PRODUCTS

2-HYDROXYBENZOIC ACID (SALIYCLIC ACID)

2-Hydroxybenzoic acid (Saliyclic Acid), also known as 2-carboxyphenol or 2-hydroxybenzoate, belongs to the class of organic compounds known as salicylic acids.
2-Hydroxybenzoic acid (Saliyclic Acid) exists in all living species, ranging from bacteria to plants to humans.
2-Hydroxybenzoic acid (Saliyclic Acid) is an important organic synthetic raw material, widely used in medicine, pesticides, dyes, rubber, food and perfumes.

CAS Number: 69-72-7
Molecular Formula: C7H6O3
Molecular Weight: 138.12
EINECS Number: 200-712-3

salicylic acid, 2-Hydroxybenzoic acid, 69-72-7, o-hydroxybenzoic acid, 2-Carboxyphenol, o-Carboxyphenol, Rutranex, Salonil, Retarder, W, Keralyt, Duoplant, Freezone, Saligel, Ionil, Psoriacid-S-stif, Benzoic acid, 2-hydroxy-, Stri-De, Salicylic acid soap, Salicylic acid collodion, Verrugon, Phenol-2-carboxylic aciD, , Acidum salicylicum, Trans-Ver-Sal, Orthohydroxybenzoic acid, 2-Hydroxybenzenecarboxylic acid, Acidosalicilico, IonilPlus, Salicylicacid,tech., Kyselinasalicylova, Clearawaywartremover, Duofil, Domerine, Sebucare, Duofilm, Sebulex, Salicyclic acid, Ionil, plus, Dr. Scholl's corn remover, Kyselina salicylova [Czech], Dr. Scholl's callus removers, Dr. Scholl's wart remover kit, Kyselina 2-hydroxybenzoova, Occlusal, Acido salicilico [Italian], Advanced pain relief corn removers, Caswell No. 731, 2-hydroxy-benzoic acid, Kyselina 2-hydroxybenzoova [Czech], Advanced pain relief callus removers, Acido o-idrossibenzoico [Italian], NSC 180, Salicylicacid&SulfurSoap, CCRIS6714, HSDB672, AI302407, UNIIO414PZ4LPZ, MFCD00002439, EPAPestiideChemicalCode076602, BRN0774890, CHEBI:16914, CHEMBL424, O414PZ4LPZ acid inclusion complex, K 537, NSC-180, ATA fraction 10, ammonium salt, NCGC00159447-05, SMR000059163, Mediplast pads, Salicylic acid, 9 +%, Akurza Lotion, Hydrisalic Gel, Akurza Cream, Salex Lotion, Salex Cream, DSSTox_CID_6368, DuoPlant Gel, DHS Sal Shampoo, DSSTox_RID_78106, P&S Shampoo, DSSTox_GSID_26368, Salicylic acid [USAN:JAN], Acido o-idrossibenzoico, Durasal, Salicylic acid, 99+%, ACS reagent, salicylicum acidum, CAS-69- 72-7, Propa pH Peel-Off Acne Mask, NSC629474, phenol derivative, 7, Salicylic acid (TN), Benzoic acid, 2-hydroxy-, ion(1-), EINECS 200-712-3, Salicylic acid [USP:JAN], Azurechelin, Salicylic acid (6CI,8CI), Anti-blemish, Salicylic acid rs, hydroxy-benzoic acid, ortho-salicylic acid, CMC_13852, Fostex (Salt/Mix), Pernox (Salt/Mix), Duofilm Wart Remover, Phenol-2-carboxylate, Duofilm (Salt/Mix), Salicylic Acid,(S), Sebulex (Salt/Mix), 2-hydroxobenzoic acid, Domerine (Salt/Mix), Sebucare (Salt/Mix), 2-Hydroxybenzoate, I, Natural Salicylic Acid, ohydroxybenzoicacid, 2hydroxybenzoicacid, Spectrum_ 00948, Salicylicacid,medicinal, ACMC-1AZI, Opera_ID_582, Sulfasalazine Impurity H, Salicylic acid ACS grade, [O]C(=O)c1ccccc1O, WLN: QVR BQ, Benzoic acid, o-hydroxy-, Bazuka Extra Strength Gel, 2-Hydroxybenzenecarboxylate, bmse000252, Epitope ID:124929, RetarderSAX(Salt/Mix), UPCMLD-DP126, E200-712- 3, SCHEMBL1967, Oprea1_040343, KBioSS_001428, ARONIS27188, BIDD:ER0602, DivK1c_000301, Salicylic acid (JP17/USP), 2-Hydroxybenzoic Acid, Natural, FEMA3985, GTPL4306, SGCUT00012, ZINC1554, Salicylic acid, >=99%, FG, Salicylic acid, LR, >=99%, component of Tinver (Salt/Mix), DTXSID7026368, FEMA NO. 3985, UPCMLD-DP126:001, BDBM26193, component of Keralyt (Salt/Mix), KBio1_000301, KBio2_001428, KBio2_003996, KBio2_006564, Alpha/BetaHydroxyAcids(GlycolicAcid,SalicylicAcid), E9A559BE383B4F83BC023031D03D558A, NINDS_000301 02, NCGC00159447-04, NCGC00159447-06, NCGC00257065-01, NCGC00259022-01, AK112186, BP-12826, KSC-11-207-4, Lamivudine related compound salicylic acid, Salicylic acid & Sulfur Soap (Salt/Mix), Salicylic acid, ACS reagent, >=99.0%, Salicylic acid, plant cell culture tested, Salicylic acid, ReagentPlus(R), >=99%, SC-18305, TS-03583, Salicylic Acid 1.0 mg/ml , SBI0051510.P003, FT0645123, FT-0674502, FT-0674503, Salicylic acid, tested according to Ph.Eur., ST51046715, Salicylic acid, SAJ first grade, >=99.0%, Salicylic acid, Vetec(TM)reagentgrade98%, 44642EP2281819A1, 44642EP2292619A1, 44642EP2305659A1, 44642EP2311818A1, AB00489876_15, ENZOICACID,2HYDROXYSALICYLICACID, Salicylicacid,p of Solarcaine first aid spray (Salt/Mix), J-509667, component of Fostex medicated bar and cream (Salt/Mix), F2191-0216, Salicylic acid, certified reference material, TraceCERT(R), UNII-I3P9R8317T component YGSDEFSMJLZEOE-UHFFFAOYSA-N, Salicylic acid, British Pharmacopoeia (BP) Reference Standard, Salicylic acid, European Pharmacopoeia (EP) Reference Standard, Salicylic acid, United States Pharmacopeia (USP) Reference Standard, Salicylic acid, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Salicylic acid, Pharmaceutical Secondary Standard, Certified Reference Material, 8052-31-1, Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance),2 Hydroxybenzoic Acid, 2-Hydroxybenzoic Acid, Acid, 2-Hydroxybenzoic, Acid, o-Hydroxybenzoic, Acid, ortho-Hydroxybenzoi Hydroxybenzoic Acid, o-Hydroxybenzoic Acid, ortho Hydroxybenzoic Acid, ortho-Hydroxybenzoic Acidİ, Salicylic Acid, Hydroxybenzoic acid, 69-72-7, o- hydroxybenzoic acid, 2-Carboxyphenol, o-Carboxyphenol, Rutranex, Salonil, Retarder W, Freezone, Saligel, Ionil, Psoriacid-S-stift, salicylate, Stri-Dex, Salicylic acid soap, Benzoic acid, 2-hydroxy-, Salicylic acid co Phenol-2-carboxylic acid, Acidum salicylicum, Trans-Ver-Sal, Orthohydroxybenzoic acid, 2-Hydroxybenzenecarboxylic acid, Ac Plus, Salicylic acid, tech., Kyselina salicylova, Clearaway wart remover, Duofil wart remover, Domerine, Sebucare, Duofilm, acid, Ionil plus, Dr. Scholl's corn removers, Kyselina salicylova[Czech], SALİSİLİK ASİT, Kyselina 2-hydroxybenzoova, Occlus [Italian], Mediplast pads, Advanced pain relief corn removers, Caswell No. 731, Akurza Lotion, Hydrisalic Gel, Akurza Cream, SCream, DuoPlant Gel, Kyselina 2-hydroxybenzoova [Czech], Advanced pain relief callus removers, DHS Sal Shampoo, P&S Sidrossibenzoico [Italian], NSC 180, Salicylic acid[USAN:JAN], Salicylic acid & Sulfur Soap, Acido o-idrossibenzoico, 2-hydroxy-b6714, HSDB 672, ortho-Hydroxybenzoic Acid, Retarder SAX, AI3-02407, UNII-O414PZ4LPZ, Propa pH Peel-Off Acne Mask, EPA P Code 076602, BRN 0774890, Salicylic acid, tech, 2-hydroxy(1-14c)benzoic acidphenol derivative, 7, Salicylic acid (TN), CHEBI:1712-3, CHEMBL424, SALICYLIC ACID, ACS, O414PZ4LPZ, Salicylic acid (6CI,8CI), MLS000069653, NSC180, K 537, ATA fraction 10 YGSDEFSMJLZEOE-UHFFFAOYSA-N, choline subsalicylate, CMC_13852, NCGC00159447-05, DSSTox_CID_6368, DSSTox_RID_78106, DSSTox_GSID_26368, SALICYLIC ACID (SEE ALSO ALPHA HYDROXY ACIDS), Salicylic SALİSİLİK ASİT, Alpha/Beta Hydroxy Acids (Glycolic Acid,Salicylic Acid), E9A559BE-383B-4F83-BC02-3031D03D558A, Duras salicylicum acidum, ALPHA/BETA HYDROXY ACIDS (SALICYLIC ACID) (SEEALPHA/BETA HYDROXY ACIDS), CAS-69-72-7, 8Hydroxybenzoic Acid, NSC629474, 2 Hydroxybenzoic Acid, Acid, o-Hydroxybenzoic, Benzoic acid,hydroxy-, Acid, 2-HydrHydroxybenzoic Acid, Acid, ortho-Hydroxybenzoic, Salicylic acid [USP:JAN], salicylic, Anti-blemish, hydroxy-benzoicacid, o Fostex (Salt/Mix), Pernox (Salt/Mix), Duofilm Wart Remover, Phenol-2-carboxylate, Duofilm (Salt/Mix), Salicylic Acid,(S), Domerine (Salt/Mix), Sebucare (Salt/Mix), 2-Hydroxybenzoate, Natural Salicylic Acid, o-hydroxy benzoic acid, 2 acid, Spectrum_000948, Salicylic acid,medicinal, ACMC-1AZIK, Opera_ID_582, AC1Q1HCK, WLN: QVR BQ, Benzoic acid, o-hydr Strength Gel, 2-Hydroxybenzenecarboxylate, bmse000252, D03RXH, D07HBX, Epitope ID:124929, Retarder SAX (Salt/Mix), U 200-712-3, AC1Q72IF, SCHEMBL1967, Oprea1_040343, KBioSS_001428, KSC203I1R, ARONIS27188, BIDD:ER0602, DivK1c_000 (JP15/USP), Salicylic acid (JP17/USP), 2-HydroxybenzoicAcid, Natural, AC1L190M, GTPL430, SGCUT00012, ZINC1554, Salicylic Salicylic acid, LR, >=99%, component of Tinver (Salt/Mix), DTXSID7026368, Salicylic acid, 99% 250g, UPCMLD-DP126:0 component of Keralyt (Salt/Mix), CTK1A3418, KBio1_000301, KBio2_001428, KBio2_003996, KBio2_006564KS-00000KPH, Benzo (9CI), NSC-180, MolPort-001-769-476, NINDS_000301, HMS2233A10, SALİSİLİK ASİT, HMS3373M19, KUC106694N, Sa 99.0%, Benzoic acid, 2-hydroxy- (9CI), HY-B0167, to_000004, Tox21_113453, Tox21_201471, Tox21_303109, ANW-43703, MFCD SBB052826, STK258681, AKOS000118979, Salicylic acid, BioXtra, >=99.0%, CCG-212792, DB00936, Salicylic acid, United Sta (USP) Reference Standard, InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10, Salicylic acid, 1.0 mg/mL in acetonitrile certified reference material, Salicylic acid,Pharmaceutical Secondary Standard, Certified Reference Material, 1186130-36-8, acid, meets analytical specification of Ph. Eur., BP, USP,99.5-100.5% (calc. to the dried substance), LS-2169, J-509667, com medicated bar and cream (Salt/Mix) F2191-0216, Salicylic acid, certifiedreference material, TraceCERT(R), UNII-I3P9R8 YGSDEFSMJLZEOE-UHFFFAOYSA-N, Salicylic acid, British Pharmacopoeia (BP) Reference Standard, Salicylic acid, European Ph Reference Standard, 44642-EP2281819A1, 44642-EP2292619A1, 44642-EP2305659A1, 44642-EP2311818A1, AB00489876_15, HYDROXY SALICYLIC ACID, Salicylic acid, puriss. p.a., >=99.0% (T), 197900-EP2269975A2, 197900-EP2269997A2, 197 component of Solarcaine first aid spray (Salt/Mix), I04-0192, MCULE-8407868694, NE10196, RP20408, RTR-032850, IDI1_0003 SMP2_000145, NCGC00159447-02, NCGC00159447-04, NCGC00159447-06, NCGC00257065-01, NCGC00259022-01, 29656-58 41922, BC221968, BP-12826, KB-60386, KSC-11-207-4, Salicylic acid & Sulfur Soap (Salt/Mix), Salicylic acid, ACS reagent, >=99 plant cell culture tested, Salicylic acid, ReagentPlus(R), >=99%, SC-18305, TS-03583, Salicylic Acid 1.0 mg/ml in Acetonitrile, AB1002436, ST2416966, TR-032850, BENZOIC ACID,2-HYDROXY SALICYLIC ACID, FT-0645123, Salicylic acid, tested acco ST51046715, Salicylic acid, SAJ first grade, >=99.0%, 3253-EP2269610A2, 3253-EP2269988A2

