Aloe vera is one of the most widely explored folk medicines, and its use for skin disorders dates back to thousands of years. The Aloe plant-derived medicinal and cosmetic products are among the biggest natural product-based industries all over the world. This succulent herb belongs to the family of Alliaceae.
CAS no.: 85507-69-3
EC no.: 287-390-8
Aloe vera extract
Aloe vera, ext.
aloe vera, extract
ALOEVERA;Aloevera,ext.;AloinfromAloeVera20%;Aloeextractacc.;Aloeveradryextract;ALOEVERA,200:1,POWDER;ALOEVERA,FREEZEDRIDEPOWDER;ALOEVERA,LUMP,USP;Aloe vera; Aloe Barbadensis Leaf Extract; extract of the flowers of the aloe, aloe barbadensis, liliaceae; aloe vera flower extract; aloe barbadensis var. chinensis flower extract; aloe chinensis flower extract; barbados aloe flower extract; curacao aloe flower extract; medicinal aloe flower extract; true aloe flower extract; aloe perfoliata var. vera flower extract; aloe vera flower extract; aloe vera var. chinensis flower extract; aloe vulgaris flower extract; urguentine- cactus flower extract; chirukattali flower extract; extract of the flowers of the aloe, aloe barbadensis, liliaceae cas no:85507-69-3; aloe vera özü; aloe vera özütü; aloe vera ekstatı; aloe vera ekstrası; extrait d'aloe vera; extrait aloe vera ; экстракт алоэ вера; алоэ вер;1-(4-methylphenyl)-3-(3-nitrophenyl)prop-2-en-1-one;57026-80-9;NSC640537;1-(4-Methylphenyl)3-(3-nitrophenyl)-2-propen-1-one;(E)-1-(4-methylphenyl)-3-(3-nitrophenyl)prop-2-en-1-one;CHEMBL1998311;SCHEMBL15807305;ZINC4289062;MFCD00017029;AKOS000956204;NSC-640537;A831451;(E)-3-(3-nitrophenyl)-1-p-tolylprop-2-en-1-one;(E)-3-(3-nitrophenyl)-1-(p-tolyl)prop-2-en-1-one;(E)-1-(4-methylphenyl)-3-(3-nitrophenyl)-2-propen-1-on;3-(3-(Hydroxy(oxido)amino)phenyl)-1-(4-methylphenyl)-2-propen-1-one;(2E)-1-(4-Methylphenyl)-3-(3-nitrophenyl)-2-propen-1-on [German] [ACD/IUPAC Name];(2E)-1-(4-Methylphenyl)-3-(3-nitrophenyl)-2-propen-1-one [ACD/IUPAC Name];(2E)-1-(4-Méthylphényl)-3-(3-nitrophényl)-2-propén-1-one [French] [ACD/IUPAC Name];1-(4-methylphenyl)-3-(3-nitrophenyl)prop-2-en-1-one;2-Propen-1-one, 1-(4-methylphenyl)-3-(3-nitrophenyl)-, (2E)- [ACD/Index Name];57026-80-9 [RN];(2E)-1-(4-methylphenyl)-3-(3-nitrophenyl)prop-2-en-1-one;(E)-1-(4-methylphenyl)-3-(3-nitrophenyl)prop-2-en-1-one;3-(3-Nitrophenyl)-1-(p-tolyl)prop-2-en-1-one;5747-23-9 [RN];851914-79-9 [RN];85507-69-3 [RN];Aloe vera;Aloe VeraExtractPowderExtraPure(IP);aloevera,200:1,powder;MFCD00017029
Aloe vera is one of the most widely explored folk medicines, and its use for skin disorders dates back to thousands of years. The Aloe plant-derived medicinal and cosmetic products are among the biggest natural product-based industries all over the world. This succulent herb belongs to the family of Alliaceae. Many a times also referred as Aloe barbadensis Miller, it is native to Southern and Eastern Africa. In India and China, since ancient times Aloe has been an important medicine for its cathartic, stomachic, and emmenagogue properties (Grindley and Reynolds 1986). The therapeutic and medicinal uses of Aloe vera have been reviewed in detail by Sahu et al. (2013), which describe the anti-inflammatory, antioxidant, antimicrobial, antifungal, anti-helminthic, antiseptic, emollient, purgative, laxative, and aphrodisiac properties of the plant’s leaves. Aloe vera gel is known for its healing properties for skin injury and as a remedy for sunburns, burns and cuts, acne, injury to epithelial cells, and even skin cancer (Shelton 1991). Its antiviral, antidiabetic, and stress-reducing effects are also well documented (Noor et al. 2008; Sahu et al. 2013). Among the various active components of Aloe are anthraquinones; chromones; monosaccharides; polysaccharides; vitamins B1, B2, B6, and C; niacinamide; choline and enzymes like acid and alkaline phosphatase; amylase; lactate dehydrogenase; lipase; and many inorganic ingredients, but most important among them is the long chain of acetylated mannose (Hayes 1999; Djeraba and Quere 2000).
The anticancer activity of Aloe vera gel is also being explored. The glycoproteins present in the gel have antiulcer and antitumor activities (Yagi et al. 2003). Aloe vera gel was tested for its efficacy in the management of oral submucous fibrosis (OSMF), a potentially malignant disorder frequently associated with gutkha and betel nut chewing. The topical application of gel for 3 months significantly improved the clinical symptoms in all studied subjects with reduced burning and improved mouth opening or cheek flexibility (Sudarshan et al. 2012). The gel has also shown promising results in reducing oral mucositis, which is a frequent complication in radiation therapy in head and neck cancer patients (Ahmadi 2012). Because of its antifungal properties, topical application of Aloe vera gel is also effective in oral candidiasis, another risk factor in such patients.
Uses aloe vera is an emollient and film-forming gum resin with hydrating, softening, healing, anti-microbial, and anti-inflammatory proper ties. It is most widely recognized for its moisturizing capacity. Aloe vera supplies moisture directly to the skin tissue. other properties include moisture regulation and an apparent ability to absorb uV light. It has a slightly relaxing effect on the skin, making it valuable for sensitive, sunburned, and sun-exposed skins. Aloe vera was popular in traditional medicine to heal burns. It is often used in gels to refresh and calm irritated skin, hence its popularity in sun preparations for cooling and soothing. In addition, it is found to be effective in emulsions formulated for regulating dry skin. There is some indication that aloe vera has a synergistic effect when used in conjunction with other anti-inflammatory substances. Concentrations over 50 percent have been shown to increase the blood supply to the area of application. Although aloe vera’s important constituents are minerals, polysaccharides, amino acids, and carbohydrates, it is about 99.5 percent water. Its benefit in a skin care product depends on the appropriate concentration, as different concentrations result in different benefits and end products. An almost odorless and nearly colorless extract, it is derived from the sap of the aloe leaf. It is used in cosmetics in a gel form (also referred to as an extract) or in a diluted version referred to as aloe vera juice.
