PRODUCTS

2-HEPTANONE

2-Heptanone is a colorless liquid with a strong, sweet odor.
2-Heptanone is a member of the ketone family of organic compounds and has a molecular formula of C6H12O.
2-Heptanone is commonly used as a solvent in various industrial applications due to 2-Heptanone unique properties and advantages.

CAS Number: 110-43-0
EC Number: 203-767-1
IUPAC Name: Heptan-2-one
Chemical Formula: C7H14O

Other names: Heptan-2-one, 110-43-0, Methyl pentyl ketone, Butylacetone, Amyl methyl ketone, Methyl amyl ketone, Methyl n-amyl ketone, n-Amyl methyl ketone, n-Pentyl methyl ketone, Heptanone, Pentyl methyl ketone, Methyl n-pentyl ketone, Ketone, methyl pentyl, Amyl-methyl-cetone, Methyl-amyl-cetone, Ketone C-7, FEMA No. 2544, NSC 7313, CHEMBL18893, CHEBI:5672, DTXSID5021916, 89VVP1B008, NSC-7313, Methyl-n-amylketone, DTXCID601916, 2-Heptanone (natural), FEMA Number 2544, Amyl-methyl-cetone [French], Methyl-amyl-cetone [French], CAS-110-43-0, HSDB 1122, EINECS 203-767-1, UN1110, BRN 1699063, UNII-89VVP1B008, AI3-01230, CCRIS 8809, 1-Methylhexanal, 2-Ketoheptane, heptanone-2, methylpentylketone, 2-heptanal, 2-Oxoheptane, Nat. 2-Heptanone, 2-Heptanone, 98%, 2-Heptanone, 99%, 2-HEPTANONE [MI], EC 203-767-1, n-C5H11COCH3, 2-HEPTANONE [FCC], 2-HEPTANONE [FHFI], 2-HEPTANONE [HSDB], SCHEMBL29364, 4-01-00-03318 (Beilstein Handbook Reference), 2-heptanone_GurudeebanSatyavani, SCHEMBL1122991, WLN: 5V1, 2-Heptanone, analytical standard, 2-Heptanone(Methyl Amyl Ketone), NSC7313, 2-Heptanone, natural, 98%, FG, Methyl n-Amyl Ketone Reagent Grade, ZINC1531087, Tox21_202164, Tox21_302935, BBL011381, BDBM50028842, LMFA12000004, MFCD00009513, STL146482, 2-Heptanone, >=98%, FCC, FG, Methyl Amyl Ketone (Fragrance Grade), AKOS000120708, UN 1110, NCGC00249180-01, NCGC00256611-01, NCGC00259713-01, VS-02935, FT-0612484, H0037, EN300-21047, C08380, A802193, Q517266, J-509557, n-Amyl methyl ketone [UN1110] [Flammable liquid], Ick, MAK, hICK, LCK2, fj04c02, KIAA0936, kinase ICK, 2-Heptanal, 2-Heptanon, 2-Heptanone, heptan-2-one, 2-Oxoheptane, 2-Ketoheptane, 1-Methylhexanal, Methyl amyl ketone, Amyl-methyl-cetone, n-Amyl methyl ketone, Methyl n-pentyl ketone, Intestinal cell kinase, Laryngeal cancer kinase 2, amyl-methyl-cetone(french)

2-Heptanone, also known Heptan-2-one, is a ketone with the molecular formula C7H14O.
2-Heptanone is a colorless, water-like liquid with a banana-like, fruity odor.
2-Heptanone has a neutral formal charge, and is only slightly soluble in water.

2-Heptanone is a natural product found in Aloe africana, Zingiber mioga, and other organisms with data available.
2-Heptanone is a metabolite found in or produced by Saccharomyces cerevisiae.

2-Heptanone is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
2-Heptanone is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

2-Heptanone is listed by the FDA as a "food additive permitted for direct addition to food for human consumption" (21 CFR 172.515), and 2-Heptanone occurs naturally in certain foods (e.g., beer, white bread, butter, various cheeses and potato chips).

The mechanism of action of 2-Heptanone as a pheromone at odorant receptors in rodents has been investigated.
2-Heptanone is present in the urine of stressed rats and believe that 2-Heptanone is used as a means to alert other rats.

Certain species of worms are attracted to 2-Heptanone and bacteria can use this as a means of pathogenesis.
2-Heptanone has also been found to be excreted by honey bees when they bite small pests within the colony such as wax moth larvae and Varroa mites.

Though 2-Heptanone was historically believed to be an alarm pheromone, 2-Heptanone has been shown to act as an anaesthetic on the pests, enabling the honey bee to stun the pest and eject 2-Heptanone from the hive.
The work could lead to the use of 2-Heptanone as an alternative local anaesthetic to lidocaine, which although well established for clinical use, has the disadvantage of provoking allergic reactions in some people.

