PRODUCTS

2-METHYL-4-ISOTHIAZOLIN-3-ONE

2-Methyl-4-isothiazolin-3-one is also used to control the growth of mold, mildew, and sapstain on wood products.
2-Methyl-4-isothiazolin-3-one is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents.

CAS Number: 2682-20-4
EC Number: 220-239-6
MDL number: MFCD01742315
Empirical Formula (Hill Notation): C4H5NOS
Molar mass: 115.1 g/mol

SYNONYMS:
2-Methyl-4-isothiazolin-3-one, 2-Methyl-3(2H)-isothiazolone, 2-Methylisothiazol-3(2H)-one, 2-Methyl-4-isothiazolin-3-on, Methylisothiazolone, 2-methyl-2H-isothiazol-3-one, 2-Methyl-4-isothiazoline-3-one, 2-Methyl-3-isothiazolone, MIT, MI, 2-Methyl-1,2-thiazol-3(2H)-one, 2-Methylisothiazol-3(2H)-one, 2-Methyl-4-isothiazolin-3-one, 2-METHYL-4-ISOTHIAZOLIN-3-ONE, 2-METHYL-3(2H)-ISOTHIAZOLONE, 2-Methylisothiazol-3(2H)-one, 2-Methyl-4-isothiazolin-3-on, METHYLISOTHIAZOLONE, Casson preservatives, 2-methyl-2H-isothiazol-3-one, 2-METHYL-4-ISOTHIAZOLINE-3-ONE, 2-Methyl-3-isothiazolone, 2-Methyl-2H-isothiazole-3-one, 2-Methyl-3-isothiazolone, 2-Methyl-4-isothiazoline-3-ketone, 2-Methyl-4-isothiazoline-3-one, N-Methylisothiazolin-3-one, 2-Methyl-3(2H)-isothiazolone, 2-Methyl-4-isothiazolin-3-one, 2-Methyl-2H-isothiazol-3-one, 2-Methyl-4-isothiazolin-3-one calcium chloride, 3(2H)-Isothiazolone, 2-methyl-, 2-Methyl-2,3-dihydroisothiazol-3-one, Neolone 950, 2-Methylisothiazol-3(2H)-one, UN3261, Methylisothiazolinone, 3(2H)-Isothiazolone, 2-methyl-, 2-Methyl-2H-isothiazol-3-one, 2-Methyl-4-isothiazolin-3-one, 2-Methyl-3(2H)-isothiazolone, MI, MIT, 2-Methyl-4-isothiazoline-3-one, Neolone 950 preservative, OriStar MIT, Microcare MT, 2-Methyl-3(2H)-isothiazolone, 2-Methyl-1,2-thiazol-3(2H)-one, 2-Methylisothiazol-3(2H)-one, 2-Methyl-4-isothiazolin-3-one, 2682-20-4, Methylisothiazolinone, 2-Methyl-4-isothiazolin-3-one, 2-Methyl-3(2H)-isothiazolone, 2-Methyl-4-isothiazoline-3-one, N-methylisothiazolone, 3(2H)-Isothiazolone, 2-methyl-, 2-methyl-3-isothiazolone, n-methylisothiazolin-3-one, Neolone 950, 2-methyl-1,2-thiazol-3(2H)-one, 229D0E1QFA, DTXSID2034259, 2-Methyl-4-isothiazoline-3-ketone, DTXCID0014259, CHEBI:53620, methyl-isothiazolinone, methylisothiazolidinone, RefChem:158243, 220-239-6, methylisothiazolone, 2-methylisothiazol-3(2h)-one, N-METHYL-3-OXODIHYDRO ISOTHIAZOLE, MFCD01742315, 2-METHYL-2H-ISOTHIAZOL-3-ONE, N-Methyl-3-oxodihydroisothiazole, Neolone, 2682-20-4 (free base), Kordek 50, Kordek 50C, Caswell No. 572A, Kathon CG 243, Microcare MT, Kordek MLX, EINECS 220-239-6, MIT (biocide), Acticide M 10, Acticide M 20, Bestcide 600, 2-methyl-1,2-thiazol-3-one, Kordek 573F, 2-methylisothiazol-3-one, UNII-229D0E1QFA, 2-methyl-2,3-dihydro-1,2-thiazol-3-one, HSDB 8200, MIT 950, MT 10, KB 838, 2-Methyl-4-isothiazolin-3-one (MI), 