Anticancer Research Aloe vera is an herbal remedy promoted as treating a variety of illness (Lust 2014).These two herbal remedies act together as a means to cleanse the colon and eliminatetoxins which could accumulate in the digestive tract causing disease; they alsofunction as an anti-inflammatory agent (Kapoor 2000).
Aloe Vera, Spectrum's freeze dried aloe vera powder is easy to use. Just add 199 parts distilled or deionized water to 1 part aloe vera powder to reconstitute the oil derived from the Aloe Vera plant. It is known for its moisturizing and healing qualities and can be used in a wide range of personal care products. It is also a humectant, hair conditioners, and to relieve dandruff and dry scalp. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Aloe vera is a natural product that is now a day frequently used in the field of cosmetology. Though there are various indications for its use, controlled trials are needed to determine its real efficacy. The aloe vera plant, its properties, mechanism of action and clinical uses are briefly reviewed here.
Seeds Muséum de Toulouse (MHNT)
Aloe vera is a succulent plant species of the genus Aloe. An evergreen perennial, it originates from the Arabian Peninsula, but grows wild in tropical, semi-tropical, and arid climates around the world. It is cultivated for agricultural and medicinal uses. The species is also used for decorative purposes and grows successfully indoors as a potted plant.
It is found in many consumer products including beverages, skin lotion, cosmetics, ointments or in the form of gel for minor burns and sunburns. There is little clinical evidence for the effectiveness or safety of Aloe vera extract as a cosmetic or medicine.
The species has a number of synonyms: A. barbadensis Mill., Aloe indica ing to 60–100 cm (24–39 in) tall, spreading by offsets. The leaves are thick and fleshy, green to grey-green, with some varieties showing white flecks on their upper and lower stem surfaces. The margin of the leaf is serrated and has small white teeth. The flowers are produced in summer on a spike up to 90 cm (35 in) tall, each flower being pendulous, with a yellow tubular corolla 2–3 cm (0.8–1.2 in) long. Like other Aloe species, Aloe vera forms arbuscular mycorrhiza, a symbiosis that allows the plant better access to mineral nutrients in soil.
Aloe vera leaves contain phytochemicals under study for possible bioactivity, such as acetylated mannans, polymannans, anthraquinone C-glycosides, anthrones, and other anthraquinones, such as emodin and various lectins.
Techniques based on DNA comparison suggest Aloe vera is relatively closely related to Aloe perryi, a species endemic to Yemen. Similar techniques, using chloroplast DNA sequence comparison and ISSR profiling have also suggested it is closely related to Aloe forbesii, Aloe inermis, Aloe scobinifolia, Aloe sinkatana, and Aloe striata. With the exception of the South African species A. striata, these Aloe species are native to Socotra (Yemen), Somalia, and Sudan. The lack of obvious natural populations of the species has led some authors to suggest Aloe vera may be of hybrid origin.
Aloe vera is considered to be native only to the south-east Arabian Peninsula in the Al-Hajar mountains in north-eastern Oman.However, it has been widely cultivated around the world, and has become naturalized in North Africa, as well as Sudan and neighboring countries, along with the Canary Islands, Cape Verde, and Madeira Islands. It has also naturalized in the Algarve region of Portugal and in wild areas across southern Spain, especially in the region of Murcia.
As an ornamental plant
Aloe vera has been widely grown as an ornamental plant. The species is popular with modern gardeners as a putatively medicinal plant and for its interesting flowers, form, and succulence. This succulence enables the species to survive in areas of low natural rainfall, making it ideal for rockeries and other low water-use gardens. The species is hardy in zones 8–11, and is intolerant of heavy frost and snow.The species is relatively resistant to most insect pests, though spider mites, mealy bugs, scale insects, and aphid species may cause a decline in plant health. This plant has gained the Royal Horticultural Society's Award of Garden Merit.
In pots, the species requires well-drained, sandy potting soil and bright, sunny conditions. Aloe plants can burn under too much sun or shrivel when the pot does not drain water. The use of a good-quality commercial propagation mix or packaged "cacti and succulent mix" is recommended, as they allow good drainage. Terra cotta pots are preferable as they are porous. Potted plants should be allowed to completely dry before rewat
Aloe Vera gel is contained in the leaves of the plant of the same name. To extract it, simply make a cut at the end and press on it. This gel must be stabilized fairly quickly since in contact with oxygen it degrades rapidly. Aloe Vera Gel has a PH close to that of the skin (4,5), it is an excellent moisturizer, it promotes its elasticity and prevents skin aging. For the scalp, it would help collagen production and delay alopecia (hair loss). Several studies have also shown its anti-inflammatory, antimicrobial properties, promoting healing, the treatment of canker sores, gingivitis or oral lichen planus.
Features & Benefits:
Plant Derived / Vegetal Based
Skin Hydration Agent
Aloe Vera is one of the most common and oldest medicinal plants. The robust plant flourishes in warm climatic regions on calcareous and sandy soils. Aloe Vera is cultivated in large plantations in Central America, USA, China and many other countries. Harvested from at least 3-year-old plants, a maximum of 4 outer leaves per crop are cut. The leaves are washed first. Subsequently peeled and the gel removed. The genuine gel is a viscous mucus of 5% heteropolysaccharides in water and is not storable. Therefore, only gently stabilized and concentrated forms are offered: 10 or 40 fold thickened gel as well as approximately 200 fold concentrated freeze-dried powders. The production of aloe vera gel depends on the combination of care, experience and “know-how”. Satcotek’s suppliers are experienced producers who are well practiced in the process.