2-Heptanone was one of the metabolites of n-heptane found in the urine of employees exposed to heptane in shoe and tire factories.
This commonly occurs from exposure to plasticisers.

2-Heptanone can be absorbed through the skin, inhaled and consumed.
Exposure to 2-Heptanone can cause irritation of skin/eyes, respiratory system, headaches, vomiting, and nausea.

In mice 2-H is a urinary component and pheromone.
2-Heptanone has a high affinity for the main olfactory epithelium.
Gaillard et al 2002 found that 2-Heptanone agonizes one specific olfactory receptor, and that that OR only binds 2-H.

One of the key advantages of 2-Heptanone is its high solvency power.
2-Heptanone is a very effective solvent for many organic compounds, particularly those that are insoluble in water.

This makes 2-Heptanone useful in applications such as paint and coating formulations, adhesives, and inks.
2-Heptanone is also used as a solvent in the production of various chemicals, such as pharmaceuticals and pesticides.

Another advantage of 2-Heptanone is relatively low toxicity compared to other ketones.
2-Heptanone has a lower vapor pressure and boiling point than other ketones, which means that 2-Heptanone is less likely to vaporize and become a hazard in the workplace.

However, 2-Heptanone is still important to handle with care and use in accordance with appropriate safety protocols.
This includes the use of protective equipment, such as gloves and safety goggles, as well as proper ventilation and storage.

2-Heptanone is also used in the production of fragrances and flavors, as well as in the production of resins and polymers.
2-Heptanone is a useful intermediate in the production of other chemicals and is used as a starting material in the production of other ketones.
2-Heptanone is also used as a fuel additive to improve the combustion efficiency of gasoline.

2-Heptanone has a high solvent activity, slow evaporation rate, low density, low surface tension, and high boiling point.
These properties make 2-Heptanone a very good solvent for cellulosic lacquers, acrylic lacquers, and high-solids coatings.
Because regulations limit the weight of solvent per gallon of coating, formulators favor the use of low-density solvents that help reduce the VOC content of a coating.

2-Heptanone is lower in density than ester, aromatic hydrocarbons, and glycol ether solvents with similar evaporation rates.
The low density and high activity of 2-Heptanone are significant advantages when formulating high-solids coatings to meet VOC guidelines.
2-Heptanone is also used as a polymerization solvent for high solids acrylic resins.

The chemical substances for 2-Heptanone are listed as Inert Ingredients Permitted for Use in Nonfood Use Pesticide Products, and in Food Use Pesticide Products with limitations, under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).

Applications of 2-Heptanone:
Auto OEM
Auto refinish
General industrial coatings
Herbicides int
Paints & coatings
Process solvents

Uses of 2-Heptanone:
2-Heptanone is used for the synthesis of industrial solvents and fragrances, such as the components used to make caryophyllum oil.

Micro-amounts are suitable for carnation or other octyl fragrance types, which can be shared with Artemisia or basil, seashell oil in herb fragrance types, the formation of a new head fragrance.
With the spice, fruit flavor can coordinate and good synthesis.

In the food flavor, for the banana type food flavor can increase the milk fat flavor, also suitable for coconut, cream, cheese flavor food flavor.
GB 2760-96 provides for the permitted use of flavorants.

2-Heptanone is mainly used in the preparation of cheese, banana, cream and coconut flavor.
2-Heptanone is used for the synthesis of industrial solvents and fragrances, such as the components used to make caryophyllum oil.

2-Heptanone is widely used in industrial solvent, fiber, medicine, pesticide, perfume chemical industry and other fields
2-Heptanone is used in organic synthesis; Trace suitable for carnation or other octanoaromatic type, in the herb fragrance can be shared with the grass Artemisia or basil, Sea oil, the formation of new head fragrance.

With the spice, fruit flavor can coordinate and good synthesis.
In the food flavor, for the banana type food flavor can increase the milk fat flavor, also suitable for coconut, cream, cheese flavor food flavor; For industrial solvents, fiber, medicine, pesticide, perfume and Chemical Industry.

2-Heptanone is used as a solvent for resins and lacquers, a fragrance for cosmetics, and a flavor for foods.
2-Heptanone is solvent for nitrocellulose lacquers.

2-Heptanone is used in perfumery as constituent of artificial carnation oils; as industrial solvent
2-Heptanone is used as a solvent in metal roll coatings and in synthetic resin finishes and lacquers, as a flavoring agent, and in perfumes.

