Quick Search
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is a colorless transparent liquid used a primer or additive and for chemical modification in sealants and adhesives.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane can also be used in paints and coatings as an additive and primer for improving adhesion to the substrate.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane, Silane coupling agent SCA-A30M, is a triamino-functional propyltrimethoxysilane.
CAS Number: 35141-30-1
Molecular Formula: C10H27N3O3Si
Molecular Weight: 265.43
EINECS Number: 252-390-9
Synonyms: 35141-30-1, N1-(2-Aminoethyl)-N2-(3-(trimethoxysilyl)propyl)ethane-1,2-diamine, (3-Trimethoxysilylpropyl)diethylenetriamine, Dynasylan TRIAMO, N'-[2-(3-trimethoxysilylpropylamino)ethyl]ethane-1,2-diamine, 1,2-Ethanediamine, N-(2-aminoethyl)-N'-[3-(trimethoxysilyl)propyl]-, 4,7,10-triazadecyltrimethoxysilane, EINECS 252-390-9, 3W3E2D4706, 3-(2-(2-Aminoethyl)ethylamino)propyltrimethoxysilane, 3-Diethylenetriaminopropyltrimethoxysilane, 1,2-Ethanediamine, N-(2-aminoethyl)-N'-(3-(trimethoxysilyl)propyl)-, trimethoxy silylpropyldiethylenetriamine, 10-trimethoxysilyl-1,4,7-triazadecan, n-(2-aminoethyl)-n'-[3-(trimethoxysilyl)propyl]ethylenediamine, J289.914K, N-(2-aminoethyl)-N'-(3-(trimethoxysilyl)propyl)ethane-1,2-diamine, 1,2-Ethanediamine, N1-(2-aminoethyl)-N2-(3-(trimethoxysilyl)propyl)-, 1-(3-(trimethoxysilyl)propyl)diethylenetriamine, N-3-(TRIMETHOXYSILYL)PROPYL)DIETHYLENETRIAMINE, TRIMETHOXY(9-AMINO-4,7-DIAZANONANE-1-YL)SILANE, N-(2-Aminoethyl)-N'-(3-(trimethoxysilyl)propyl)ethylenediamine, N'-(2-(3-TRIMETHOXYSILYLPROPYLAMINO)ETHYL)ETHANE-1,2-DIAMINE, N-(2-Aminoethyl)-N'-[3-(trimethoxysilyl)propyl]ethane-1,2-diamine, (2-((2-AMINOETHYL)AMINO)ETHYL)(3-(TRIMETHOXYSILYL)PROPYL)AMINE, (3-(2-(2-(2-AMINOETHYLAMINO)ETHYL)AMINO)PROPYL)TRIMETHOXYSILANE, N-(2-AMINOETHYL)-N'-(3-(TRIMETHOXYSILYL)PROPYL)-1,2-ETHANEDIAMINE, 1,2-Ethanediamine, N1-(2-aminoethyl)-N2-[3-(trimethoxysilyl)propyl]-, AEEA cpd, 3propyltrimethoxysilane, (3(Trimethoxysilyl)propyl)diethylenetriamine, N(2Aminoethyl)N'(3(trimethoxysilyl)propyl)ethylenediamine, 1,2Ethanediamine, N(2aminoethyl)N'(3(trimethoxysilyl)propyl), 1,2Ethanediamine, N1(2aminoethyl)N2(3(trimethoxysilyl)propyl), 3-(2-(2-aminoethyl)-ethylamino)-propyl-trimethoxysilane, 3-[2-(2-Aminoethylamino)ethylamino]propyl-trimethoxysilane, 2-[2-(3-Trimethoxysilylpropylamino)ethylamino]ethylamine, N1-(3-Trimethoxysilylpropyl)diethylenetriamine, DTXSID2044422, (3-(Trimethoxysilyl)propyl)diethylenetriamine, UNII-3W3E2D4706, MFCD00069173, 3-[2-(2-Aminoethylamino)ethylamino]propyltrimethoxysilane, TRIMETHOXYSILYLPROPYLDIETHYLENETRIAMINE, n-[3-(trimethoxysilyl)propyl]diethylenetriamine, SCHEMBL37873, CHEMBL3561898, DTXCID0024422, NHBRUUFBSBSTHM-UHFFFAOYSA-N, Tox21_303768, AKOS015901807, Diethylenetriaminopropyltrimethoxysilane, 3-Trimethoxysilylpropyldiethylenetriamine, s18300, NCGC00357015-01, CAS-35141-30-1, CS-0451534, NS00055389, F71294, 2-[2-(3-Trimethoxysilylpropylami)ethylami]ethylamine, Q27258112, 3-[2-(2-aminoethylamino)-ethylamino]-propyl trimethoxysilane, N'-[2-(3-trimethoxysilylpropylamino)ethyl]ethane-1,2-diamine, N1-(3-Trimethoxysilylpropyl)diethylenetriamine, technical grade, (3-(TRIMETHOXYSILYL)PROPYL)DIETHYLENETRIAMINE, DIETHYLENETRIAMINO PROPYLTRIMETHOXYSILANE, TRIMETHOXYSILYLPROPYLDIETHYLENETRIAMINE, N-[3-(Trimethoxysilyl)propyl][2,2'-iminobis(ethanamine)], N-[3-(Trimethoxysilyl)propyl]-N'-(2-aminoethyl)ethylenediamine, Trimethoxy(9-amino-4,7-diazanonane-1-yl)silane, 3-[2-(2-Aminoethylamino)ethylamino]propyl-trimethoxysilane,95%, GE A-1130
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is a versatile amino functional coupling agents used over a broad range of applications to provide superior bonds between inorganic substrates and organic polymers.
