2-BUTYL-1-OCTANOL (C12 GUERBET ALCOHOL)

2-butyl-1-octanol (C12 Guerbet alcohol) is a long-chain glass forming monohydroxy alcohol.
2-butyl-1-octanol (C12 Guerbet alcohol) can be chemically described as 2-butyl-1-octanol and is also referred to as C12 Guerbet alcohol. 
2-butyl-1-octanol (C12 Guerbet alcohol) is a light emollient, solvent, basic material for the production of emollient esters.

CAS Number: 3913-02-8
Molecular Formula: C12H26O
Molecular Weight: 186.33
EINECS Number: 223-470-0

Synonyms: 2-BUTYL-1-OCTANOL, 2-Butyloctan-1-ol, 3913-02-8, 2-Butyloctanol, Butyloctanol, 1-Octanol, 2-butyl-, 2-Butyloctyl alcohol, 2-Butyl-1-n-octanol, 5-(Hydroxymethyl)undecane, Michel XO-150-12, DTXSID0044818, Jarcol I-12, CHEBI:84235, 5-Hydroxymethylundecane, GUERBET DODECANOL, N442D9VO79, NSC 2414, NSC-2414, EINECS 223-470-0, MFCD00053508, ISOFOL 12 ALCOHOL, BRN 1738522, UNII-N442D9VO79, AI3-19958, DTXCID8024818, (+/-)-2-BUTYLOCTANOL, 2-BUTYLOCTANOL, (+/-)-, MICHEL XO-150-12 ISO-LAURYL ALCOHOL, EC 223-470-0, 4-01-00-01855 (Beilstein Handbook Reference), 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole, dl-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazole, 2,3,5,6-Tetrahydro-6-phenyl-(S)-Imidazo[2,1-b]thiazole, 2,3,5,6-Tetrahydro-6-phenyl-(+-)-Imidazo(2,1-b)thiazole, 6-Phenyl-2,3,5,6-tetrahydro-imidazo(2,1-b)thiazole, 2,3,5,6-Tetrahydro-6-phenyl-(S)-imidazo(2,1-b)thiazole, 2butyloctanol, 2Butyl1octanol, 2Butyloctan1ol, 2-butyl octanol, Isolauryl aclohohol, 1Octanol, 2butyl, 2Butyloctyl alcohol, 2-butyl-octan-1-ol, (.+-.)-Tetramisole, 5(Hydroxymethyl)undecane, 2-Butyl-n-octyl Alcohol, BUTYLOCTANOL [INCI], SCHEMBL15370, 2-Butyl-1-octanol, 95%, CHEMBL3183262, WLN: Q1Y6&4, NSC2414, Tox21_301274, LMFA05000612, AKOS015912690, NCGC00256026-01, AS-81317, BP-31207, SY052296, CAS-3913-02-8, DB-121797, B3457, CS-0152304, NS00002827, C22404, D97420, Q27157606, 2-butyl-1-octano,2-Butyloctyl alcohol,2-butyloctylalcohol,5-(Hydroxymethyl)undecane,Isododecyl alcohol,Michel XO-150-12,2-BUTYL-1-OCTANOL,2-BUTYLOCTAN-1-OL 

2-butyl-1-octanol (C12 Guerbet alcohol), also known as C12 Guerbet alcohol, is a long-chain fatty alcohol with the chemical formula C12H26O. 
2-butyl-1-octanol (C12 Guerbet alcohol) is primarily used in the production of surfactants, emulsifiers, and cosmetic formulations due to its emulsifying properties.
A primary alcohol that is 1-octanol substituted by a butyl group at position 2. Metabolite observed in cancer metabolism.

2-butyl-1-octanol (C12 Guerbet alcohol) is a primary, saturated alcohol with defined branching of the carbon chain. 
It can be chemically described as 2-butyl-1-octanol and is also referred to as C12 guerbet alcohol. 
2-butyl-1-octanol (C12 Guerbet alcohol) is designed for adhesives.

2-butyl-1-octanol (C12 Guerbet alcohol) is a primary alcohol that is 1-octanol substituted by a butyl group at position 2. 
2-butyl-1-octanol (C12 Guerbet alcohol) has a role as a human metabolite. 
It is a primary alcohol, a fatty alcohol and an alkyl alcohol. 

2-butyl-1-octanol (C12 Guerbet alcohol) derives from a hydride of an octane.
2-butyl-1-octanol (C12 Guerbet alcohol) has a straight-chain structure with a butyl group (C4H9) attached to the first carbon of an octanol chain (C8H17).
Commonly found in personal care products, pharmaceuticals, and industrial applications. It can act as an emollient, solvent, and viscosity agent.

Typically has a waxy texture and is insoluble in water but soluble in organic solvents.
The production of 2-butyl-1-octanol primarily occurs through the Guerbet reaction, which involves.
Typically, butanol and octanol are reacted in the presence of a catalyst (like copper or nickel).

Under specific conditions (elevated temperature and pressure), the reaction results in the formation of longer-chain alcohols.
This process may involve several steps of dehydration and rearrangement to yield the final product.
The demand for natural and biodegradable ingredients in personal care and cosmetic products has led to increased interest in long-chain fatty alcohols like 2-butyl-1-octanol.

Manufacturers are exploring more sustainable and eco-friendly production methods to align with consumer preferences for greener products.
Enhances spreadability and wear time of foundations and powders.
Improves the moisturizing properties and creates a creamy texture.

Can enhance the permeation of drugs through the skin barrier, making it useful in patches and topical gels.
Acts as a solvent and stabilizer in various pharmaceutical formulations.
While not common, certain long-chain alcohols can be evaluated for use as food-grade emulsifiers or flavor carriers, depending on regulatory status.

2-butyl-1-octanol (C12 Guerbet alcohol) is used to improve the wetting properties and effectiveness of surfactants in cleaning products.
As an adjuvant, it helps improve the efficacy of herbicides and insecticides by enhancing their ability to spread and penetrate.
Organizations like the FDA, EPA, and EU Cosmetic Regulation monitor the use of chemical compounds like 2-butyl-1-octanol to ensure safety in consumer products.

Generally considered low in toxicity, but like all chemicals, it can pose risks if misused or ingested. 
Risk assessments typically include skin and eye irritation studies, as well as potential allergic reactions.
While biodegradable, the persistence of long-chain alcohols in the environment can vary. 

Factors like microbial activity and environmental conditions influence degradation rates.
As a fatty alcohol, 2-butyl-1-octanol can affect aquatic organisms if released into waterways, necessitating appropriate disposal methods.

Ongoing research is aimed at optimizing the formulation of products containing 2-butyl-1-octanol to enhance its performance while maintaining safety and environmental responsibility.
As sustainability becomes a focal point in product development, research into biobased or renewable sources of fatty alcohols is gaining momentum.

Melting point: -80°C(lit.)
Boiling point: 145-149 °C(lit.)
Density: 0.833 g/mL at 25 °C(lit.)
vapor pressure: 8.1Pa at 37.8℃
refractive index: 1.4400 to 1.4440
Flash point: 113 °C
form: clear liquid
pka: 15.09±0.10(Predicted)
color: Colorless to Almost colorless
Water Solubility: 1mg/L at 23℃
Stability: Stable. Incompatible with strong oxidizing agents. Combustible.
LogP: 5.5 at 23℃

2-butyl-1-octanol (C12 Guerbet alcohol) is synthesized through the Guerbet reaction, where lower-chain alcohols (like butanol and octanol) are reacted in the presence of a catalyst. 
Converting unsaturated fatty acids or alcohols into their saturated counterparts.
Short-chain alcohols undergo condensation to form longer-chain alcohols.

