Quick Search
2-Phenoxyethanol is the organic compound with the formula C6H5OC2H4OH.
2-Phenoxyethanol is a colorless oily liquid.
2-Phenoxyethanol can be classified as a glycol ether and a phenol ether.
CAS: 122-99-6
MF: C8H10O2
MW: 138.16
EINECS: 204-589-7
Synonyms
Ethylene Glycol Monophenyl Ether Phenyl Cellosolve Phenyl Glycol;ETHYLENE GLYCOL MONOPHENYL ETHER FOR SYN;(2-Hydroxyethoxy)benzene;PhG;Protectol PE;ACETONITRILE ACS GRADE;beta-Phenoxyethanol;beta-phenoxyethanol[qr]
2-Phenoxyethanol is a common preservative in vaccine formulations.
2-Phenoxyethanol has a faint rose-like aroma.
2-Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen.
2-Phenoxyethanol is a colorless oily liquid.
2-Phenoxyethanol is a bactericide (usually used in conjunction with quaternary ammonium compounds).
Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.
Phenoxyethanol is a sticky and oily substance that is generally used in cosmetic and skincare products as a preservative.
2-Phenoxyethanol is known as glycol ether in chemical terms and is also a solvent that stabilizes various ingredients because it does not react with light or air.
The chemical formula of Phenoxyethanol is C8H10O2.
2-Phenoxyethanol increases the shelf life of products that may otherwise spoil too quickly by developing a bacterial or fungal layer on them.
What makes Phenoxyethanol a really popular ingredient in the cosmetic industry is its faint rose-like smell that is very pleasant.
From sunscreens and shampoos to mascara and hair sprays - 2-Phenoxyethanol is found in almost every product.
2-Phenoxyethanol is used as a preservative in cosmetic products and also as a stabilizer in perfumes and soaps.
Exposure to 2-Phenoxyethanol has been linked to reactions ranging from eczema to severe, life-threatening allergic reactions.
Infant oral exposure to 2-Phenoxyethanol can acutely affect nervous system function.
Phenoxyethanol is used as a preservative in cosmetic products to limit bacterial growth.
A review of 43 cosmetic products demonstrated that only 25 percent of the products had concentrations of phenoxyethanol greater than 0.6 percent and the mean concentration of 2-Phenoxyethanol was 0.46 percent.
2-Phenoxyethanol is also used as to stabilize components found in perfumes and soaps.
2-Phenoxyethanol Chemical Properties
Melting point: 11-13 °C (lit.)
Boiling point: 247 °C (lit.)
Density: 1.102 g/mL at 25 °C (lit.)
Vapor density: 4.8 (vs air)
Vapor pressure: 0.01 mm Hg ( 20 °C)
Refractive index: n20/D 1.539
FEMA: 4620 | 2-PHENOXYETHANOL
Fp: >230 °F
Storage temp.: Store below +30°C.
Solubility: soluble, clear, colorless to very faintly yellow
pka: 14.36±0.10(Predicted)
Form: Liquid
Color: Clear colorless
Specific Gravity: 1.109 (20/4℃)
Odor: Faint aromatic odor
PH Range: 7 at 10 g/l at 23 °C
PH: 7 (10g/l, H2O, 23℃)
Explosive limit: 1.4-9.0%(V)
Odor Type: floral
Water Solubility: 30 g/L (20 ºC)
Merck: 14,7257
BRN: 1364011
InChIKey: QCDWFXQBSFUVSP-UHFFFAOYSA-N
LogP: 1.2 at 23℃
CAS DataBase Reference: 122-99-6(CAS DataBase Reference)
NIST Chemistry Reference: 2-Phenoxyethanol(122-99-6)
EPA Substance Registry System: 2-Phenoxyethanol (122-99-6)
2-Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk.
2-Phenoxyethanol can be used over a wide pH range.
This means that other preservatives can lose their effectiveness if the product is not within the right pH range.
2-Phenoxyethanol does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.
History and synthesis
2-Phenoxyethanol was first prepared by W. H. Perkin Jr. and his graduate student Edward Haworth in 1896.
They reacted sodium, phenol and 2-chloroethanol in anhydrous ethanol.
Starting from the 1920s, 2-Phenoxyethanol has been commercially available as a cellulose acetate solvent under the trademark of "Phenyl cellosolve".
2-Phenoxyethanol is produced in the industry by the hydroxyethylation of phenol (Williamson synthesis), for example, in the presence of alkali-metal hydroxides or alkali-metal borohydrides.
Uses
2-Phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties.
2-Phenoxyethanol has a relatively low sensitizing factor in leave-on cosmetics.
2-Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens.
In addition, 2-Phenoxyethanol is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types.
2-Phenoxyethanol can be obtained from phenol.