Pure Aloe Vera gel has a pH of about pH 4.5 (TDS). The main ingredients of the cosmetically used “inner leaf gel” are: polysaccharides such as acemannan, glucomannan and mannose derivatives. In addition, there are small amounts of vitamins (B1, B2, tocopherol), amino acids (lysine, threonine, valine), enzymes (oxidase, amylase, lipase) and anthraquinones (e.g. aloin, barbaloin, emodin) and further secondary components (e.g. phytosterols, salicylic acid) . The anthraquinones (alonine) derived from the leaf and cell tissue are removed to levels below 10 ppm. A maximum of 50 ppm is recommended.
The combination of more than 200 active ingredients makes Aloe Vera unique:
Pure aloe gel reduces itching, is cooling, anti-inflammatory, antibacterial and moisturizing. The antioxidant effect of aloe vera gel is well known. The Aloe Vera gel stimulates collagen and elastin fiber production as well as cell division and improves the elasticity of the skin.
Because of its rich active spectrum, the Aloe Vera Gel is used in an almost unmanageable range of cosmetics. In cleansing milk and body lotions. In lip care, makeup and facial masks; In hair conditioners and conditioners, in shower gels, as a component of sun cream and self-tanning agents; In depilatories and moisturizers.
For a sufficient effect in cosmetics Aloe Vera gel 1: 1 should be added about 10-20%. The weakly acidic pH-value must be taken into account during formulation.
The most active ingredient is Aloe Vera Gel 1: 1. As alternatives to fresh gel, sprayed or freeze-dried pure Aloe Vera powder 100: 1 and 200: 1 is available. These concentrates are sterile and preservative-free and can be easily formulated.
Aloe Vera Gel 200: 1 is used with 0.1-0.5%. The gel prepared there from can be easily incorporated into warm O / W emulsions.
0.1% aloe vera powder 200: 1 corresponds to about 20% aloe vera 1: 1 gel. With 0.5% Aloe Vera Powder 200: 1 or 1% Aloe Vera Powder 100: 1 in water you can get a liquid product which corresponds to the pure Aloe Vera Gel 1: 1.
* Skin conditioning - Maintains the skin in good condition
* Masking - Reduces or inhibits the basic odour or taste of the product
* Emollient - Softens and smooth the skin
* Humectant - Holds and retains moisture
* Oral care - Provides cosmetic effects to the oral cavity, e.g.cleansing, deodorising, protecting
Aloe vera (Aloe barbadensis) is utilized as an ingredient in a wide range of health and cosmetic products, principally due to its valuable softening effects on skin, e.g. face cleansers, hand creams, lotions, shampoos, skin moisturizers and makeup:
relieves itching caused by mosquito bites . Aloe is used topically for osteoarthritis, burns, sunburns, and psoriasis (mostly unproven effects – and claims that place the
product automatically within the scoop of the medicinal legislation).
UV filters (“sun-blocking”): Some of the yellow sap constituents (i.e. anthraquinones ) show an inherent ability to absorb UV radiation – i.e. effectively sun blocking
agents. In these instances the extract is not termed an UV filter but something else, e.g. a soothing agent. This is because Aloe is not listed as an approved UV filter (for safety
reasons) in any industrialized country.
Aloe vera is a cactus-like plant that has been used for traditional medical purposes at least two thousand years. Aloe vera leaves can be separated in two basic products (see illustration, section “Origin”, below):
- the latex: bitter yellow liquid (‘yellow sap’) from pericycle cell layer beneath the epidermis of the leaf
- the gel: colorless, tasteless substances; inner part of the leaf For cosmetic products, three distinct preparations of the plant are used: Aloe vera latex, Aloe vera gel, and Aloe vera whole leaf extract(purified ‘decolorized’ or unpurified ‘non- decolorized’ for yellow sap
Aloe vera extracts (up to 100%) are frequently used in ‘after sun products’, which appears to have soothing or cooling effect on sun burns. A minimum concentration of 5 –10% is necessary to get a healing response against skin irritation, and even more for effects
against other ailments. Aloe vera gel is applied up to 30% for cosmetic purposes only.
Aloe vera has been widely used as an ingredient in diverse health products; drinks, foods, and supplements. The Aloe vera gel is sometimes used as an ingredient in commercial jellies. Aloe vera is used as an alternative solution to conventional synthetic preservatives.
Aloe vera has been used in folk medicine for over 2000 years.Aloe vera has been used in folk medicine for over 2000 years.Traditionally, aloe was used topically to heal wounds and for various skin conditions (skin wounds, burns, frostbite injuries and skin disorders like acne, dermatitis, psoriasis, eczema), and orally as a laxative. Today, in addition to traditional uses, people take aloe orally to treat a variety of conditions, including diabetes, asthma, epilepsy, and osteoarthritis. However, there is little evidence in the scientific literature to substantiate claims of usefulness for systemic conditions other than as a laxative.
Aloe is a large group of different succulent plants consisting of more than 400 different species of Aloe. The leaves of the species Aloe barbadensis Miller (commonly known as Aloe vera) are most often used for production of Aloe ingredients in cosmetic products, in
addition to dietary supplements and herbal medicines.
Aloe leaves contain a clear gel that is often used as a topical ointment. The gel is the water reservoir of the plant, consisting of approx. 99.5% water and only 0.5% of non-water substances like polysaccharides, phytostereoles etc. (e.g. Danhof 1999 + Annex 1).
The green part of the leaf that surrounds the gel is used to produce a juice or a dried substance (called latex), taken by mouth.
Aloe gel is likely safe when applied to the skin and possibly safe when taken by mouth in adults. Occasionally, aloe gel might cause burning and itching of the skin. Aloe latex is possibly unsafe at any dose, but likely unsafe when taken in high doses. Aloe latex can cause some side effects such as stomach pain and cramps. Long-term use of large amounts of aloe latex might cause diarrhea, kidney problems, blood in the urine, low potassium, muscle weakness, weight loss, and heart disturbances. Taking aloe latex 1 gram per day for several days can be fatal. There have been a few reports of liver problems in some people who have taken an aloe leaf extract; however, this is uncommon. It is thought to only occur in people who are extra sensitive (hypersensitive) to aloe.
Although Aloe vera has for many years been used as an ingredient in cosmetics such as face and hand creams, lotions, and skin moisturisers the FDA has recently become concerned about the widespread distribution of Aloe Vera products promoted for selftreatment of human complaints. Exaggerated and unsubstantiated claims are being made that these products can cure or alleviate a variety of unrelated conditions including colitis, asthma, glaucoma, haemorrhoids, arthritis, acne, anaemia, tuberculosis, cancer, diabetes, depressions multiple sclerosis and even blindness. Such products are often sold as food supplements and cosmetics in health stores but the manufacturer are careful to make no health claims on the product labels and in order to remove them from the market FDA would have to prove them to be adulterated or misbranded. Serious harm may follow when proper medicinal treatment of serious illness is neglected or abandoned in favour of such products with no proven value.
