Quick Search
DESCRIPTION
2-Amino-2-methyl-1-propanol (AMP) is a versatile organic compound with a tertiary amine and an alcohol functional group.
2-Amino-2-methyl-1-propanol (AMP) is a colorless to light yellow, hygroscopic liquid or crystalline solid with a mild ammonia-like odor.
The compound is highly soluble in water and polar organic solvents.
CAS NUMBER 124-68-5
EC Number: 204-709-8
Molecular Weight: 89.14
SYNONYMS
2-Amino-2-methylpropan-1-ol,Aminomethylpropanol,1-Propanol, 2-amino-2-methyl-,2-Aminoisobutanol,Isobutanol-2-amine,AMP Regular,2-AMINO-2-METHYLPROPANOL,Aminomethyl propanol,2-Methyl-2-aminopropanol,2-Aminodimethylethanol,2-Amino-2-methyl-propan-1-ol,Hydroxy-tert-butylamine,Corrguard 75,2-Amino-2,2-dimethylethanol,AMP (thinner),Amp-95,Isobutanolamine,1,1-Dimethyl-2-hydroxyethylamine,2-Methyl-2-aminopropanol-1,2-Hydroxymethyl-2-propylamine,AMP 95,2-Amino-1-hydroxy-2-methylpropane,.beta.-Aminoisobutanol,AMP 75,NSC 441,beta-Aminoisobutyl alcohol,MFCD00008051,KV 5088,DTXSID8027032,NSC-441,LU49E6626Q,2-Amino-2-methylpropanol (~95%),beta-Aminoisobutanol,DTXCID407032,Caswell No. 037,CAS-124-68-5,HSDB 5606,EINECS 204-709-8,EPA Pesticide Chemical Code 005801,BRN 0505979,UNII-LU49E6626Q,2-Methyl-2-amino-1-propanol,AI3-03947,2-Amino-2-methyl-1-propanol, 95%,A-Aminoisobutyl alcohol,2,2-Dimethyl-ethanolamine,Amino-2,2-dimethylethanol,2-amino 2-methyl propanol,2-amino-2-methyl propanol,2-Amino-2-methyl-1-propanol (90% or less),EC 204-709-8,Hydroxymethyl-2-propylamine,2-Amino-2-methyl-propanol,Amino-2-methyl-1-propanol,H2NC(CH3)2CH2OH,NCIOpen2_009031,2-amino-2-methyl-1propanol,2-amino-2-methylpropan-1ol,2amino-2-methyl-1-propanol,Oprea1_147215,2-amino-2-methylpropan-l-ol,2-amino-2-methyl 1-propanol,2-amino-2-methyl-1 propanol,2-methyl-2-aminopropan-1-ol,1-Propanol-2-amino-2-methyl,2-amino-2,2,dimethyl-ethanol,CHEMBL122588,NSC441,2-amino-2 -methyl-1-propanol,2-amino-2- methylpropan-1-ol,2-amino-2-methyl-1 –propanol,AMINOMETHYLPROPANOL [II],2-Amino-2-methyl-propane-1-ol,2-hydroxy-1,1-dimethylethylamine,1-hydroxy-2-methyl-2-propylamine,3-hydroxy-2-methyl-2-propylamine,1-hydroxy-2-methyl-2-aminopropane,propane, 2-amino-2-hydroxymethyl-,STR01693,Tox21_201780,Tox21_303149,BBL023024,STL284638,1-PROPANOL,2-AMINO,2-METHYL,AKOS000119511,WLN: ZX1 & 1 & 1Q,CS-W013743,HY-W013027,SB83772,propane, 2-amino-1-hydroxy-2-methyl-,2-AMINO-2-METHYLPROPANOL [HSDB],NCGC00249118-01,NCGC00257048-01,NCGC00259329-01,2-Amino-2-methyl-1-propanol, 93-97%,2-AMINO-2-METHYL-1-PROPANOL [MI],DB-041780,A0333,NS00008488,2-AMINO-2-METHYL-1-PROPANOL [VANDF],EN300-19785,2-AMINO-2-METHYL-1-PROPANOL [WHO-DD],P20005,Q32703,2-Amino-2-methyl-1-propanol, BioXtra, >=95%,Q-200228,2-Amino-2-methyl-1-propanol, purum, >=97.0% (GC),2-Amino-2-methyl-1-propanol, technical, >=90% (GC),F2190-0372,2-Amino-2-methyl-1-propanol, BioUltra, >=99.0% (GC),2-Amino-2-methyl-1-propanol, SAJ first grade, >=98.0%,InChI=1/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H,2-Amino-2-methyl-1-propanol, ~5% Water, technical grade, 90%,2-Amino-2-methyl-propan-1-ol; Karl Fischer; Aqualine Electrolyte AD-G
2-amino-2-methyl-1-propanol appears as a clear light colored liquid. Insoluble in water and about the same density as water.
Flash point of 2-amino-2-methyl-1-propanol is 172 °F.
2-amino-2-methyl-1-propanol is Used to make other chemicals.
