3-AMINO-1H-1,2,4-TRIAZOLE,95%

3-Amino-1H-1,2,4-Triazole,95% is used catalase inhibitor.
3-Amino-1H-1,2,4-Triazole,95% is used Herbicide; plant regulator.
3-Amino-1H-1,2,4-Triazole,95% is used as a post-emergence herbicide.

CAS No.61-82-5
EC Number: 200-521-5
Molecular Formula:C2H4N4
MDL Number:MFCD00005230

SYNONYMS:
3-AMINO-1,2,4-TRIAZOLE, AMITROLE, 3-AT, AT, 1H-1,2,4-Triazol-3-amine, AMINOTRIAZOLE, 3-AMINO-1H-1,2,4-TRIAZOLE, 3-Aminotriazole, 1H-1,2,3-triazol-4-amine, 3-amino-s-triazole, 3-amino-1,2,4-triazole, amitrole, aminotriazole, 4h-1,2,4-triazol-3-amine, 1h-1,2,4-triazol-3-amine, amitrol, amerol, amizol, emisol, vorox, 1H-1,2,4-Triazol-3-amine, s-Triazole, 3-amino-, Aminotriazole (plant regulator), Amitrol, Amitrol 90, Amitrole, Amizol, Azaplant, ATA, Cytrol, Cytrole, ENT 25445, Herbidal Total, Weedazol, 3-Amino-1,2,4-triazol, 3-Amino-1,2,4-triazole, 3-Amino-1H-1,2,4-triazole, 3-Aminotriazole, 3-AT, 1,2,4-triazol-3-ylamine, x-all Liquid, Amerol, Aminotriazol-spritzpulver, Aminotriazole, Amitolamitril, Amitril T.L., Amitrol-T, Amizol D, Amizol DP NAU, Amizol F, Azaplant kombi, Azolan, Azole, AT, Campaprim A 1544, Diurol 5030, Elmasil, Emisol, Emisol F, Emisol 50, Fenavar, Herbizole, Kleer-Lot, Orga-414, Radoxone TL, Ramizol, Solution concentree T271, Triazolamine, USAF XR-22, Vorox, Vorox AA, Vorox AS, Weedar ADS, Weedar AT, Weedazin, Weedazin arginit, Weedazol super, Weedazol GP2, Weedazol T, Weedex granulat, Weedoclor, 2-Amino-1,3,4-triazole, 5-Amino-1H-1,2,4-triazole, 1H-1,2,4-Triazole-3-amine, Aminotriazole bayer, MSS aminotriazole, 1H-1,2,4-Triazol-5-amine, Maxata, 1H-1,2,4-Triazole, 3-amino-, 1H-1,2,4-Triazol-3-ylamine, 5-Amino-1,2,4-triazole, 2,3,5,6-Tetraazabicyclo[2.1.1]hex-1-ene, TMG, Aminotriazole, ATA, 3-Amino-s-triazole, 1,2,4-Triazol-3-amine, Triazolamine, 1H-1,2,4-Triazol-3-amine, 1,2,4-Triazol-3-amine, aminotriazole, Amitrol, Amitrole, 3-Aminotriazole, 2-Amino-1,3,4-triazole

3-Amino-1H-1,2,4-Triazole,95% is a heterocyclic organic compound that consists of 1,2,4-triazole with an amino group as a substituent.
3-Amino-1H-1,2,4-Triazole,95% is a competitive inhibitor of the product of the HIS3 gene, imidazoleglycerol-phosphate dehydratase.
Imidazoleglycerol-phosphate dehydratase is an enzyme catalyzing the sixth step of histidine production.

3-Amino-1H-1,2,4-Triazole,95% is also a nonselective systemic triazole herbicide used on nonfood croplands to control annual grasses and broadleaf and aquatic weeds. 
As an herbicide, 3-Amino-1H-1,2,4-Triazole,95% is known as aminotriazole, amitrole or amitrol.

3-Amino-1H-1,2,4-Triazole,95% was included in a biocide ban proposed by the Swedish Chemicals Agency and approved by the European Parliament on January 13, 2009.
3-Amino-1H-1,2,4-Triazole,95%'s mode of action is unknown, though it is classed as a resistance group Q herbicide.

3-Amino-1H-1,2,4-Triazole,95% is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H2O2 into H2O and O2. 
Impeding the natural clearance of H2O2 from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 

3-Amino-1H-1,2,4-Triazole,95% also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. 
When 3-Amino-1H-1,2,4-Triazole,95% is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.

3-Amino-1H-1,2,4-Triazole,95% is a triazine herbicide. 
3-Amino-1H-1,2,4-Triazole,95% is a white powder or crystals
3-Amino-1H-1,2,4-Triazole,95% is a colorless to off-white crystalline solid or white powder. 

