Quick Search
ACUMER 1510 Polymer is a high molecular weight polyacrylic acid homopolymer from Dow Inc. used as a water treatment antiscalant, anticorrosion processing aid, and formulation modifier.
ACUMER 1510 Polymer is a hydrophilic colloidal solution, similar in properties to water-soluble natural gums.
ACUMER 1510 Polymer is a clear, colorless, viscous stable solution.
CAS: 9003-01-4
MF: C5H10O2
MW: 102.1317
EINECS: 618-347-7
Synonyms
940;Carbopol®;CARBOPOL(TM) 941;CARBOPOL(R) 940;CARBOPOL(TM) 940;CARBOPOL(TM) 934;CARBOPOL(TM) 910;CARBOPOL(R) 941
Applications include the modification of aqueous formulations for such end uses as cleaners, binders, adhesives, and emulsion paints.
The sodium, potassium, and ammonium salts are effective thickeners and dispersants useful in both natural and synthetic latex systems.
ACUMER 1510 Polymer in ceramic applications improves dry strength, dispersant action, and improved workability of the clays.
ACUMER 1510 Polymer is stable to hydrolysis and is not susceptible to bacterial degradation.
For a description of unrelated compounds expanded by two carbon units, Poly acrylic acid (PAA or Carbomer) is generic name for synthetic high molecular weight polymers of acrylic acid.
They may be homopolymers of acrylic acid, crosslinked with an allyl ether pentaerythritol, allyl ether of sucrose or allyl ether of propylene.
In a water solution at neutral pH, PAA is an anionic polymer, i.e. many of the side chains of ACUMER 1510 Polymer will lose their protons and acquire a negative charge.
This makes ACUMER 1510 Polymer's polyelectrolytes, with the ability to absorb and retain water and swell to many times their original volume.
Dry ACUMER 1510 Polymer's are found in the market as white and fluffy powders.
Carbomer codes (910, 934, 940, 941 and 934P) are an indication of molecular weight and the specific components of the polymer.
For many applications ACUMER 1510 Polymer's are used in form of alkali metal or amonium salts e.g. sodium polyacrylate.
Carbomers are white-colored, ‘fluffy’, acidic, hygroscopic powders with a characteristic slight odor. A granular carbomer is also available (Carbopol 71G).
ACUMER 1510 Polymer is an anionic polymer that can be synthesized by the free radical polymerization of acrylic acid.
ACUMER 1510 Polymer has a swelling nature that tends to absorb and retain the water.
ACUMER 1510 Polymer's high ion exchange capacity makes it useful in the formation of membranes.
An acrylic macromolecule, composed of acrylic acid repeating units.
ACUMER 1510 Polymer Chemical Properties
Melting point: 95 °C
Boiling point: 116 °C
density: 1.2 g/mL at 25 °C
Tg: 106
vapor pressure: 2.64-3.57hPa at 20-25℃
refractive index: n20/D 1.442
Fp: 100 °C
storage temp.: 2-8°C
solubility: Swellable in water and gzalycerin and, after neutralization, in ethanol (95%). Carbomers do not dissolve but merely swell to a remarkable extent, since they are three-dimensionally crosslinked microgels.
form: Powder
color: White
pH: 2.5 -3.0 (1% water solution)
Water Solubility: Soluble in water.
Dielectric constant: 2.7 - 4.5(0.0℃)
Cosmetics Ingredients Functions: FILM FORMING
BINDING
GEL FORMING
VISCOSITY CONTROLLING
EMULSION STABILISING
InChI: 1S/C3H4O2.Na/c1-2-3(4)5;/h2H,1H2,(H,4,5);/q;+1/p-1
InChIKey: WLAMNBDJUVNPJU-UHFFFAOYSA-N
LogP: 0.23-0.27 at 20℃ and pH3.59-3.63
IARC: 3 (Vol. 19, Sup 7) 1987
EPA Substance Registry System: ACUMER 1510 Polymer (9003-01-4)
Uses
ACUMER 1510 Polymer is used in disposable diapers and in ion exchange resins.
