ACETAMIDE MEA

Acetamide MEA a member of the class of ethanolamines that is 2-aminoethanol in which one of the hydrogens of the amino group is replaced by an acetyl group.
Acetamide MEA is a cosmetic ingredient widely used for its moisturizing and conditioning properties. 
Acetamide MEA is a clear and colorless liquid with a mild odor. 

CAS Number: 142-26-7
Molecular Formula: C4H9NO2
Molecular Weight: 103.12
EINECS Number: 205-530-8

Synonyms: N-(2-Hydroxyethyl)acetamide, N-Acetylethanolamine, 142-26-7, 2-Acetamidoethanol, Acetylcolamine, Acetamide, N-(2-hydroxyethyl)-, Acetamide MEA, 2-Acetylaminoethanol, N-Ethanolacetamide, N-Acetyl-2-aminoethanol, Hydroxyethyl acetamide, N-Acetyl ethanolamine, ACETYLETHANOLAMINE, N-2-Hydroxyethylacetamide, Acetic monoethanolamide, beta-Hydroxyethylacetamide, N-beta-Hydroxyethylacetamide, NSC 5999, HSDB 2713, EINECS 205-530-8, BRN 1811708, A9O0818TWD, Acetic acid amide, N-(2-hydroxyethyl)-, DTXSID6044804, AI3-02836, NSC-5999, ACETAMIDE MEA [VANDF], acetamide, N-(2-hydroxyethyl), DTXCID4024804, ACETYLETHANOLAMINE [HSDB], CHEBI:74687, 4-04-00-01535 (Beilstein Handbook Reference), NEthanolacetamide, 2Acetamidoethanol, NAcetylethanolamine, 2Acetylaminoethanol, NAcetyl ethanolamine, NAcetyl2aminoethanol, betaHydroxyethylacetamide, NbetaHydroxyethylacetamide, RefChem:552499, N(2Hydroxyethyl)acetamide, ACETAMIDE MEA [INCI], N-(beta-Hydroxyethyl)acetamide, Acetic acid amide, N(2hydroxyethyl), ACETIC ACID, AMIDE, N(2-HYDROXYETHYL)-, InChI=1/C4H9NO2/c1-4(7)5-2-3-6/h6H,2-3H2,1H3,(H,5,7), MFCD00002836, .beta.-Hydroxyethylacetamide, N-(.beta.-Hydroxyethyl)acetamide, N-Acetylethanolamine (~90%), UNII-A9O0818TWD, Hetamide MA, Carsamide AMEA, Lipamide MEAA, Amidex AME, Upamide ACMEA, N-acetyl-ethanolamine, Schercomid AME 70, Foamid AME-70, Foamid AME-75, Mackamide AME-100, Foamid AME-100, Incromectant AMEA-70, Incromectant AMEA-100, n-2-hydroxyethyl-acetamide, WLN: Q2MV1, SCHEMBL48502, N-(2-hydroxyethyl)-acetamide, SCHEMBL149184, SCHEMBL209977, N-(2-hydroxy-ethyl)-acetamide, SCHEMBL1563041, SCHEMBL5753972, SCHEMBL5754056, CHEMBL3188272, NSC5999, Tox21_301724, N-Acetylethanolamine, technical grade, SBB007954, STL283925, AKOS005206796, CS-W013689, FD10637, FS-4296, NCGC00256051-01, CAS-142-26-7, FA183124, SY007881, DB-000300, A0075, A1935, NS00001024, EN300-15590, F094790, Q27144824, 2-acetylamino-ethanol;Acetamide MEA;Acetamide MEA (1:1);Acetylcolamine;Lipamide MEAA;Mackamide AME-75, AME-100;n-(2-hydroxyethyl)-acetamid;N-(beta-Hydroxyethyl)acetamide

Acetamide MEA functions as a humectant, helping to attract and retain moisture in the skin and hair, promoting hydration and softness. 
Acetamide MEA can act as a pH adjuster and emulsifier, enhancing the stability of formulations. 
Due to its versatility and beneficial effects on the skin and hair, Acetamide MEA is commonly found in various personal care products. 

The chemical formula of Acetamide MEA is CH3CONH2.
Acetamide MEA belongs to the group of alkanolamides, which are widely used to enhance the performance of surfactant systems.
These compounds combine amide functionality with alcohol groups.

This gives them both hydrophilic and mild surface-active properties.
The molecule exhibits good water-binding capacity, allowing it to function effectively as a humectant.
It helps retain moisture in formulations and on the skin.

This contributes to improved hydration and softness.
Acetamide MEA is often used to improve formulation texture and feel.
It provides a smooth, non-greasy sensory profile.

This enhances the overall user experience.
Acetamide MEA can act as a secondary surfactant or co-surfactant.
Acetamide MEA helps improve foam quality and stability in cleansing systems.

This is useful in shampoos and liquid cleansers.
Acetamide MEA shows good compatibility with common cosmetic ingredients, including anionic and nonionic surfactants.
Acetamide MEA can be incorporated into aqueous and emulsion systems.

This versatility supports a wide range of formulations.
The presence of both amide and hydroxyl groups allows it to participate in hydrogen bonding interactions.
These interactions help stabilize formulations.