2-methyl-4-isothiazolinone, 2-methyl-isothiazol-3-one, SCHEMBL17863, Methylisothiazolinone free base, orb1306885, Methylisothiazolinone (Standard), CHEMBL1620780, SCHEMBL20718809, METHYLISOTHIAZOLINONE [II], METHYLISOTHIAZOLINONE [MI], MSK2158, 2-Methyl-4-isothiazolin-3-one 100 microg/mL in Acetonitrile, 2-Methyl-3(2H)-isothiazolone #, HY-W010520R, METHYLISOTHIAZOLINONE [VANDF], Tox21_303814, BBL104136, EBC-48037, METHYLISOTHIAZOLINONE [MART.], STL557951, AKOS007930246, CS-W011236, FM16100, HY-W010520, 2-Methyl-4-isothiazolin-3-one, 95%, 2-Methyl-4-isothiazolin-3-one - 96%, NCGC00357093-01, FM164967, CAS-2682-20-4, DB-005250, NS00003875, F21330, EN300-1708622, 682M204, F221572, Q423870, 2-Methyl-4-isothiazolin-3-one, analytical standard, 2-Methyl-4-isothiazolin-3-one - 50% aqueous solution, 2-Methyl-4-isothiazoline-3-one, 50% aqueous solution, Z3227502095, 2-METHYL-4-ISOTHIAZOLIN-3-ONE, 2-METHYL-3(2H)-ISOTHIAZOLONE, 2-Methylisothiazol-3(2H)-one, 2-Methyl-4-isothiazolin-3-on, METHYLISOTHIAZOLONE, Casson preservatives, 2-methyl-2H-isothiazol-3-one, 2-METHYL-4-ISOTHIAZOLINE-3-ONE, 2-Methyl-3-isothiazolone, 2-Methyl-2H-isothiazole-3-one, 1,5- diethyl-3-methyl-2,4-dinitrobenzene, kathon, 2- methyl isothiazol-3-one, 2- methyl-1,2-thiazol-3-one, 2- methyl-1,2-thiazol-3(2H)-one, 2- methyl-2-hydroisothiazol-3-one, 2- methyl-2H-isothiazol-3-one, 2- methyl-3-isothiazolone, 2- methyl-3(2H)-isothiazolone, 2- methyl-4-isothiazolin-3-one, 2- methyl-4-isothiazoline-3-one, 2- methylisothiazol-3(2H)-one, methylisothiazolinone, N- methylisothiazolone, neolone, skycide 100, iso thiazolin-3-one, 2-methyl-, 3(2H)-iso thiazolone, 2-methyl-, MIT, Skycide 100, Methylisothiazolinone, Isothiazolone,2-methyl-, 2-Methyl-3-isothiazolone, Isothiazolone, 2-methyl-, 2-Methylisothiazol-3-one, Methyl-3(2H)-isothiazolone, 2-Methyl-Isothiazolin-3-one, 2-methyl-3(2h)-isothiazolon, 2-METHYL-3(2H)-ISOTHIAZOLONE, 2-Methyl-4-Isothiazolin-3-One, 2-METHYL-4-ISOTHIAZOLIN-3-ONE, 2-METHYL-4-ISOTHIAZOLINE-3-ONE, 2-Methyl-4-Isothiazoline-3-one, 2-Methyl-4-Isothiazolin-3-Ketone, N-METHYL-3-OXODIHYDRO ISOTHIAZOLE, 2-Methyl-4-Isothiazoline-3-Ketone, 2-Methyl-2,3-dihydroisothiazol-3-one, 1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA, 2-Methyl-4-isothiazolin-3-one, Methylisothiazolinone, 2-Methylisothiazol-3(2H)-one, MIT, MI, 2-Methyl-3-isothiazolone, Isothiazolone 2-methyl, Methyl-3(2H)-isothiazolone, 2-Methyl-4-Isothiazoline-3-One, 2-Methyl-4-Isothiazolin-3-Ketone, 2-Methyl-2H-isothiazol-3-one

2-Methyl-4-isothiazolin-3-one is a potent biocide useful for controlling microbial growth.
2-Methyl-4-isothiazolin-3-one (/ˌmɛθəlˌaɪsoʊˌθaɪ.əˈzoʊlɪnoʊn/), MIT, or MI, is the organic compound with the formula S(CH)2C(O)NCH3.
2-Methyl-4-isothiazolin-3-one is a white solid.

Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications.
2-Methyl-4-isothiazolin-3-one and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis.
2-Methyl-4-isothiazolin-3-one is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom.

2-Methyl-4-isothiazolin-3-one is a powerful biocide and preservative.
2-Methyl-4-isothiazolin-3-one has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.
Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one) is a powerful synthetic biocide and preservative within the group of isothiazolinones.

2-Methyl-4-isothiazolin-3-one is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.
2-Methyl-4-isothiazolin-3-one has a pH range of 2.0-12.0 and is miscible with water.

2-Methyl-4-isothiazolin-3-one's chemical structure is similar to formaldehyde.
2-Methyl-4-isothiazolin-3-one biocide (CAS No. 2682-20-4) is cytotoxic and affects a wide variety of cells.
2-Methyl-4-isothiazolin-3-one is a powerful antimicrobial and antifungal agent which is widely used in personal care products.

2-Methyl-4-isothiazolin-3-one (commonly abbreviated MIT or MI) is a heterocyclic organic compound in the isothiazolinone family.
2-Methyl-4-isothiazolin-3-one functions primarily as a biocide and preservative used to inhibit the growth of bacteria, fungi, and algae in a wide range of industrial and consumer products.

2-Methyl-4-isothiazolin-3-one is often found alone or combined with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) in commercial formulations such as Kathon solutions used in paints, adhesives, and personal care products.

USES and APPLICATIONS of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
2-Methyl-4-isothiazolin-3-one is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems.
And 2-Methyl-4-isothiazolin-3-one is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative.

2-Methyl-4-isothiazolin-3-one, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products.
2-Methyl-4-isothiazolin-3-one is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”
Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal.

Ultimately, 2-Methyl-4-isothiazolin-3-one is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo.
2-Methyl-4-isothiazolin-3-one is only approved for use in rinse-off formulas and at low concentrations.

2-Methyl-4-isothiazolin-3-one is used for controlling microbial growth in water-containing solutions.
2-Methyl-4-isothiazolin-3-one is typically used in a formulation with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon.

In addition, 2-Methyl-4-isothiazolin-3-one serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food.
2-Methyl-4-isothiazolin-3-one is recognized for its role in the field of industrial and applied microbiology, where it is employed as a biocide in a range of applications.

In research, 2-Methyl-4-isothiazolin-3-one′s often used to explore the efficacy of antimicrobial agents in various environmental conditions, providing insights into the preservation of materials.
Its mechanism of action, which involves the inhibition of microbial growth by interfering with certain enzymatic activities within the cell, makes 2-Methyl-4-isothiazolin-3-one an interesting subject for studies on microbial resistance and biofilm formation.

2-Methyl-4-isothiazolin-3-one is also a topic of interest in the development of novel industrial preservatives, with researchers investigating its stability and activity in a wide range of products and environments.
Furthermore, 2-Methyl-4-isothiazolin-3-one′s role in the degradation of polymers offers a pathway to understand and improve the longevity and durability of materials exposed to microbial threats.

2-Methyl-4-isothiazolin-3-one is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
2-Methyl-4-isothiazolin-3-one is approved for use as a biocide in the EEA and/or Switzerland, for: product preservation, preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.

2-Methyl-4-isothiazolin-3-one is used in the following products: cosmetics and personal care products, fertilisers, plant protection products and perfumes and fragrances.
Other release to the environment of 2-Methyl-4-isothiazolin-3-one is likely to occur from: outdoor use as processing aid and indoor use as processing aid.

2-Methyl-4-isothiazolin-3-one is used in the following products: fertilisers, laboratory chemicals, plant protection products, perfumes and fragrances, cosmetics and personal care products and pH regulators and water treatment products.
2-Methyl-4-isothiazolin-3-one is used in the following areas: agriculture, forestry and fishing, health services and scientific research and development.

Other release to the environment of 2-Methyl-4-isothiazolin-3-one is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.
2-Methyl-4-isothiazolin-3-one is used in the following products: laboratory chemicals, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), fertilisers, plant protection products and perfumes and fragrances.