The primary amine function reacts with a wide array of thermoset, thermoplastic and elastomeric materials.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane, also written as 3-(2-(2-aminoethylamino)ethylamino)propyltrimethoxysilane, is a specialized organosilane compound that belongs to the family of amino-functional silanes, widely used in materials science, surface chemistry, and polymer industries due to its ability to bond with both inorganic and organic materials through its distinct functional groups.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane consists of a trimethoxysilane group attached to a propyl chain, which is further linked to a tri-amine structure composed of two ethylene bridges bearing three nitrogen atoms with primary and secondary amine functionalities.
These amine groups make the molecule highly reactive toward a variety of substrates, especially surfaces containing hydroxyl groups, such as glass, metal oxides, ceramics, and silica, allowing it to form strong covalent bonds through siloxane linkages after hydrolysis and condensation reactions.
The trimethoxysilyl end of the molecule undergoes hydrolysis in the presence of moisture to form silanol groups (Si–OH), which can then react with surface –OH groups or undergo condensation to form stable Si–O–Si bonds, effectively anchoring the molecule to inorganic surfaces.
Meanwhile, the amine-containing side can interact chemically with epoxies, isocyanates, carboxylic acids, or other reactive groups, allowing this compound to serve as a coupling agent, adhesion promoter, or surface modifier in a wide range of applications, especially where both organic and inorganic components must be integrated.
Because of this dual reactivity, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is often used to enhance adhesion between dissimilar materials, improve dispersion of fillers or pigments in polymers, and modify surface properties such as hydrophilicity, reactivity, or corrosion resistance.
Its application is especially common in the formulation of advanced coatings, sealants, adhesives, composites, and fiber-reinforced plastics, as well as in biomedical fields where surface functionalization of materials like silica nanoparticles or glass devices is required.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is an advanced, multifunctional organofunctional silane coupling agent that contains both alkoxysilane and polyamine functional groups, allowing it to serve as a powerful molecular bridge between inorganic substrates (such as metal oxides, glass, or minerals) and organic polymers or resins, which do not normally adhere well to each other without chemical modification.
The molecule is structured with a central propyl backbone bonded to a trimethoxysilyl group on one end, and an extended tri-amine chain—consisting of a linear sequence of ethylene groups interlinked with primary and secondary amines—on the other, creating a highly reactive and adaptable surface-modifying agent.
The trimethoxysilane functionality at one end of the molecule is hydrolytically active, meaning it readily reacts with ambient moisture or added water to form silanol (Si–OH) groups, which then condense with hydroxyl-containing surfaces such as glass fibers, silica particles, aluminum, stainless steel, and ceramic oxides, forming durable siloxane (Si–O–Si) bonds.
This bonding process effectively anchors the organosilane molecule to the inorganic surface, creating a stable, covalently bonded interface layer that is both chemically and mechanically robust.
On the opposite end, the polyamine chain contains nucleophilic nitrogen atoms that can interact or form covalent bonds with a wide variety of organic functional groups found in thermosetting resins (such as epoxies, polyurethanes, phenolics), isocyanates, acrylates, or carboxylic acids.