2-Hydroxybenzoic acid (Saliyclic Acid) has antipyretic and analgesic effects, can cure rheumatism and so on.
In the pharmaceutical industry, the main drug productions of 2-Hydroxybenzoic acid (Saliyclic Acid) are sodium salicylate, wintergreen oil (methyl salicylate), aspirin (acetylsalicylic acid), salicylic acid amine, phenyl salicylate.
2-Hydroxybenzoic acid (Saliyclic Acid) is perfume material, used for the preparation of methyl salicylate, salicylic acid ethyl ester; food preservatives, its sodium Salt is mostly used, now a number of countries have been banned; methyl salicylate can be used as oral cleaning agents, such as toothpaste flavor.

2-Hydroxybenzoic acid (Saliyclic Acid)'s all esters can be used as drug and spices.
2-Hydroxybenzoic acid (Saliyclic Acid) has pleasant aromas of holly, is used for the preparation of perfume and soap flavor.
The methyl salicylate is coated on the skin, can penetrate into the muscle and let out of 2-Hydroxybenzoic acid (Saliyclic Acid) to release local pain, so it also can be used for the treatment of pain, contusion, sprain and other medication.

Isoamyl salicylate has orchid aroma, benzyl salicylate has weak ester aroma, both can prepare perfume or soap flavor.
The common name of phenyl salicylate is Salo, was hydrolyzed into phenol and 2-Hydroxybenzoic acid (Saliyclic Acid) in the intestine, is a kind of effective enteral preservatives.
Another Kind drug related to 2-Hydroxybenzoic acid (Saliyclic Acid) is para aminosalicylic acid (PAS, see "Para amino salicylic acid), Its sodium and calcium salts are used as anti TB drugs for acute exudative pulmonary tuberculosis (TB) and mucosal tuberculosis, is a weak antimicrobial drug, the effect is only 2% of streptomycin, often combined with streptomycin and isoniazid, in order to enhance the curative effect.

