PRODUCTS

2-AMINOETHANOIC ACID

CAS NUMBER: 56-40-6

EC NUMBER: 200-272-2

MOLECULAR FORMULA: C2H5NO2

MOLECULAR WEIGHT: 75.07

IUPAC NAME: 2-aminoacetic acid

2-Aminoethanoic Acid is usually called glycine.
2-Aminoethanoic Acid is an amino acid that has a single hydrogen atom as its side chain.

2-Aminoethanoic Acid is the simplest stable amino acid (carbamic acid is unstable), with the chemical formula NH2‐CH2‐COOH.
2-Aminoethanoic Acid is one of the proteinogenic amino acids.

2-Aminoethanoic Acid is encoded by all the codons starting with GG (GGU, GGC, GGA, GGG).
2-Aminoethanoic Acid is integral to the formation of alpha-helices in secondary protein structure due to its compact form.

For the same reason, 2-Aminoethanoic Acid is the most abundant amino acid in collagen triple-helices.
2-Aminoethanoic Acid is also an inhibitory neurotransmitter – interference with its release within the spinal cord (such as during a Clostridium tetani infection) can cause spastic paralysis due to uninhibited muscle contraction.

2-Aminoethanoic Acid is the only achiral proteinogenic amino acid.
2-Aminoethanoic Acid can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom.

2-Aminoethanoic Acid was discovered in 1820 by the French chemist Henri Braconnot when he hydrolyzed gelatin by boiling it with sulfuric acid.
2-Aminoethanoic Acid is also called "sugar of gelatin"

2-Aminoethanoic Acid is also cogenerated as an impurity in the synthesis of EDTA, arising from reactions of the ammonia coproduct.
2-Aminoethanoic Acid functions as a bidentate ligand for many metal ions, forming amino acid complexes.

2-Aminoethanoic Acid forms esters with alcohols.
As a bifunctional molecule, 2-Aminoethanoic Acid reacts with many reagents.
These can be classified into N-centered and carboxylate-center reactions.

Biosynthesis of 2-Aminoethanoic Acid:
2-Aminoethanoic Acid is not essential to the human diet, as it is biosynthesized in the body from the amino acid serine, which is in turn derived from 3-phosphoglycerate, but the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis
In addition to being synthesized from serine, 2-Aminoethanoic Acid can also be derived from threonine, choline or hydroxyproline via inter-organ metabolism of the liver and kidneys

Physiological Function:
The principal function of 2-Aminoethanoic Acid is it act as a precursor to proteins.
Most proteins incorporate only small quantities of 2-Aminoethanoic Acid, a notable exception being collagen, which contains about 35% glycine due to its periodically repeated role in the formation of collagen's helix structure in conjunction with hydroxyproline.
In the genetic code, 2-Aminoethanoic Acid is coded by all codons starting with GG, namely GGU, GGC, GGA and GGG.

As a biosynthetic intermediate:
In higher eukaryotes, δ-aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from 2-Aminoethanoic Acid and succinyl-CoA by the enzyme ALA synthase.
2-Aminoethanoic Acid provides the central C2N subunit of all purines

As a neurotransmitter:
2-Aminoethanoic Acid is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina.
When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an inhibitory postsynaptic potential (IPSP).

Strychnine is a strong antagonist at ionotropic 2-Aminoethanoic Acid receptors, whereas bicuculline is a weak one.
2-Aminoethanoic Acid is a required co-agonist along with glutamate for NMDA receptors.
In contrast to the inhibitory role of 2-Aminoethanoic Acid in the spinal cord, this behaviour is facilitated at the (NMDA) glutamatergic receptors which are excitatory.

USES:
-Animal and human foods: 2-Aminoethanoic Acid is not widely used in foods for its nutritional value, except in infusions.
Instead 2-Aminoethanoic Acid's role in food chemistry is as a flavorant.

2-Aminoethanoic Acid is mildly sweet
2-Aminoethanoic Acid counters the aftertaste of saccharine.