Release to the environment of 2-Methyl-4-isothiazolin-3-one can occur from industrial use: formulation of mixtures and formulation in materials.
2-Methyl-4-isothiazolin-3-one is used in the following products: laboratory chemicals and pH regulators and water treatment products.
2-Methyl-4-isothiazolin-3-one is used in the following areas: scientific research and development and health services.

2-Methyl-4-isothiazolin-3-one is used for the manufacture of: chemicals.
Release to the environment of 2-Methyl-4-isothiazolin-3-one can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Release to the environment of 2-Methyl-4-isothiazolin-3-one can occur from industrial use: manufacturing of the substance.
2-Methyl-4-isothiazolin-3-one is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI).

2-Methyl-4-isothiazolin-3-one is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone.
MIC values are 7 to 200-fold lower when 2-Methyl-4-isothiazolin-3-one is used in combination with MCI.

2-Methyl-4-isothiazolin-3-one decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays.
2-Methyl-4-isothiazolin-3-one, alone and as a mixture with MCI, can elicit contact sensitization.

2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products.
2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.
2-Methyl-4-isothiazolin-3-one is a preservative compound widely used in cosmetics.

2-Methyl-4-isothiazolin-3-one is an antimicrobial.
2-Methyl-4-isothiazolin-3-one is used to control slime-forming bacteria, fungi and algae in cooling water systems, fuel storage tanks, pulp, and paper mill water systems, oil extraction systems, and other industrial settings.

2-Methyl-4-isothiazolin-3-one is frequently used in personal care products.
Such as shampoos and other hair care products, as well as certain paint formulations.
Moreover, 2-Methyl-4-isothiazolin-3-one biocide is often used in combination with either Chloromethylisothiazolinone or Benzisothiazolinone (an added antiseptic).

2-Methyl-4-isothiazolin-3-one is also used to control the growth of mold, mildew, and sapstain on wood products.
2-Methyl-4-isothiazolin-3-one is a broad range of bactericidal preservatives, can effectively kill algae, bacteria and fungi.
2-Methyl-4-isothiazolin-3-one can be widely used in industrial cooling water, oil field back tank water, paper industry, pipeline, paint, paint, rubber and cosmetics, photographic film and washing products and other industries.

The effective dosage is small, non-toxic and pollution-free, and 2-Methyl-4-isothiazolin-3-one is easy to mix in various formulations, and the PH is widely used.
After dilution and use concentration, 2-Methyl-4-isothiazolin-3-one is easy to be biodegradable into non-toxic and pollution-free substances.

2-Methyl-4-isothiazolin-3-one can effectively kill a variety of bacteria at low concentrations, especially suitable for the preservation of cosmetics and personal care products.
2-Methyl-4-isothiazolin-3-one is applicable pH range pH2.0-12.0, miscible with water, can be added in any process, easy to operate.

2-Methyl-4-isothiazolin-3-one is also used in industrial applications as a preservative and antifouling agent.
2-Methyl-4-isothiazolin-3-one (MIT) is a widely used antimicrobial agent and preservative defined by CAS number 2682-20-4 and EC number 220-239-6.

2-Methyl-4-isothiazolin-3-one’s effective at low doses, versatile across industries, but has safety concerns—particularly skin sensitization and toxicity—that have led to regulatory use limits, especially in cosmetics.
2-Methyl-4-isothiazolin-3-one is generally used as preservative in bath, shampoo and washing liquid, industrially used in cooling water, circulating water, papermaking and paint coatings.

2-Methyl-4-isothiazolin-3-one is an efficient antimicrobial drug with broad-spectrum bacteriostatic ability, used for sterilization and anticorrosion of papermaking coatings, oil field water injection, daily chemical industry, etc.
2-Methyl-4-isothiazolin-3-one is a widely used sterilization preservative, can effectively kill algae, bacteria and fungi.

2-Methyl-4-isothiazolin-3-one can be widely used in industrial cooling water, oil field return tank water, paper industry, pipeline, coating, paint, rubber, cosmetics, photosensitive film and washing products and other industries.
The effective dosage of 2-Methyl-4-isothiazolin-3-one is small, non-toxic and non-polluting, and it is easy to mix in various formulas.