They also contribute to viscosity and texture control.
Acetamide MEA is typically stable under normal processing conditions, including moderate heating.
Acetamide MEA maintains performance over typical cosmetic pH ranges.

This ensures consistent product quality.
Because it is derived from simple organic components, acetamide MEA is often used as a functional additive in personal-care formulations.
Its performance depends on concentration and formulation type.

Different grades may be available.
Acetamide MEA is a multifunctional, water-soluble alkanolamide that provides moisture retention, conditioning, and formulation stability, particularly in cosmetic and cleansing systems.
Acetamide MEA provides mild conditioning effects on both skin and hair surfaces.

It helps improve softness and smoothness after application.
This contributes to a more pleasant sensory experience.
Acetamide MEA can enhance foam texture rather than foam volume.

Acetamide MEA produces a creamier and more stable lather.
This is desirable in personal-care cleansing products.
Acetamide MEA helps improve viscosity and formulation body in aqueous systems.

It contributes to thicker, more stable products.
This supports better handling and appearance.
Because of its hydrophilic nature, it supports moisture retention in formulations.

Acetamide MEA helps prevent drying of the skin after cleansing.
This is beneficial in mild and moisturizing products.
The molecule can assist in solubilizing certain ingredients, such as fragrances or actives.

It helps maintain uniform distribution.
This improves formulation stability.
Acetamide MEA is often used in systems where mildness is important, such as sensitive-skin products.

Acetamide MEA does not significantly increase irritation potential.
This makes it suitable for gentle formulations.

Melting point: 15.8 °C
Boiling point: 151–155 °C / 5 mmHg (lit.)
Density: 1.12 g/mL at 25 °C (lit.)
Vapor pressure: 0.368–10.5 Pa at 25–70 °C
Refractive index: n20/D 1.472 (lit.)
Flash point: 350 °F
Storage temperature: Sealed in dry conditions, room temperature
Solubility: Chloroform (sparingly), Methanol (slightly)
pKa: 14.56 ± 0.10 (predicted)
Form: Liquid
Color: Clear white to yellow
Water solubility: Soluble in water (1×10⁶ mg/L at 25 °C, estimated); also soluble in alcohol and ether
Cosmetics ingredients functions: Surfactant – cleansing; Hair conditioning; Humectant; Skin conditioning; Surfactant – foam boosting; Viscosity controlling
Cosmetic Ingredient Review (CIR): 2-Acetylaminoethanol (CAS 142-26-7)
InChI: 1S/C4H9NO2/c1-4(7)5-2-3-6/h6H,2-3H2,1H3,(H,5,7)
InChIKey: PVCJKHHOXFKFRP-UHFFFAOYSA-N
SMILES: CC(=O)NCCO
LogP: −0.117 at 22.2 °C and pH 5.4
Surface tension: 72.1 mN/m at 1 g/L and 21.4 °C

Acetamide MEA is a synthetic organic compound derived from acetic acid and monoethanolamine, commonly used as a surfactant, humectant, and conditioning agent in cosmetic and personal-care formulations.
It belongs to the class of alkanolamides.
These compounds are widely used in cleansing and care products.

Chemically, acetamide MEA is formed by the reaction of acetic acid (or acetamide derivatives) with monoethanolamine (MEA).
The molecule contains both a polar amide group and a hydroxyl group.
This structure gives it hydrophilic and surface-active properties.

Physically, acetamide MEA appears as a clear to slightly yellow liquid or viscous substance.
It is soluble in water and compatible with many aqueous systems.
It has a mild odor.

Acetamide MEA functions as a humectant, helping to retain moisture in formulations.
It attracts and holds water.
This contributes to improved hydration in cosmetic products.

The compound also acts as a conditioning and softening agent.
It improves the feel of skin and hair.
This enhances the sensory properties of formulations.

Acetamide MEA can function as a co-surfactant or formulation aid.
It helps stabilize emulsions and improve ingredient compatibility.
This supports formulation performance.

Acetamide MEA is generally stable under normal cosmetic formulation conditions.
It performs well over a typical pH range.
This makes it suitable for a variety of personal-care products.

Acetamide MEA is best described as a water-soluble alkanolamide used as a humectant, conditioning agent, and formulation aid in cosmetic and personal-care applications.
Acetamide MEA may also contribute to improved spreadability and application properties.
Products containing it tend to apply smoothly.

The ingredient is generally compatible with water-based formulations and emulsions.
Acetamide MEA can be used alongside other conditioning agents and surfactants.
This allows flexible formulation design.

Acetamide MEA is a mild, multifunctional ingredient that enhances moisture retention, foam quality, viscosity, and sensory performance in cosmetic and personal-care formulations.
Acetamide MEA can contribute to improved formulation stability by supporting uniform dispersion of ingredients.
It helps prevent separation in aqueous and emulsion systems.

This ensures consistent product performance over time.
The compound enhances hydration balance in cleansing formulations.
It reduces the drying effect often associated with strong surfactants.

This makes products feel gentler on the skin.
Acetamide MEA may assist in forming structured liquid systems through hydrogen bonding interactions.
These structures contribute to viscosity and product body.