ACUMER 1510 Polymer is also used to study solute diffusion in polyvinyl alcohol/polyacrylic acid copolymer hydrogel.
ACUMER 1510 Polymer is also employed as a thickening, suspending, emulsifying and dispersing agent in pharmaceuticals, cosmetics, adhesives and paints.
Further, ACUMER 1510 Polymer is used for the preparation of poly(N-isopropylacrylamide)-block-polyacrylic acid copolymer which responds to both temperature and pH stimuli.
In addition to this, ACUMER 1510 Polymer is used in preparing block copolymer of oligo (methyl methacrylate)/PAA for micellar delivery of hydrophobic drugs.
Applications of ACUMER 1510 Polymer may include: · to study solute diffusion in Polyvinyl alcohol/PAA copolymer hydrogel · synthesizing poly(N-isopropylacrylamide)-block-PAA copolymer which responds to both temperature and pH stimuli · in preparing block copolymer of oligo ACUMER 1510 Polymer for micellar delivery of hydrophobic drugs as thickening agent for adhesives.
ACUMER 1510 Polymer is a binder, film-former and emulsion stabilizer.
ACUMER 1510 Polymer can also help increase product viscosity.
ACUMER 1510 Polymer and its derivatives are used in disposable diapers,ion exchange resins and adhesives.
They are also popular as a thickening, dispersing, suspending and emulsifying agents in pharmaceuticals, cosmetics and paints.
ACUMER 1510 Polymer inactivates the antiseptic chlorhexidine gluconate.
Pharmaceutical Applications
Carbomers are used in liquid or semisolid pharmaceutical formulations as rheology modifiers. Formulations include creams, gels, lotions and ointments for use in ophthalmic, rectal, topical and vaginal preparations.
Carbomer grades with residual benzene content greater than 2 ppm do not meet the specifications of the PhEur 6.4 monograph.
However, carbomer having low residuals of other solvents than the ICH-defined ‘Class I OVI solvents’ may be used in Europe.
Carbomer having low residuals of ethyl acetate, such as Carbopol 971P NF or Carbopol 974P NF, may be used in oral preparations, in suspensions, capsules or tablets.
In tablet formulations, carbomers are used as controlled release agents and/or as binders.
In contrast to linear polymers, higher viscosity does not result in slower drug release with carbomers.
Lightly crosslinked carbomers (lower viscosity) are generally more efficient in controlling drug release than highly crosslinked carbomers (higher viscosity).
In wet granulation processes, water, solvents or their mixtures can be used as the granulating fluid.
The tackiness of the wet mass may be reduced by including talc in the formulation or by adding certain cationic species to the granulating fluid.
However, the presence of cationic salts may accelerate drug release rates and reduce bioadhesive properties.
ACUMER 1510 Polymers have also been investigated in the preparation of sustained-release matrix beads, as enzyme inhibitors of intestinal proteases in peptide-containing dosage forms, as a bioadhesive for a cervical patch and for intranasally administered microspheres, in magnetic granules for site-specific drug delivery to the esophagus, and in oral mucoadhesive controlled drug delivery systems.
ACUMER 1510 Polymers are also employed as emulsifying agents in the preparation of oil-in-water emulsions for external administration.
ACUMER 1510 Polymer has been investigated as a viscosity-increasing aid in the preparation of multiple emulsion microspheres.
ACUMER 1510 Polymers are also used in cosmetics.
Therapeutically, ACUMER 1510 Polymer formulations have proved efficacious in improving symptoms of moderate-to-severe dry eye syndrome.
Production Methods
ACUMER 1510 Polymers are synthetic, high-molecular-weight, crosslinked polymers of acrylic acid.
These acrylic acid polymers are crosslinked with allyl sucrose or allyl pentaerythritol.
The polymerization solvent used previously was benzene; however, some of the newer commercially available grades of carbomer are manufactured using either ethyl acetate or a cyclohexane–ethyl acetate cosolvent mixture.
The Carbopol ETD and Carbopol Ultrez polymers are produced in the cosolvent mixture with a proprietary polymerization aid.
