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CAS Number : 1071-93-8
EC Number : 213-999-5
ECHA InfoCard : 100.012.727
PubChem CID : 66117
ChemSpider : 59505
Chemical formula : C6H14N4O2
Molar mass : 174.20 g/mol
Melting point : 176 to 185 °C
Adipic dihydrazide is a chemical used for cross-linking water-based emulsions.
Adipic dihydrazide can also be used as a hardener for certain epoxy resins.
Adipic dihydrazide is a symmetrical molecule with a C4 backbone and the reactive group is C=ONHNH2.
Dihydrazides are made by the reaction of an organic acid with hydrazine.
Other dihydrazides with different backbones are also common, including isophthalic dihydrazide (IDH) and sebacic dihydrazide (SDH).
Industry Uses of Adipic dihydrazide
-Adhesives and sealant chemicals
-Crosslinking agent for resin
-Dyes
-Intermediates
-Paint additives and coating additives not described by other categories
-Processing aids, not otherwise listed
-Thermal paper coating
Consumer Uses of Adipic dihydrazide
-Automotive care products
-Paints and coatings
-Paper products
General Manufacturing Information
Industry Processing Sectors
-All other basic organic chemical manufacturing
-Paint and coating manufacturing
-Paper manufacturing
-Plastic material and resin manufacturing
-Plastics product manufacturing
-Textiles, apparel, and leather manufacturing
Adipic dihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes. This results in relatively stable hydrazone linkages. Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation. Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Adipic dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.
Adipic dihydrazide is also employed as a paint additive and coating additive.
Adipic dihydrazide is also used as an intermediate.
Further, Adipic dihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.
Applications of Adipic dihydrazide
Adipic dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air.
Adipic dihydrazide is also employed as a paint additive and coating additive.
Adipic dihydrazide is also used as an intermediate.
Further, Adipic dihydrazide is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.
Adipic dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages.
Adipic dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation.
Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Adipic dihydrazide is used to functionalize magnetic nanoparticles for gylcopeptitde enrichment and identification.
Adipic dihydrazide can also be used as a chain extension for liquid rubber.
Adipic dihydrazide is an effective crosslinking agent, curative and hardener.
Adipic dihydrazide is the most common dihydrazide crosslinking agent within a series of dihydrazides such as sebacic dihydrazide (SDH) and isophthalic dihydrazide (IDH).
Adipic dihydrazide’s has a melting point of 180 °C and a molecular weight of 174; both are lower than the alternative dihydrazides SDH and IDH.
Adipic dihydrazide is used as a difunctional crosslinking agent in paints and coatings for certain water-based acrylic emulsions.
Adipic dihydrazide is used as a hardener for epoxy resins and a chain extender for polyurethanes.
A small use is as a formaldehyde scavenger preventing the liberation of formaldehyde.
First-aid measures of Adipic dihydrazide
General Advice :
If symptoms persist, call a physician.
Eye Contact :
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Get medical attention.
Skin Contact :
Wash off immediately with plenty of water for at least 15 minutes.
If skin irritation persists,call a physician.
Inhalation :
Remove to fresh air.
If not breathing, give artificial respiration.
Get medical attention if symptoms occur.
Ingestion :
Clean mouth with water and drink afterwards plenty of water.
Get medical attention if symptoms occur.
Substance identity
EC / List no.: 213-999-5
CAS no.: 1071-93-8
Mol. formula: C6H14N4O2
Hazard classification & labelling of Adipic dihydrazide
Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is toxic to aquatic life with long lasting effects and may cause an allergic skin reaction.
About Adipic dihydrazide
Adipic dihydrazide is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Adipic dihydrazide is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses of Adipic dihydrazide
Adipic dihydrazide is used in the following products: coating products, adhesives and sealants, fillers, putties, plasters, modelling clay, finger paints, polymers, non-metal-surface treatment products, textile treatment products and dyes and washing & cleaning products.
Other release to the environment of Adipic dihydrazide is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).
Article service life of Adipic dihydrazide
Other release to the environment of Adipic dihydrazide is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Adipic dihydrazide can be found in complex articles, with no release intended: vehicles covered by End of Life Vehicles (ELV) directive (e.g. personal vehicles or delivery vans).
Widespread uses by professional workers of Adipic dihydrazide
Adipic dihydrazide is used in the following products: adhesives and sealants, coating products, paper chemicals and dyes, textile treatment products and dyes and washing & cleaning products.
Adipic dihydrazide is used for the manufacture of: textile, leather or fur and wood and wood products. Other release to the environment of this substance is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).
Formulation or re-packing of Adipic dihydrazide
Adipic dihydrazide is used in the following products: adhesives and sealants, coating products, fillers, putties, plasters, modelling clay, polymers, textile treatment products and dyes and finger paints.
