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DESCRIPTION:
2-Bromo-2-nitro-1,3-propanediol is an organic compound that is used as an antimicrobial.
2-Bromo-2-nitro-1,3-propanediol is a white solid although commercial samples appear yellow.
2-Bromo-2-nitro-1,3-propanediol is a nitro compound.
CAS NUMBER: 52-51-7
EC NUMBER: 200-143-0
MOLECULAR FORMULA: HOCH2C(Br)(NO2)CH2OH
MOLECULAR WEIGHT: 199.99
DESCRIPTION:
2-Bromo-2-nitro-1,3-propanediol is supplied as crystals or crystalline powder, which may vary from white to pale yellow in colour depending on the grade.
The yellow coloration is due to chelation of iron during the manufacturing process.
As a pure material, 2-Bromo-2-nitro-1,3-propanediol has a melting point of about 130 °C.
However, due to its polymorphic characteristics, bronopol undergoes a lattice rearrangement at 100 to 105 °C and this can often be wrongly interpreted as the melting point.
At temperatures above 140 °C, 2-Bromo-2-nitro-1,3-propanediol decomposes exothermically releasing hydrogen bromide and oxides of nitrogen.
2-Bromo-2-nitro-1,3-propanediol is readily soluble in water; the dissolution process is endothermic. Solutions containing up to 28% w/v are possible at ambient temperature.
2-Bromo-2-nitro-1,3-propanediol is poorly soluble in non-polar solvents but shows a high affinity for polar organic solvents.
2-Bromo-2-nitro-1,3-propanediol is a preservative that is used in wastewater treatment.
2-Bromo-2-nitro-1,3-propanediol is an antimicrobial agent that has synergistic effects with other antimicrobial agents such as triclosan, benzalkonium chloride and sesquiterpene lactones.
2-Bromo-2-nitro-1,3-propanediol has been shown to have a phase transition temperature of -28°C, which can be used to identify it in the laboratory.
2-Bromo-2-nitro-1,3-propanediol also has a pK value of 4.4, which indicates that it is weakly acidic.
2-Bromo-2-nitro-1,3-propanediol can be used as an analytical method for the determination of p - hydroxybenzoic acid in aqueous samples by electrochemical impedance spectroscopy (EIS).
2-Bromo-2-nitro-1,3-propanediol was subsequently adopted as an antimicrobial in other industrial environments such as paper mills, oil exploration, and production facilities, as well as cooling water disinfection plants.
2-Bromo-2-nitro-1,3-propanediol is a preservative boosting humectant and ingredient that delivers high perfomance for cosmetics, personal care, food, laundry, household cleaning, pharmaceutical and dietary supplements.
2-Bromo-2-nitro-1,3-propanediol is a pure, naturally-derived carrier and solvent and flavours and extracts.
2-Bromo-2-nitro-1,3-propanediol is a skin friendly preservative boosting.
2-Bromo-2-nitro-1,3-propanediol also is an alternative to petroleum based glycols for liquid laundry detergents, liquid hand and automatic dish detergents, carpet and rug cleaners, hard surface cleaners and glass cleaners, pharmaceuticals, dietary supplements, personal care and other applications.
2-Bromo-2-nitro-1,3-propanediol is an antimicrobial preservative that works by forming formaldehyde in cosmetic products.
2-Bromo-2-nitro-1,3-propanediol is used as a bactericide, in seed treatment for control of Xanthomonas malvacearum, as a foliar spray for control of a wide range of plant-pathogenic bacteria (especially Erwinia amylovora), in antiseptics and as a preservative in cosmetics, cooling fluids, hand & face creams, shampoos, hair dressings, mascaras, cleansing lotions, milk sampling, paints, textiles, humidifiers, pharmaceutical products, washing detergents.
2-Bromo-2-nitro-1,3-propanediol is an organic compound with wide-spectrum antimicrobial properties.
2-Bromo-2-nitro-1,3-propanediol is a highly active antimicrobial compound whose chemical formula is 2-bromo-2-nitropropane 1, 3-diol.