2-Hydroxybenzoic acid (Saliyclic Acid) can be acetylated to the aspirin.
2-Hydroxybenzoic acid (Saliyclic Acid) is regarded to be less irritating than benzoyl peroxide and has less allergy potential, but it is also less aggressive in treating acne.
2-Hydroxybenzoic acid (Saliyclic Acid) is often used for treating milder forms of acne.

The concentration in OTC drugs is limited to 2 percent.
2-Hydroxybenzoic acid (Saliyclic Acid) is also used as a performance ingredient exfoliant in smaller concentrations, without making a drug claim.
2-Hydroxybenzoic acid (Saliyclic Acid) as a medication is commonly used to remove the outer layer of the skin.

As such, 2-Hydroxybenzoic acid (Saliyclic Acid) is used to treat warts, psoriasis, acne vulgaris, ringworm, dandruff, and ichthyosis.
Similar to other hydroxy acids, 2-Hydroxybenzoic acid (Saliyclic Acid) is an ingredient in many skincare products for the treatment of seborrhoeic dermatitis, acne, psoriasis, calluses, corns, keratosis pilaris, acanthosis nigricans, ichthyosis, and warts.
2-Hydroxybenzoic acid (Saliyclic Acid) is a mono hydroxy benzoic acid, a type of phenolic acid and a beta hydroxy acid.

This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone.
2-Hydroxybenzoic acid (Saliyclic Acid) is a white powder with an acrid taste that is stable in air but gradually discolored by light.
Soluble in acetone, oil of turpentine, alcohol, ether,benzene; slightly soluble in water,and combustible.

Derived by reacting a hot solution of sodium phenolate with carbon dioxide and acidifying the sodium salt thus formed.
2-Hydroxybenzoic acid (Saliyclic Acid) is used in the manufacture of aspirin and salicylates, resins, dyestuff intermediate, prevulcanization inhibitor, analytical reagent,and fungicide.
2-Hydroxybenzoic acid (Saliyclic Acid) is a white solid first isolated from the bark of willow trees (Salix spp.), from which it gets its name.

2-Hydroxybenzoic acid (Saliyclic Acid) also occurs as the free acid or its esters in many plant species.
2-Hydroxybenzoic acid (Saliyclic Acid) is a beta hydroxy acid that also sloughs dead cell buildup within the follicle, acts as a mild antibacterial, and has soothing properties.
Based on a literature review a significant number of articles have been published on 2-Hydroxybenzoic acid (Saliyclic Acid).

2-Hydroxybenzoic acid (Saliyclic Acid), is a monohydroxybenzoic acid.
2-Hydroxybenzoic acid (Saliyclic Acid) is a type of beta hydroxy acid (BHA) and is derived from the bark of the willow tree.
2-Hydroxybenzoic acid (Saliyclic Acid) has both anti-inflammatory and exfoliating properties, making it a common ingredient in skincare products.

2-Hydroxybenzoic acid (Saliyclic Acid) has sterilization ability, 2.5% alcohol solution (called spiritus) is used as a topical medicine in the treatment of tinea manus and tinea pedis, also can be made into ointment.
2-Hydroxybenzoic acid (Saliyclic Acid) can be used for food preservative or preservatives, also can be used for the preparation of toothpaste, mouthwash.
In dye industry, 2-Hydroxybenzoic acid (Saliyclic Acid) is used for production mordant pure yellow, direct yellow 3GN, direct yellow GR, direct brown 3GN, acid mordant brown G, acid mordant yellow GG, acid yellow dye complex.

2-Hydroxybenzoic acid (Saliyclic Acid) is an organic compound with the formula HOC6H4COOH.
The name is from Latin salix for willow tree, from which it was initially identified and derived.
2-Hydroxybenzoic acid (Saliyclic Acid) is an ingredient in some anti-acne products.

2-Hydroxybenzoic acid (Saliyclic Acid) is involved in endogenous signaling, mediating plant defense against pathogens.
2-Hydroxybenzoic acid (Saliyclic Acid) plays a role in the resistance to pathogens (i.e. systemic acquired resistance) by inducing the production of pathogenesis-related proteins and other defensive metabolites.
2-Hydroxybenzoic acid (Saliyclic Acid)'s defense signaling role is most clearly demonstrated by experiments which do away with it: Delaney et al. 1994, Gaffney et al. 1993, Lawton et al. 1995, and Vernooij et al. 1994 each use Nicotiana tabacum or Arabidopsis expressing nahG, for salicylate hydroxylase.

Pathogen inoculation did not produce the customarily high 2-Hydroxybenzoic acid (Saliyclic Acid) levels, SAR was not produced, and no PR genes were expressed in systemic leaves.
Indeed, the subjects were more susceptible to virulent – and even normally avirulent – pathogens.
2-Hydroxybenzoic acid (Saliyclic Acid) is a beta-hydroxy acid with keratolytic and antiinflammatory activity.

Salts and esters of 2-Hydroxybenzoic acid (Saliyclic Acid) are known as salicylates.
2-Hydroxybenzoic acid (Saliyclic Acid) a colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid).
2-Hydroxybenzoic acid (Saliyclic Acid) is a plant hormone, and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen.

2-Hydroxybenzoic acid (Saliyclic Acid) is derived from the metabolism of salicin.
In addition to being an important active metabolite of aspirin (acetylsalicylic acid), which acts in part as a prod rug to 2-Hydroxybenzoic acid (Saliyclic Acid), it is probably best known for its use in anti-acne treatments.
The salts and esters of 2-Hydroxybenzoic acid (Saliyclic Acid) are known as salicylates.

2-Hydroxybenzoic acid (Saliyclic Acid) has the formula C6H4(OH) COOH, where the OH group is ortho to the carboxyl group.
2-Hydroxybenzoic acid (Saliyclic Acid) is also known as 2- hydroxybenzoic acid.
2-Hydroxybenzoic acid (Saliyclic Acid) is poorly soluble in water.

Aspirin (acetyl salicylic acid or ASA) can be prepared by the esterification of the phenolic hydroxyl group of 2-Hydroxybenzoic acid (Saliyclic Acid) with the acetyl group from acetic anhydride or acetyl chloride.
2-Hydroxybenzoic acid (Saliyclic Acid) helps dissolve the top layer of stratum corneum cells, improving the look and feel of the skin.
2-Hydroxybenzoic acid (Saliyclic Acid) is an effective ingredient in acne products and as such is widely used in acne soaps and lotions.

Because 2-Hydroxybenzoic acid (Saliyclic Acid) is lipid soluble, it can more easily reduce sebaceous follicle blockage by penetrating the pores and exfoliating the cellular buildup.
2-Hydroxybenzoic acid (Saliyclic Acid) is antimicrobial, anti-septic, enhances the activity of preservatives, and can be used to adjust the pH of products.
For the treatment of aging skin, it appears to help improve skin wrinkles, roughness, and tone.

2-Hydroxybenzoic acid (Saliyclic Acid) is a useful ingredient for products formulated to treat psoriasis, callouses, corns, and warts-cases where there is a buildup of dead skin cells.
When applied topically, 2-Hydroxybenzoic acid (Saliyclic Acid) is reported to penetrate 3 to 4 mm into the epidermis.
2-Hydroxybenzoic acid (Saliyclic Acid) can convert to copper salicylate, a powerful anti-inflammatory.

2-Hydroxybenzoic acid (Saliyclic Acid) is used at high concentrations, 2-Hydroxybenzoic acid (Saliyclic Acid) may cause skin redness and rashes.
This is a naturally occurring organic acid, related to aspirin.
2-Hydroxybenzoic acid (Saliyclic Acid) is found in some plants, particularly the leaves of wintergreen, willow bark, and the bark of sweet birch.

2-Hydroxybenzoic acid (Saliyclic Acid) is also synthetically manufactured.
2-Hydroxybenzoic acid (Saliyclic Acid) is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB (20 mg/mL) activation.
2-Hydroxybenzoic acid (Saliyclic Acid) inhibits prostaglandin E2 release when add together with interleukin 1β for 24 hr with an IC50 value of 5 μg/mL, an effect that is independent of NF-κB activation or COX-2 transcription or translation.