2-Aminoethanoic Acid also has preservative properties, perhaps owing to its complexation to metal ions.
Metal glycinate complexes, e.g. copper (II) glycinate are used as supplements for animal feeds

-Chemical feedstock: 2-Aminoethanoic Acid is an intermediate in the synthesis of a variety of chemical products.
2-Aminoethanoic Acid is used in the manufacture of the herbicides glyphosate, iprodione, glyphosine, imiprothrin, and eglinazine.
2-Aminoethanoic Acid is used as an intermediate of the medicine such as thiamphenicol.

-Laboratory research: 2-Aminoethanoic Acid is a significant component of some solutions used in the SDS-PAGE method of protein analysis.
2-Aminoethanoic Acid serves as a buffering agent, maintaining pH and preventing sample damage during electrophoresis.

2-Aminoethanoic Acid is also used to remove protein-labeling antibodies from Western blot membranes to enable the probing of numerous proteins of interest from SDS-PAGE gel.
This allows more data to be drawn from the same specimen, increasing the reliability of the data, reducing the amount of sample processing, and number of samples required.
This process is known as stripping.

2-Aminoethanoic Acid is a non-essential, non-polar, non-optical, glucogenic amino acid.
2-Aminoethanoic Acid, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential.

In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
2-Aminoethanoic Acid is an important component and precursor for many macromolecules in the cells.

2-Aminoethanoic Acid is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.
2-Aminoethanoic Acid has a role as a nutraceutical

2-Aminoethanoic Acid is a hepatoprotective agent
2-Aminoethanoic Acid is an EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor

2-Aminoethanoic Acid is a NMDA receptor agonist
2-Aminoethanoic Acid is a micronutrient

2-Aminoethanoic Acid is a fundamental metabolite
2-Aminoethanoic Acid is a neurotransmitter.

2-Aminoethanoic Acid is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid.
2-Aminoethanoic Acid is a conjugate base of a glycinium.

2-Aminoethanoic Acid is a conjugate acid of a glycinate.
2-Aminoethanoic Acid is a tautomer of a glycine zwitterion.

2-Aminoethanoic Acid appears as white crystals.
2-Aminoethanoic Acid is an amino acid, one of 20 used to make proteins in the human body.
The body produces 2-Aminoethanoic Acid naturally.

2-Aminoethanoic Acid is also found in high-protein foods such as:
-Meat

-Fish

-Dairy products

-Legumes

2-Aminoethanoic Acid has numerous proposed uses.
2-Aminoethanoic Acid is an amino acid that your body uses to create proteins, which it needs for the growth and maintenance of tissue and for making important substances, such as hormones and enzymes.

2-Aminoethanoic Acid is one of three amino acids that your body uses to make glutathione, a powerful antioxidant that helps protect your cells against oxidative damage caused by free radicals, which are thought to underlie many diseases
2-Aminoethanoic Acid is also one of three amino acids that your body uses to make a compound called creatine.

2-Aminoethanoic Acid is a non-essential amino acid that is produced naturally by the body.
2-Aminoethanoic Acid is one of 20 amino acids in the human body that synthesize proteins

2-Aminoethanoic Acid plays a key role in the creation of several other important compounds and proteins.
The primary function 2-Aminoethanoic Acid takes on in the body is to synthesize proteins.

2-Aminoethanoic Acid is also essential for the healthy development of the skeleton, muscles, and tissues.
2-Aminoethanoic Acid can prevent muscles from breaking down by boosting the level of creatine in the body, which is a compound found in muscle cells and made by glycine and two other amino acids.

2-Aminoethanoic Acid is found in high amounts in collagen, which is a structural protein that promotes strength and elasticity in the skin.
2-Aminoethanoic Acid is the main element that makes up the fascia, cartilage, ligaments, tendons, and bones, and is the most abundant protein in the human body.

2-Aminoethanoic Acid is also an inhibitory neurotransmitter in the central nervous system and plays a role in the processing of motor and sensory information.
2-Aminoethanoic Acid is found in the spinal cord, the brainstem, and the retina, and can both inhibit and promote excitability in various neurotransmitters.