2-Bromo-2-nitro-1,3-propanediol is a white pale yellow crystalline solid with strong odor.
2-Bromo-2-nitro-1,3-propanediol is readily soluble in non-polar solvents but shows a high affinity for polar organic solvents.
2-Bromo-2-nitro-1,3-propanediol is used in consumer products as an effective preservative agent, as well as a wide variety of industrial applications as an antimicrobial in cosmetics, external medicaments, shampoos and bath preparations.
2-Bromo-2-nitro-1,3-propanediol is also used as a substitute for formaldehyde in chemical toilets.
2-Bromo-2-nitro-1,3-propanediol is an organic compound that is used as an antimicrobial and preservative.
2-Bromo-2-nitro-1,3-propanediol then became popular as a preservative in many consumer products such as shampoos and cosmetics.
The use of 2-Bromo-2-nitro-1,3-propanediol in personal care products (cosmetics, toiletries) has declined since the late 1980s due to the potential formation of nitrosamines.
2-Bromo-2-nitro-1,3-propanediol is used as preservative for storing milk samples.
2-Bromo-2-nitro-1,3-propanediol is an organic compound with wide-spectrum antimicrobial properties.
2-Bromo-2-nitro-1,3-propanediol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives.
2-Bromo-2-nitro-1,3-propanediol is used as a microbicide or microbiostat in various commercial and industrial applications, including oil field systems, air washer systems, air conditioning or humidifying systems, cooling water systems, papermills, absorbent clays, metal working fluids, printing inks, paints, adhesives and consumer products.
Compared to other aliphatic halogen-nitro compounds, 2-Bromo-2-nitro-1,3-propanediol is more stable to hydrolysis in aqueous media under normal conditions.
The inhibitory activity against various bacteria, including Pseudomonas aeruginosa, was demonstrated in vitro.
The agent is largely available commercially as an antibacterial for a variety of industrial purposes while it is predominantly available for purchase litter antibacterial at the domestic consumer level.
Nevertheless, ongoing contemporary re-evaluations of 2-Bromo-2-nitro-1,3-propanediol use in large markets such as Canada now place various compositional and product restrictions on the use of the agent in cosmetic products and in other products where it may not primarily be used in the role of a non-medicinal preservative antimicrobial.
PROPERTIES:
-assay: 98%
-form: crystals
-mp: 130-133 °C (lit.)
-solubility: H2O: soluble 100 mg/mL, clear, colorless to faintly yellow
-InChI: 1S/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2
SPECIFICATION:
-CAS Min %: 97.5
-CAS Max %: 100.0
-Melting Point: >120.0°C
-Color: White to Yellow
-Assay Percent Range: 97.5% min. (GC)
PRODUCTION:
2-Bromo-2-nitro-1,3-propanediol is produced by the bromination of di(hydroxymethyl)nitromethane, which is derived from nitromethane by a nitroaldol reaction.
FUNCTION:
-Drilling Fluid Additives
-Biocide
APPLICATION:
2-Bromo-2-nitro-1,3-propanediol is used in consumer products as an effective preservative agent, as well as a wide variety of industrial applications (almost any industrial water system is a potential environment for bacterial growth, leading to slime and corrosion problems in many of these systems bronopol can be a highly effective treatment).
The use of 2-Bromo-2-nitro-1,3-propanediol in personal care products (cosmetics, toiletries) has declined since the late 1980s due to the potential formation of nitrosamines.
While 2-Bromo-2-nitro-1,3-propanediol is not in itself a nitrosating agent, under conditions where it decomposes (alkaline solution and/or elevated temperatures) it can liberate nitrite and low levels of formaldehyde and these decomposition products can react with any contaminant secondary amines or amides in a personal care formulation to produce significant levels of nitrosamines (due to the toxicity of these substances, the term 'significant' means levels as low as 10s of parts per billion).