2-Hydroxybenzoic acid (Saliyclic Acid) acutely (30 min) also causes a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 μM exogenous arachidonic acid.
2-Hydroxybenzoic acid (Saliyclic Acid) is absolutely soluble in ethanol, soluble in ether and chloroform, slightly soluble in water and anhydrous ether.
2-Hydroxybenzoic acid (Saliyclic Acid) stable at room temperature, discomposes into phenol and carbon dioxide after rapidly heated.

2-Hydroxybenzoic acid (Saliyclic Acid) causes a concentration-dependent inhibition of COX-2 activity in the absence of added arachidonic acid or in the presence of 1 or 10 μM exogenous substrate with an apparent IC50 value of approximately 5 μg/mL.
However, when the same experiments are performed using 30 μM arachidonic acid, 2-Hydroxybenzoic acid (Saliyclic Acid) is an ineffective inhibitor of COX-2 activity, with an apparent IC50 value of more than 100 μg/mL, and achieves a maximal inhibition of less than 50%.

2-Hydroxybenzoic acid (Saliyclic Acid) is lipophilic monohydroxybenzoic acid.
2-Hydroxybenzoic acid (Saliyclic Acid) a type of phenolic acid and a beta-hydroxy acid (BHA).
Beta hydroxy acid is found as a natural compound in plants.

This colourless crystalline organic acid is broadly in use in organic synthesis.
2-Hydroxybenzoic acid (Saliyclic Acid) is derived from the metabolism of salicin.
2-Hydroxybenzoic acid (Saliyclic Acid) is an ingredient in some anti-acne products.

Salts and esters of 2-Hydroxybenzoic acid (Saliyclic Acid) are known as salicylates.
2-Hydroxybenzoic acid (Saliyclic Acid) is an organic compound with the formula HOC6H4CO2H.
A colorless, bitter-tasting solid, 2-Hydroxybenzoic acid (Saliyclic Acid) is a precursor to and a metabolite of aspirin (acetylsalicylic acid).

2-Hydroxybenzoic acid (Saliyclic Acid) is a plant hormone and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen.
The name is from Latin salix for willow tree.
2-Hydroxybenzoic acid (Saliyclic Acid) is an ingredient in some anti-acne products.

Salts and esters of 2-Hydroxybenzoic acid (Saliyclic Acid) are known as salicylates.
2-Hydroxybenzoic acid (Saliyclic Acid) is a white, crystalline powder with the chemical formula C7H6O3.
2-Hydroxybenzoic acid (Saliyclic Acid) is chemical structure consists of a benzene ring with a hydroxyl group (-OH) and a carboxyl group (-COOH) attached.

This structure is responsible for its exfoliating and anti-inflammatory properties.
2-Hydroxybenzoic acid (Saliyclic Acid) works by softening and breaking down keratin, a protein that forms part of the skin structure.
This keratolytic action helps to unclog pores and prevent the formation of comedones (blackheads and whiteheads).

2-Hydroxybenzoic acid (Saliyclic Acid) also has anti-inflammatory effects, which can reduce the redness and swelling associated with acne.
2-Hydroxybenzoic acid (Saliyclic Acid) is commonly found in over-the-counter skincare products at concentrations ranging from 0.5% to 2%.
Higher concentrations may be used in professional treatments, but it's important to follow product instructions to avoid overuse and potential irritation.

When incorporating 2-Hydroxybenzoic acid (Saliyclic Acid) into a skincare routine, it's recommended to start with a lower concentration and gradually increase if needed.
2-Hydroxybenzoic acid (Saliyclic Acid) is often used in leave-on products like toners, serums, and spot treatments.
Sunscreen should be applied during the day when using products containing 2-Hydroxybenzoic acid (Saliyclic Acid), as it can increase sensitivity to sunlight.

2-Hydroxybenzoic acid (Saliyclic Acid) is sometimes combined with other active ingredients, such as benzoyl peroxide or alpha hydroxy acids (AHAs), to enhance its effectiveness in treating acne and improving skin texture.
2-Hydroxybenzoic acid (Saliyclic Acid) is a crystalline organic carboxylic acid and has keratolytic, bacteriostatic and fungicidal properties.
2-Hydroxybenzoic acid (Saliyclic Acid) is poisonous to our body when consumed in large.

2-Hydroxybenzoic acid (Saliyclic Acid) can be in use as an antiseptic and as a food preservative when consumed in small quantities.
2-Hydroxybenzoic acid (Saliyclic Acid) has a carboxyl group attached to it i.e., COOH.

2-Hydroxybenzoic acid (Saliyclic Acid) is odourless and is colourless.
2-Hydroxybenzoic acid (Saliyclic Acid) is an organic compound with the formula HOC6H4COOH.
2-Hydroxybenzoic acid (Saliyclic Acid) is a precursor to acetylsalicylic acid, commonly known as aspirin, which is used for its analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties.

Individuals with known allergies to aspirin (acetylsalicylic acid) should exercise caution when using products containing 2-Hydroxybenzoic acid (Saliyclic Acid).
Allergic reactions can include redness, itching, or swelling.
If such reactions occur, discontinuing use and seeking medical advice is recommended.

2-Hydroxybenzoic acid (Saliyclic Acid) is an important organic synthetic raw material, widely used in medicine, pesticides, dyes, rubber, food, and perfumes.
In the pharmaceutical industry, the main drug productions of 2-Hydroxybenzoic acid (Saliyclic Acid) are sodium salicylate, wintergreen oil (methyl salicylate), aspirin (acetylsalicylic acid), and 2-Hydroxybenzoic acid (Saliyclic Acid) amine, phenyl salicylate.
In the dye industry, 2-Hydroxybenzoic acid (Saliyclic Acid) is used to producepure morda yellow , direct yellow 3GN, direct yellow GR, direct brown 3GN, acid mordant brown G, acid mordant yellow GG, acid yellow dye complex.

In pesticide production, 2-Hydroxybenzoic acid (Saliyclic Acid) is used for the synthesis of organic phosphorus pesticide Isocarbophos, intermediate isopropyl salicylate isofenphos methyl and Rodenticide warfarin, coumatetralyl intermediate 4-hydroxycoumarin.
In rubber industry, 2-Hydroxybenzoic acid (Saliyclic Acid) is used as anti scorching agent and production of ultraviolet absorbent and foaming agent.
2-Hydroxybenzoic acid (Saliyclic Acid) is perfume material, used for the preparation of methyl salicylate, 2-Hydroxybenzoic acid (Saliyclic Acid) ethyl ester; food preservatives, its sodium

Salt is mostly used, now a number of countries have been banned; methyl salicylate can be used as oral cleaning agents, such as toothpaste flavor.
2-Hydroxybenzoic acid (Saliyclic Acid) has sterilization ability, 2.5% alcohol solution (called spiritus) is used as a topical medicine in the treatment of tinea manus and tinea pedis, also can be made into ointment.
2-Hydroxybenzoic acid (Saliyclic Acid) can be used for food preservative or preservatives, also can be used for the preparation of toothpaste, mouthwash.

2-Hydroxybenzoic acid (Saliyclic Acid) has antipyretic and analgesic effects, can cure rheumatism and so on.
2-Hydroxybenzoic acid (Saliyclic Acid)'s all esters can be used as drug and spices.
2-Hydroxybenzoic acid (Saliyclic Acid) has pleasant aromas of holly, is used for the preparation of perfume and soap flavor.

The methyl salicylate is coated on the skin, can penetrate into the muscle and let out of 2-Hydroxybenzoic acid (Saliyclic Acid) to release local pain, so it also can be used for the treatment of pain, contusion, sprain and other medication.
Isoamyl salicylate has orchid aroma, 2-Hydroxybenzoic acid (Saliyclic Acid) has weak ester aroma, both can prepare perfume or soap flavor.
The common name of phenyl salicylate is Salo, was hydrolyzed into phenol and 2-Hydroxybenzoic acid (Saliyclic Acid) in the intestine , is a kind of effective enteral preservatives.