Aloe vera is widely used in a variety of cosmetics including creams and toiletries, but is also sold in the beverage and dietary supplement industries. Aloe vera makes up 99% of the aloe market. Aloe vera is processed by using the entire leaf and removing the hydroxy-anthraquinones while retaining many of the components found in the fresh leaf. Aloe vera (purified extract or gel) is almost free of the hydroxy-anthraquinones with contaminant levels (usually) ranging from 50 ppm to less than 1 ppm.
Aloe preparations as bitter yellow latex (juice), also known as yellow sap.
Aloe vera extract is a colorless, transparent to brown, slightly viscous liquid, which is yellow fine powder after drying. No smell or slightly peculiar smell. It is usually used to make facial masks and is loved by women. Has a strong hydrating performance.
The anthraquinone compounds of aloe vera have the properties of astringent, softening, moisturizing, anti-inflammatory and bleaching. It also relieves hardening, keratosis, and improves scars. It not only prevents small wrinkles, eye bags, and sagging skin, but also keeps the skin moist and delicate. At the same time, it can also treat skin inflammation. It is effective for acne, freckles, acne, and burns. Injuries, insect bites, etc. are also effective. It is also effective on hair, keeping hair moist and smooth and preventing hair loss.
Thickener, stabilizer, gelling agent, binder. Used for general food. It is also used in cosmetics.
Aloe has a long and wide using history in food, medicines, beauty products. Anthraquinone compounds are the main active ingredients of Aloe, it is contain Barbaloin (also called as aloin, aloe-emodin), aloe-emodin anthranol, isobarbaloin, alomycin, aloin A, aloesin and so on. Barbaloin is the basic component, which can be hydrolysed into aloe-emodin under the action of bacterial parasite in human body. Aloe-emodin can stimulate the move of intestinal wall, so it has effective function to adjust the intestine and stomach action of intestine and stomach.
The active constituents for aloe's laxative effect are known as anthraquinone glycosides, which are converted by intestinal bacteria into aglycones. The active compounds responsible for aloe's wound healing properties are less well-described but are likely a combination of several saccharide molecules. When the leaf is consumed, the high fiber content of the plant has been shown to exert beneficial effects on cardiac disease risk factors by reducing blood levels of cholesterol, triglycerides and glucose.
1. With the function of anti-bactericidal and anti-inflammatory, it can accelerate the concrescence of the wounds.
2. Eliminating waste materials from the body and promoting the blood circulation.
3. With the function of whitening and moisturizing skin, especially in treating acne.
4. Eliminating the pain and treating hangover, sickness and seasickness.
5. Preventing the skin being damaged from UV radiation and making skin soft and elastic.
Aloe barbadensis contains numerous components with a natural composite. The innteraction of those ingredients leads to the well-known healing effects.
- Moisturising, cooling and soothing effect
- Relieve itchiness and irriation
With over 500 species of the Aloe genus, Aloe vera is the main commercially cultivated specie of the genus Aloe. It is widely cultivated in India, Mexico, the Dominican Republic, South Africa, China and Costa Rica. Aloe vera has many applications and is used by the cosmetics, food and toiletries and pharmaceutical industries. This study focuses on the use of Aloe vera in the European natural health products market.
Aloe vera has a number of health benefits; this is because Aloe vera has vitamins, minerals and amino acids; antibacterial, antiviral and antiseptic properties; the ability to accelerate wound healing, reduce dental plaque and help treat mouth ulcers; positive laxative effects; and the ability to improve skin and prevent wrinkles. It can also lower blood sugar levels.
Leaf processing method – with this method, Aloe vera leaf juice is obtained by grinding or macerating the entire Aloe vera leaf, followed by purification to remove the phenolic compounds found in the latex. This purification step is usually accomplished through activated carbon filtration in a process known as decolourisation.
Inner leaf processing method – with this method, Aloe vera leaf juice is obtained by stripping away the outer leaf rind, rinsing or washing away the latex and processing the remaining inner leaf material. Decolourisation is also sometimes employed in this method.
The processing of Aloe vera leaves provides gels and saps which are used by the health products, food and cosmetics industries. The processing of Aloe vera can be done in developing countries or in Europe. However, processing is usually done in developing countries, as this helps to retain most of Aloe vera’s beneficial properties.
Several types of Aloe vera gel extracts are present in the market. These include:
- Aloe vera gel extract;
- Aloe vera whole leaf extract/juice;
- Decolourised whole leaf extract/whole leaf Aloe vera gel;
- Dried Aloe vera latex.
Aloe vera is used in herbal medicinal products: it is only permitted as dried, concentrated leaf juice (for example, the latex). In food supplements, the use of Aloe vera gels, extract and latex is permitted, although its latex is only permitted with exceptions (see Specific requirements for food supplements). Dried Aloe vera latex is used for medicinal purposes and its composition is specified in several official pharmacopoeias.
Two substances from Aloe vera – a clear gel and its yellow latex – are used to manufacture commercial products.Aloe gel typically is used to make topical medications for skin conditions, such as burns, wounds, frostbite, rashes, psoriasis, cold sores, or dry skin.
Aloe latex is used individually or manufactured as a product with other ingredients to be ingested for relief of constipation.Aloe latex may be obtained in a dried form called resin or as "aloe dried juice".
There is conflicting evidence regarding whether Aloe vera is effective as a treatment for wounds or burns.There is some evidence that topical use of aloe products might relieve symptoms of certain skin disorders, such as psoriasis, acne, or rashes.
Aloe vera is used in traditional medicine as a skin treatment.Early records of Aloe vera use appear in the Ebers Papyrus from the 16th century BC, and in Dioscorides' De Materia Medica and Pliny the Elder's Natural History – both written in the mid-first century AD.It is also written of in the Juliana Anicia Codex of 512 AD.
Aloe vera is used on facial tissues where it is promoted as a moisturizer and anti-irritant to reduce chafing of the nose.Cosmetic companies commonly add sap or other derivatives from Aloe vera to products such as makeup, tissues, moisturizers, soaps, sunscreens, incense, shaving cream, or shampoos.A review of academic literature notes that its inclusion in many hygiene products is due to its "moisturizing emollient effect".