These interactions allow this compound to act as a chemical compatibilizer, significantly improving the interfacial adhesion and stress transfer between reinforcement materials (e.g., glass fibers, mineral fillers) and polymer matrices in composite materials.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is notable for being one of the most highly reactive and versatile amino silanes because of its three nitrogen atoms, arranged in a linear ethylene-bridged configuration.
The primary and secondary amines provide a high density of nucleophilic sites, allowing the molecule to interact with a wide variety of chemical species—including electrophilic resins, reactive surfaces, and metal ions.
Each methoxy group (–OCH₃) on the silicon atom is capable of undergoing hydrolysis in the presence of moisture, converting into silanol (–Si–OH) groups.
These silanols readily condense with other silanols or with –OH groups on glass, silica, alumina, zirconia, or titania surfaces, forming strong, covalent siloxane (Si–O–Si) or Si–O–metal bonds.
This makes the silane irreversibly anchored to surfaces, enabling long-lasting surface modification, even under thermal or chemical stress.
Boiling point: 114-118 °C/2 mmHg (lit.)
Density: 1.03 g/mL at 25 °C (lit.)
Vapor pressure: 1 mm Hg (20 °C)
Refractive index: n20/D 1.459 (lit.)
Flash point: 257 °F
Form: Liquid
pKa: 10.17 ± 0.19 (Predicted)
Specific Gravity: 1.03
Color: Clear yellow
Odor: Amine-like odor
Water Solubility: 1000 g/L at 20 ℃
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
BRN: 8421470
LogP: -3.9 – -0.74 at 20 ℃
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is widely employed as an additive in adhesives and sealants to improve bonding to substrates like aluminum, concrete, glass, and ceramics.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is also used as a surface treatment agent for fillers, such as calcium carbonate, silica, or titanium dioxide, enhancing their dispersion in polymer matrices and improving mechanical and barrier properties.
In the coatings and paints industry, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane serves as a corrosion inhibitor and adhesion promoter, helping coatings bond more effectively to metal surfaces and resist delamination, even in moist or chemically aggressive environments.
In fiber-reinforced plastics, such as glass fiber composites used in automotive, aerospace, and construction industries, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane ensures that the resin matrix bonds tightly to the reinforcing fibers, resulting in materials that are stronger, lighter, and more resistant to environmental degradation.
Because of its hydrophilic amino groups and hydrolyzable alkoxy groups, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is amphiphilic in nature, meaning it can orient itself at material interfaces, reduce interfacial energy, and promote wetting, dispersion, and adhesion.
This makes it highly suitable for surface functionalization applications in nanotechnology, biomedical engineering, and surface coatings, where precise chemical reactivity at the material boundary is required.
For instance, it is commonly used to modify the surfaces of silica nanoparticles, glass microbeads, or metal oxide films, making them more compatible with organic phases or enhancing their ability to bind biomolecules, dyes, or drugs.
Furthermore, its multiamine structure allows for multiple simultaneous interactions, which increases crosslink density, improves chemical anchoring, and enhances resistance to mechanical shear and thermal degradation.
These features are especially valuable in high-performance composites, where long-term durability and reliability are essential under harsh conditions.
In electronics and semiconductor manufacturing, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is used to modify silicon wafers, glass slides, and microelectromechanical systems (MEMS), enhancing chemical reactivity and supporting thin-film deposition or sensor layer immobilization.
Its ability to be further functionalized with biomolecules also makes it useful in biosensors, microfluidics, and medical diagnostics, where it can facilitate the binding of proteins, enzymes, DNA, or antibodies to glass or silicon substrates.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is a multifunctional organosilane commonly used as a coupling agent, adhesion promoter, and surface modifier in various industrial applications.
The molecule 3-[2-(2-Aminoethylamino)ethylamino]propyltrimethoxysilane (often abbreviated as DETA-silane or AEEA-silane) stands out among silane coupling agents due to its high density of reactive amine groups, which dramatically increases its ability to form chemical bonds with organic resins and functional surfaces.
Its structure contains one primary and two secondary amine groups, spaced across ethylene bridges, which significantly broadens its reactivity profile compared to mono-amine silanes.
This means 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane can not only anchor itself securely to inorganic surfaces via the silane end, but also form multiple simultaneous interactions or crosslinking points with organic polymer chains.