Another Kind drug related to 2-Hydroxybenzoic acid (Saliyclic Acid) is para amino2-Hydroxybenzoic acid (salicylic acid) (PAS, see "Para amino salicylic acid), Its sodium and calcium salts are used as anti TB drugs for acute exudative pulmonary tuberculosis (TB) and mucosal tuberculosis, is a weak antimicrobial drug, the effect is only 2% of streptomycin, often combined with streptomycin and isoniazid , in order to enhance the curative effect.
2-Hydroxybenzoic acid (Saliyclic Acid) is a precursor to and a metabolite of aspirin (acetylsalicylic acid).
2-Hydroxybenzoic acid (Saliyclic Acid) is a plant hormone, and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen.

2-Hydroxybenzoic acid (Saliyclic Acid) is biosynthesized from the amino acid phenylalanine.
In Arabidopsis thaliana, 2-Hydroxybenzoic acid (Saliyclic Acid) can be synthesized via a phenylalanine-independent pathway.
2-Hydroxybenzoic acid (Saliyclic Acid) can be acetylated to the aspirin

2-Hydroxybenzoic acid (Saliyclic Acid) is a natural product extract from Willow bark, well known as an antiinflammatory and antinociceptive agent and a close structural relative to acetylsalicylic acid (aspirin).
2-Hydroxybenzoic acid (Saliyclic Acid) is a ubiquitous plant hormone with many regulatory functions involved in local disease resistance mechanisms and systemic acquired resistance.
2-Hydroxybenzoic acid (Saliyclic Acid) is a phenolic phytohormone, and is found in plants with roles in plant growth and development, photosynthesis, transpiration, and ion uptake and transport.

The antiinflammatory and antinociceptive effects produced by 2-Hydroxybenzoic acid (Saliyclic Acid) and its derivatives in animals are due to inhibition of COX-1 and COX-2 (cyclooxygenase) enzyme activity and suppression of prostaglandin biosynthesis.
2-Hydroxybenzoic acid (Saliyclic Acid) is also of interest as a starting material for the organic synthesis of more elaborate COX suppressors and other chemical structures.
This helps prevent clogged pores and reduces the formation of acne lesions.

2-Hydroxybenzoic acid (Saliyclic Acid) has anti-inflammatory properties, which can help reduce redness and irritation associated with various skin conditions, including acne.
As a keratolytic agent, 2-Hydroxybenzoic acid (Saliyclic Acid) helps to soften and loosen the outer layer of the skin.
This makes it easier to remove dead skin cells and encourages the growth of new, healthier skin.
2-Hydroxybenzoic acid (Saliyclic Acid) is also used in some over-the-counter products designed for the removal of common warts and plantar warts.

The acid works by breaking down the protein in the skin cells of the wart.
2-Hydroxybenzoic acid (Saliyclic Acid) is often used in skincare products, such as cleansers, toners, and spot treatments, due to its ability to exfoliate the skin.
2-Hydroxybenzoic acid (Saliyclic Acid) penetrates into the pores and helps to remove dead skin cells, excess oil, and debris, making it effective for treating acne and improving overall skin texture.

2-Hydroxybenzoic acid (Saliyclic Acid) is particularly beneficial for those with acne-prone skin.
2-Hydroxybenzoic acid (Saliyclic Acid) works by dissolving the substance that causes skin cells to stick together, promoting the shedding of dead skin cells.

Melting point: 158-161 °C(lit.)
Boiling point: 211 °C(lit.)
Density: 1.44
vapor density: 4.8 (vs air)
vapor pressure: 1 mm Hg ( 114 °C)
refractive index: 1,565
FEMA: 3985 | 2-HYDROXYBENZOIC ACID
Flash point: 157 °C
storage temp.: 2-8°C
solubility: ethanol: 1 M at 20 °C, clear, colorless
pka: 2.98(at 25℃)
form: Solid
color: White to off-white
PH Range: Non0 uorescence (2.5) to dark blue 0 uorescence (4.0)
Odor: at 100.00 %. faint phenolic nutty
PH: 3.21(1 mM solution);2.57(10 mM solution);2.02(100 mM solution);
Odor Type: nutty
Water Solubility: 1.8 g/L (20 ºC)
Sensitive: Light Sensitive
λmax: 210nm, 234nm, 303nm
Merck: 14,8332
JECFA Number: 958
Sublimation: 70 ºC
LogP: 2.01

2-Hydroxybenzoic acid (Saliyclic Acid) is on the World Health Organization’s List of Essential Medicines.
In Arabidopsis thaliana 2-Hydroxybenzoic acid (Saliyclic Acid) can also be synthesized via a phenylalanine - independent pathway.
Sodium salicylate is commercially prepared by treating sodium phenolate (the sodium salt of phenol) with carbon dioxide at high pressure (100 atm) and high temperature (390K) -a method known as the Kolbe-Schmitt reaction.

Acidification of the product with sulfuric acid gives 2-Hydroxybenzoic acid (Saliyclic Acid).
2-Hydroxybenzoic acid (Saliyclic Acid) can also be prepared by the hydrolysis of aspirin (acetylsalicylic acid) or methyl salicylate (oil of winter green) with a strong acid or base.
2-Hydroxybenzoic acid (Saliyclic Acid) is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them.

They react in this way with all bases, both organic (for example, the amines) and inorganic.
Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.

Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.
Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of 2-Hydroxybenzoic acid (Saliyclic Acid)s is therefore less than 7.0.

Many insoluble 2-Hydroxybenzoic acid (Saliyclic Acid)s react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.
Carboxylic acids in aqueous solution and liquid or molten 2-Hydroxybenzoic acid (Saliyclic Acid) can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid 2-Hydroxybenzoic acid (Saliyclic Acid) as well, but are slow if the solid acid remains dry.

2-Hydroxybenzoic acid (Saliyclic Acid), like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.

Flammable and/or toxic gases and heat are generated by the reaction of 2-Hydroxybenzoic acid (Saliyclic Acid) with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.
2-Hydroxybenzoic acid (Saliyclic Acid), especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.
Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.

Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.
Like other acids, 2-Hydroxybenzoic acid (Saliyclic Acid) may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

2-Hydroxybenzoic acid (Saliyclic Acid) has been shown to work through several different pathways.
2-Hydroxybenzoic acid (Saliyclic Acid) produces its anti - inflammatory effects via suppressing the activity of cyclo oxygenase (COX), an enzyme which is responsible for the production of pro - inflammatory mediators such as the prostaglandins.
The middle dose of aspirin (0.5–3? g/day) has antipyretic analgesic effects, so it is commonly used in the treatment of fever, headache, toothache, neuralgia, muscle pain and menstrual pain.

High doses of aspirin (more than 4g/day) have anti-inflammatory and antirheumatic effects for the treatment of acute rheumatic fever and rheumatoid arthritis.
In addition, aspirin is used for the treatment of skin and mucous membrane lymphadenopathy (Kawasaki disease) in paediatric.
Often combined with sulfur, 2-Hydroxybenzoic acid (Saliyclic Acid) shampoos are often employed to treat patients with seborrheic disorders (seborrhea sicca and oleosa) exhibiting mild to moderate scaling, with mild waxy and keratinous debris.

In higher concentrations, topicals such as Kerasolv Gel (6.6% 2-Hydroxybenzoic acid (Saliyclic Acid)) can be used to remove localized excessive tissues associated with hyperkeratotic disorders, such as calluses and idiopathic thickening of the planum nasale and footpads.
2-Hydroxybenzoic acid (Saliyclic Acid) has mildly antipruritic, antibacterial (bacteriostatic), keratoplastic and keratolytic actions.
Lower concentrations are primarily keratoplastic and higher concentrations, keratolytic.

2-Hydroxybenzoic acid (Saliyclic Acid) lowers skin pH, increases corneocyte hydration and dissolves the intercellular binder between corneocytes.
2-Hydroxybenzoic acid (Saliyclic Acid) and sulfur are thought to be synergistic in their keratolytic actions.
2-Hydroxybenzoic acid (Saliyclic Acid) is a phenolic phytohormone and is found in plants with roles in plant growth and development, photosynthesis, transpiration, ion uptake and transport.

2-Hydroxybenzoic acid (Saliyclic Acid) also induces specific changes in leaf anatomy and chloroplast structure.
2-Hydroxybenzoic acid (Saliyclic Acid) is involved in endogenous signaling, mediating in plant defense against pathogens.
2-Hydroxybenzoic acid (Saliyclic Acid) plays a role in the resistance to pathogens by inducing the production of pathogenesis-related proteins.

2-Hydroxybenzoic acid (Saliyclic Acid) is involved in the systemic acquired resistance (SAR) in which a pathogenic attack on one part of the plant induces resistance in other parts.
The signal can also move to nearby plants by 2-Hydroxybenzoic acid (Saliyclic Acid) being converted to the volatile ester, methyl salicylate.
2-Hydroxybenzoic acid (Saliyclic Acid) modulates COX-1 enzymatic activity to decrease the formation of pro-inflammatory prostaglandins.

2-Hydroxybenzoic acid (Saliyclic Acid) may competitively inhibit prostaglandin formation.
2-Hydroxybenzoic acid (Saliyclic Acid)'s antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms.
2-Hydroxybenzoic acid (Saliyclic Acid) does this not by direct inhibition of COX, unlike most other non-steroidal anti-inflammatory drugs (NSAIDs), but instead by suppression of the expression of the enzyme (via a yet-un elucidated mechanism).

2-Hydroxybenzoic acid (Saliyclic Acid) has also been shown to activate adenosine monophosphate-activated protein kinase (AMPK), and it is thought that this action may play a role in the anticancer effects of the compound and its prod rugs aspirin and salsalate.
In addition, the anti diabetic effects of 2-Hydroxybenzoic acid (Saliyclic Acid) are likely mediated by AMPK activation primarily through allosteric conformational change that increases levels of phosphorylation.

2-Hydroxybenzoic acid (Saliyclic Acid) also uncouples oxidative phosphorylation which leads to increased ADP:ATP and AMP:ATP ratios in the cell.
Consequently, 2-Hydroxybenzoic acid (Saliyclic Acid) may alter AMPK activity and subsequently exert its anti-diabetic properties through altered energy status of the cell.
The clinical application of aspirin varies with the therapeutic dose.

Low-dose aspirin (75–300?mg/day) has antiplatelet aggregation effect and can be used to prevent and treat the coronary and cerebrovascular thrombosis and other postoperative thrombosis.
Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 2-Hydroxybenzoic acid (Saliyclic Acid) to corrode or dissolve iron, steel, and aluminum parts and containers.
2-Hydroxybenzoic acid (Saliyclic Acid) is the safest and most effective medicines needed in a health system.

2-Hydroxybenzoic acid (Saliyclic Acid) is biosynthesized from the amino acid phenylalanine.
2-Hydroxybenzoic acid (Saliyclic Acid), when applied to the skin surface, works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth.
2-Hydroxybenzoic acid (Saliyclic Acid) inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with NADH and noncompetitively with UDPG.

2-Hydroxybenzoic acid (Saliyclic Acid) also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid to the phenolic acceptor.
The wound-healing retardation action of 2-Hydroxybenzoic acid (Saliyclic Acid) is probably due mainly to its inhibitory action on mucopolysaccharide synthesis.
2-Hydroxybenzoic acid (Saliyclic Acid) occurs in plants as free 2-Hydroxybenzoic acid (Saliyclic Acid) and its carboxylated esters and phenolic glycosides.

Several studies suggest that humans metabolize 2-Hydroxybenzoic acid (Saliyclic Acid) in measurable quantities from these plants.
High-2-Hydroxybenzoic acid (Saliyclic Acid) beverages and foods include beer, coffee, tea, numerous fruits and vegetables, sweet potato, nuts, and olive oil.
Meat, poultry, fish, eggs, dairy products, sugar, breads and cereals have low salicylate content.

Some people with sensitivity to dietary 2-Hydroxybenzoic acid (Saliyclic Acid) may have symptoms of allergic reaction, such as bronchial asthma, rhinitis, gastrointestinal disorders, or diarrhea, so may need to adopt a low-salicylate diet.
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically.
2-Hydroxybenzoic acid (Saliyclic Acid) has bacteriostatic, fungicidal, and keratolytic actions.

2-Hydroxybenzoic acid (Saliyclic Acid) is salts, the salicylates, are used as analgesics.
2-Hydroxybenzoic acid (Saliyclic Acid) is used in the production of other pharmaceuticals, including 4-aminosalicylic acid, sandulpiride, and landetimide (via salethamide).
2-Hydroxybenzoic acid (Saliyclic Acid) has long been a key starting material for making acetyl2-Hydroxybenzoic acid (salicylic acid) (aspirin).

2-Hydroxybenzoic acid (Saliyclic Acid) is prepared by the esterification of the phenolic hydroxyl group of 2-Hydroxybenzoic acid (Saliyclic Acid) with the acetyl group from acetic anhydride or acetyl chloride.
2-Hydroxybenzoic acid (Saliyclic Acid) may be obtained (1) from oil of wintergreen, which contains methyl salicylate, or by heating dry sodium phenate C6H5ONa plus carbon dioxide under pressure at 130 °C (266°F) and recovering from the resulting sodium salicylate by adding dilute sulfuric acid.
2-Hydroxybenzoic acid (Saliyclic Acid) is a β-hydroxy acid that penetrates into the sebaceous gland and has comedolytic and anti-inflammatory properties.

2-Hydroxybenzoic acid (Saliyclic Acid) can be used as an adjunctive therapy and is found in cleansers, toners, masks, and peels.
2-Hydroxybenzoic acid (Saliyclic Acid) is keratolytic and at concentrations between 3% and 6% causes softening of the horny layers and shedding of scales.
2-Hydroxybenzoic acid (Saliyclic Acid) produces this desquamation by solubilizing the intercellular cement and enhances the shedding of corneocytes by decreasing cell-to-cell cohesion.

In concentrations >6%, 2-Hydroxybenzoic acid (Saliyclic Acid) can be destructive to tissue.
Application of large amounts of the higher concentration of 2-Hydroxybenzoic acid (Saliyclic Acid) can also result in systemic toxicity.
2-Hydroxybenzoic acid (Saliyclic Acid) is used in the treatment of superficial fungal infections, acne, psoriasis, seborrheic dermatitis, warts, and other scaling dermatoses.

When it 2-Hydroxybenzoic acid (Saliyclic Acid) combined with sulfur, some believe that a synergistic keratolytic effect is produced.
Common preparations include a 3% and 6% ointment with equal concentration of sulfur; 6% propylene glycol solution (Keralyt); 5% to 20% with equal parts of lactic acid in flexible collodion for warts (Duofilm, Occlusal); in a cream base at any concentration for keratolytic effects; as a 60% ointment for plantar warts; and in a 40% plaster on velvet cloth for the treatment of calluses and warts (40% 2-Hydroxybenzoic acid (Saliyclic Acid) plaster).

A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position.
2-Hydroxybenzoic acid (Saliyclic Acid) is obtained from the bark of the white willow and wintergreen leaves.

2-Hydroxybenzoic acid (Saliyclic Acid) is probably known for its use as an important ingredient in topical anti-acne products.
The salts and esters of 2-Hydroxybenzoic acid (Saliyclic Acid) are salicylates

Methods of production Of 2-Hydroxybenzoic acid (Saliyclic Acid):
The phenol and sodium hydroxide react to produce phenol sodium, distillation and dehydration, CO2 carboxylation reaction to obtain sodium salicylate, then using sulfuric acid and produce crude product.
The crude product through the sublimation refined to the finished product.

Raw materials consumption quota: phenol (98%) 704kg/t, alkali burn (95%) 417kg/t, sulfate (95%) 500kg/t, carbon dioxide (99%) 467kg/t.
The preparation method of the method is that the sodium salt of phenol and carbon dioxide can be obtained by acidification.
phenol and liquid caustic soda are produced into solution of the sodium salt of phenol, vacuum drying, and then to 100℃, slowly put to the dry carbon dioxide, when the pressure reaches 0.7~0.8MPa, stop passing carbon dioxide, warming up to 140 to 180℃.

After the reaction with water, sodium salicylate dissolved and decolorization, filtering, coupled with the sulfuric acid, namely precipitation 2-Hydroxybenzoic acid (Saliyclic Acid), after filtering, washing and drying to obtain the product.

History Of 2-Hydroxybenzoic acid (Saliyclic Acid):
Willow has long been used for medicinal purposes.
Dioscorides, whose writings were highly influential for more than 1,500 years, used 'Itea' (which was possibly a species of willow) as a treatment for 'painful intestinal obstructions,' birth control, for 'those who spit blood,' to remove calluses and corns and, externally, as a 'warm pack for gout.'

William Turner, in 1597, repeated this, saying that willow bark, 'being burnt to ashes, and steeped in vinegar, takes away corns and other like risings in the feet and toes.
Some of these cures may describe the action of 2-Hydroxybenzoic acid (Saliyclic Acid), which can be derived from the salicin present in willow.

2-Hydroxybenzoic acid (Saliyclic Acid) is, however, a modern myth that Hippocrates used willow as a painkiller.
Hippocrates, Galen, Pliny the Elder, and others knew that decoctions containing salicylate could ease pain and reduce fevers.
2-Hydroxybenzoic acid (Saliyclic Acid) was used in Europe and China to treat these conditions.

This remedy is mentioned in texts from Ancient Egypt, Sumer, and Assyria.
The Cherokee and other Native Americans use an infusion of the bark for fever and other medicinal purposes.
In 2014, archaeologists identified traces of 2-Hydroxybenzoic acid (Saliyclic Acid) on seventh-century pottery fragments found in east-central Colorado.

The Reverend Edward Stone, a vicar from Chipping Norton, Oxfordshire, England, reported in 1763 that the bark of the willow was effective in reducing a fever.
An extract of willow bark, called 2-Hydroxybenzoic acid (Saliyclic Acid), after the Latin name for the white willow (Salix alba), was isolated and named by German chemist Johann Andreas Buchner in 1828.
A larger amount of the substance was isolated in 1829 by Henri Leroux, a French pharmacist.

Raffaele Piria, an Italian chemist, was able to convert the substance into a sugar and a second component, which on oxidation becomes 2-Hydroxybenzoic acid (Saliyclic Acid).
2-Hydroxybenzoic acid (Saliyclic Acid) was also isolated from the herb meadowsweet (Filipendula ulmaria, formerly classified as Spiraea ulmaria) by German researchers in 1839.
Their extract caused digestive problems such as gastric irritation, bleeding, diarrhea, and even death when consumed in high doses.

In 1874 the Scottish physician Thomas MacLagan experimented with 2-Hydroxybenzoic acid (Saliyclic Acid) as a treatment for acute rheumatism, with considerable success, as he reported in The Lancet in 1876.
Meanwhile, German scientists tried sodium salicylate with less success and more severe side effects.

In 1979, salicylates were found to be involved in induced defenses of tobacco against tobacco mosaic virus.
In 1987, salicylic acid was identified as the long-sought signal that causes thermogenic plants, such as the voodoo lily, Sauromatum guttatum, to produce heat.

Uses Of 2-Hydroxybenzoic acid (Saliyclic Acid):
2-Hydroxybenzoic acid (Saliyclic Acid) is widely used, eczema, psoriasis, salicylic acid can be used in acne, dandruff.
The concentration of 3%~6% can be used to horny, higher than 6% of salicylic acid can damage to tissue.
2-Hydroxybenzoic acid (Saliyclic Acid) can also be added in the treatment of acne and dandruff.

Nowadays many famous cosmetic ingredients: in 1993, Clinique CLINIQUE first launched 1% 2-Hydroxybenzoic acid (Saliyclic Acid) in soft water cream, immediately became one of Clinique's most successful products; In 1998, SK-II crystal induced skin cream added 1.5%BHA ingredients to the original, and salicylic acid has effect of treatment pores and cutin like the egg peeling analogy that caused the market boom; open access Olay popular products activating cream also contains 1.5% BHA components.
However, due to the high concentration of 2-Hydroxybenzoic acid (Saliyclic Acid), it has a certain degree of damage, cosmetics containing salicylic acid concentration has generally been limited between 0.2%~1.5%, containing s2-Hydroxybenzoic acid (Saliyclic Acid) cosmetics shall be added to the note of warning signs to determine the safety of long-term use and children under 3 years of age also shall not be used.

2-Hydroxybenzoic acid (Saliyclic Acid) is a beta-hydroxy acid with keratolytic and antiinflammatory activity.
2-Hydroxybenzoic acid (Saliyclic Acid) helps dissolve the top layer of stratum corneum cells, improving the look and feel of the skin.
2-Hydroxybenzoic acid (Saliyclic Acid) is an effective ingredient in acne products and as such is widely used in acne soaps and lotions.

For the treatment of aging skin, 2-Hydroxybenzoic acid (Saliyclic Acid) appears to help improve skin wrinkles, roughness, and tone.
In addition, 2-Hydroxybenzoic acid (Saliyclic Acid) is a useful ingredient for products formulated to treat psoriasis, callouses, corns, and warts-cases where there is a buildup of dead skin cells.
When applied topically, 2-Hydroxybenzoic acid (Saliyclic Acid) is reported to penetrate 3 to 4 mm into the epidermis.

A small amount of 2-Hydroxybenzoic acid (Saliyclic Acid) can convert to copper salicylate, a powerful anti-inflammatory.
It is used at high concentrations, 2-Hydroxybenzoic acid (Saliyclic Acid) may cause skin redness and rashes.
This is a naturally occurring organic acid, related to aspirin.

2-Hydroxybenzoic acid (Saliyclic Acid) is found in some plants, particularly the leaves of wintergreen, willow bark, and the bark of sweet birch.
Below 40% of concentration is suitable for the treatment of thick cocoon, corns and warts.
2-Hydroxybenzoic acid (Saliyclic Acid) is an FDA approved skin care ingredient used for the topical treatment of acne, and it's the only beta hydroxy acid (BHA) used in skin care products.

Perfect for oily skin, 2-Hydroxybenzoic acid (Saliyclic Acid) is best known for its ability to deep clean excess oil out of pores and reduce oil production moving forward. Because salicylic acid keeps pores clean and unclogged, it prevents future whiteheads and blackheads from developing.

2-Hydroxybenzoic acid (Saliyclic Acid) also exfoliates dead skin, and its anti-inflammatory properties make it a prime ingredient for those with psoriasis.
2-Hydroxybenzoic acid (Saliyclic Acid) naturally occurs in willow bark, sweet birch bark, and wintergreen leaves, but synthetic versions are also used in skin care products.
Although toxic in large quantities, 2-Hydroxybenzoic acid (Saliyclic Acid) is used as a food preservative and as bactericidal and an antiseptic.

For some people with 2-Hydroxybenzoic acid (Saliyclic Acid) sensitivity even these small doses can be harmful.
2-Hydroxybenzoic acid (Saliyclic Acid) is a useful phosphor in the vacuum ultraviolet with nearly flat quantum efficiency for wavelengths between 10 to 100 nm.
2-Hydroxybenzoic acid (Saliyclic Acid) is also synthetically manufactured.

2-Hydroxybenzoic acid (Saliyclic Acid) can be beneficial in addressing post-inflammatory hyperpigmentation (dark spots) left behind by acne lesions.
2-Hydroxybenzoic acid (Saliyclic Acid) is exfoliating properties help in promoting skin renewal and fading discoloration over time.
2-Hydroxybenzoic acid (Saliyclic Acid) is effective in managing excess oil production on the skin.

By unclogging pores and reducing sebum, 2-Hydroxybenzoic acid (Saliyclic Acid) can contribute to a more balanced complexion.
Regular use of 2-Hydroxybenzoic acid (Saliyclic Acid) can be a preventive measure against acne breakouts.
2-Hydroxybenzoic acid (Saliyclic Acid) helps maintain clear pores and prevents the accumulation of dead skin cells that can lead to blemishes.

2-Hydroxybenzoic acid (Saliyclic Acid) is often used in combination with other active ingredients, such as benzoyl peroxide or retinoids, for a more comprehensive approach to acne treatment.
2-Hydroxybenzoic acid (Saliyclic Acid)'s exfoliating properties make it useful in preventing and treating ingrown hairs.
2-Hydroxybenzoic acid (Saliyclic Acid) helps to keep hair follicles clear and reduce inflammation.