2-butyl-1-octanol (C12 Guerbet alcohol) helps mix oil and water in formulations, stabilizing creams and lotions.
2-butyl-1-octanol (C12 Guerbet alcohol) increases the viscosity of products.
2-butyl-1-octanol (C12 Guerbet alcohol) is used as a solubilizer and stabilizer in various medicinal formulations.

Acts as a base for synthetic lubricants.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in protective coatings for various surfaces.
Employed in some agricultural formulations to improve the delivery of active ingredients.

Generally considered safe for use in cosmetics and personal care products when used in appropriate concentrations. 
However, like many chemicals, it should be handled with care.
Long-chain fatty alcohols are often biodegradable, making them preferable in eco-friendly formulations.

2-butyl-1-octanol (C12 Guerbet alcohol) is subject to regulations depending on its application. 
In cosmetics, it is often listed on ingredient labels and must comply with safety assessments.
The molecular structure consists of a butyl group (C4H9) attached to a linear octanol chain (C8H17). 

The hydroxyl (-OH) functional group is located at the end of the octanol chain, classifying it as a primary alcohol.
While it is insoluble in water, it is soluble in many organic solvents such as ethanol, diethyl ether, and chloroform. 
This property makes it suitable for use in oil-based formulations.

2-butyl-1-octanol (C12 Guerbet alcohol) has a relatively high viscosity compared to lower-chain alcohols, which can enhance the texture of formulations.
Acts by forming a barrier on the skin, helping to retain moisture. 
This property is beneficial in preventing dryness and enhancing skin feel.

Its amphiphilic nature (having both hydrophilic and hydrophobic parts) allows it to stabilize oil-water mixtures, making it essential in creams and lotions.
Helps dissolve other active ingredients, improving the efficacy of formulations and ensuring an even distribution of components.
2-butyl-1-octanol (C12 Guerbet alcohol) is used to improve the texture and moisturizing properties.

Acts as a solvent and helps in spreading the formulation evenly on the skin.
Enhances shine and manageability in conditioners and styling products.
Utilized in ointments and creams for its ability to enhance skin absorption of active ingredients.

Incorporated into plastics to improve flexibility and durability.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in paints and varnishes to enhance application properties and finish.
Functions as an adjuvant in pesticide formulations, improving the wetting and spreading of active ingredients on plant surfaces.

2-butyl-1-octanol (C12 Guerbet alcohol) is generally biodegradable, reducing its environmental footprint. 
However, its long-chain structure means that while it may break down, the rate of degradation can vary based on environmental conditions.
As with many organic compounds, there are concerns about potential toxicity to aquatic life, emphasizing the importance of proper disposal and use.

2-butyl-1-octanol (C12 Guerbet alcohol) is important to follow regulatory guidelines for usage levels in cosmetic and industrial applications.
Users should refer to the SDS for information on handling, exposure limits, and personal protective equipment (PPE) recommendations.
Although generally considered safe, it can cause irritation in sensitive individuals, making patch testing advisable for new formulations.

Uses:
2-Butyl-1-octanol (BuOA) has been used to synthesize, hydrophobic polyesters in miniemulsion in the presence of large amounts of water.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in lotions, creams, and hair care products for its moisturizing and emulsifying properties.
Employed in the production of lubricants, plasticizers, and coatings.

Adds moisture and softness to skin and hair products.
Stabilizes oil-water mixtures in creams, lotions, and gels.
Increases viscosity in formulations like creams and conditioners.

Helps dissolve active ingredients in cosmetic formulations, ensuring even distribution.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in ointments and creams to enhance skin absorption of active ingredients.
2-butyl-1-octanol (C12 Guerbet alcohol) improves permeation of drugs through the skin in patches and gels.

Maintains the integrity of various pharmaceutical formulations.
Acts as a base for surfactants in detergents and cleaning products, enhancing cleaning efficiency.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in the formulation of synthetic lubricants, providing stability and performance.

Included in paints, varnishes, and protective coatings to improve application properties.
Enhances the efficacy of pesticides and herbicides by improving their spreadability and penetration on plant surfaces.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in formulations to help active ingredients mix with water and spread evenly.

