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Alkyl gylceryl hydrolyzed hyaluronate is a chemically modified derivative of hyaluronic acid, designed to enhance the molecule's penetration ability, skin affinity, and long-term moisturization effects in cosmetic and dermatological formulations.
Alkyl gylceryl hydrolyzed hyaluronate is created by taking hydrolyzed hyaluronic acid—a lower molecular weight version of naturally occurring hyaluronic acid—and further modifying it by attaching alkyl glyceryl groups, which are hydrophobic (oil-attracting) components derived from fatty alcohols and glycerin.
Alkyl gylceryl hydrolyzed hyaluronate is a next-generation moisturizing agent that combines the deep hydration benefits of hyaluronic acid with the emollient and skin-affinity benefits of alkylated glyceryl groups, making it especially effective in products aimed at long-term skin hydration, repair, and comfort.
CAS Number: 9004-61-9
Molecular Formula: C14H22NNaO11
Molecular Weight: 403.31
EINECS Number: 232-678-0
Synonyms: NCGC00167966-01, Sodium Hyaluronate, DSSTox_CID_26750, DSSTox_RID_81875, DSSTox_GSID_46750, CHEMBL1874250, DTXSID20858848, KIUKXJAPPMFGSW-YXBJCWEESA-N, Tox21_112595, AKOS015960603, AC-11740, AC-31947, PD086811, CAS-9004-61-9, (2S,4S,5R,6S)-6-[(2S,3R,5S,6R)-3-acetamido-2-[(3S,4R,5R,6R)-6-[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid, (4xi)-alpha-D-xylo-Hexopyranuronosyl-(1->3)-(3xi)-2-(acetylamino)-2-deoxy-beta-D-ribo-hexopyranosyl-(1->4)-(5xi)-beta-D-xylo-hexopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-D-glucopyranose, [BETA-SODIUM-GLUCONATE-(1,3)-BETA-N-ACETYL-D-GLUCOSAMINE-1,4-]N, COPOLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4] SODIUM SALT, HYALURONIC ACID NA-SALT, HYALURONIC ACID, SODIUM SALT, STREPTOCOCCUS SPECIES, HYALURONIC ACID SODIUM, HYALURONIC ACID HUMAN SODIUM SALT, acid hyaluronic, sodiuM (2S,3S,4R,5R,6R)-3-((2S,3R,5S,6R)-3-acetaMido-5-hydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yloxy)-4,5,6-trihydroxytetrahydro-2H-pyran-2-carboxylate
Alkyl gylceryl hydrolyzed hyaluronate is a completely transparent, non-adhesive, water-soluble and grease-free acid mucopolysaccharide.
Alkyl gylceryl hydrolyzed hyaluronates molecular weight is between a few hundred thousand to millions, and it makes up the dermis layer of the skin.
Its unique molecular structure and physicochemical properties has many important physiological functions inside the body, such as lubricating joints, adjusting vascular permeability, adjusting proteins, diffusing and transporting water electrolytes, and promoting wound healing.
Alkyl gylceryl hydrolyzed hyaluronate has a unique water retention effect and has the best known natural moisturizing properties, making it the ideal natural moisturizer.
Alkyl gylceryl hydrolyzed hyaluronate is an essential drug in ophthalmic “sticky surgeries”.
It is used in cataract surgery, in which its sodium salt remains in the anterior chamber to maintain depth in the anterior chamber and ensure a clear surgical view.
Alkyl gylceryl hydrolyzed hyaluronate reduces the occurences of postoperative inflammation and complications, thus improving the vision-correcting effects of the surgery.
It is also used in complicated retinol detachment surgery.
Alkyl gylceryl hydrolyzed hyaluronate has a low molecular weight and is considered the ideal natural moisturizing agent, so it is used as an additive in high-end makeup and as a moisturizer in creams, gels, lotions, masks, and serums.
Alkyl gylceryl hydrolyzed hyaluronate is also used medically as a moisturizer to improve moisture retention and lubrication, and it also expands capillaries and improves skin health.
For example, Alkyl gylceryl hydrolyzed hyaluronate with a low molecular weight can be used as a lubricant in surgeries (such as knee surgery), while those with high molecular weight can be used as surgical lubricant and as a substitute for vitreous in ophthalmic surgery.