CHEMICAL AND PHYSICAL PROPERTIES
Molecular Weight
89.14 g/mol
Computed by PubChem 2.2 (PubChem release 2024.11.20)
XLogP3-AA
-0.8
Computed by XLogP3 3.0 (PubChem release 2024.11.20)
Hydrogen Bond Donor Count
2
Computed by Cactvs 3.4.8.18 (PubChem release 2024.11.20)
Hydrogen Bond Acceptor Count
2
Computed by Cactvs 3.4.8.18 (PubChem release 2024.11.20)
Rotatable Bond Count
1
Computed by Cactvs 3.4.8.18 (PubChem release 2024.11.20)
Exact Mass
89.084063974 Da
Computed by PubChem 2.2 (PubChem release 2024.11.20)
Monoisotopic Mass
89.084063974 Da
Computed by PubChem 2.2 (PubChem release 2024.11.20)
Topological Polar Surface Area
46.3Ų
Computed by Cactvs 3.4.8.18 (PubChem release 2024.11.20)
Heavy Atom Count
6
Computed by PubChem
Formal Charge
0
Computed by PubChem
Complexity
42.8
Computed by Cactvs 3.4.8.18 (PubChem release 2024.11.20)
Isotope Atom Count
0
Computed by PubChem
Defined Atom Stereocenter Count
0
Computed by PubChem
Undefined Atom Stereocenter Count
0
Computed by PubChem
Defined Bond Stereocenter Count
0
Computed by PubChem
Undefined Bond Stereocenter Count
0
Computed by PubChem
Covalently-Bonded Unit Count
1
Computed by PubChem
Compound Is Canonicalized
Yes
Chemical formula C4H11NO
Molar mass 89.138 g•mol−1
Density 0.934 g/cm3
Melting point 30–31 °C (86–88 °F; 303–304 K)
Boiling point 165.5 °C (329.9 °F; 438.6 K)
Solubility in water Miscible
Solubility in alcohols Soluble
FormLiquid
ColorColorless
pKa @ 25°C9.7
Boiling point of active material (°C)165
Molecular weight89.1
Flash point (Tag closed cup °C)81
Solubility in waterMiscible
2-amino-2-methyl-1-propanol (AMP) is an organic compound with the formula H2NC(CH3)2CH2OH.
2-amino-2-methyl-1-propanol is colorless liquid that is classified as an alkanolamine.
2-amino-2-methyl-1-propanol is a useful buffer and a precursor to numerous other organic compounds.[2]
Aminomethyl propanol is typically sold as a solution of the material in water, for which different concentrations are available.
SYNTHESIS
Aminomethyl propanol can be produced by the hydrogenation of 2-aminoisobutyric acid or its esters.
Aminomethyl propanol is soluble in water[3][4] and about the same density as water.
USES OF 2-AMINO-2-METHYL-1-PROPANOL:
Aminomethyl propanol is used for the preparation of buffer solutions.[3]
2-amino-2-methyl-1-propanol is a component of the drugs ambuphylline and pamabrom.
2-amino-2-methyl-1-propanol is also used in cosmetics.[2]
2-amino-2-methyl-1-propanol is a precursor to oxazolines via its reaction with acyl chlorides.[5]
Via sulfation of the alcohol, the compound is also a precursor to 2,2-dimethylaziridine.[6]
Aminomethyl propanol is used as an intermediate the synthesis of fepradinol, isobucaine, and radafaxine
APPLICATIONS OF 2-AMINO-2-METHYL-1-PROPANOL
Chemical Industry Applications
2-amino-2-methyl-1-propanol is Used as a building block in the production of surfactants, coatings, and detergents.
Role in pharmaceuticals as a precursor for drug synthesis.
BİOTECHNOLOGİCAL AND PHARMACEUTİCAL USES
2-amino-2-methyl-1-propanol is used as a buffer in biochemical research.
2-amino-2-methyl-1-propanol has a Role in the synthesis of active pharmaceutical ingredients (APIs).
AGRİCULTURAL USES
2-amino-2-methyl-1-propanol has a Utilization in herbicides, fungicides, and plant growth regulators.
ENVİRONMENTAL APPLİCATİONS
2-amino-2-methyl-1-propanol has Possible role in pollution control and environmental protection.
ANALYTICAL METHODS FOR AMP
Spectroscopic Techniques
Use of NMR, FTIR, and UV-Vis spectroscopy for structural identification.
Chromatography Methods
HPLC and GC analysis for purity and quality control.
Mass Spectrometry and Other Techniques
Role in determining molecular mass and fragmentation patterns.
RESEARCH FRONTIERS AND FUTURE DIRECTIONS
NEW SYNTHESIS STRATEGIES
Exploration of greener and more efficient methods for AMP production.
INNOVATIVE APPLICATIONS
Use of AMP in emerging technologies such as nanotechnology and advanced drug delivery systems.
SAFETY INFORMATION ABOUT 2-AMINO-2-METHYL-1-PROPANOL (AMP)
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