Although 2-Aminoethanoic Acid is the simplest amino acid, it has a complex array of functions and effects on the body.
While 2-Aminoethanoic Acid can inhibit certain neurotransmitters that can improve certain psychological conditions, it can also excite neurotransmitters that cause muscular convulsions and potentially fatal brain hyperexcitability.

2-Aminoethanoic Acid is safe to consume as a dietary supplement in appropriate doses, both for short- and long-term use, however, the body will usually receive the right amount of glycine from a varied, healthy diet.
2-Aminoethanoic Acid has a range of benefits that include the bones, tissues, muscles, and central nervous system, and as such is one of the most important non-essential amino acids in the body.

PHYSICAL PROPERTIES:

-Molecular Weight: 75.07

-XLogP3: -3.2

-Exact Mass: 75.032028402

-Monoisotopic Mass: 75.032028402

-Topological Polar Surface Area: 63.3 Å²

-Physical Description: Glycine appears as white crystals.

-Color: White

-Form: crystals

-Odor: Odorless

-Taste: Sweet

-Melting Point: 262°C

-Solubility: 3.32 M

-Density: 1.161 g/cu cm

-LogP: -3.21

2-Aminoethanoic Acid counters the aftertaste of saccharine.
2-Aminoethanoic Acid is the most abundant amino acid in collagen triple-helices.

2-Aminoethanoic Acid is also an inhibitory neurotransmitter – interference with its release within the spinal cord (such as during a Clostridium tetani infection) can cause spastic paralysis due to uninhibited muscle contraction.
2-Aminoethanoic Acid is usually called glycine.
2-Aminoethanoic Acid is an amino acid that has a single hydrogen atom as its side chain.

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 2

-Hydrogen Bond Acceptor Count: 3

-Rotatable Bond Count: 1

-Heavy Atom Count: 5

-Formal Charge: 0

-Complexity: 42.9

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

2-Aminoethanoic Acid is the simplest stable amino acid (carbamic acid is unstable), with the chemical formula NH2‐CH2‐COOH.
2-Aminoethanoic Acid is one of the proteinogenic amino acids.
2-Aminoethanoic Acid is encoded by all the codons starting with GG (GGU, GGC, GGA, GGG).

2-Aminoethanoic Acid is integral to the formation of alpha-helices in secondary protein structure due to its compact form.
2-Aminoethanoic Acid is the only achiral proteinogenic amino acid.

2-Aminoethanoic Acid can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom.
2-Aminoethanoic Acid was discovered in 1820 by the French chemist Henri Braconnot when he hydrolyzed gelatin by boiling it with sulfuric acid.

2-Aminoethanoic Acid is also called "sugar of gelatin"
2-Aminoethanoic Acid is also cogenerated as an impurity in the synthesis of EDTA, arising from reactions of the ammonia coproduct.

2-Aminoethanoic Acid functions as a bidentate ligand for many metal ions, forming amino acid complexes.
2-Aminoethanoic Acid forms esters with alcohols.
2-Aminoethanoic Acid also has preservative properties, perhaps owing to its complexation to metal ions.

2-Aminoethanoic Acid is an intermediate in the synthesis of a variety of chemical products.
2-Aminoethanoic Acid is used in the manufacture of the herbicides glyphosate, iprodione, glyphosine, imiprothrin, and eglinazine.

2-Aminoethanoic Acid is used as an intermediate of the medicine such as thiamphenicol.
2-Aminoethanoic Acid is a significant component of some solutions used in the SDS-PAGE method of protein analysis.

2-Aminoethanoic Acid serves as a buffering agent, maintaining pH and preventing sample damage during electrophoresis.
2-Aminoethanoic Acid is also used to remove protein-labeling antibodies from Western blot membranes to enable the probing of numerous proteins of interest from SDS-PAGE gel.