The PH has a wide range of applications.
After diluting the concentration, 2-Methyl-4-isothiazolin-3-one is easy to be biodegraded into non-toxic and non-polluting substances.

2-Methyl-4-isothiazolin-3-one can effectively kill a variety of bacteria at low concentrations, especially suitable for the preservation of cosmetics and personal care preparations.
The applicable pH range of 2-Methyl-4-isothiazolin-3-one is pH2.0-12.0, miscible with water, can be added in any process, and is easy to operate

-Industrial & Household Uses of 2-Methyl-4-isothiazolin-3-one:
Preservative in paints and coatings to prevent microbial spoilage.
Adhesives, sealants, and bonding compounds.

Metalworking fluids and cutting fluids.
Detergents and cleaning products.

Cooling water systems, fuel tanks, and industrial process waters.
Textiles, paper/pulp mills, and wood products.
Personal care and cosmetic products (shampoos, conditioners, lotions) in low concentrations, especially when combined with CMIT.

CHEMICAL PROPERTIES of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
2-Methyl-4-isothiazolin-3-one is a colorless,clear liquid with amild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene.
2-Methyl-4-isothiazolin-3-one is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%.

BENEFITS of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
Highly effective at low concentrations against broad spectrum microbes.
Compatible with many formulations; water-soluble.
Useful across personal care and industrial products.

MECHANISM OF ACTION of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
2-Methyl-4-isothiazolin-3-one acts as a biocide by interfering with cell membrane integrity and metabolic processes in microorganisms, leading to cell death.
2-Methyl-4-isothiazolin-3-one penetrates microbial cells and disrupts enzyme function and structural components.

CHEMISTRY of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
2-Methyl-4-isothiazolin-3-one is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide.
NCSCH=CHC(O)NHCH3 → SCH=CHC(O)NCH3 + HCN
The crystal and molecular structure of 2-Methyl-4-isothiazolin-3-one, as determined by in situ cryocrystallography, was reported for the first time in 2024.

PREPARATION of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
2-Methyl-4-isothiazolin-3-one is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide: NCSCH=CHC(O)NHCH3?SCH=CHC(O)NCH3+HCN

PROPERTIES of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
2-Methyl-4-isothiazolin-3-one is sometimes called methylisothiazolinone.
2-Methyl-4-isothiazolin-3-one is a powerful biocide and preservative within the group of isothiazolinones.
2-Methyl-4-isothiazolin-3-one (CAS No. 2682-20-4) is widely used in cosmetics, shampoos, and body care products.

MECHANISM OF ACTION of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
isothiazolinone is a water treatment agent with excellent performance, good miscibility, and can be mixed with various corrosion inhibitors such as chlorine, scale inhibitor and dispersant, Most anion, cationic and non-ionic surfactants are miscible, commodities circulating on the market are usually composed of 5-chloro-2-methyl-4-isothiazolin-3-one (CMI) and 2-Methyl-4-isothiazolin-3-one

At the same time, metal nitrite or metal nitrate will be added to improve stability and prevent decomposition,
the mechanism of action of isothiazolinone is to kill by breaking the bonds between bacteria and algae proteins.

After contact with microorganisms, 2-Methyl-4-isothiazolin-3-one can quickly and irreversibly inhibit its growth, resulting in the death of microbial cells.
Bacteria (sulfate reducing bacteria, mud forming bacteria), fungi (iron oxidizing bacteria, mold, yeast), algae, etc. have strong inhibitory and killing effects.

2-Methyl-4-isothiazolin-3-one has the characteristics of high killing efficiency, good degradability, no residue, safe operation, good compatibility, strong stability, low use cost, etc.
At high doses, 2-Methyl-4-isothiazolin-3-one has a significant effect on biological slime peeling.

2-Methyl-4-isothiazolin-3-one has been widely used in steel smelting, oilfield water injection, thermal power generation, papermaking, oil refining, chemical industry, textile, industrial cleaning, pesticides, cutting oil water-based coatings, daily chemicals,
Ink, dyes, leather and other fields.

