzothiazole) care should be taken to prevent release into waterways.
Low biodegradability means 2-(morpholinothio)-benzothiazole) can persist in the environment, leading to potential accumulation in aquatic organisms.
2-(morpholinothio)-benzothiazole) accidental spills or improper disposal can lead to soil contamination, affecting plant and microbial life.
2-(morpholinothio)-benzothiazole) store in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids.
Containers should be tightly sealed to prevent moisture absorption and contamination.
Use personal protective equipment (PPE) such as gloves, safety glasses, and respirators to avoid direct contact and inhalation.
Employ proper ventilation or local exhaust systems in areas where dust or fumes may be generated.
2-(morpholinothio)-benzothiazole) contain the spill with inert materials (e.g., sand, earth) and collect for disposal.
Avoid creating dust and ventilate the area.
Clean up should be done by trained personnel using appropriate protective equipment.
Move the affected person to fresh air.
If breathing is difficult, administer oxygen and seek medical attention.
Wash with plenty of soap and water.
2-(morpholinothio)-benzothiazole) remove contaminated clothing and seek medical attention if irritation persists.
2-(morpholinothio)-benzothiazole) rinse immediately with plenty of water for at least 15 minutes. Seek medical attention.
Rinse mouth and seek medical attention immediately.
Uses:
2-(morpholinothio)-benzothiazole) is a vulcanizing accelerator with delayed reaction and short cure time.
2-(morpholinothio)-benzothiazole) is widely used in NR, IR, SBR, NBR and EPDM.
2-(morpholinothio)-benzothiazole) can be used alone or with other vulcanization accelerators such as thiurams, guanidines and dithiocarbamates to improve activity.
2-(morpholinothio)-benzothiazole) delayed-action vulcanization accelerator.
2-(morpholinothio)-benzothiazole) is an aftereffect vulcanization accelerator with short vulcanization time, excellent scorch resistance and safe processing. Suitable for natural rubber and synthetic rubber.
2-(morpholinothio)-benzothiazole) is mainly used to manufacture industrial rubber products such as tires, rubber hoses, rubber shoes, and transportation belts.
2-(morpholinothio)-benzothiazole) is used to control the vulcanization process, ensuring that the rubber does not begin to cure too quickly.
This allows for better processing and molding of rubber products before they set.
2-(morpholinothio)-benzothiazole) enhances the tensile strength, elasticity, and overall durability of the vulcanized rubber.
Tires, conveyor belts, hoses, rubber mats, gaskets, and footwear.
2-(morpholinothio)-benzothiazole)'s particularly valuable in manufacturing large rubber goods where a controlled and slower curing process is beneficial.
Provides better resistance to wear and tear, thus improving the lifespan and safety of tires.
2-(morpholinothio)-benzothiazole) is used in both radial and bias-ply tire constructions to enhance performance characteristics.
2-(morpholinothio)-benzothiazole) applied in various automotive parts such as engine mounts, bushings, seals, and gaskets, where enhanced durability and resistance to mechanical stress are crucial.
2-(morpholinothio)-benzothiazole) is used in the production of mechanical rubber goods like seals, O-rings, vibration dampeners, and shock absorbers.
These products benefit from the improved resilience and longevity imparted by the accelerator.
Found in products like rubber gloves, footwear, and other household rubber items where enhanced elasticity and strength are desirable.
By facilitating the formation of strong cross-links between polymer chains, it helps produce rubber with superior mechanical properties, including resistance to abrasion, heat, and aging.
The delayed-action property allows for more precise and controlled processing, reducing the risk of premature curing and making it easier to mold complex shapes and designs.
Ensures consistent and reliable performance of rubber products by providing uniform curing characteristics, which is critical in applications requiring high-quality standards such as automotive and aerospace industries.
Products containing 2-(morpholinothio)-benzothiazole) must comply with various international safety and environmental regulations, including those set by OSHA, EPA, and REACH.
2-(morpholinothio)-benzothiazole) has high antiscorching qualities and a processing safety.
2-(morpholinothio)-benzothiazole) is used in the manufacture of tires, rubber tubes, rubber footwear and hoses.
2-(morpholinothio)-benzothiazole) is especially suitable for synthetic rubber mixed with ne furnace carbon black.
2-(morpholinothio)-benzothiazole) is soluble in acetone organic liquids, including fats and oils of ether.
