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5-BROMO-5-NITRO-1,3-DIOXANE

CAS Number 30007-47-7 

SYNONYMS :
1,3-DIOXANE, 5-BROMO-5-NITRO-, 1,3DIOXANE, 5BROMO5NITRO, 5-BROMO-5-NITRO- 1,3-DIOXANE, 5-BROMO-5-NITRO-1,3 DIOXANE, 5-BROMO-5-NITRO-1,3 DIOXANE (FORMALDEHYDE RELEASER), and 5-BROMO-5-NITRO-1,3-DIOXANE
5-Bromo-5-nitro-1,3-dioxane
5-    bromo-5-nitro-m-dioxane
     bronidox
     bronidox L
1,3-    dioxane, 5-bromo-5-nitro-
m-    dioxane, 5-bromo-5-nitro-
5-Brom-5-Nitro-1,3-Dioxan
5-Bromo-5-nitro-m-Dioxan or 5-Bromo-5-nitro-m-Dioxane
1,3-Dioxane, 5-Bromo-5-Nitro-
BRONIDOX® L5
BRONIDOX® L
BND;BRONIDOX;BRONIDOX L;5-BROMO-5-NITRO-1,3-DIOXANE;3-Dioxane,5-bromo-5-nitro-1;5-Brom-5-nitro-1,3-dioxan;5-bromo-5-nitro-3-dioxane;5-bromo-5-nitro-m-dioxan
5-Bromo-5-Nitro-1,3-DioxolaneBNDBronidoxBronidox L3-Dioxane,5-bromo-5-nitro-15-Brom-5-nitro-1,3-dioxan5-Bromo-5-Nitro-3-Dioxane5-Bromo-5-Nitro-M-Dioxan5-Bromo-5-Nitro-1,3-Dioxame
BND;BRONIDOX;BRONIDOX L;MicrocideItm;5-bromo-5-nitro-m-dioxan;5-Bromo-5-nitro-m-dioxane;5-bromo-5-nitro-3-dioxane;5-Brom-5-nitro-1,3-dioxan;3-Dioxane,5-bromo-5-nitro-1;5-BROMO-5-NITRO-1,3-DIOXANE
Bronidox L
30007-47-7
5-bromo-5-nitro-1,3-dioxolane
BND
BRONIDOX
BRONIDOX L
3-Dioxane,5-bromo-5-nitro-1
5-Brom-5-nitro-1,3-dioxan
5-bromo-5-nitro-3-dioxane
5-bromo-5-nitro-m-dioxan
5-Bromo-5-Nitro-1,3-Dioxame
Bronidox

1,3-Dioxane, 5-bromo-5-nitro-

5-Bromo-5-nitro-m-dioxane

UNII-U184I9QBNM

5-Brom-5-nitro-1,3-dioxan

EINECS 250-001-7

m-DIOXANE, 5-BROMO-5-NITRO-

5-Brom-5-nitro-1,3-dioxan [German]

BRN 4668673

U184I9QBNM

C4H6BrNO4

Bronidox L

ACMC-209hcf

DSSTox_CID_24560

DSSTox_RID_80313

DSSTox_GSID_44560

SCHEMBL97282

[DID-no:2403]

CHEMBL3185787

DTXSID1044560

SCHEMBL17347337

CTK1C2254

KS-00000WZD

ZINC2011293

Tox21_301588

ANW-26749

MFCD00101855

AKOS015834980

CS-W015032

HY-W014316

5-BROMO-5-NITRO-1,3- DIOXANE

NCGC00255969-01

AS-15941

LS-62273

R448

5-Bromo-5-nitro-1,3-dioxane, >=99%

CAS-30007-47-7

DB-047687

B3156

B3769

FT-0620143

NS00005997

A-3302

5-Bromo-5-nitro-1,3-dioxane, analytical standard

Q-200534

Q4973879
Biozen-L10 (5-Bromo-5-Nitro-1,3-Dioxane)


Formal Name
5-bromo-5-nitro-1,3-dioxane
CAS Number
30007-47-7
Synonyms
Bronidox
Molecular Formula
C4H6BrNO4
Formula Weight
212.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
(Learn about Variance in Solubility)
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
Ethanol: 25 mg/ml
SMILES
BrC1([N+]([O-])=O)COCOC1
InChi Code
InChI=1S/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2
InChi Key
XVBRCOKDZVQYAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years

Product Description
5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.1 Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth.1 This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.

WARNING This product is not for human or veterinary use.

Technical Support & Resources
Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.


Applications
5-Bromo-5-nitro-1,3-dioxane is used as a stabilizer and preserving agent for biological molecules and solutions such as antibodies and antisera. Bronidox is used in a variety of rinse-off cosmetic. It can be used alone or in combination with methylisothiazolone.

Solubility
Soluble in water at 12.5mg/ml

Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Safety and Handling
GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

H302-H315-H319-H335

EINECSNumber : 250-001-7

RTECSNumber : JG9650000

TSCA : Yes

Recommended Storage : Keep cold


5-Bromo-5-nitro-1,3-dioxane is used as a stabilizer and preserving agent for biological molecules and solutions such as antibodies and antisera. Bronidox is used in a variety of rinse-off cosmetic. It can be used alone or in combination with methylisothiazolone.

5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol.