This modification changes the natural behavior of Alkyl gylceryl hydrolyzed hyaluronate, which is usually highly water-loving (hydrophilic) and forms a film on the skin surface, by giving it amphiphilic properties—meaning it has both water-loving and oil-loving regions in its structure.
As a result, Alkyl Glyceryl Hydrolyzed Hyaluronate is able to better penetrate into the skin’s deeper layers, interact with both aqueous and lipidic environments, and bind moisture not just on the surface but also within the epidermis, offering long-lasting hydration and a silky, smooth skin feel.
A glycosaminoglycan(mucopolysaccharide) that is part of the matrix of connective tissue.
Alkyl gylceryl hydrolyzed hyaluronate binds cells together and helps to lubricate joints.
Alkyl gylceryl hydrolyzed hyaluronate may play a role in the migration of cells at wounds, this activity ceases when hyaluronidase breaks down hyaluronic acid.
Alkyl gylceryl hydrolyzed hyaluronate is modified hyaluronic acid which acts as a barrier recovery agent and provides the skin with high moisture retention and skin lubrication.
With glycerin backbone attached, it is suitable for skin care, serum and even lip balm. We also acquired data with hair which can be used for shampoo and scalp.
This hyaluronic acid Alkyl gylceryl hydrolyzed hyaluronate repairs damaged and rough skin by improving moisture content in stratum corneum and transepidermal water loss.
A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits.
Alkyl gylceryl hydrolyzed hyaluronate is found in the connective tissues of vertebrates.
Alkyl gylceryl hydrolyzed hyaluronate is a natural complex sugar of the glycosaminoglycan family and is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine.
Alkyl gylceryl hydrolyzed hyaluronate is indicated for use as a surgical aid in cataract extraction (intra-and extracapsular), IOL implantation, corneal transplant, glaucoma filtration and retinal attachment surgery.
In surgical procedures in the anterior segment of the eye, instillation of hyaluronic acid serves to maintain a deep anterior chamber within corneal endothelium and other surrounding tissues.
Furthermore, its viscoelasticity helps to push back the vitreous face and prevent formation of a postoperative flat chamber.
In posterior segment surgery Alkyl gylceryl hydrolyzed hyaluronate serves as a surgical aid to gently separate, maneuver and hold tissues.
Alkyl gylceryl hydrolyzed hyaluronate creates a clear field of vision thereby facilitating intra- and post-operative inspection of the retina and photocoagulation.
This ingredient is a derivative of Alkyl gylceryl hydrolyzed hyaluronate, combined with alkyl and glyceryl groups.
It offers both hydrating and barrier-strengthening benefits, making it a versatile ingredient in skincare formulations.
Alkyl gylceryl hydrolyzed hyaluronate hydrates the skin deeply while providing a silky, non-greasy feel.
Sodium Acetylated Hyaluronate is a highly active ingredient of the latest generation, which is used in exclusive premium anti-aging products.
With good reason: sodium acetylated hyaluronate is in fact able to penetrate the skin significantly deeper than other classic hyaluronic acids.
Alkyl gylceryl hydrolyzed hyaluronate has both lipophilic and hydrophilic properties.
The acetyl group, which is strongly lipophilic, helps acetylated hyaluronic acid adhere firmly, which significantly reduces an evaporative effect.
Because of its enhanced skin permeability, it is commonly used in premium skincare formulations, including anti-aging serums, moisturizers, and eye creams, where it helps to reduce the appearance of fine lines, improve skin elasticity, and protect the skin barrier from environmental stress.
The glyceryl groups also contribute to skin-conditioning effects, giving the product a non-sticky, soft texture after application, which is highly desirable in modern cosmetic formulations.
storage temp.: −20°C
solubility: H2O: 5 mg/mL, clear, colorless
form: Lyophilized Powder
color: White
Odor: Odorless
optical activity: -70～-80
Water Solubility: Soluble in water.
