ADIPIC ACID DIHYDRAZIDE

Adipic acid dihydrazide is a symmetrical molecule with a C4 backbone, and the reactive group is C=ONHNH2. 
Adipic acid dihydrazide finds major applications as a latent curing agent for B-stageable epoxy resins and as an ambient temperature crosslinking agent for high-performance acrylic emulsion architectural coatings. 
Adipic acid dihydrazide is also employed as a paint additive and coating additive.

CAS Number: 1071-93-8
Molecular Formula: C6H14N4O2
Molecular Weight: 174.2
EINECS Number: 213-999-5

Synonyms: Adipic dihydrazide, 1071-93-8, Adipohydrazide, Adipic acid dihydrazide, Hexanedihydrazide, Hexanedioic acid, dihydrazide, Adipic acid, dihydrazide, Adipoyldihydrazine, adipoyl dihydrazide, MFCD00007614, VK98I9YW5M, DTXSID0044361, Hexanedioic acid, 1,6-dihydrazide, NSC-3378, NSC-29542, WLN: ZMV4VMZ, Adipyl hydrazide, Adipodihydrazide, Adip dihydr, adipic hydrazide, Adipoyl hydrazide, adipic dihydrazone, Hexanedihydrazide #, NSC 3378, EINECS 213-999-5, NSC 29542, Adipic acid dihyrazide, Hexanedioic dihydrazide, AJICURE ADH, QUALIMER ADH, AI3-22640, ULTRALINK HYDRAZIDE, UNII-VK98I9YW5M, EC 213-999-5, Hexanedioic acid dihydrazide, SCHEMBL49856, CHEMBL3185968, DTXCID8024361, SCHEMBL11037942, NSC3378, 1,4-Butanedicarboxylic dihydrazide, ALBB-011767, BK 1000Z, BT 1000Z, NSC29542, STR02658, Tox21_301067, BBL022965, STK709135, AKOS000267183, NCGC00248276-01, NCGC00257525-01, CAS-1071-93-8, DB-022418, A0170, Adipic acid dihydrazide, >=98% (titration), CS-0010116, NS00003709, EN300-03706, D72486, T 2210, Adipic acid dihydrazide, purum, >=97.0% (NT), Q4682936, Z56812730, F1943-0024, InChI=1/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12), ADH, ADIPINIC DIHYDRAZIDE, ADIPIC DIHYDRAZIDE, ADIPIC ACID DIHYDRAZIDE, ADIPIC ACID DIHYDRIZIDE, adipoyl hydrazide, ADIPODIHYDRAZIDE;Adipohydrazide

Adipic acid dihydrazide serves as a difunctional crosslinking agent in paints and coatings applied to specific water-based acrylic emulsions. 
Adipic acid dihydrazide acts as a hardener for epoxy resins and a chain extender for polyurethanes. 
Moreover, it finds a minor application as a formaldehyde scavenger, preventing the release of formaldehyde.

Adipic acid dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.
Adipic acid dihydrazide is also used as an intermediate.
Materials crosslinked or cured with ADH demonstrate excellent colour stability, weathering resistance, adhesion, durability, hardness, and toughness.

Adipic acid dihydrazide is a chemical used for cross-linking water-based emulsions.
Adipic acid dihydrazide can also be used as a hardener for certain epoxy resins.
Adipic acid dihydrazide is used in the linking of glycoproteins, such as antibodies, in a site specic fashion following periodate oxidation.

Adipic acid dihydrazide is a chemical used for cross-linking water-based emulsions.
Adipic acid dihydrazide can also be used as a hardener for certain epoxy resins.
Adipic acid dihydrazide is a symmetrical molecule with a C4 backbone and the reactive group is C=ONHNH2.

Adipic acid dihydrazide are made by the reaction of an organic acid with hydrazine.
Adipic acid dihydrazide with dierent backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).
A notable fact with regard to Adipic acid dihydrazide in epoxy formulations is that each of the primary amine end groups has a functionality of two, so the ADH molecule has an equivalency of four per epoxy moiety.

Accordingly, the active hydrogen equivalent weight of Adipic acid dihydrazide is 43.5.
When formulated with epoxy resins, the Adipic acid dihydrazide index can range between 0.85-1.15 of stoichiometric proportions, without a signicant eect on mechanical properties.
The cure temperature for epoxy resins (glycidyl types) formulated with Adipic acid dihydrazide is inuenced by the melt-out temperature of the ADH, which allows an extended pot life at low temperatures.

Storage stability can be up to six-months at room temperature, with cure times of about one-hour at 130 °C.
Cure rates can be accelerated using tin or titanate catalysts, or imidazoles.
One-component Adipic acid dihydrazide epoxy systems can be partially cured or “B-staged”, and later fully cured.