In some cases, evaluated for use as food-grade emulsifiers or flavor carriers, though not commonly applied.
Included in formulations for household cleaners and detergents to improve wetting properties.
2-butyl-1-octanol (C12 Guerbet alcohol)is used to enhance the feel and softness of fabrics.

Enhances moisturizing properties and provides a smooth texture. 
Helps prevent water loss by forming a protective barrier on the skin.
Improves the feel and application of cleansing products, helping to remove impurities while maintaining skin moisture.

Acts as a conditioning agent, improving hair softness, manageability, and shine.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in gels and sprays to enhance product performance and ease of application.
Enhances spreadability and wear time, providing a smooth finish.

Functions as a solvent and emollient, improving texture and comfort.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in topical formulations to aid in the delivery of active ingredients, ensuring better skin penetration and therapeutic effect.
Enhances the absorption of medications through the skin, making it valuable in drug delivery patches.

Helps maintain the stability and consistency of various liquid and semi-solid pharmaceutical formulations.
Acts as a key ingredient in the formulation of various surfactants, which are essential for reducing surface tension in cleaning products.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in synthetic lubricants for machinery and automotive applications, improving lubrication efficiency and reducing wear.

Included in protective coatings for metals, plastics, and wood, enhancing durability and resistance to environmental factors.
Improves the efficacy of pesticides and herbicides by increasing their ability to spread and adhere to plant surfaces, ensuring better coverage and penetration.
Sometimes used to enhance the solubility and effectiveness of liquid fertilizers.

Although not widely used in food applications, 2-butyl-1-octanol (C12 Guerbet alcohol) can be evaluated as a food-grade emulsifier in certain products where regulatory approvals are obtained.
Enhances the performance of household cleaners, dishwashing liquids, and laundry detergents, improving cleaning efficiency and reducing surface tension.
2-butyl-1-octanol (C12 Guerbet alcohol) is used in formulations to provide softness to fabrics and enhance their feel after washing.

Employed as a wetting agent and softener in textile processing, improving the finish of fabrics.
2-butyl-1-octanol (C12 Guerbet alcohol) utilized in formulations for paints and inks to improve flow and application properties, as well as enhance stability.
As a fatty alcohol, 2-butyl-1-octanol is generally biodegradable, making it more environmentally friendly compared to many synthetic alternatives.

Typically recognized as safe when used in appropriate concentrations. 
However, as with any chemical, 2-butyl-1-octanol (C12 Guerbet alcohol) is essential to follow safety data sheets (SDS) and regulatory guidelines.

Safety Profile:
2-butyl-1-octanol (C12 Guerbet alcohol) mildly toxic by ingestion, A skin and eye irritant. 
Combustible when exposed to heat or flame. 
2-butyl-1-octanol (C12 Guerbet alcohol) incompatible with oxidizing materials. 

To fight fire, use CO2, dry chemical.
2-butyl-1-octanol (C12 Guerbet alcohol) when heated to decomposition it emits acrid and irritating fumes.
May cause mild irritation upon direct contact, particularly in sensitive individuals.

2-butyl-1-octanol (C12 Guerbet alcohol) can cause irritation if it comes into contact with the eyes, leading to redness and discomfort.
Inhalation of vapors or mist can potentially cause irritation to the respiratory tract.
There is a possibility of allergic skin reactions in some individuals, especially with prolonged exposure.

While generally biodegradable, 2-butyl-1-octanol (C12 Guerbet alcohol) can be toxic to aquatic organisms at high concentrations, necessitating careful disposal and management to prevent environmental contamination.
Long-chain fatty alcohols may persist in the environment, which could lead to bioaccumulation in aquatic life.
Although 2-butyl-1-octanol (C12 Guerbet alcohol) has a relatively high flash point (around 100°C or 212°F), it can still pose a fire hazard if exposed to open flames or high heat.