Manufacturers of personal care products are therefore instructed by regulatory authorities to avoid the formation of nitrosamines which might mean removing amines or amides from the formulation, removing 2-Bromo-2-nitro-1,3-propanediol from a formulation, or using nitrosamine inhibitors.
USES:
-Cosmetic and personal care
-Food and flavours
-Laundry and household cleaning
-Pharmaceutical and dietary supplements
FEATURES AND BENEFITS:
Cosmetics and personal care:
-Lack of skin irritation or sensitization
-Improved humectancy
-High purity
-Boosts preservative efficacy
-Excellent sensory characteristics
-Favorable environmental profile
Food and Flavours:
- Reduced bitterness
- Enhanced sweetness
- Alternative to petroleum-based carriers and additives
- Unique solubility properties
- Improved humectancy
- Lowers water activity
- Antimicrobial properties
- GMO Free
Laundry and household cleaning:
- Lack of skin irritation or sensitization
- Improved humectancy
- Good stability
- High purity
- Favorable environmental profile
- Enhanced clarity
Pharmaceutical and dietary supplements:
-Lack of skin irritation or sensitization
-Improved humectancy
-Excellent sensory characteristics
-May help deliver actives to the skin
-Boosts preservative efficacy
-Reduced bitterness
-Enhanced sweetness
-Enhanced flavor sensory
-Favorable environmental profile
PHYSICAL AND CHEMICAL PROPERTIES:
-Formula: HOCH2CBr(NO2)CH2OH / C3H6O4BrN
-Molecular mass: 200
-Melting point: 120-122°C
-Relative density (water = 1): 1.9
-Solubility in water, g/100ml at 23°C: 28 (freely soluble)
-Vapour pressure, Pa at 20°C: <0.01
-Flash point: 167°C
-Octanol/water partition coefficient as log Pow: 0.18
STORAGE:
Fireproof.
Separated from food and feedstuffs and incompatible materials.
Dry.
Well closed.
Keep in a well-ventilated room.
Store in an area without drain or sewer access.
Provision to contain effluent from fire extinguishing.
SYNONYM:
bronopol
2-Bromo-2-nitro-1,3-propanediol
52-51-7
2-Bromo-2-nitropropane-1,3-diol
Bronosol
Bronocot
Bronidiol
Bronopolu
Bronotak
1,3-Propanediol, 2-bromo-2-nitro-
Onyxide 500
Lexgard bronopol
2-Nitro-2-bromo-1,3-propanediol
BNPD
MFCD00007390
beta-Bromo-beta-nitrotrimethyleneglycol
NSC 141021
CHEBI:31306
NSC-141021
6PU1E16C9W
NCGC00164057-01
Bronopolum
DSSTox_CID_4652
DSSTox_RID_77484
DSSTox_GSID_24652
Bronopolu
Caswell No. 116A
Bioban
Bronopolum
Myacide AS plus
Myacide BT
CAS-52-51-7
Bronopol
Myacide Pharma BP
Canguard 409
BNPK
HSDB 7195
EINECS 200-143-0
UN3241
EPA Pesticide Chemical Code 216400
BRN 1705868
UNII-6PU1E16C9W
AI3-61639
2-Bromo-2-nitropropan-1,3-diol
2-bromo-2-nitro-propane-1,3-diol
Bronopol
BRONOPOL
BRONOPOL
BRONOPOL
BRONOPOL
BRONOPOL
BRONOPOL
WLN: WNXE1Q1Q
1, 2-bromo-2-nitro-
2-Bromo-2-nitropropane-1,3-diol
BRONOPOL
EC 200-143-0
SCHEMBL23260
Bioban BNPD-40 (Salt/Mix
CHEMBL1408862
DTXSID8024652
SCHEMBL16556987
LVDKZNITIUWNER-UHFFFAOYSA-
2-bromo-2nitro-1,3-propanediol
AMY8948
2-bromo-2-nitro-1,3-propandiol
2-Bromo-2-nitropropane-1,3-diol
ALBB-031641
HY-B1217
ZINC1088216
Tox21_112079
Tox21_300126