Adipic acid dihydrazide is an eective room temperature curative for solution polyurethanes.
Adipic acid dihydrazide provides polyurea coatings with higher hardness, toughness and adhesion properties, excellent mechanical properties, abrasion and chemical resistance.
Adipic acid dihydrazide cured polyurethane coatings exhibit good color stability and weathering properties, which is not observed with standard amine curatives.

Adipic acid dihydrazide, white crystalline solid, with symmetrical molecular structure, is double-functional group compound.
Adipic acid dihydrazide is a kind of good crosslinking agent, can be crosslinked with carbonyl, more typically has and is applied to medicine and pharmacology with cross-linking hyaluronic acid.

Adipic acid dihydrazide is a homobifunctional cross-linking reagent specic for aldehydes resulting in relatively stable hydrazone linkages.
Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specic fashion following periodate oxidation.
Adipic acid dihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which nds application in powder coating.

Adipic dihydrazides (C6H14N4O2) are made by the reaction of an organic acid with hydrazine. Other dihydrazides with different backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).
Adipic acid dihydrazide is a distinctive crosslinking agent and curative that provides controlled reactivity and performance improvements in epoxy resins, polyurethane dispersions (PUDs), solvent-based polyurethanes (PURs), and emulsion acrylic resins. 

Adipic acid dihydrazide is the most suitable hydrazide cross-linking agent, and ADH has been widely used in water-based paint emulsions in combination with diacetone acrylamide. 
Adipic acid dihydrazide is commonly used as a crosslinking agent in water-based coatings, adhesives, and epoxy resins, enhancing durability and flexibility. 
Additionally, Adipic acid dihydrazide serves as an intermediate in pharmaceuticals, textiles, and polymer chemistry. 

The compound appears as a white crystalline powder, is relatively stable under normal conditions, and is soluble in water and certain organic solvents. 
Due to its bifunctional reactive sites, it participates in various condensation and polymerization reactions.
Adipic acid dihydrazide is a chemical used for cross-linking water-based emulsions. 

It can also be used as a hardener for certain epoxy resins.
Adipic acid dihydrazide is weakly alkaline, and there is a possibility of agglomeration when solid ADH is added directly to the emulsion, so usually ADH should be dissolved in hot water before use.
Adipic acid dihydrazide is an organic compound derived from adipic acid, where both carboxyl groups (-COOH) are replaced by hydrazide (-CONHNH₂) functional groups. 

Melting point: 180-182 °C (lit.)
Boiling point: 305.18°C (rough estimate)
Density: 1.2297 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.6700 (estimate)
Flash point: 150 °C
storage temp.: -20°C
solubility: H2O: 100 mg/mL
form: Crystalline Powder
pka: 12.93±0.35(Predicted)
color: White to slightly yellow
Water Solubility: soluble
BRN: 973863
InChIKey: IBVAQQYNSHJXBV-UHFFFAOYSA-N
LogP: -2.7 at 20℃
CAS DataBase Reference: 1071-93-8(CAS DataBase Reference)
EWG's Food Scores: 1-3

Adipic acid dihydrazide is an eective crosslinking agent, curative and hardener.
Adipic acid dihydrazide is the most common dihydrazide crosslinking agent within a series of dihydrazides such as sebacic dihydrazide (SDH) and isophthalic dihydrazide (IDH).
Adipic acid dihydrazide’s has a melting point of 180 °C and a molecular weight of 174; both are lower than the alternative dihydrazides SDH and IDH.

Adipic acid dihydrazide is a low molecular weight compound that comprises a hydrazide group at each end. 
This leads to the supply of extra adsorption sites for heavy metals that maintain or elevate the adsorption capacities of the cross-linked adsorbents. 
Adipic acid dihydrazide is used as a crosslinker in various fields, like making mechanical latexes films and injectable oxidized hyaluronic acid hydrogel.

Adipic acid dihydrazide is an organic compound with the molecular formula C₆H₁₄N₄O₂, derived from adipic acid (a common dicarboxylic acid) by replacing both carboxyl (-COOH) groups with hydrazide (-CONHNH₂) functional groups. 
This modification gives ADH its unique reactivity, making it an important crosslinking agent, curing agent, and chemical intermediate in various industries.

Adipic acid dihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes. 
This results in relatively stable hydrazone linkages. 
Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation. 

Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Adipic acid dihydrazide is a chemical used for cross-linking water-based emulsions.
Adipic acid dihydrazide can also be used as a hardener for certain epoxy resins.

Adipic acid dihydrazide is a symmetrical molecule with a C4 backbone and the reactive group is C=ONHNH2.
Dihydrazides are made by the reaction of an organic acid with hydrazine.
Adipic acid dihydrazide with dierent backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).

Adipic acid dihydrazide is pure white crystals.
Adipic acid dihydrazide is easily soluble in water and poisoned.
Adipic acid dihydrazide is used as epoxy powder coating curing agent and coating additive, metal deactivator and other polymer additives and water treatment agent.