2-Heptanone can be used in the following industries:
Food & Feed, Pharma & Life Science, Other Industries, Cosmetics & Personal Care

2-Heptanone can be applied as:
Oleochemicals, Fragrances, Food Additives

Consumer Uses:
2-Heptanone is used in the following products: plant protection products, adhesives and sealants, coating products, fillers, putties, plasters, modelling clay, cosmetics and personal care products, air care products, biocides (e.g. disinfectants, pest control products), perfumes and fragrances, polishes and waxes and washing & cleaning products.
Other release to the environment of 2-Heptanone is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

Other Consumer Uses:
Binder
Paint additives and coating additives not described by other categories
Solvent
Solvents (which become part of product formulation or mixture)

Widespread uses by professional workers:
2-Heptanone is used in the following products: washing & cleaning products, fertilisers, plant protection products, coating products, cosmetics and personal care products, polishes and waxes, laboratory chemicals and polymers.
2-Heptanone is used in the following areas: agriculture, forestry and fishing.

2-Heptanone is used for the manufacture of: machinery and vehicles.
Other release to the environment of 2-Heptanone is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industry
2-Heptanone is used in the following products: coating products, photo-chemicals, laboratory chemicals and semiconductors.
2-Heptanone is used in the following areas: scientific research and development.

2-Heptanone is used for the manufacture of: machinery and vehicles, chemicals and electrical, electronic and optical equipment.
Release to the environment of 2-Heptanone can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Industry Uses:
Cleaning agent
Intermediates
Paint additives and coating additives not described by other categories
Solvent
Solvents (which become part of product formulation or mixture)

Industrial Processes with risk of exposure:
Painting (Solvents)
Plastic Composites Manufacturing

Key attributes of 2-Heptanone:
Excellent solvent activity
High dilution ratio
Inert - Food use with limitations
Inert - Nonfood use
Low density

Low surface tension
Non-HAP
Non-SARA
REACH compliant
Readily Biodegradable
Slow evaporation rate
Urethane grade

Nature of 2-Heptanone:
2-Heptanone is colorless, fragrant, stable liquid.
2-Heptanone is slightly soluble in water.

2-Heptanone is melting Point -35 °c.
2-Heptanone is boiling point 151.5 °c.

2-Heptanone is relative density 0.8166.
2-Heptanone is refractive index 4067.

2-Heptanone is viscosity (25 °c) 0.766MPA.
2-Heptanone is flash point 47.
2-Heptanone is very slightly soluble in water, soluble in ethanol, ether.

Preparation Method of 2-Heptanone:
The extraction method is obtained by extracting clove oil or cinnamon oil.
2-heptanol method is prepared by dehydrogenation of 2-heptanol.
n-butyl acetoacetate method.

Production Method of 2-Heptanone:
1. Obtained by saponification of ethyl butyl acetoacetate.
Ethyl butyl acetoacetate was added to 5% sodium hydroxide solution and stirred at room temperature for 4H.

The layers were allowed to stand and separated.
The aqueous layer reacts with 50% sulfuric acid, and as the reaction becomes moderate to the release of carbon dioxide, the reaction is slowly heated to boil, distilling from 0.33 to 0.5% of the original total volume.

The distillate was made alkaline with solid sodium hydroxide and then distilled off 80-90%.
The distillate is layered, the ketone is separated into layers, and the water layer is distilled out for one third.

After the ketone is removed from the distilled material, the water layer is further distilled out for one third, which is repeated in this way, the resulting 2-Heptanone was collected as far as possible.
The resulting 2-Heptanone was combined and washed with calcium chloride solution.
After drying, 2-Heptanone was obtained by distillation with a yield of 50-60%.

The extraction method is obtained by extracting clove oil or cinnamon oil.
2-heptanol method from 2-heptanol dehydrogenation.
At room temperature with sodium hydroxide saponification of butyl acetyl ethyl acetate, then add sulfuric acid, heating distillation, distillate with sodium hydroxide neutralization, distillation, plus calcium chloride concentrated solution to remove residual ethanol, after drying and distillation.

Manufacturing Methods of 2-Heptanone:
Produced industrially by reductive condensation of acetone with butyraldehyde in one or two steps.

General Manufacturing Information of 2-Heptanone:
Industry Processing Sectors:
All Other Basic Organic Chemical Manufacturing
Computer and Electronic Product Manufacturing
Construction
Furniture and Related Product Manufacturing
Miscellaneous Manufacturing

Molecular Weight: 114.19
XLogP3: 2
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 4
Exact Mass: 114.104465066

Monoisotopic Mass: 114.104465066
Topological Polar Surface Area: 17.1 Å²
Heavy Atom Count: 8
Complexity: 66.8
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes