PRODUCTS

2-METHYL-2H-ISOTHIAZOL-3-ONE (MIT)

CAS Number : 2682-20-4
EC Number : 220-239-6
Molecular Formula : C4H5NOS
Molecular Weight : 115.16

2-methyl-2H-isothiazol-3-one (MIT) is the organic compound with the formula S(CH)2C(O)NCH3.
2-methyl-2H-isothiazol-3-one (MIT) is a white solid.
2-methyl-2H-isothiazol-3-one (MIT) a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications.
2-methyl-2H-isothiazol-3-one (MIT) and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis.

Preparation of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:

NCSCH=CHC(O)NHCH3 ⟶ SCHn=CHC(O)NCH3+HCN

Applications of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is used for controlling microbial growth in water-containing solutions.
2-methyl-2H-isothiazol-3-one (MIT) is typically used in a formulation with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon.
2-methyl-2H-isothiazol-3-one (MIT) is supplied to manufacturers as a concentrated stock solution containing from 1.5–15% of CMIT/MIT.
2-methyl-2H-isothiazol-3-one (MIT) also has been used to control slime in the manufacture of paper products that contact food.
In addition, 2-methyl-2H-isothiazol-3-one (MIT) serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food.

2-methyl-2H-isothiazol-3-one (MIT) is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom.
2-methyl-2H-isothiazol-3-one (MIT) is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM).
2-methyl-2H-isothiazol-3-one (MIT) has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.

Use and Manufacturing of 2-methyl-2H-isothiazol-3-one (MIT)
Used as a biocide and preservative in cosmetics, paints, and glues; it is present in Kathon KG, MCI/MI, and Euxyl K100; Used as an antimicrobial in cosmetics, hygiene products, paints, emulsions, cutting oils, paper coatings, and water storage and cooling units; Used as a biocide in textile production; Used as a preservative in pesticide products; Used as a biocide in pulp/paper mills, industrial process and cooling water systems, oil field operations, and air cleaner systems, and as a preservative in adhesives, coatings, fuels, metalworking fluids, resin emulsions, paints, and wood products

Industry Uses of 2-methyl-2H-isothiazol-3-one (MIT)
Adhesion/cohesion promoter
Adhesives and sealant chemicals
Anti-adhesive agents
Cleaning agent
Not Known or Reasonably Ascertainable
Preservative
Surface modifier
UV stabilizer
Viscosity modifiers

Consumer Uses of 2-methyl-2H-isothiazol-3-one (MIT)
Adhesives and sealant chemicals
Agricultural chemicals (non-pesticidal)
Brightener
Paint additives and coating additives not described by other categories
Preservative
Sizing agent

General Manufacturing Information
Industry Processing Sectors
Adhesive Manufacturing
Fabricated Metal Product Manufacturing
Not Known or Reasonably Ascertainable
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Wholesale and Retail Trade
Wood Product Manufacturing

First aid measures of 2-methyl-2H-isothiazol-3-one (MIT)

General notes
Do not leave affected person unattended.
Remove victim out of the danger area.
Keep affected person warm, still and covered.
Take off immediately all contaminated clothing.
In all cases of doubt, or when symptoms persist, seek medical advice.
In case of unconsciousness place person in the recovery position.
Never give anything by mouth.

Following inhalation
If breathing is irregular or stopped, immediately seek medical assistance and start first aid actions.
In case of respiratory tract irritation, consult a physician.
Provide fresh air.

Following skin contact
Rinse skin with water/shower.

Following eye contact
Remove contact lenses, if present and easy to do.
Continue rinsing.
Irrigate copiously with clean, fresh water for at least 10 minutes, holding the eyelids apart.

Following ingestion
Rinse mouth with water (only if the person is conscious).
Do NOT induce vomiting.

Substance identity

EC / List no.: 220-239-6
CAS no.: 2682-20-4
Mol. formula: C4H5NOS

Hazard classification & labelling of 2-methyl-2H-isothiazol-3-one (MIT)
Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance is fatal if inhaled, is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, causes serious eye damage and may cause an allergic skin reaction.

About 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.
2-methyl-2H-isothiazol-3-one (MIT) is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Biocidal Uses of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is approved for use as a biocide in the EEA and/or Switzerland, for: preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.
2-methyl-2H-isothiazol-3-one (MIT) is being reviewed for use as a biocide in the EEA and/or Switzerland, for: product preservation.

Consumer Uses of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is used in the following products: cosmetics and personal care products, fertilisers, plant protection products and perfumes and fragrances.
Other release to the environment of 2-methyl-2H-isothiazol-3-one (MIT) is likely to occur from: outdoor use as processing aid and indoor use as processing aid.

Article service life of 2-methyl-2H-isothiazol-3-one (MIT)
ECHA has no public registered data on the routes by which 2-methyl-2H-isothiazol-3-one (MIT) is most likely to be released to the environment.
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is used in the following products: fertilisers, laboratory chemicals, plant protection products, perfumes and fragrances, cosmetics and personal care products and pH regulators and water treatment products.
2-methyl-2H-isothiazol-3-one (MIT) is used in the following areas: agriculture, forestry and fishing, health services and scientific research and development.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

Formulation or re-packing of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is used in the following products: laboratory chemicals, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), fertilisers, plant protection products and perfumes and fragrances.
Release to the environment of 2-methyl-2H-isothiazol-3-one (MIT) can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industrial sites of 2-methyl-2H-isothiazol-3-one (MIT)
2-methyl-2H-isothiazol-3-one (MIT) is used in the following products: laboratory chemicals and pH regulators and water treatment products.
2-methyl-2H-isothiazol-3-one (MIT) is used in the following areas: scientific research and development and health services.
2-methyl-2H-isothiazol-3-one (MIT) is used for the manufacture of: chemicals.
Release to the environment of 2-methyl-2H-isothiazol-3-one (MIT) can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Manufacture of 2-methyl-2H-isothiazol-3-one (MIT)
Release to the environment of 2-methyl-2H-isothiazol-3-one (MIT) can occur from industrial use: manufacturing of the substance.