PHYSICAL and CHEMICAL PROPERTIES of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
Chemical formula: C4H5NOS
Molar mass: 115.1 g/mol
Appearance: white solid
Physical state Powder with lumps
Color: dark yellow
Odor: No data available
Melting point/freezing point:
Melting point/range: 46,7 - 48,3 °C
Initial boiling point and boiling range: > 130 °C at 16 hPa
Flammability (solid, gas): No data available

Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: 396 °C at 1.012 hPa
Decomposition temperature: No data available
pH: 2,58 at 50 g/l at 25 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: soluble

Partition coefficient: n-octanol/water:
log Pow: -0,34 at 30 °C
Bioaccumulation is not expected.
Vapor pressure: 0,0099 hPa at 20 °C
Density: 1,39 g/cm3 at 20 °C
Relative density: 1,39 at 20 °C
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none

Other safety information:
Surface tension: 68,8 mN/m at 1g/l at 19,5 °C
Dissociation constant: > 2,81 at 21 °C
Melting point: 254-256 °C(lit.)
Boiling point: bp0.03 93°
Density: 1.25 (14% aq.)
vapor pressure: <0.1 mm Hg ( 25 °C)
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate

pka: -2.03±0.20(Predicted)
form: neat
color: Yellow
Water Solubility: 489g/L at 20℃
CAS No: [2682-20-4]
Product Code: FM164967
MDL No: MFCD01742315
MOL file: Download
Chemical Formula: C4H5NOS
Molecular Weight: 115.15 g/mol
Smiles: CN1C(=O)C=CS1

Melting Point: 49 °C
Long Term Storage: store at 10°C - 25°C, keep under inert gas: Nitrogen
CAS: 2682-20-4
EINECS: 220-239-6
InChI: InChI=1/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3
InChIKey: BEGLCMHJXHIJLR-UHFFFAOYSA-N
Molecular Formula: C4H5NOS
Molar Mass: 115.15
Density: 1.25 (14% aq.)
Melting Point: 254-256°C(lit.)
Boling Point: bp0.03 93°

Water Solubility: 489g/L at 20℃
Solubility: Chloroform, Ethyl Acetate
Vapor Presure: <0.1 mm Hg ( 25 °C)
Appearance: neat
Color: Yellow Low melting
BRN: 606203
pKa: -2.03±0.20(Predicted)
Storage Condition: 2-8°C
Sensitive: Sensitive to air
MDL: MFCD01742315

Physical and Chemical Properties: white or off-white crystalline powder
Molecular Weight:115.16 g/mol
XLogP3-AA:0
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:115.00918496 Da
Monoisotopic Mass:115.00918496 Da
Topological Polar Surface Area:45.6 Å²

Heavy Atom Count:7
Formal Charge:0
Complexity:121
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
CAS:2682-20-4

IUPAC Name:hydrogen 2-methyl-2,3-dihydro-1,2-thiazol-3-one chloride
Molecular Formula:C4H6ClNOS
InChI Key:SJXPQSRCFCPWQQ-UHFFFAOYSA-N
SMILES:[H+].[Cl-].CN1SC=CC1=O
Molecular Weight (g/mol):151.61
Synonym:methylisothiazolinone
Preferred Name:2-Methyl-4-isothiazolin-3-one
Common Name:Methylisothiazolinone
Abbreviations:MIT, MI
Chemical Formula:C₄H₅NOS
Molar Mass:~115.15 g/mol

EC (EINECS) Number:220-239-6
CAS (Chemical Abstracts Service) Number:2682-20-4
PubChem CID:39800
ChemSpider ID:36393
UNII:229D0E1QFA
Empirical Formula (Hill Notation):C4H5NOS
CAS Number:2682-20-4
Molecular Weight:115.15
UNSPSC Code:12352100
NACRES:NA.21

PubChem Substance ID:329764182
EC Number:220-239-6
Beilstein/REAXYS Number:606203
MDL number:MFCD01742315
Physical state:Powder with lumps
Color:dark yellow
Odor:No data available
Melting point/freezing point:
Melting point/ range: 46,7 - 48,3 °C
Initial boiling point and boiling range:> 130 °C at 16 hPa

Flammability (solid, gas):No data available
Upper/lower flammability or explosive limits:No data available
Flash point:Not applicable
Autoignition temperature:396 °C at 1.012 hPa
Decomposition temperature:No data available
pH:2,58 at 50 g/l at 25 °C - OCSPP 830.7000
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available

Water solubility:soluble
Partition coefficient n-octanol/water:log Pow: -0,34 at 30 °C
Bioaccumulation:is not expected.
Vapor pressure:0,0099 hPa at 20 °C
Density:1,39 g/cm3 at 20 °C
Relative density:1,39 at 20 °C
Relative vapour density:
Particle characteristics:No data available
Explosive properties:Not classified as explosive.