InChIKey: MAKUBRYLFHZREJ-IUPJJCKZNA-M
SMILES: [C@@H]1(O[C@H]2[C@H](O)[C@H]([C@H](O)O[C@@H]2C(=O)[O-])O)O[C@H](CO)[C@@H](O)C[C@H]1NC(=O)C.[Na+] |&1:0,2,3,5,6,9,15,18,21,r|
LogP: -6.623 (est)
Alkyl gylceryl hydrolyzed hyaluronate is a biotechnologically advanced skincare ingredient developed by chemically modifying hydrolyzed hyaluronic acid (a low-molecular-weight version of natural hyaluronic acid) through alkyl glyceryl etherification—a process that attaches hydrophobic alkyl chains and glycerin-derived units to the hydrophilic sugar backbone of hyaluronic acid.
Alkyl gylceryl hydrolyzed hyaluronate modification transforms the original, purely hydrophilic molecule into a more amphiphilic (both water- and oil-compatible) substance, allowing it to interact with and remain stable in both aqueous and lipid environments, which is not typical of native hyaluronic acid.
Alkyl gylceryl hydrolyzed hyaluronate is celebrated for its superior and long-lasting moisturizing effect, which goes beyond that of standard or even hydrolyzed hyaluronic acid.
It not only attracts and retains water molecules (due to its hygroscopic nature), but also anchors moisture more effectively to the skin thanks to its lipid-friendly modifications.
This means it forms a moisture reservoir that supports skin hydration for extended periods, making the skin feel plump, smooth, and nourished throughout the day.
The hydrophobic parts of the molecule help it adhere more strongly to the skin, resisting evaporation and loss of hydration.
Alkyl gylceryl hydrolyzed hyaluronate is the product obtained by the reaction of a C12-13 alkyl ether of glycerin with Hydrolyzed Hyaluronic Acid.
In its natural form, hyaluronic acid is a highly polar polysaccharide that attracts and retains water but struggles to pass through the lipid-rich stratum corneum (outermost layer of the skin) due to its size and polarity.
When hydrolyzed into smaller fragments, it becomes more skin-penetrative but still primarily functions at the surface level.
By attaching alkyl (fatty) chains and glyceryl groups, scientists enhance its skin permeability, bioavailability, and its ability to bind within lipid domains of the skin, giving it the capacity to deliver moisture deeper into the epidermis and even into intercellular spaces between skin cells.
This amphiphilic nature is key to its superior performance in modern cosmetic systems.
Alkyl gylceryl hydrolyzed hyaluronate is an extra low molecular weight hyaluronic acid that has been alkylated so that it can have a barrier function with both hydrophobic and hydrophilic aspects for skin care.
It is a moisturizing and anti-aging agent with sun care concept.
Alkyl gylceryl hydrolyzed hyaluronate repairs and recovers the barrier which helps the skin to retain moisture.
Alkyl gylceryl hydrolyzed hyaluronate is derived from a non-animal source and is a biotechnology & fermentation technology product.
Alkyl gylceryl hydrolyzed hyaluronate is applicable in skin-, hair- and sun care products.
Alkyl gylceryl hydrolyzed hyaluronate has long been considered a veritable wonder weapon in the anti-aging segment.
Just one gram can bind up to six liters of water, which means it gives the skin more elasticity and tone by acting like a water reservoir.
There are different types of hyaluronic acid on the market.
Short-chain hyaluronic acid fragments penetrate relatively deeply into the skin and cushion it there from the inside, while long-chain hyaluronic acid can provide long-lasting moisture and protect against dehydration, especially in the superficial layers of the skin.
Alkyl gylceryl hydrolyzed hyaluronate is even more effective.
It is considered a real innovation and is the ultimate in exclusive cosmetic products.
Alkyl gylceryl hydrolyzed hyaluronate is a chemical process and describes the exchange of a hydrogen atom by an acetyl group.
The exchange can take place either at the functional groups (-OH, -SH, -NH2) or directly at a -C-H bond.
An acetyl group in turn denotes the chemical structure -C(O)CH3.
Alkyl gylceryl hydrolyzed hyaluronate is composed of the carbonyl and methyl groups and forms the acyl radical of acetic acid.
For example, drugs obtained by acetylation have been known for a very long time: Alkyl gylceryl hydrolyzed hyaluronate obtained in chemically pure form is certainly the preparation most commonly used in this context.