This is useful in shampoos and liquid cleansers.
Acetamide MEA can improve compatibility between different formulation components, such as surfactants, fragrances, and actives.
This reduces formulation instability issues.

Acetamide MEA helps maintain homogeneous mixtures.
The ingredient supports mild emulsification effects, helping oil and water phases remain mixed.

Uses Of Acetamide MEA:
Acetamide MEA finds its uses as antistatic agent, foam boosting agent, hair conditioning humectant, skin conditioning surfactant and viscosity controlling agent in cosmetics industry. 
Acetamide MEA is a non-tacky glycerine alternative for use in skin and hair care. 
Acetamide MEA has humectant and lubricant properties for use in shampoos, treatment products and hair conditioners.

Acetamide MEA is widely used in shampoos as a humectant and co-surfactant.
Acetamide MEA helps improve moisture retention and foam quality.
This enhances both cleansing performance and hair feel.

In body washes and liquid soaps, it functions as a conditioning and moisturizing agent.
Acetamide MEA reduces dryness caused by surfactants.
This results in a smoother skin feel after washing.

Acetamide MEA is used in facial cleansers to provide mild cleansing with added hydration.
Acetamide MEA supports gentle formulations suitable for daily use.
This improves comfort for sensitive skin.

In hair-care products, including conditioning shampoos, it helps improve softness and manageability.
Acetamide MEA enhances the distribution of conditioning ingredients.
This contributes to better hair texture.

Acetamide MEA is applied in creams and lotions as a humectant and formulation stabilizer.
It helps retain moisture and improve product consistency.
This supports smooth application.

In cosmetic emulsions, it acts as a co-emulsifier and stabilizer.
It helps maintain uniform dispersion of oil and water phases.
This improves product stability.

Acetamide MEA is used in bubble baths to enhance foam stability and texture.
It produces a creamy, long-lasting lather.
This improves the bathing experience.

In personal-care gels and liquid formulations, it helps control viscosity and texture.
Acetamide MEA contributes to thicker, more stable products.
This enhances handling and appearance.

Acetamide MEA is also used in mild and sensitive-skin formulations due to its low irritation potential.
It helps maintain hydration while supporting gentle cleansing.

This makes it suitable for daily-use products.
Acetamide MEA is used wherever moisture retention, foam enhancement, mild conditioning, and formulation stability are required in cosmetic and personal-care products.

Acetamide MEA is used in 2-in-1 shampoo and conditioning formulations to enhance both cleansing and conditioning performance.
It helps maintain a creamy texture while improving moisture retention.
This supports multifunctional hair-care products.

In moisturizing body cleansers, it contributes to reduced skin dryness after washing.
It helps maintain hydration balance.
This improves the overall skin feel.

Acetamide MEA is applied in gentle baby-care products such as mild shampoos and washes.
Its low irritation profile supports sensitive formulations.
This makes it suitable for delicate skin.

In leave-on skin-care products, such as lotions and light creams, it acts as a humectant.
It helps retain moisture in the skin over time.
This enhances hydration performance.

It is used in cleansing gels and micellar-type products to improve ingredient compatibility.
It helps maintain uniform dispersion of actives and surfactants.
This supports formulation clarity and stability.

Acetamide MEA is applied in men’s grooming products, including facial cleansers and shaving products.
It improves lubrication and skin feel.
This enhances comfort during use.

In hair treatment formulations, it helps improve spreadability and product texture.
It supports even distribution of conditioning agents.
This contributes to better performance.

Acetamide MEA is used in cosmetic formulations requiring mildness and hydration, such as products for dry or sensitive skin.
It helps balance cleansing and moisturizing effects.
Acetamide MEA is used wherever hydration support, mild conditioning, improved foam quality, and formulation stability are required, particularly in gentle and daily-use personal-care products.

Safety Profile Of Acetamide MEA:
Acetamide MEA is generally considered to have low to moderate hazard potential, but it should be handled with standard safety precautions in industrial and laboratory settings.
Risks are mainly related to irritation and prolonged exposure to concentrated material.
Proper hygiene and protective measures are recommended.

Skin contact may cause mild irritation, especially with prolonged or repeated exposure.
Symptoms may include redness or dryness.
Protective gloves are recommended during bulk handling.

Eye contact can cause irritation and discomfort.
Exposure may result in redness, tearing, or a burning sensation.
Eyes should be rinsed thoroughly with water if contact occurs.

Inhalation risk is generally low, but vapors or aerosols in industrial environments may cause respiratory irritation.
Symptoms can include coughing or throat discomfort.
Adequate ventilation should be maintained.

Ingestion may cause gastrointestinal irritation.
Symptoms can include nausea or stomach discomfort if large amounts are swallowed.
It is not intended for oral consumption unless specifically approved.

Acetamide MEA is not highly flammable, but it can burn if exposed to strong heat or flame.
Thermal decomposition may produce carbon oxides and nitrogen-containing fumes.
Standard fire safety precautions should be followed.

The material is chemically stable under normal storage conditions.
Acetamide MEA should be stored in tightly closed containers, protected from excessive heat and moisture.