Synonyms:
2-methyl-2H-isothiazol-3-one
2-Methyl-2H-isothiazol-3-one
2-methyl-2H-isothiazol-3-one
2-methyl-2H-isothiazol-3-one (MIT)
2-Methyl-4-Isothiazolin-3-one
2-methyl-4-isothiazolin-3-one
2-methylisothiazol-3(2H)-one
2-methylisothiazolin-3(2H)-one
3(2H)-Isothiazolone, 2-methyl-
Methylisothiazolinone
2-Methyl-(2H)-isothiazol-3-on (de)
2-methyl-2H-isothiazol-3-on (MIT) (da)
Biocidal active substances
2-Methyl-2H-isothiazol-3-on (MIT) (de)
Biocidal active substances
2-methyl-2H-isothiazol-3-one (MIT) (mt)
Biocidal active substances
2-methyl-2H-isothiazol-3-one (MIT) (no)
Biocidal active substances
2-Methyl-2H-isothiazool-3-on (MIT) (nl)
Biocidal active substances
2-methylisothiazol-3(2H)-on (cs)
2-methylisothiazol-3(2H)-on (da)
2-methylisothiazool-3(2H)-on (nl)
2-methyltetrahydroisothiazol-3(2H)-on (MIT) (cs)
Biocidal active substances
2-Metil-2H-isotiazol-3-ona (MIT) (es)
Biocidal active substances
2-Metil-2H-isotiazol-3-ona (MIT) (pt)
Biocidal active substances
2-metil-2H-isotiazol-3-one (MIT) (it)
Biocidal active substances
2-metil-2H-isotiazol-3-onă (MIT) (ro)
Biocidal active substances
2-metil-2H-izotiazol-3-on (MIT) (hr)
Biocidal active substances
2-metil-2H-izotiazol-3-on (MIT) (hu)
Biocidal active substances
2-metil-2H-izotiazol-3-on (MIT) (sl)
Biocidal active substances
2-metil-2H-izotiazol-3-onas (MIT) (lt)
Biocidal active substances
2-Metil-2H-izotiazol-3-ons (MIT) (lv)
Biocidal active substances
2-metilisotiazol-3(2H)-on (hu)
2-metilisotiazol-3(2H)-on (mt)
2-Metilisotiazol-3(2H)-ona (es)
2-metilisotiazol-3(2H)-ona (pt)
2-metilisotiazol-3(2H)-one (it)
2-metilizotiazol-3(2H)-on (hr)
2-metilizotiazol-3(2H)-on (sl)
2-metilizotiazol-3(2H)-onas (lt)
2-metilizotiazol-3(2H)-ons (lv)
2-metilizotiazol-3(2H)-onă (ro)
2-metyl-(2H)-izotiazol-3-ón (sk)
2-metyl-2H-isotiazol-3-on (MIT) (sv)
Biocidal active substances
2-metyl-2H-izotiazol-3-ón (MIT) (sk)
Biocidal active substances
2-metylisotiazol-3(2H)-on (sv)
2-metylo-2H-izotiazol-3-on (MIT) (pl)
Biocidal active substances
2-metyloizotiazol-3(2H)-on (pl)
2-metyyli-2H-isotiatsol-3-oni (MIT) (fi)
Biocidal active substances
2-metyyli-isotiatsol-3(2H)-oni (fi)
2-metüül-2H-isotiasool-3-oon (MIT) (et)
Biocidal active substances
2-metüülisotiasool-3(2H)-oon (et)
2-méthyl-2H-isothiazole-3-one (MIT) (fr)
Biocidal active substances
2-méthylisothiazol-3(2H)-one (fr)
2-Μεθυλ-2H-ισοδιαζολ-3-όνη (MIT) (el)
Biocidal active substances
2-μεθυλισοθειαζολ-3(2H)-όνη (el)
2-метил-2H-изотиазол-3-он (MIT) (bg)
Biocidal active substances
2-метилизотиазол-3(2H)-он (bg)
125794-71-0
1610617-47-4
184720-17-0
2-Methyl-1,2-thiazol-3(2H)-one
2-methyl-1,2-thiazol-3(2H)-one
2-methyl-1,2-thiazol-3-one
2-methyl-1,2-thiazol-3-one hydrochloride
2-methyl-2,3-dihydro-1,2-thiazol-3-one
2-Methyl-2H-isothiazol-3-one
2-methyl-2H-isothiazol-3-one
2-methyl-2H-isothiazol-3-one
2-Methyl-3(2H)-isothiazolon
2-Methyl-3(2H)-isothiazolone
2-Methyl-4-isothiazolin-3-one
2682-20-4
Methylisothiazolinone
2-methylisothiazol-3(2h)-one
2-Methyl-3(2H)-isothiazolone
2-Methyl-4-isothiazoline-3-one
3(2H)-Isothiazolone, 2-methyl-
2-methyl-1,2-thiazol-3-one
N-Methyl-3-oxodihydroisothiazole
2-methyl-3-isothiazolone
N-METHYL-3-OXODIHYDRO ISOTHIAZOLE
MIT
2-methyl-1,2-thiazol-3(2H)-one
229D0E1QFA
DTXSID2034259
CHEBI:53620
n-methylisothiazolin-3-one
2682-20-4 (free base)
Neolone
Caswell No. 572A
Microcare MT
Kordek MLX
EINECS 220-239-6
MIT (biocide)
Acticide M 10
Acticide M 20
Bestcide 600
Kordek 50
Kordek 50C
Kordek 573F
Kathon CG 243
2-METHYL-2H-ISOTHIAZOL-3-ONE
UNII-229D0E1QFA
HSDB 8200
MIT 950
MT 10
2-Methyl-4-isothiazoline-3-ketone
KB 838
MFCD01742315
2-Methyl-4-isothiazolin-3-one (MI)
2-methyl-4-isothiazolinone
SCHEMBL17863
SCHEMBL113898
Methylisothiazolinone free base
CHEMBL1620780
DTXCID0014259
2-Methyl 4-Isothiazoline 3-one
METHYLISOTHIAZOLINONE [II]
METHYLISOTHIAZOLINONE [MI]
2-Methyl-3(2H)-isothiazolone #
METHYLISOTHIAZOLINONE [INCI]
ZINC1849933
METHYLISOTHIAZOLINONE [VANDF]
Tox21_303814
BBL104136
METHYLISOTHIAZOLINONE [MART.]
STL557951
AKOS007930246
AM84857
CS-W011236
HY-W010520
2-Methyl-4-isothiazolin-3-one, 95%
NCGC00357093-01
CAS-2682-20-4
2-methyl-2,3-dihydro-1,2-thiazol-3-one
DB-005250
FT-0601044
F21330
EN300-1708622
Q423870
2-Methyl-4-isothiazolin-3-one, analytical standard
W-107150
Z3227502095
2-Methyl-4-isothiazolin-3-one 100 microg/mL in Acetonitrile
220-239-6 [EINECS]
2682-20-4 [RN]
2-Methyl-1,2-thiazol-3(2H)-on [German] [ACD/IUPAC Name]
2-Methyl-1,2-thiazol-3(2H)-one [ACD/IUPAC Name]
2-Méthyl-1,2-thiazol-3(2H)-one [French] [ACD/IUPAC Name]
2-methyl-4-isothiazolin-3-one
2-Methyl-4-isothiazoline-3-one
2-Methylisothiazol-3(2H)-one [ACD/IUPAC Name]
3(2H)-Isothiazolone, 2-methyl- [ACD/Index Name]
606203 [Beilstein]
methylisothiazolinone [Wiki]
MFCD01742315 [MDL number]
MI
MIT
N-Methylisothiazolone
NX8157080
2682-20-4 (free base)
2-Methyl 4-Isothiazoline 3-one
2-methyl-1,2-thiazol-3-one
2-methyl-2,3-dihydro-1,2-thiazol-3-one
2-Methyl-2H-isothiazol-3-one
2-methyl-3-isothiazolidinone
2-methyl-3-isothiazolone
2-Methyl-4-isothiazolin-3-one (MI)
2-methyl-4-isothiazolin-3-one(mit)
2-methylisothiazol-3-one
3(2H)-ISOTHIAZOLONE, METHYL-
4670-10-4 [RN]
Methylisothiazolinone|2-methyl-3(2H)-isothiazolone
NCGC00164391-01
N-Methyl-3-oxodihydroisothiazole
甲基异噻唑啉酮 [Chinese]