Another example: the acetylation of morphine produces heroin (diacetylmorphine).
And oxaceprol, a very well-known active ingredient used, among other things, in drugs to treat degenerative joint diseases such as arthritis, is also obtained by acetylation.
Another key function of this molecule lies in its ability to restore and support the skin’s natural barrier function.
The presence of glyceryl and alkyl chains allows it to integrate more readily into the stratum corneum, reinforcing the skin’s lipid matrix and reducing transepidermal water loss (TEWL).
This leads to healthier, more resilient skin that is better protected against environmental aggressors such as pollutants, dry air, and UV-induced oxidative stress.
Due to its multifunctionality, Alkyl gylceryl hydrolyzed hyaluronate is widely used in advanced cosmetic formulations, especially in premium facial serums, moisturizing emulsions, sheet masks, eye creams, and anti-aging treatments.
It is also suitable for sensitive skin, as it provides hydration without irritation, and can enhance the sensory profile of formulations by reducing tackiness and improving spreadability.
Alkyl gylceryl hydrolyzed hyaluronates dual affinity for water and oil phases makes it particularly versatile in both water-based and oil-in-water emulsion systems, as well as in nanoemulsions and micellar systems.
Uses Of Alkyl gylceryl hydrolyzed hyaluronate:
Alkyl gylceryl hydrolyzed hyaluronate is a naturally derived, non - immunogenic, non - adhesive glycosaminoglycan that plays a prominent role in various wound - healing processes, as it as it is naturally angiogenic when degraded to small fragments.
Alkyl gylceryl hydrolyzed hyaluronate promotes early inflammation which is critical for initiating wound healing, but then moderates later stages of the process, allowing matrix stabilization and reduction of long term inflammation.
Alkyl gylceryl hydrolyzed hyaluronate is a main source for pharmaceutical, medical and cosmetic application.
Alkyl gylceryl hydrolyzed hyaluronate is a glycosaminoglycan component. Hyaluronic acid occurs naturally in the dermis.
It is thought to play a critical role in healthy skin by controlling the physical and biochemical characteristics of epidermal cells.
Alkyl gylceryl hydrolyzed hyaluronate also regulates general skin activity, such as water content, elasticity, and the distribution of nutrients.
Its water-absorption abilities and large molecular structure allow the epidermis to achieve greater suppleness, proper plasticity, and turgor.
Alkyl gylceryl hydrolyzed hyaluronate is a natural moisturizer with excellent water-binding capabilities.
In a solution of 2 percent hyaluronic acid and 98 percent water, the hyaluronic acid holds the water so tightly that it appears to create a gel.
However, it is a true liquid in that it can be diluted and will exhibit a liquid’s normal viscous flow properties.
When applied to the skin, hyaluronic acid forms a viscoelastic film in a manner similar to the way it holds water in the intercellular matrix of dermal connective tissues.
This performance and behavior suggests that hyaluronic acid makes an ideal moisturizer base, allowing for the delivery of other agents to the skin.
Manufacturers claim that the use of hyaluronic acid in cosmetics results in the need for much lower levels of lubricants and emollients in a formulation, thereby providing an essentially greaseless product.
Furthermore, its ability to retain water gives immediate smoothness to rough skin surfaces and significantly improves skin appearance.
For the benefits of hyaluronic acid to be realized in a cosmetic, the product needs to be applied on a regular basis as it is broken down in skin within 24 to 48 hours of application.
Alkyl gylceryl hydrolyzed hyaluronate is not the case with hyaluronic acid injections as the technology used is different.
Alkyl gylceryl hydrolyzed hyaluronate is widely used in moisturizers, hydrating serums, and facial creams because of its superior ability to attract and retain water molecules, providing long-lasting hydration that penetrates beyond the skin’s surface.
Unlike conventional hyaluronic acid, which mainly works on the outermost layer of the skin, this modified form can penetrate more deeply into the epidermis, delivering moisture to lower skin layers and helping the skin remain plump and supple throughout the day.
Alkyl gylceryl hydrolyzed hyaluronate is particularly valued in products designed for dry, dehydrated, or mature skin, where maintaining water balance is crucial for skin health and elasticity.