2-Hydroxybenzoic acid (Saliyclic Acid) may be included in formulations to address certain skin conditions, such as seborrheic dermatitis or psoriasis.
2-Hydroxybenzoic acid (Saliyclic Acid) can help manage scaling and flaking associated with these conditions.
In higher concentrations, 2-Hydroxybenzoic acid (Saliyclic Acid) is used in professional chemical peels.

These peels are performed by dermatologists or skincare professionals to exfoliate the skin, reduce fine lines, and improve skin texture.
2-Hydroxybenzoic acid (Saliyclic Acid) is a common ingredient in various cosmetic formulations, including cleansers, toners, serums, and spot treatments.
2-Hydroxybenzoic acid (Saliyclic Acid) is versatility makes it suitable for a range of skincare products.

When using products containing 2-Hydroxybenzoic acid (Saliyclic Acid), it's crucial to use sunscreen during the day.
2-Hydroxybenzoic acid (Saliyclic Acid) can increase sensitivity to sunlight, and regular sun protection helps prevent further skin damage.
Many over-the-counter products, such as face washes, pads, and spot treatments, contain 2-Hydroxybenzoic acid (Saliyclic Acid).

These products are readily available for consumers to use in their daily skincare routines.
2-Hydroxybenzoic acid (Saliyclic Acid) is known for its ability to ease aches and pains and reduce fevers.
These medicinal properties, particularly fever relief, have been known since ancient times, and it is used as an antiinflammatory drug.

2-Hydroxybenzoic acid (Saliyclic Acid) is used as a food preservative, a bactericide, and an antiseptic.
2-Hydroxybenzoic acid (Saliyclic Acid) is used in the production of other pharmaceuticals, including 4-aminosalicylic acid, sandulpiride, and landetimide (via salethamide).
2-Hydroxybenzoic acid (Saliyclic Acid) has long been a key starting material for making acetylsalicylic acid (aspirin).

2-Hydroxybenzoic acid (Saliyclic Acid) is prepared by the esterification of the phenolic hydroxyl group of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride.
2-Hydroxybenzoic acid (Saliyclic Acid) is the standard to which all the other non-steroidal anti-inflammatory drugs (NSAIDs) are compared.
In veterinary medicine, this group of drugs is mainly used for treatment of inflammatory musculoskeletal disorders.

Bismuth subsalicylate, a salt of bismuth and 2-Hydroxybenzoic acid (Saliyclic Acid), "displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic".
2-Hydroxybenzoic acid (Saliyclic Acid) is the active ingredient in stomach-relief aids such as Pepto-Bismol and some formulations of Kaopectate.
Other derivatives include methyl 2-Hydroxybenzoic acid (Saliyclic Acid) used as a liniment to soothe joint and muscle pain and choline salicylate used topically to relieve the pain of mouth ulcers.

2-Hydroxybenzoic acid (Saliyclic Acid) is used to induce remission in ulcerative colitis, and has been used as an antitubercular agent often administered in association with isoniazid.
2-Hydroxybenzoic acid (Saliyclic Acid) is a useful phosphor in the vacuum ultraviolet spectral range, with nearly flat quantum efficiency for wavelengths between 10 and 100 nm.
2-Hydroxybenzoic acid (Saliyclic Acid) fluoresces in the blue at 420 nm.

2-Hydroxybenzoic acid (Saliyclic Acid) is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation
Other derivatives include 2-Hydroxybenzoic acid (Saliyclic Acid) used as a liniment to soothe joint and muscle pain and choline salicylate used topically to relieve the pain of mouth ulcers.
2-Hydroxybenzoic acid (Saliyclic Acid) is used to induce remission in ulcerative colitis and has been used as an antitubercular agent often administered in association with isoniazid.

2-Hydroxybenzoic acid (Saliyclic Acid) has mild anti-inflammatory effects, and this property is utilized in skincare for reducing redness and irritation.
Dermatologists may prescribe higher concentrations of 2-Hydroxybenzoic acid (Saliyclic Acid) for specific skin conditions, such as more severe acne or certain types of dermatitis.
Some shampoos and scalp treatments contain salicylic acid to help exfoliate the scalp, remove dead skin cells, and address conditions like dandruff.

2-Hydroxybenzoic acid (Saliyclic Acid) is used in over-the-counter treatments for the removal of corns and calluses.
2-Hydroxybenzoic acid (Saliyclic Acid) helps break down the thickened skin.

2-Hydroxybenzoic acid (Saliyclic Acid) is included in some foot creams and treatments to soften calluses and rough skin on the feet.
2-Hydroxybenzoic acid (Saliyclic Acid) is a useful phosphor in the vacuum ultraviolet spectral range, with nearly flat quantum efficiency for wavelengths between 10 and 100 nm.
2-Hydroxybenzoic acid (Saliyclic Acid) fluoresces in the blue at 420 nm.

2-Hydroxybenzoic acid (Saliyclic Acid) is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation.
2-Hydroxybenzoic acid (Saliyclic Acid) is widely used to treat acne.

2-Hydroxybenzoic acid (Saliyclic Acid) penetrates the pores and helps to exfoliate dead skin cells, unclog pores, and reduce inflammation.
2-Hydroxybenzoic acid (Saliyclic Acid) is effective for both non-inflammatory acne (blackheads and whiteheads) and inflammatory acne (pimples and cysts).
2-Hydroxybenzoic acid (Saliyclic Acid)'s exfoliating properties make it useful for improving skin texture, promoting cell turnover, and addressing issues like rough or uneven skin.

2-Hydroxybenzoic acid (Saliyclic Acid) is used in some over-the-counter products designed for the removal of common warts and plantar warts.
2-Hydroxybenzoic acid (Saliyclic Acid) works by breaking down the structure of the wart.
2-Hydroxybenzoic acid (Saliyclic Acid) is a precursor to acetylsalicylic acid, commonly known as aspirin.

2-Hydroxybenzoic acid (Saliyclic Acid) is used for its analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties.
In modern medicine, 2-Hydroxybenzoic acid (Saliyclic Acid) and its derivatives are used as constituents of some rubefacient products.
For example, 2-Hydroxybenzoic acid (Saliyclic Acid) is used as a liniment to soothe joint and muscle pain, and choline salicylate is used topically to relieve the pain of mouth ulcers.

2-Hydroxybenzoic acid (Saliyclic Acid) fluoresces in the blue at 420 nm.
2-Hydroxybenzoic acid (Saliyclic Acid) is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation.

Safety Profile Of 2-Hydroxybenzoic acid (Saliyclic Acid):
2-Hydroxybenzoic acid (Saliyclic Acid)'s advisable to perform a patch test before widespread use, especially for those with sensitive skin.
Overusing products containing 2-Hydroxybenzoic acid (Saliyclic Acid) or using higher concentrations than recommended can lead to excessive dryness and peeling.

Following product instructions and incorporating 2-Hydroxybenzoic acid (Saliyclic Acid) gradually into a skincare routine is crucial.
2-Hydroxybenzoic acid (Saliyclic Acid) can increase skin sensitivity to sunlight.
2-Hydroxybenzoic acid (Saliyclic Acid), poison by ingestion, intravenous, and intraperitoneal routes.

Moderately toxic by subcutaneous route.
An experimental teratogen.
Human systemic effects by skin contact: ear tinnitus.

Mutation data reported.
2-Hydroxybenzoic acid (Saliyclic Acid) a skin and severe eye irritant.
Experimental reproductive effects.

Incompatible with iron salts, spirit nitrous ether, lead acetate, iodine.
2-Hydroxybenzoic acid (Saliyclic Acid) is used in the manufacture of aspirin.
When heated to decomposition it emits acrid smoke and irritating fumes.

If high concentrations of 2-Hydroxybenzoic acid (Saliyclic Acid) ointment are used topically, high levels of salicylic acid can enter the blood, requiring hemodialysis to avoid further complications.
Some individuals may be more sensitive to salicylic acid, experiencing redness, irritation, or dryness.