Oxidizing properties:none
Other safety information:Surface tension 68,8 mN/m at 1g/l at 19,5 °C
Dissociation constant:> 2,81 at 21 °C
pH:5.0 to 7.0 (1 % in water)
Appearance (Color):Clear colorless to yellow
Appearance (Form):Solution
Concentration:>=50 %
CBNumber:CB0193926
Molecular Formula:C4H5NOS

Molecular Weight:115.15
MDL Number:MFCD00013254
MOL File:2682-20-4.mol
Melting point:254-256 °C(lit.)
Boiling point:bp0.03 93°
Density:1.25 (14% aq.)
vapor pressure:<0.1 mm Hg ( 25 °C)
storage temp.:2-8°C
solubility:Chloroform, Ethyl Acetate

form:Solid
pka:-2.03±0.20(Predicted)
color:Yellow
Water Solubility:489g/L at 20℃
BRN:606203
Cosmetics Ingredients Functions:PRESERVATIVE
InChIKey:BEGLCMHJXHIJLR-UHFFFAOYSA-N
LogP:-0.486 at 20℃
CAS DataBase Reference:2682-20-4(CAS DataBase Reference)

Indirect Additives used in Food Contact Substances:2-METHYL-4-ISOTHIAZOLIN-3-ONE
EWG's Food Scores:4-7
FDA UNII:229D0E1QFA
NIST Chemistry Reference:3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System:2-Methyl-3(2H)-isothiazolone (2682-20-4)
UNSPSC Code:41116107
NACRES:NA.24
Assay:50.00 to 100.00
Food Chemicals Codex Listed:No

Boiling Point:182.00 to 183.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.797000 mmHg @ 25.00 °C. (est)
Flash Point:148.00 °F. TCC ( 64.30 °C. ) (est)
logP (o/w):0.119 (est)
Soluble in:water, 5.367e+005 mg/L @ 25 °C (est)
Common Name:Methylisothiazolinone
Abbreviations:MIT, MI
Chemical Formula:C₄H₅NOS
Molar Mass:~115.15 g/mol

NACRES:NA.21
PubChem Substance ID:329764182
EC Number:220-239-6
Beilstein/REAXYS Number:606203
MDL number:MFCD01742315
Physical state:Powder with lumps
Color:dark yellow
Odor:No data available
Melting point/freezing point:Melting point/ range: 46,7 - 48,3 °C

Initial boiling point and boiling range:> 130 °C at 16 hPa
Flammability (solid, gas):No data available
Upper/lower flammability or explosive limits:No data available
Flash point:Not applicable
Autoignition temperature:396 °C at 1.012 hPa
Decomposition temperature:No data available
pH:2,58 at 50 g/l at 25 °C - OCSPP 830.7000

Viscosity:
Viscosity, kinematic: No data available;
Viscosity, dynamic: No data available
Water solubility:soluble
Partition coefficient n-octanol/water:log Pow: -0,34 at 30 °C
Bioaccumulation:is not expected.
Vapor pressure:0,0099 hPa at 20 °C
Density:1,39 g/cm3 at 20 °C

Relative density:1,39 at 20 °C
Relative vapour density:
Particle characteristics:No data available
Explosive properties:Not classified as explosive.
Oxidizing properties:none
Other safety information:Surface tension 68,8 mN/m at 1g/l at 19,5 °C
Dissociation constant:> 2,81 at 21 °C

FIRST AID MEASURES of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Call a physician immediately.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
Give water to drink (two glasses at most).
Seek medical advice immediately.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up carefully.
Dispose of properly.

FIRE FIGHTING MEASURES of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Use tightly fitting safety goggles
*Body Protection:
Acid-resistant protective clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Hygiene measures:
Immediately change contaminated clothing.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas.

STABILITY and REACTIVITY of 2-METHYL-4-ISOTHIAZOLIN-3-ONE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
no information available