This multi-functionality gives it an exceptional ability to act as a chemical crosslinker, chain extender, or reactive modifier in thermosetting systems like epoxies, polyurethanes, and polyamides, improving their flexibility, toughness, and adhesive strength.
Because of the three amines, this silane can also chelate metal ions, making it useful in modifying surfaces for metal ion sorption, catalytic activity, or anti-corrosion coatings.
The high nucleophilicity of the amines allows it to bond with carbonyl-containing surfaces (e.g., carboxylic acids or anhydrides), while the trimethoxysilane group enables it to participate in sol-gel chemistry, producing silica-like hybrid materials with tailored mechanical, optical, or barrier properti
In glass fiber-reinforced epoxy laminates (used in printed circuit boards or structural panels), this silane is applied as a sizing agent to the glass fibers.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane chemically bonds to both the glass and the epoxy resin, dramatically improving the interlaminar shear strength and preventing delamination over time.
In carbon fiber composites, especially for aerospace and automotive applications, it improves matrix wetting, reducing voids and improving load transfer between the resin and fibers.
In marine coatings and automotive primers, this silane enhances adhesion to steel and aluminum surfaces, providing better resistance to salt spray, UV exposure, and humidity.
When applied in thin films, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane helps to create anti-corrosion coatings on metals, acting as a barrier and reactive interface that binds anti-corrosive agents or pigments.
In microchip fabrication, it is used to functionalize silicon wafers and glass slides, making them compatible with photoresists, spin-on polymers, or nanocoatings.
It can be used in sensor technologies, where its amine groups act as binding sites for enzymes, antibodies, or fluorophores in biosensors or lab-on-a-chip devices.
In drug delivery systems, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is used to coat or functionalize mesoporous silica nanoparticles, enabling the attachment of bioactive molecules or targeting ligands.
In tissue engineering, this silane is used to modify surfaces of bio-inert materials like glass or titanium, enhancing their compatibility with proteins or cells for scaffold preparation.
In construction sealants and PU-based adhesives, it serves as a chain extender and adhesion promoter, increasing the bond strength to mineral or metallic substrates.
In windshield adhesives and structural glazing, this silane improves adhesion to glass and enhances durability in outdoor conditions.
Silanized glass and quartz slides using this molecule are often used in optical sensors, microfluidic chips, or laser alignment equipment, where high optical clarity and surface functionality are needed.
Amino-functional surfaces can be used for covalent immobilization of fluorophores, quantum dots, or dyes, enabling stable, high-performance fluorescence imaging or biosensing platforms.
Uses:
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is a multifunctional organosilane commonly used as a coupling agent, adhesion promoter, and surface modifier in various industrial applications.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane can be used as a grafting agent to incorporate amine functional group onto the surface of various ordered mesoporous silica.
It can be also used in CO2 capture applications.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane has been used in the synthesis of various polyhedral silsesquioxanes, (RSiO1.5)n (SSQO).
It can be functionalized onto the mesoporous SBA-15 silica to be used as matrices for controlled drug delivery.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is also used in the synthesis of silane-based polymer, which is used in conducting instant adhesives.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is used as a precursor in creating flexible, transparent hybrid materials with tailored optical or barrier properties, suitable for antifogging or abrasion-resistant coatings.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilanes structure allows easy grafting onto graphene oxide, carbon nanotubes, or quantum dots, creating dispersible, functionalized nanomaterials with uses in energy storage, electronics, and water purification.
It is being investigated in the development of self-healing polymers, shape-memory materials, and 3D printable resins, due to its ability to form responsive, reversible bonds under specific stimuli.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is used to derivatize solid surfaces for chromatographic separation media, where its amino groups can selectively bind acidic analytes or metal ions.
One of the primary uses of 3-[2-(2-Aminoethylamino)ethylamino]propyltrimethoxysilane is as a surface treatment agent for inorganic materials such as glass, metal oxides, silica, and ceramics, where it functions by chemically bonding to surface hydroxyl groups through its trimethoxysilane moiety, forming a durable siloxane layer that improves the material’s compatibility with organic coatings, adhesives, and resins.
This makes it highly effective as a molecular bridge that enhances adhesion between otherwise incompatible surfaces, such as between glass fibers and polymer matrices in composite materials.