3-Amino-1H-1,2,4-Triazole,95% is odorless when pure.
3-Amino-1H-1,2,4-Triazole,95% is a powerful plant growth suppressant and cotton defoliant that is readily absorbed by leaves and roots. 
3-Amino-1H-1,2,4-Triazole,95% inhibits many aspects of growth and differentiation including cell division in the primary root meristems in some plants.

3-Amino-1H-1,2,4-Triazole,95% is a odorless white crystals or white powder. 
3-Amino-1H-1,2,4-Triazole,95% has bitter taste. 

Melting point of 3-Amino-1H-1,2,4-Triazole,95% is 147-159°C. 
3-Amino-1H-1,2,4-Triazole,95% sublimes undecomposed at reduced pressure. 

USES and APPLICATIONS of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
3-Amino-1H-1,2,4-Triazole,95% is used to destroy quackgrass and other deep-rooted perennials in certain areas such as vineyards or orchards but also for weeding alleys, parks, pavements, roadsides. 
3-Amino-1H-1,2,4-Triazole,95% is generally used in combination with thiocyanate, ammonium, which acts as an activator, and with other herbicides.

3-Amino-1H-1,2,4-Triazole,95% is not used on food crops because of its carcinogenic properties. 
Herbicide: 3-Amino-1H-1,2,4-Triazole,95% is used to control weeds by inhibiting catalase enzymes in plants.
Research Chemical: 3-Amino-1H-1,2,4-Triazole,95% is applied in biochemical and pharmaceutical studies.

Industrial Applications: 3-Amino-1H-1,2,4-Triazole,95% is utilized as an intermediate in the synthesis of various organic compounds, including polymers and pharmaceuticals.
Agricultural Uses of 3-Amino-1H-1,2,4-Triazole,95%: Herbicide, Plant growth regulator: A non-food use herbicide for control of grasses, woody plants and broad-leaf weeds on hard surface and in areas where crops are not normally grown.

3-Amino-1H-1,2,4-Triazole,95% is used nonselective, foliage-applied, systemic, triazole herbicide used in uncropped land and orchards to control certain grasses and to kill annual and perennial grasses and weeds. 
3-Amino-1H-1,2,4-Triazole,95% is also effective on poison ivy, poison oak and aquatic weeds.

3-Amino-1H-1,2,4-Triazole,95% is used catalase inhibitor.
3-Amino-1H-1,2,4-Triazole,95% is used Herbicide; plant regulator.
3-Amino-1H-1,2,4-Triazole,95% is used as a post-emergence herbicide.

APPLICATIONS OF 3-AMINO-1H-1,2,4-TRIAZOLE,95% IN MICROBIOLOGY:
Applications in microbiology
By applying 3-Amino-1H-1,2,4-Triazole,95% to a yeast cell culture which is dependent upon a plasmid containing HIS3 to produce histidine (i.e. its own HIS3 analogue is not present or nonfunctional), an increased level of HIS3 expression is required in order for the yeast cell to survive. 

This has proved useful in various two-hybrid system, where a high-affinity binding between two proteins (i.e., higher expression of the HIS3 gene) will allow the yeast cell to survive in media containing higher concentrations of 3-Amino-1H-1,2,4-Triazole,95%. 
This selection process is performed using selective media, containing no histidine.

PRODUCTION METHODS OF 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
3-Amino-1H-1,2,4-Triazole,95% is synthesized by condensing formic acid with aminoguanidine and can be purified by recrystallization from methanol.

PROPERTIES AND BENEFITS OF 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
*Functions as a nitrogen-rich precursor for chemical reactions.
*Known for its role in studying enzyme inhibition mechanisms.
*Effective in selective weed management due to its mode of action.

AIR & WATER REACTIONS OF 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
3-Amino-1H-1,2,4-Triazole,95% is water soluble.
Aqueous solutions of 3-Amino-1H-1,2,4-Triazole,95% are neutral. 

REACTIVITY PROFILE OF 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
3-Amino-1H-1,2,4-Triazole,95% is a triazole derivative. 
The triazoles are a group that contain several derivatives that are highly explosive materials. 

They are sensitive to heat, friction, and impact. 
Sensitivity varies with the type substitution to the triazole ring. 
Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. 

Azido and nitro derivatives have been employed as high explosives. 
No matter the derivative these materials should be treated as explosives. 
3-Amino-1H-1,2,4-Triazole,95% forms chelates with some metals. 

3-Amino-1H-1,2,4-Triazole,95% is corrosive to iron, copper and aluminum. 
Forms salts with most acids and alkalis. 
3-Amino-1H-1,2,4-Triazole,95% is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides .

PHYSICAL and CHEMICAL PROPERTIES of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
CBNumber: CB6767936
Molecular Formula: C2H4N4
Molecular Weight: 84.08
MDL Number: MFCD00005230
MOL File: 61-82-5.mol
Chemical Formula: C2H4N4
Molecular Weight: 84.07996 g/mol
IUPAC Name: 1H-1,2,4-triazol-5-amine
SMILES String: Nc1ncn[nH]1

InChI: InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)
InChIKey: KLSJWNVTNUYHDU-UHFFFAOYSA-N
Melting point: 150-153 °C (lit.)
Boiling point: 144.35°C (rough estimate)
Density: 1.138
Vapor pressure: <0.1 hPa (20 °C)
Refractive index: 1.6260 (estimate)
Storage temp.: Store below +30°C.
Solubility: 280g/l

Form: Powder or Flakes
pKa: 11.14±0.20 (Predicted)
Color: White to off-white or yellow
pH: 6.4-7.4 (100g/l, H2O, 20℃)
Water Solubility: 280 g/L (20 ºC)
Merck: 14,489
BRN: 107687
Exposure limits: NIOSH REL: TWA 0.2 mg/m3; 
ACGIH TLV: TWA 0.2 mg/m3.

Stability: Stable. 
Incompatible with iron, copper, 
aluminium, acids, alkalies, strong oxidizing agents, 
acid chlorides, acid anhydrides. 
Forms chelates with some metals. 
Moisture sensitive.
LogP: -0.860
CAS DataBase Reference: 61-82-5 (CAS DataBase Reference)
EWG's Food Scores: 7

FDA UNII: ZF80H5GXUF
IARC: 3 (Vol. 79, Sup 7) 2001
Proposition 65 List: Amitrole
NIST Chemistry Reference: 3-Amino-s-triazole (61-82-5)
EPA Substance Registry System: Amitrole (61-82-5)
Pesticides Freedom of Information Act (FOIA): Amitrole
CAS Min %: 94.0
CAS Max %: 100.0
Melting Point: 149°C to 156°C

Color: White or Yellow
Infrared Spectrum: Authentic
Assay Percent Range: 95%
Beilstein: 26, 137
Merck Index: 15, 485
Solubility Information: Solubility in water: 280g/L (20°C). 
Other solubilities: 520g/L (50°C), sparingly soluble in chloroform, 
dichloromethane, and acetonitrile, slightly soluble in ethyl acetate, 
practically insoluble in diethyl ether, hydrocarbons, acetone

Formula Weight: 84.08
Percent Purity: 95%
Physical Form: Powder or Flakes
Chemical Name or Material: 3-Amino-1H-1, 2, 4-triazole, 95%
PubChem CID: 1639
ChEBI: CHEBI:40036
IUPAC Name: 1H-1,2,4-triazol-5-amine
SMILES: NC1=NC=NN1
CAS: 61-82-5

Molecular Formula: C2H4N4
Molecular Weight (g/mol): 84.08
MDL Number: MFCD00005230, MFCD00053362
InChI Key: KLSJWNVTNUYHDU-UHFFFAOYSA-N
IUPAC Name: 1H-1,2,4-triazol-5-amine
Molecular Formula: C2H4N4
InChI Key: KLSJWNVTNUYHDU-UHFFFAOYSA-N
SMILES: NC1=NC=NN1
Molecular Weight (g/mol): 84.08
Synonym: 5-amino-1H-1,2,4-triazole amitrole (iso)

CAS: 61-82-5
Appearance (Form): Powder or flakes
Titration with HClO4: >=94 %
Appearance (Color): White to off-white to yellow
Infrared spectrum: Conforms
Melting point: 147°C to 156°C
CAS number: 61-82-5
EC index number: 613-011-00-6
EC number: 200-521-5

Hill Formula: C₂H₄N₄
Molar Mass: 84.08 g/mol
HS Code: 2933 99 99
Density: 1.54 g/cm³ (20 °C)
Ignition temperature: >225 °C
Melting Point: 159 °C
pH value: 6.4 - 7.4 (100 g/l, H₂O, 20 °C)
Vapor pressure: <0.1 hPa (20 °C)
Bulk density: 650 kg/m³
Solubility: 280 g/l

CAS Number: 61-82-5
EC Number: 200-521-5
Molecular Formula: C₂H₄N₄
Molecular Weight: 84.08 g/mol
Appearance: White to off-white crystalline powder
Melting Point: 155-160°C
Boiling Point: Decomposes before boiling
Density: ~1.56 g/cm³
Solubility in Water: Soluble (approximately 12 g/L at 20°C)
pH: Weakly acidic in aqueous solutions

Vapor Pressure: Negligible under standard conditions
Chemical formula: C2H4N4
Molar mass: 84.082 g·mol−1
Appearance: Colorless/white crystals or powder
Odor: Odorless
Density: 1.138 g/mL
Melting point: 157 to 159 °C (315 to 318 °F; 430 to 432 K)
Boiling point: 347
Solubility in water: 28 g/100 mL
Solubility: Soluble in acetonitrile, chloroform, ethanol, methanol, 
methylene chloride, negligible in ethyl acetate
Vapor pressure: 3.13x10⁻⁹ mmHg

FIRST AID MEASURES of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of 3-AMINO-1H-1,2,4-TRIAZOLE,95%:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available