Functions:preservative

    5-Bromo-5-nitro-1,3-dioxane, an antimicrobial agent active against bacteria, yeast and fungi, may be used as a stabilizer and preserving agent for biological molecules and solutions such as antibodies and antisera. It is used as preservative to avoid use of sodium azide.

5-Bromo-5-nitro-1,3-dioxane is used as a stabilizer and preserving agent for biological molecules and solutions such as antibodies and antisera. Bronidox is used in a variety of rinse-off cosmetic. It can be used alone or in combination with methylisothiazolone.

Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Biological Significance    5-Bromo-5-nitro-1,3-dioxane is an antimicrobial chemical compound and causes inhibition of enzyme activity in bacteria

5-Bromo-5-Nitro-1,3-Dioxane is a white powder. In cosmetics and personal care products, 5-Bromo-5-Nitro-1,3-Dioxane is used as a preservative in bath, hair and personal cleanliness products.

Why is it used in cosmetics and personal care products?
5-Bromo-5-Nitro-1,3-Dioxane functions as a preservative. It prevents or retards bacterial growth, and thus protects cosmetic and personal care products from spoilage. Follow this link for more information about how a preservatives protect cosmetics and personal care products.

Scientific Facts: 
5-Bromo-5-Nitro-1,3-Dioxane is a cyclic aliphatic ether. It is also used as a preservative in water systems, paints, cutting oils and in leather processing.

Hazard statements
Harmful if swallowed. (Acute toxicity, oral, category 4)nIrritating to skin. (Skin corrosion/irritation, category 2)nMay be irritating to mucous membrane and upper respiratory system. (Specific target organ toxicity, single exposure; Respiratory tract irritation, category 3)
Precautionary statements
Eye contact: Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. (P338)nSkin contact: Wash thoroughly with soap and water. Get medical attention if irritation develops or persists. (P352)nInhalation: Remove to fresh air.
 If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. (P340)nStore in a tightly closed container. 
(P404)nStore in a cool dry place. (P235)nDo not breathe dust. (P260)nDo not get in eyes, on skin or clothing. (P262)nThis product should only by used by persons trained in the safe handling of hazardous chemicals. (P202)nWash thoroughly after handling. Do not take internally. Eye wash and safety equipment should be readily available. (P264)nRespiratory Protection:
 If workplace exposure limit(s) of product or any component is exceeded (see TLV/PEL), or a risk assessment shows air-purifying respirators are appropriate, use of a NIOSH/MSHA approved air supplied respirator is advised. Use a full-face respirator with multi-purpose combination (US) or type ABEK (EN14387) respirator cartridges in absence of proper environmental control.
 Always use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Engineering and/or administrative controls should be implemented to reduce exposure.

5-Bromo-5-nitro-1,3-dioxane is used as a stabilizer and preserving agent for biological molecules and solutions such as antibodies and antisera. Bronidox is used in a variety of rinse-off cosmetic. It can be used alone or in combination with methylisothiazolone.

5-Bromo-5-nitro-1,3-dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.

 Bronidox® (Registered Tradmark of Cognis Corp) is chemical compound 5-Bromo-5-Nitro-1,3-Dioxane. Its use on goods without license from Cognis is strictly prohibited.
pH: 6-7
Stable under normal conditions
Non reactive with enzyme/substrate in assays but causes inhibition of enzyme activity n Bacteria [3]
BRONIDOX® L5 is corrosive on metals [4]

Used as
Stabilizer
Surfactant
It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
Bactericide. Very effective against yeast and fungi.
used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1 %.
Safety
Harmful
Harmful if swallowed R22
Toxic - tremor, convulsions, excitement
Irritating to skin R38 - dermatitis
wear suitable protective clothing S36
relatively non-toxic to mammals
some users do not recommend use in preparations destined for in vivo or tissue culture work [6]
Combustion products: carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen bromide gas, sulphur oxides, hydrogen chloride gas [7]
Toxicology
according to FSASAX

Oral:
LD50, mouse, oral 590 mg/kg 24 hours
LD50, rat, oral 455 mg/kg 24 hours
LD50, rat, ipr. 31 mg/kg 24 hours
Skin:
LD50, mouse, skin 2500 µg/24 hours
LD50, rat, skin 2500 µg/24 hours


5-Bromo-5-nitro-1,3-dioxane is used as a stabilizer and preserving agent for biological molecules and solutions such as antibodies and antisera. Bronidox is used in a variety of rinse-off cosmetic. It can be used alone or in combination with methylisothiazolone.

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound. In cosmetics and personal care products, 5-Bromo-5-Nitro-1,3-Dioxane is used as a preservative in bath, hair and personal cleanliness products. Bronidox causes inhibition of enzyme activity in bacteria. 5-Bromo-5-Nitro-1,3-Dioxane functions as a preservative. It prevents or retards bacterial growth, and thus protects cosmetic and personal care products from spoilage. 5-Bromo-5-Nitro-1,3-Dioxane is a cyclic aliphatic ether. It is also used as a preservative in water systems, paints, cutting oils and in leather processing.

5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth. This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.

 5-Bromo-5-nitro-1,3-dioxane may be used as an analytical reference standard for the determination of the analyte in rinse-off cosmetics by solid-phase microextraction gas chromatography with microelectron-capture detection method (SPME-GC-μECD).[1]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.



 

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