Interactions with prescribed drugs
Ingested aloe products may have adverse interactions with prescription drugs, such as those used to treat blood clots, diabetes, heart disease and potassium-lowering agents (such as Digoxin), and diuretics, among others. Aloe vera is a stemless or very short-stemmed plant growing to 60–100 centimetres (24–39 inches) tall, spreading by offsets.
The leaves are thick and fleshy, green to grey-green, with some varieties showing white flecks on their upper and lower stem surfaces. The margin of the leaf is serrated and has small white teeth. The flowers are produced in summer on a spike up to 90 cm (35 in) tall, each flower being pendulous, with a yellow tubular corolla 2–3 cm (3⁄4–1 1⁄4 in) long.
Like other Aloe species, Aloe vera forms arbuscular mycorrhiza, a symbiosis that allows the plant better access to mineral nutrients in soil.
Medicinal aloe vera (Aloe vera) is a type of aloe vera used for medicinal purposes from the Asphodelaceae family. The leaf consists of two parts. The green peel section containing substances used as laxatives and called anthraquinones, and the mucilage section called aloe gel.
In the gel part, 18 amino acids, 20 minerals, 12 vitamins and polysaccharides such as acemannan, glucomannan, mannose-6 phosphate, alloerid, which have been shown to be immunostimulants in various scientific studies; various enzymes, alprogen, which has been experimentally shown to be antihistaminic; There are sterols such as lupeol, beta-sitosterol and campesterol, and substances such as lignin and salicylate, which are reported to be effective on blood cholesterol levels and benign prostatic hypertrophy in various studies. The part obtained by evaporating the water of the shell part containing anthraquinones and used as a laxative is called Aloe. The colorless mucilage-like part located inside the leaf and produced by parenchymal cells is called Aloe vera Gel. Since these two parts consistently cause confusion, the World Health Organization's (WHO) Selected Medicinal Plants monograph has been examined in separate chapters.
The preparation of aloe vera gel both superficially and as a nutritional supplement in the form of a drink requires special methods and the products are controlled by today's highly sophisticated analysis methods. The purpose of this is that the substances known to be present in the gel are also preserved in the product.
As an ornamental plant
"Aloe vera" is widely grown as an ornamental plant. The species is popular with modern gardeners as a default medicinal plant and for its interesting flowers, form, and juicy nature. This core allows the species to survive in areas with low natural rainfall, making it ideal for stone paved gardens and other low water use gardens.  The species is hardy in regions 8-11 and is intolerant of severe frost and snow.   The species is relatively resistant to most insect pests, although spider mites, mealybugs, scale insects, and aphid species can cause a decline in plant health.   This plant won the Garden Merit Award from the Royal Horticultural Society. 
In pot, species require well-drained, sandy potting soil and bright, sunny conditions. Aloe plants can burn in too much sun or shrink when the pot is not drained. It is recommended to use a quality commercial growing soil mix or packaged "cacti and slurry soil" as they provide good drainage.  Terracotta pots are preferred because they are porous.  Potted plants should be allowed to dry completely before watering again. Potted aloe can get crowded with "offspring" growing from the sides of the "parent plant". Plants that have become crowded should be divided and stored to make room for further growth and help prevent pest infestation. During the winter, Aloe vera can stay dormant, requiring very little moisture. Species are best kept indoors or in heated greenhouses in areas with frost or snow. 
To supply the cosmetics industry, Australia,  Cuba, Dominican Republic, China, Mexico,  India,  Jamaica,  even inland Spain  Kenya, Tanzania and South Africa [ 13] Along with the USA  there is a large-scale agricultural production of "Aloe vera" .
WHAT IS ALOE VERA?
Aloe vera, whose homeland is Africa, is also known as "immortality plant" and "medicine plant". It is known that the plant, which was used in the treatment of infections and parasites as well as the treatment of burns in Ancient Egypt in 1500 BC, was one of the beauty secrets of the famous Egyptian Queen Cleopatra, and she was massaged with aloe vera to keep her skin fresh. It is also stated that African hunters rub aloe vera on their skin to remove perspiration and body odor.
The leaves of the plant, which consist of 96 percent water, also contain essential oils, amino acids, minerals, vitamins, enzymes, glycoproteins (glycoproteins), resin and anthracene or anthraquinone derivatives. The plant, which creates miracles with regular use on the digestive system, epithelial tissue, respiratory tract and immune system, also contains salicylic acid, the main ingredient of aspirin.
Aloe vera gel:
*It accelerates the healing of burns.
*It can be used as supportive treatment in skin diseases.
*It can prevent wrinkles.
*It helps to treat cancer wounds.
*It nourishes and brightens the hair.
Aloe vera gives the impression of a very simple plant in appearance. The main reason why the plant, which has an appearance consisting of plump curved leaves resembling a spear, is very valuable in the commercial field is the content of these leaves. While the outer surface of the leaves in question is covered with a shell part, there is a gel structure called aloe vera extract on the inside. Among the nutritional values of this extract, there are approximately 20 mineral and amino acid types and dozens of vitamins. Aloe vera, which contains all of these together, also contains various benefits in terms of human health.
Thanks to its benefits for human health, aloe vera is not only a medicinal plant, but also makes a name for itself among medicinal plants. Because today, the world's leading pharmaceutical and cosmetic companies make the most of the aloe vera plant. Thanks to the minerals and vitamins in its structure, it can be used in a wide variety of ways in the field of medicine. However, it is a plant that is frequently used as a herbal treatment tool within the framework of methods known as alternative medicine.
Aloe Vera Benefits
*It functions as a completely natural antioxidant,
*It is a very effective solution tool against constipation problem.
*It can be very useful against wounds and burns on the skin with external use,
*It can also be used in the treatment of eczema and similar skin diseases.
*Helps maintain the health of the stomach,
*It can be an effective treatment method in combating skin cancer.
Except for severe skin cancers such as “malignant melanoma”, skin diseases are diseases that do not lead to fatal consequences, but cause distress by significantly affecting the quality of life. Apart from genetic predisposition, stress, unhealthy diet, digestive problems, especially liver disorders caused by intestinal fungi and chemical drug accumulation, obesity, polluted air, vitamin deficiencies or excesses, excessive sunlight, microbial and bacterial formations cause the immune system to collapse. This collapse shows its first effect on the skin. In fact, this reaction of the skin is the body's insurance or a harbinger of another underlying disease. From this aspect, it is seen that most of the diseases that occur on the surface of the skin (except fungal formations) are not contagious.