2-(morpholinothio)-benzothiazole) is insoluble in water.
2-(morpholinothio)-benzothiazole) is regulated for use under the following sections of FDA 21 CFR: 177.2600 – Rubber Articles Intended for Repeated Use in Food Contact.
2-(morpholinothio)-benzothiazole) is recommended for applications where extended processing safety is required.
2-(morpholinothio)-benzothiazole) is particularly useful for thick cross section articles where delayed scorch and rapid cure completion are a must.
Typical dosages range from 0.5 to 3.5 PHR depending on the length of timed needed to prevent onset of cure.
2-(morpholinothio)-benzothiazole) provides an eective compounding tool to improve bin stability.
2-(morpholinothio)-benzothiazole)'s long scorch delay is also advantageous in injection molding allowing the safe use of high injection temperatures.
Widely used in tread, carcass, and other tire components to achieve optimal cure characteristics, including scorch safety, cure rate, and reversion resistance.
Contributes to high unaged adhesion in Natural Rubber (NR) and NR/BR blends, particularly when combined with Ncyclohexylthiophthalimide.
Employed as a primary accelerator in bonding rubber compounds for solid tires, contributing to desired physicalmechanical and bonding properties.
Incorporated as a component in formulations designed for hightemperature applications, such as PERT steelwire mesh skeleton pipes.
Due to its potential health hazards, appropriate safety measures must be taken when handling 2-(morpholinothio)-benzothiazole).
This includes using personal protective equipment (PPE), proper ventilation, and following safe storage practices to prevent exposure.
Waste containing this compound must be disposed of in accordance with local environmental regulations to prevent contamination of soil and water bodies.
Ongoing research aims to develop more environmentally friendly alternatives and synthesis methods to reduce the ecological footprint of rubber accelerators.
Research is focused on creating formulations that offer even better performance, such as increased speed of vulcanization without compromising on the quality of the rubber.
Efforts are being made to develop accelerators that are less harmful to the environment and human health, aligning with the principles of green chemistry.
Enhances the durability and performance of tires for cars, trucks, and buses.
2-(morpholinothio)-benzothiazole) is used in tires for agricultural, mining, and construction equipment, where resistance to harsh conditions is essential.
Industrial Belts and Hoses: Provides enhanced mechanical properties to conveyor belts, hydraulic hoses, and industrial hoses.
Ensures durability and longevity in seals and gaskets used in various industrial applications, including machinery and piping systems.
Improves the resilience and comfort of rubber soles in sports and safety footwear, offering better performance and safety.
Includes engine mounts, bushings, and other components that require high strength and flexibility.
2-(morpholinothio)-benzothiazole) is used in the manufacturing of rubber gloves, mats, and other household items that benefit from enhanced durability.
Enhances the rubber’s resistance to chemicals, oils, and solvents, making it suitable for use in harsh environments.
Provides better performance at high temperatures, which is critical for automotive and industrial applications.
Allows for more flexible and efficient manufacturing processes, reducing downtime and increasing productivity.
Results in rubber products with longer service life, reducing the need for frequent replacements and lowering maintenance costs.
Essential to prevent skin and eye contact during handling.
Necessary when working in environments with dust or fumes to avoid inhalation hazards.
Should be stored in cool, dry places away from direct sunlight and incompatible substances like strong oxidizers.
Safety Profile:
As a sulfonamide accelerator, it is acidic.
2-(morpholinothio)-benzothiazole) has the characteristics of a long scorch time and high vulcanization activity.
The vulcanized rubber has a high degree of sulfurization, excellent physical and mechanical properties, and good aging resistance.
Currently, sulfonamide accelerators are widely used worldwide, including CZ, NOBS, NS, DZ, and OTOS, all of which are derivatives of mercaptobenzothiazole.
Among the sulfonamide accelerators currently used, 2-(morpholinothio)-benzothiazole), accelerator DIBS, and accelerator DZ are known to produce nitrosamines that can cause cancer.
2-(morpholinothio)-benzothiazole) poison by intraperitoneal route.
Moderately toxic by ingestion.
Questionable carcinogenwith experimental neoplastigenic data.
2-(morpholinothio)-benzothiazole) experimentalteratogenic effects.
An eye irritant. Mutation datareported.
When heated to decomposition it emits very toxic fum.