In the manufacture of fiber-reinforced plastics, particularly those containing glass fibers, this silane acts as a coupling agent that significantly improves the mechanical integrity of the composite by forming chemical bonds between the inorganic fiber surface and the surrounding polymer matrix.
This leads to stronger, more durable, and more weather-resistant composite materials used in automotive parts, construction panels, wind turbine blades, and aerospace structures, where strength-to-weight ratio and environmental durability are critical.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is also widely used in industrial and architectural coatings, primers, sealants, and adhesives, where it serves as an adhesion promoter that enhances bonding to metal, concrete, glass, and ceramic surfaces.
By introducing reactive amine groups onto the treated surface, it enables stronger interactions with resins such as epoxy, polyurethane, or acrylic polymers, thereby improving peel strength, water resistance, and long-term adhesion, even under harsh environmental conditions such as high humidity, temperature cycling, or chemical exposure.
Thanks to its tri-amine structure, this silane is used as a crosslinking agent or chain extender in reactive resin systems, particularly in epoxy and polyurethane formulations, where it reacts with isocyanate or epoxy groups to form highly crosslinked polymer networks.
This results in materials with enhanced toughness, chemical resistance, and thermal stability, making it suitable for high-performance coatings, structural adhesives, and potting compounds used in electronics and automotive applications.
In nanotechnology and biomedical fields, this silane is used to functionalize nanoparticles, such as silica, titania, or iron oxide, by creating a reactive amino-functional shell that allows further attachment of biomolecules, targeting ligands, or drugs.
This makes it highly valuable for drug delivery systems, diagnostic imaging, and biosensor platforms, where specific interactions between the nanoparticle surface and biological targets are required for functionality and selectivity.
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is also employed in the semiconductor and electronics industries to modify silicon wafers, glass slides, or other dielectric substrates, improving their surface reactivity for thin film deposition, micro-patterning, or sensor fabrication.
Its amine groups can be used to immobilize biomolecules or conductive species, making it suitable for use in biosensors, lab-on-a-chip devices, or microfluidic systems that require stable and reactive surface chemistry.
Due to its ability to participate in sol-gel reactions, it is often added to organosilicate or hybrid coating formulations, where it contributes to the formation of flexible, transparent, and chemically resistant films.
These films are used in applications such as anti-fogging coatings, protective optical layers, or barrier films for packaging, where a combination of flexibility and environmental resistance is desired.
In analytical chemistry, this silane is used to modify the surface of silica-based chromatographic media by introducing amine groups that can bind to acidic or polar analytes, thereby altering the selectivity and retention behavior in liquid chromatography (LC) or solid-phase extraction (SPE) applications.
Its high density of reactive groups makes it especially effective for preparing customized stationary phases with tailored binding characteristics.
Safety Profile:
3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is classified as an irritant to skin and eyes, primarily due to the presence of amine groups, which are known to be corrosive or irritating to biological tissues.
Upon contact, the amine functionality may cause redness, burning, or even chemical burns, particularly with prolonged or repeated exposure.
The irritation is often more severe if the compound is used in concentrated or unneutralized form.
For this reason, direct contact with skin and mucous membranes should be avoided, and appropriate protective equipment—such as gloves, safety goggles, and lab coats—should always be used when handling the substance.
Inhalation of the vapors, aerosols, or decomposition products of this silane can irritate the respiratory tract, causing symptoms such as coughing, throat discomfort, or shortness of breath, especially in poorly ventilated spaces.
The amine odor is typically strong and unpleasant, and excessive exposure may lead to inflammatory responses in the lungs, especially in sensitive individuals.
Industrial use should take place in areas with local exhaust ventilation, and respiratory protection should be considered when airborne concentrations might exceed occupational exposure limits (if applicable).
While not highly flammable under normal conditions, 3-2-2-Aminoethylamino(ethylamino)propyltrimethoxysilane is combustible, and in the event of a fire, it may decompose into toxic vapors, including nitrogen oxides (NOₓ), carbon oxides (CO, CO₂), and silicon oxides (SiO₂).
These by-products can pose additional respiratory risks for anyone nearby.
When exposed to moisture—either during use or storage—this trimethoxysilane compound may hydrolyze, producing methanol as a by-product.
Methanol is a highly toxic substance, known for causing central nervous system depression, visual disturbances, and potentially irreversible organ damage upon ingestion, inhalation, or significant dermal exposure.