The most common skin diseases are eczema (dermatitis) and psoriasis, which are generally defined as the body's hypersensitivity to food, chemicals, contact, air, drugs, dust or animal hair, and the development of allergies, except for the "atopic" or genetic type seen in babies. In both diseases, as in all diseases, the effect of immune system weakness is great.
The aloe vera plant has been examined in scientific institutions in countries such as America, Japan and Germany, and it has been proven that it is a medicinal plant that strengthens the immune system thanks to the "polysaccharide chains" and especially the "acemannan" substance. Also known as desert lily or medicinal aloe vera, the plant is a skin healer that has been used since ancient times to treat all kinds of burns and wounds, including sunburn.
99% of the leaves of the plant, which is a type of cactus, is water. The healing effect is seen in the remaining 1%. This sticky gel consistency contains 12 vitamins, 20 minerals, 18 amino acids and various enzymes (160 ingredients). Care should be taken as the direct use of the plant will cause skin irritations due to the aloin and aloe resin it contains. Or best, to use a medicinal product called Aloe Vera Gel, which is prepared under the control of a herbalist by reducing irritation power and preserving all other properties.
Aloe Vera Gel is a special product that strengthens the immune system when used internally, improves the digestive system, supports the regeneration of the liver, increases the collagen production and moisturizes the skin. The effects of this product have been examined by the World Health Organization and accepted as a "medicinal product".
Aloe vera differs from many plant species in terms of its properties. The differences in question are clearly evident in both the structure and benefits of aloe vera. Aloe vera looks like a cluster of leaves growing from the ground as a plant. Each of the leaves is in the shape of a lance, with serrated edges. For those who have never seen it, we can say that it resembles lily leaves. However, aloe vera leaf structure is meaty and it can only be mentioned that it is similar to lily leaves in terms of appearance. There is a plasmatic liquid called aloe vera extract inside these fleshy leaves. The essential medicinal properties of the plant stem from this essence. Aloe vera extract, which contains many amino acids, vitamins and minerals in its chemical composition, has thus managed to become an indispensable herbal treatment instrument.
The contributions of aloe vera to the human body are countless, both internally and externally. In order to benefit from all these additives, it would be more logical to use aloe vera products instead of consuming the plant directly. One of the products in question is known as aloe vera gel (aloe vera syrup mixed with herbs). Thanks to aloe vera gel, it will be possible to benefit from many effects of aloe vera, from its benefits to the healthy functioning of the digestive system, to its antioxidant properties. Aloe vera, which is very effective in removing many external and internal inflammations from the body, is now presented in an easily accessible form thanks to this gel mixture.
Aloe Vera is a medicinal plant that has been used by ancient cultures for a long time.
The Aloe Vera plant, which is one of the lilies, is of African origin, and the Egyptians used this medicinal plant in BC. Records have been found that they have been using it for herbal treatment since 1500. Today it is grown for commercial purposes in the West Indies and Southwest America.The most useful type of Aloe Vera plant, which has many types, is Aloe Barbadensis. Aloe Vera is a plant with strong nutritional properties with its structure containing vitamins, minerals, amino acids and enzymes. It is used in a wide range of areas in the cosmetics industry due to its moisturizing, soothing and healing effects.
Aloe Vera is one of the oldest medicinal plants due to its biological properties and health benefits. The name Aloe Vera is derived from the Arabic word "Alloeh" which means "bright bitter substance". The Latin "Vera" means "Right". History tells us that ancient Chinese and Egyptians used Aloe Vera to treat burns, treat wounds and reduce fever. Aloe Vera is one of the most studied herbs in the natural products category, known for its natural healing power for skin care and mild problems.
Aloe vera; Contains 75 biologically active and naturally occurring compounds - including polysaccharides, vitamins, enzymes, amino acids and minerals - that work with other components of the body to provide numerous benefits to human health.
Aloe Vera has been recognized as a natural remedy since its discovery thousands of years ago. However, its main use has been in the cosmetic and pharmaceutical industries.
Aloe Vera ingredients are thought to have medicinal properties. The plant is considered a watery species due to its thick leaves that help retain water in hot, arid climates. When talking about Aloe Vera, it is necessary to mention the distinction between each layer of the leaf. There are 3 layers inside the leaf: The transparent gel inside, known as the adhesive layer, is thought to be responsible for most of its therapeutic properties. Approximately 99% of this layer is water and the remainder is made up of glucomannan, amino acids, lipids, sterols and vitamins.
When dry, Aloe gel contains about 55% polysaccharide, 17% sugar, 16% mineral, 7% protein, 4% lipid and 1% phenolic compound.
The middle layer consists of latex. The bitter yellow sap contains anthraquinones and glycosides. Molecules in this layer give Aloe its laxative effects.
Finally: the outer thick layer or shell of 15-20 cells has a protective function and synthesizes carbohydrates and proteins. The vascular bundles inside the shell are made up of xylem and phloem. Xylem helps transport water and minerals from roots to leaves and phloem starch and other small organic molecules.
The chemical composition of the Aloe Vera plant varies depending on the species, climate and growing conditions. It is estimated that there are more than 75 bioactive components in the Aloe Vera leaf. Multiple compounds increased the known benefits of the herb.
Anti-inflammatory effects, wound healing properties, radiation damage repair benefits of Aloe Vera; antibacterial, antiviral, antifungal, antidiabetic and antineoplastic activities; hematopoietic stimulation and antioxidant effects are explained. The phenolic compounds anthraquinones of Aloe Vera leaves have proven to be effective components with strong anti-inflammatory and antioxidant effects, antibacterial activities.
When the chemical analysis of aloe vera is examined, it is seen that there are many elements such as lignin, saponin, anthraquinone, enzyme, vitamin, mineral, monosaccharides, polysaccharides, fatty acids, salicic acid and amino acids.
The ability of aloe vera to penetrate body tissues, its germ, fungal and virus-killing effect, providing new cell formation and wound healing, its relaxing effect on the nervous system, increasing the functioning of the intestines and releasing unwanted harmful substances from the body, strengthening the body's immune system, For a long time, it has been a matter of curiosity how it shows its versatile effects such as its (pain relieving) effect and the removal of dead tissues.
More than 75 nutritional elements were found in only 1% of the plant's composition. Scientists have been interested in how such small amounts of these compounds can have such beneficial effects. Today, it has been understood that these miraculous effects are not due to an unknown substance in the world in the plant structure, but because of the "synergistic" (one to increase the strength of each other) with the mixture of various elements in the optimum ratio.
Let's look briefly at what the substances in Aloe vera do in the body under 8 groups.
1. Saponin, lignin and anthraquinones
Saponin: Antiseptic property against microbes
· Lignin: It penetrates into the skin easily, and carries other substances on the sides of it.
· Anthraquinones: The most important of the 12 anthroquinones found in plant sap are Aloin and Emodin. Except for both germ and virus-killing properties, it is a powerful pain reliever. It also has laxative (intestinal softening) properties. Barbaloin, Ýzobarbaloin have analgesic and antibiotic effects. Anthranol, Anthracene and Aloetic acid exhibit antibiotic effects without side effects. Aloe emodin has a bactericidal and intestinal softening effect. Quinnamic acid ester is pain relieving and numbing, and also helps break down dead tissue. Chrysophanic acid acts as a lethal to fungi on the skin. Ethereal oil is pain reliever and tranquilizer (sedative). Rezistannol has bactericidal properties.
Vitamin A (beta-carotene), Vit.B1 (thiamine), Vit. B2 (riboflavin), Vit. B3 (niacin), Vit. B6 (pyridoxin), Vit. B12, Choline, Vit. C, Vit. E contains Folic acid. Each of these vitamins have an important role in body work and in the production of some important substances. The combination of B3, B6 and B12 vitamins with minerals such as zinc, manganese and chromium, which are also in aloe structure, has a positive effect on brain functions. All these vitamins are necessary for general body health, and many of these vitamins take part in the production of various enzymes.
Aloe vera contains enzymes such as phosphatase, amylase, bradykininase, catalase, cellulase, creatine, phosphokinase, lipase, proteolitase. Most of these enzymes play a role in digestion.
The most important of more than 20 minerals in aloe vera are: calcium, chromium, copper, iron, magnesium, phosphorus, potassium, selenium, sodium and zinc. Most of the minerals are required for the functioning of enzyme systems.
Aloe vera contains both monosaccharides like glucose and fructose and polysaccharides like acemannan. Acemannan, which constitutes approximately 90% of the polysaccharides in fresh aloe vera gel, plays an important role in strengthening the immune system, and is also effective against viruses. Acemannan increases the production of tumor cells and white blood cells, which play a role in fighting infection. It has been shown that the increase in white blood cells accelerates wound healing.
The most important plant steroids included in aloe vera are cholesterol, campesterol, ß-sisosterol and lupeol. These are important anti-inflammatory agents. In addition, lupeol has antiseptic (germicidal) and pain relieving properties.
Salicylic acid, which has the same chemical structure as aspirin, is a demolition product of aloin found in aloe fluid. It has antibacterial and anti-inflammatory properties.
Amino acids are vital building blocks for the human body. 8 of the 22 amino acids required for human beings cannot be produced in the body, they must be supplied from the outside. There are 7 of these 8 main amino acids in aloe vera. In addition, 11 of the other 14 amino acids required for our body are present in Aloe vera.
Cuts, wounds and burns
Aloe vera is used successfully in cuts, wounds and burns due to its strong pain relieving, antimicrobial and cell stimulant effects. Besides its well-known anti-inflammatory and wound healing properties, it accelerates the proliferation of epithelial cells and provides rapid wound healing. In cases where aloe vera is used after skin injuries, bad scar formation is almost not seen.
Aloe vera has been used successfully in various wounds from herpes on the lips to genital organs and severe leg ulcers. Due to its antivirutic effect, it provides recovery in cold sores and herpes zoster in a short time such as 3 days.
Aloe vera has a healing, softening, moisturizing and anti-aging effect on the skin. Cosmetic effect of aloe vera depends on 4 main reasons. These are its moisturizing role, increase collagen, decrease pigment formation and strengthen the skin immune system. The anti-aging effect of Aloe vera is versatile: As it is a very good cleanser, it removes dead cells and cleans the small pores of the skin. On the one hand, while removing waste and toxins in the skin, it nourishes the skin with the vitamins, minerals and amino acids it contains and increases new cell formation. The well-known anti-aging effect of aloe vera is due to the fact that the plant accelerates the proliferation of fibroblast cells 6-8 times than normal. Fibroblast cells prevent skin sagging by manufacturing collagen.
Acne generally respond well to topical application of Aloe vera.
Allergy, itching, eczema
The salicylic acid in aloe vera is anti-allergic due to bradykinase compounds. It is effective by relieving pain and itching. It is also used in eczema due to its anti-allergic effect.
Strengthening the immune system
Aloe vera is a powerful immunostimulant (immune system stimulant), especially with the acemannan contained in it. In addition, the lectins found in the plant also have an immunostimulating effect. Because of its stimulating effect on the immune system, it is tried in AIDS, cancer and tumors. The point to note here is that Aloe vera does not cure cancer, but strengthens the immune system that tries to fight cancer.
Multiple sclerosis (MS)
Aloe vera can be used in this progressive and incurable disease of the nervous system due to its strengthening effect on the immune system.
Those with gall bladder inflammation, bladder inflammation and uterine bleeding should not use Aloe vera.
· Diabetics should consult their doctor before using Aloe vera fluid. Due to the feature of aloe vera that enables the pancreas to make more insulin, the insulin given externally should be reduced in patients using insulin.
1) Epithelial Tissue Cells: Epithelial tissue cells are tissue cells that cover the surface of the body or that are in some way in communication with its surface. Although our skin is the largest part of the epithelial system, it is the most irritated and degraded part. Aloen has a very high restorative effect on the skin and other inner membranes.
2) Immune System: The immunity-enhancing effect of aloe vera, which is known to have very positive effects on the immune system, is a helpful element in the treatment of many inexorable diseases. Undoubtedly, although it is not as effective as a treatment method in diseases such as AIDS and cancer, which can lead to death by destroying the immune system, it is a fact that the use of aloe vera products will be beneficial for the treatment because it keeps the body fit and strengthens the immune system.
When Should Aloe Vera Be Used?