Release to the environment of Adipic dihydrazide can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites of Adipic dihydrazide
Adipic dihydrazide is used in the following products: paper chemicals and dyes, coating products, textile treatment products and dyes, adhesives and sealants, finger paints, laboratory chemicals, washing & cleaning products and water treatment chemicals.
Adipic dihydrazide is used for the manufacture of: chemicals, pulp, paper and paper products and plastic products.
Release to the environment of Adipic dihydrazide can occur from industrial use: for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles and as processing aid.
Manufacture of Adipic dihydrazide
Release to the environment of Adipic dihydrazide can occur from industrial use: manufacturing of the substance.
Synonyms:
Adipohydrazide
adipohydrazide
Hexanedioic acid, 1,6-dihydrazide
hexane dihydrazide
ADH
Adipic acid dihydrazide
adipic acid dihydraziode, adipohydrazide, hexanedihydrazide
Adipic acid, dihydrazide
Adipic Dihydrazide
Adipic dihydrazide
Adipohydrazid
ADIPOHYDRAZIDE
Adipohydrazide
adipohydrazide
adipohydrazide
adiptic acid hydrazide
Hexanedihydrazide
hexanedihydrazide
Hexanedioic acid, 1,6-dihydrazide
Adipic Acid Dihydrazide
1071-93-8
124246-54-4
98152-55-7
Adipic dihydrazide
1071-93-8
Adipohydrazide
Adipic acid dihydrazide
Hexanedihydrazide
Hexanedioic acid, dihydrazide
Adipic acid, dihydrazide
Adipyl hydrazide
Adipodihydrazide
VK98I9YW5M
Hexanediohydrazide
WLN: ZMV4VMZ
MFCD00007614
Adip dihydr
Adipoyl hydrazide
Adipoyldihydrazine
adipic dihydrazone
adipoyl dihydrazide
Hexanedioic acid, 1,6-dihydrazide
Hexanedihydrazide #
NSC 3378
EINECS 213-999-5
NSC 29542
Adipic aciddihydrazide
Adipic acid dihyrazide
Hexanedioic dihydrazide
adipic acid dihydrizide
AI3-22640
UNII-VK98I9YW5M
EC 213-999-5
Hexanedioic acid dihydrazide
DSSTox_CID_24361
DSSTox_RID_80169
DSSTox_GSID_44361
SCHEMBL49856
Adipic Acid Dihydrazide (ADH)
CHEMBL3185968
DTXSID0044361
SCHEMBL11037942
AMY3771
NSC3378
1,4-Butanedicarboxylic dihydrazide
ALBB-011767
NSC-3378
NSC29542
STR02658
ZINC1666741
Tox21_301067
BBL022965
NSC-29542
STK709135
AKOS000267183
NCGC00248276-01
NCGC00257525-01
CAS-1071-93-8
DB-022418
A0170
Adipic acid dihydrazide, >=98% (titration)
CS-0010116
FT-0621914
D72486
Adipic acid dihydrazide, purum, >=97.0% (NT)
A801603
J-660023
Q-200600
Q4682936
Z56812730
F1943-0024
Adipic acid dihydrazide
(1Z,6Z)-Hexandihydrazonsäure [German] [ACD/IUPAC Name]
(1Z,6Z)-Hexanedihydrazonic acid [ACD/IUPAC Name]
1071-93-8 [RN]
213-999-5 [EINECS]
973863 [Beilstein]
Acide (1Z,6Z)-hexanedihydrazonique [French] [ACD/IUPAC Name]
Adipic acid, dihydrazide (8CI)
Adipic dihydrazide
adipohydrazide
Hexandihydrazid [German] [ACD/IUPAC Name]
Hexanedihydrazide [ACD/IUPAC Name]
Hexanedihydrazide [French] [ACD/IUPAC Name]
Hexanedihydrazonic acid, (1Z,6Z)- [ACD/Index Name]
Hexanedioic acid dihydrazide
Hexanedioic acid, dihydrazide [ACD/Index Name]
MFCD00007614 [MDL number]
VK98I9YW5M
1,4-Butanedicarboxylic dihydrazide
124246-54-4 secondary RN [RN]
403 Adipic acid dihydrazide [Trade name]
98152-55-7 secondary RN [RN]
Adipic acid dihyrazide
Adipic acid, dihydrazide
Adipic aciddihydrazide
adipic dihydrazide(adh)
adipicdihydrazide
adipodihydrazide
Adipyl hydrazide
butane-1,4-dicarbohydrazide
hexanedihydrazide|hexanedioic acid, dihydrazide
Hexanedioic acid, 1,6-dihydrazide
Hexanedioic dihydrazide
UNII-VK98I9YW5M
ZMV4VMZ [WLN]