Due to its deep hydrating action and ability to reinforce the skin barrier, Alkyl Glyceryl Hydrolyzed Hyaluronate is used in anti-aging skincare formulations, including eye creams, lifting serums, and firming treatments, where it helps to visibly reduce the appearance of fine lines and wrinkles caused by dryness or loss of elasticity.
By maintaining hydration within the deeper layers of the skin and enhancing cellular moisture retention, it improves skin texture and tone, giving a smoother, fuller, and more youthful look over time.
Its amphiphilic nature also improves the overall skin feel and smoothness, which contributes to a refreshed, healthy-looking complexion.
Because it contains lipid-compatible alkyl groups and glycerol units, Alkyl gylceryl hydrolyzed hyaluronate is often included in barrier-repair creams, post-treatment skincare, and sensitive skin products where the skin’s natural moisture barrier is damaged or compromised.
It helps to reduce transepidermal water loss (TEWL) and promotes the recovery of the stratum corneum’s lipid matrix, which is essential for preventing moisture evaporation and shielding the skin from external irritants, allergens, and pollutants.
Its dual action of hydration and lipid reinforcement makes it a versatile solution for skin that is dry, inflamed, or recovering from cosmetic procedures.
In sunscreens and after-sun gels or lotions, this ingredient is used to counteract the drying effects of UV exposure and soothe sun-stressed skin by replenishing lost moisture and strengthening the skin’s protective functions.
When used in combination with UV filters and antioxidants, Alkyl gylceryl hydrolyzed hyaluronate helps to prevent premature aging caused by environmental damage while also reducing irritation or tightness that may follow sun exposure.
It is a common active ingredient in hydrating sheet masks, sleeping masks, and water-based gel creams, where it provides an immediate boost of hydration that leaves the skin feeling cool, smooth, and refreshed.
Its ability to bond with both oil and water makes it highly compatible with hydrogel masks and fast-absorbing textures, making it a popular choice for express skincare routines that deliver visible benefits quickly.
Formulators also use Alkyl Glyceryl Hydrolyzed Hyaluronate in products not only for its moisturizing properties but also to improve the sensory texture of the final product.
Alkyl gylceryl hydrolyzed hyaluronate imparts a silky, non-sticky, and velvety finish, making creams and lotions feel luxurious and pleasant to the touch.
Additionally, its amphiphilic nature helps to stabilize emulsions, meaning it plays a supportive role in keeping oil and water phases properly blended in complex cosmetic formulations.
Because of its biocompatibility, low irritation potential, and non-sensitizing nature, this ingredient is sometimes used in products for babies, children, and people with sensitive or allergy-prone skin, where strong or synthetic actives cannot be tolerated.
Alkyl gylceryl hydrolyzed hyaluronate helps deliver gentle, effective hydration without causing redness or itching, which is especially important in products marketed for daily use on delicate skin.
Safety Profile Of Alkyl gylceryl hydrolyzed hyaluronate:
Alkyl gylceryl hydrolyzed hyaluronate is generally considered a safe and well-tolerated ingredient, especially in its cosmetic-grade form, and does not pose major health hazards when used as directed in skincare and personal care products.
However, as with all cosmetic ingredients—especially chemically modified molecules—it is important to consider possible risks under improper use, high concentrations, or individual sensitivities.
Although Alkyl gylceryl hydrolyzed hyaluronate is typically non-irritating and biocompatible, some individuals—particularly those with very sensitive or allergy-prone skin—may experience mild irritation, redness, or a tingling sensation upon first use.
This may occur if the product contains a high concentration of the ingredient, or if it is used alongside other active compounds like acids, retinoids, or alcohol-based solvents that increase skin reactivity.
However, such reactions are rare and usually temporary and reversible upon discontinuation.
While final cosmetic products are safe, the raw powdered form of Alkyl gylceryl hydrolyzed hyaluronate—if used during manufacturing—may pose an inhalation risk to workers if not handled properly.
If airborne, inhalation of dust particles may cause respiratory irritation, coughing, or throat discomfort, particularly in enclosed or poorly ventilated production environments.
Proper industrial hygiene measures, such as local exhaust ventilation and protective respiratory equipment, should be in place during formulation and packaging processes involving the dry powder.