The aloe vera plant is ultimately harmless to the body and can be safely consumed like any fruit and vegetable. On the other hand, it should be kept in mind that aloe vera is not a medicine, but only a useful nutrient. The healing effect of aloe vera has a wide range of uses.
1. In any situation that requires the immune system to be strong
2. Skin diseases, acne, eczema, allergies, boils, inflammation that require skin healing.
3.Antiviral in viral herpes and cold sores
4. Skin conditions such as hair loss, dandruff
5.Sun burns and other burns, cuts, diseases such as psoriasis
6. In conditions such as headache, muscle pain, migraine
7. In gum problems
8.In diseases such as hepatitis and cirrhosis that affect the liver
9. Intestinal and stomach problems, ulcers, mouth sores
10. Heart disorders, high blood pressure
11. In diseases such as asthma, gout, bronchitis, colds
12. Problems with the prostate
In these cases, it helps the body because of its positive effects on the immune system or epithelial tissue. The treatment of the above diseases should definitely be done by the doctor, but it would be sensible to use aloe vera products as nutritional support with treatment.
Aloe vera is a popular medicinal herb that has been used for thousands of years and is mostly used to treat skin injuries. The herb also has other beneficial effects on health.
Aloe vera; It is a thick, short stemmed plant that stores water in its leaves. It is widely used in the cosmetics, pharmaceutical and food industries and has an estimated market value of $ 13 billion worldwide.
Aloe vera benefits
Contains healthy plant compounds
Aloe vera is known for its thick, pointed and fleshy green leaves that are about 12-19 inches (30-50cm) long. Each leaf is filled with a soft tissue that stores the leaves and water. This fine and water-filled texture is the gel that we associate with aloe vera products. Gel; Contains most of the bioactive compounds in the plant such as vitamins, minerals, amino acids and antioxidants.
• Shows antioxidant and antibacterial properties
Antioxidants are important for health. Aloe vera gel contains powerful antioxidants that belong to a broad family of substances known as polyphenols. These polyphenols, along with many other ingredients found in aloe vera, can help inhibit the growth of certain bacteria that can cause infection in humans. Aloe vera gel is also used in toothpaste because of its anti-inflammatory and antibacterial properties.
• Accelerates the healing of burns
Aloe vera is commonly used as a topical remedy, rubbed into the skin instead of oral use. It is known that it has been used in the treatment of burns for a long time. Studies suggest that aloe vera is an effective topical treatment tool for first and second degree burns. Experimental studies have shown that aloe vera can reduce the healing time of burns by about nine days compared to conventional medicines. Evidence that aloe vera can be used as a healing tool for other types of wounds is scant.
• Reduces dental plaque
Tooth decay and gum diseases are common health problems. One of the best ways to prevent these ailments is to reduce the buildup of plaque (bacterial biofilms) on the teeth. In a study of mouthwash on 300 healthy people, 100% pure aloe vera juice was compared to a standard mouthwash. Aloe vera has been found to be as effective as a mouthwash solution after four days of use. Another study found similar benefits when aloe vera was used over a period of 15 to 30 days. Aloe vera makes this effect in the mouth by killing Streptococcus Mutans and Candida Albicans, which are found in the oral flora.
• Its effect on cancer wounds
Many people face mouth ulcers or a cancer-based scar in their lives. These types of injuries usually occur under the lip, inside the mouth and disturb the patient for about 7-10 days. Studies have convincingly shown that aloe vera treatment can speed healing of mouth ulcers. In a 7-day study of 180 people with recurrent mouth ulcers; An aloe vera patch applied to the area was effective in reducing the size of ulcers. In another study, aloe vera gel not only accelerated the healing of mouth ulcers but also reduced the pain associated with them.
• Reduces constipation wounds
Aloe vera is often used to treat constipation. This time it is not the gel, but the latex that provides the benefit. Latex is a sticky yellow residue found just under the leaf skin. The key compound responsible for this effect is aloin or barbaloin, which has well established laxative effects. However, some concerns have been expressed about safety issues associated with frequent use. For this reason, aloe latex has not been available as an over-the-counter drug in the US since 2002. A 2013 trial found that aloe vera had a positive effect on reducing abdominal pain and bloating in people with irritable bowel syndrome (IBS). However, this study lacks a control group. In other words, it is not possible to determine whether the symptoms develop as a direct result of aloe vera. Symptoms may naturally improve over time or as part of the placebo effect. There is currently no evidence to support the use of aloe vera to treat IBS symptoms. Higher quality controlled studies will be required to determine the benefits that aloe vera may have for people with IBS. Contrary to popular belief, aloe vera does not appear to be effective against other digestive disorders such as irritable bowel syndrome and inflammatory bowel disease. Aloe vera can be thrown into a juice using the green part of the leaf. This juice can act as a laxative and can be used to treat constipation or diarrhea.
Can improve skin and prevent wrinkles
In a study conducted on 30 women over the age of 30, it was observed that topical application of the gel increased collagen production and increased skin elasticity over a period of 90 days. Another study found that aloe vera reduced skin redness but also dehydrated skin cells. There is little evidence that aloe vera can treat skin conditions such as psoriasis and radiation dermatitis. It is now common for people to use the plant to treat skin conditions such as removing gels from the leaves, moisturizers, and soaps.
• Lowers blood sugar levels
Aloe vera is sometimes used as a traditional diabetes medicine. It is said to increase insulin sensitivity and improve blood sugar control in the body. In many animal and human studies in type 2 diabetics, promising results have been obtained from the intake of aloe vera. However, the quality of these studies is very poor. Therefore, time is definitely needed to recommend aloe vera for this purpose. Additionally, some cases of liver damage have been reported with long-term intake of aloe vera supplements.
Side effects of aloe vera
Aloe vera juice can be either purified (colored) or uncoloured (uncolored). Undiluted juice can cause adverse side effects such as: Abdominal pain, diarrhea, dehydration or electrolyte imbalances, low blood sugar levels, allergic reactions, interactions with other medications. Juices made with the whole leaf of the plant may contain latex and may lead to negative side effects. People should only drink this type of water in small amounts.
Aloe vera has some unique therapeutic properties, especially when applied as an ointment for the skin and gums. Various aloe vera products; Aloe vera gel can be purchased at health food stores or online, such as juice, supplements, oil, and powder. Be sure to consult a doctor before using aloe vera products to treat an ailment and any possible side effects after drinking an aloe vera juice.