Adipic acid dihydrazide is a homobifunctional cross-linking reagent that is specic for aldehydes.
This results in relatively stable hydrazone linkages.

Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specic fashion following periodate oxidation.
Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Uses Of Adipic acid dihydrazide:
Adipic acid dihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which nds application in powder coating.
Adipic acid dihydrazide is used to functionalize magnetic nanoparticles for gylcopeptitde enrichment and identication.
Adipic acid dihydrazide can also be used as a chain extension for liquid rubber.

Adipic acid dihydrazide is a chemcial intermediate and specialty chemical often used in adhesive and coatingmanufacturing applications.
Adipic acid dihydrazide oers amino- and keto-functionality at either end of the molecule which makes it an excellent cross-linking agent for water-based emulsions.
Adipic dihydrazide is used as a difunctional crosslinking agent in paints and coatings for certain water-based acrylic emulsions.  

It is used as a hardener for epoxy resins and a chain extender for polyurethanes.  
A small use is as a formaldehyde scavenger preventing the liberation of formaldehyde.
Adipic acid dihydrazide is widely used as a crosslinker in water-based coatings, paints, and adhesives, where it reacts with ketone or aldehyde-based resins to form strong, durable bonds.

It improves water resistance, adhesion, and mechanical strength in industrial coatings, helping prevent cracking and wear over time.
Adipic acid dihydrazide is an essential curing agent in epoxy resins used in automotive, aerospace, and construction applications.
It enhances the flexibility, toughness, and thermal stability of polymers, making it ideal for high-performance coatings and composites.

The hydrazide groups in Adipic acid dihydrazide enable it to act as an intermediate in pharmaceutical synthesis, particularly in the development of hydrazone-based drugs used for antibacterial, anticancer, and antiviral applications.
Adipic acid dihydrazide is used in textile finishing agents to enhance the wrinkle resistance, water repellency, and durability of fabrics.
In the paper industry, it is utilized in coating formulations to improve strength and printability.

Adipic acid dihydrazide is used in water treatment as a chelating agent, helping to remove metal ions from industrial wastewater.
It serves as a precursor in synthesizing other hydrazide derivatives for applications in agrochemicals, dyes, and specialty chemicals.
Adipic acid dihydrazide reacts readily with aldehydes and ketones, forming hydrazone linkages, which is useful in crosslinking applications.

It is low in toxicity but should be handled with care, as prolonged exposure to fine powder dust may cause respiratory or skin irritation.
Storage in a cool, dry place is recommended to maintain its stability and prevent premature degradation.
Adipic acid dihydrazide is a versatile chemical with applications ranging from coatings and adhesives to pharmaceuticals and textiles. 

Its ability to form strong crosslinked structures makes it invaluable in various industrial processes, while its reactivity with aldehydes and ketones enables its use in chemical synthesis. 
As industries continue to develop high-performance materials, Adipic acid dihydrazide remains a crucial component in advancing polymer science, material engineering, and pharmaceutical innovation.

Adipic acid dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air. 
Adipic acid dihydrazide is also employed as a paint additive and coating additive. 
It is also used as an intermediate. 

Adipic acid dihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.
Adipic acid dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. 
Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. 

Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Adipic acid dihydrazide is soluble in water, alcohol and acetone.
Adipic acid dihydrazide is commonly used in the linking of glycoproteins, such as antibodies, in a site specic fashion following periodate oxidation.

Adipic acid dihydrazide is the most suitable hydrazide cross-linking agent, and ADH has been widely used in waterbased paint emulsions in combination with diacetone acrylamide. 
Adipic acid dihydrazide is weakly alkaline, and there is a possibility of agglomeration when solid ADH is added directly to the emulsion, so usually ADH should be dissolved in hot water before use.
Adipic acid dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.

Adipic acid dihydrazide is also employed as a paint additive and coating additive.
Adipic acid dihydrazide is also used as an intermediate.

Safety Profile Of Adipic acid dihydrazide:
Prolonged or repeated exposure can lead to dryness and redness.
Wear protective gloves and wash hands thoroughly after handling.
Can cause temporary eye irritation, redness, and discomfort if it comes into direct contact with the eyes.

Wear safety goggles when handling large quantities if exposure occurs, rinse eyes with plenty of water for at least 15 minutes.
While Adipic acid dihydrazide is not highly toxic, swallowing large amounts can lead to nausea, vomiting, or gastrointestinal discomfort.
Do not eat, drink, or smoke while handling the material if ingested, seek medical attention.

While Adipic acid dihydrazide is generally considered a low-toxicity chemical, proper handling and precautionary measures should be taken, as it can pose potential hazards in certain conditions.
Dust or powder may cause respiratory irritation if inhaled in large quantities.
Symptoms may include coughing, shortness of breath, and throat irritation.

Use appropriate ventilation and wear a dust mask when handling the powder.
Direct contact with Adipic acid dihydrazide may cause mild skin irritation or an allergic reaction in sensitive individuals.