2-Aminoethanoic Acid is an important component and precursor for many macromolecules in the cells.
2-Aminoethanoic Acid is the simplest proteinogenic amino acid, with a hydrogen atom as its side chain.
2-Aminoethanoic Acid has a role as a nutraceutical

2-Aminoethanoic Acid is a hepatoprotective agent
2-Aminoethanoic Acid is an EC 2.1.2.1 inhibitor

2-Aminoethanoic Acid is a micronutrient
2-Aminoethanoic Acid is a fundamental metabolite

2-Aminoethanoic Acid is a neurotransmitter.
2-Aminoethanoic Acid is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid.

2-Aminoethanoic Acid is a conjugate base of a glycinium.
2-Aminoethanoic Acid is a conjugate acid of a glycinate.

2-Aminoethanoic Acid is a tautomer of a glycine zwitterion.
2-Aminoethanoic Acid appears as white crystals.
2-Aminoethanoic Acid is an amino acid, one of 20 used to make proteins in the human body.

2-Aminoethanoic Acid is a non-essential amino acid that is produced naturally by the body.
2-Aminoethanoic Acid is one of 20 amino acids in the human body that synthesize proteins

2-Aminoethanoic Acid plays a key role in the creation of several other important compounds and proteins.
2-Aminoethanoic Acid is also essential for the healthy development of the skeleton, muscles, and tissues.

2-Aminoethanoic Acid can prevent muscles from breaking down by boosting the level of creatine in the body, which is a compound found in muscle cells and made by glycine and two other amino acids.
2-Aminoethanoic Acid is found in high amounts in collagen, which is a structural protein that promotes strength and elasticity in the skin.

2-Aminoethanoic Acid is the main element that makes up the fascia, cartilage, ligaments, tendons, and bones, and is the most abundant protein in the human body.
2-Aminoethanoic Acid is also an inhibitory neurotransmitter in the central nervous system and plays a role in the processing of motor and sensory information.
2-Aminoethanoic Acid is found in the spinal cord, the brainstem, and the retina, and can both inhibit and promote excitability in various neurotransmitters.

2-Aminoethanoic Acid is the simplest amino acid, it has a complex array of functions and effects on the body.
2-Aminoethanoic Acid is safe to consume as a dietary supplement in appropriate doses, both for short- and long-term use, however, the body will usually receive the right amount of glycine from a varied, healthy diet.
2-Aminoethanoic Acid has a range of benefits that include the bones, tissues, muscles, and central nervous system, and as such is one of the most important non-essential amino acids in the body.

SYNONYMS:

2-Aminoethanoic acid
glycine
2-Aminoacetic acid
56-40-6
aminoacetic acid
Glycocoll
Aminoethanoic acid
Glycolixir
Glycosthene
Padil
H-Gly-OH
Aciport
Glicoamin
Hampshire glycine
L-Glycine
Amitone
Leimzucker
Acetic acid, amino-
Aminoazijnzuur
Glycinum
Corilin
Glycinum
Glicina
Glyzin
Acide aminoacetique
Acido aminoacetico
Acidum aminoaceticum
amino-Acetic acid
[14C]glycine
Glycine iron sulphate (1:1)
aminoacetate
NSC25936
Athenon
glycine-13c
polyglycine
Glicina
Glycine, free base
Acido aminoacetico
25718-94-9
Acide aminoacetique
Acidum aminoaceticum
Glykokoll
Aminoessigsaeure
Hgly
CAS-56-40-6
GLYCINE 1.5% IN PLASTIC CONTAINER
EINECS 200-272-2
H2N-CH2-COOH
Aminoethanoate
amino-Acetate
2-aminoacetate
Glycine;
[3H]glycine
H-Gly
L-Gly
Gly-CO
Gly-OH
L-Glycine,(S)
[14C]-glycine
Corilin (Salt/Mix)
Glycine 1 M solution
Tocris-0219
Glycine (H-Gly-OH)
NH2CH2COOH
EC 200-272-2
2-Aminoacetic acid;
Aminoacetic acid
Tris-tricine buffer
H-Gly-OH