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CAS NUMBER: 58-95-7
EC NUMBER: 231-710-0
MOLECULAR FORMULA: C31H52O3
MOLECULAR WEIGHT: 472.7
IUPAC NAME: [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate
Alpha-Tocopherol Acetate is a tocol.
Alpha-Tocopherol Acetate, also known as vitamin E acetate, is a synthetic form of vitamin E.
Alpha-Tocopherol Acetate is the ester of acetic acid and α-tocopherol
Alpha-Tocopherol Acetate is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements.
In particular, the Alpha-Tocopherol Acetate is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the alpha-tocopherol stereoisomers.
Moreover, Alpha-Tocopherol Acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed.
Alpha-Tocopherol Acetate is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in vitamin E.
Alpha-Tocopherol Acetate itself is naturally found in various foods, added to others, or used in commercially available products as a dietary supplement.
Alpha-Tocopherol Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties.
Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols).
Alpha-Tocopherol Acetate is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production.
Alpha-Tocopherol Acetate also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
Use in Cosmetics:
Alpha-Tocopherol Acetate is often used in dermatological products such as skin creams.
Alpha-Tocopherol Acetate is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol.
Claims are made for beneficial antioxidant effects.
Alpha-Tocopherol Acetate is used as an alternative to tocopherol itself because the phenolic hydroxyl group is blocked, providing a less acidic product with a longer shelf life.
Alpha-Tocopherol Acetate is believed that the acetate is slowly hydrolyzed after it is absorbed into the skin, regenerating tocopherol and providing protection against the sun's ultraviolet rays.
Alpha-Tocopherol Acetate was first synthesized in 1963 by workers at Hoffmann-La Roche.
Although there is widespread use of Alpha-Tocopherol Acetate as a topical medication, with claims for improved wound healing and reduced scar tissue, reviews have repeatedly concluded that there is insufficient evidence to support these claims.
There are reports of Alpha-Tocopherol Acetate-induced allergic contact dermatitis from use of vitamin E derivatives such as tocopheryl linoleate and tocopherol acetate in skin care products.
Incidence is low despite widespread use.
Alternative Classes:
*Diterpenoids
*1-benzopyrans
*Alkyl aryl ethers
*Benzenoids
*Carboxylic acid esters
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds
Alpha-Tocopherol Acetate (ATA) is a specific form of vitamin E that’s often found in skin care products and dietary supplements.
Alpha-Tocopherol Acetate’s also known as tocopheryl acetate, tocopherol acetate, or vitamin E acetate.
Alpha-Tocopherol Acetate is known for its antioxidant properties.
Alpha-Tocopherol Acetate helps to protect your body from damaging compounds called free radicals.
Normally, free radicals form when your body converts food into energy.
However, free radicals can also come from UV light, cigarette smoke, and air pollution.
Substituents:
*Diterpenoid
*Chromane
*Benzopyran
*1-benzopyran
*Alkyl aryl ether
*Benzenoid
*Carboxylic acid ester
*Carboxylic acid derivative
*Oxacycle
*Organoheterocyclic compound
*Ether
*Monocarboxylic acid or derivatives
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Carbonyl group
*Organooxygen compound
*Aromatic heteropolycyclic compound
In nature, Alpha-Tocopherol Acetate comes in the form of tocopheryl or tocotrienol.
Both tocopheryl and tocotrienol have four forms, known as alpha, beta, gamma, and delta.
Alpha-Tocopherol Acetate is the most active form of vitamin E in humans.
Alpha-Tocopherol Acetate is more stable than AT, meaning it can better withstand environmental stresses such as heat, air, and light.
This makes Alpha-Tocopherol Acetate ideal for use in supplements and fortified foods because it has a longer shelf life.
In addition to dietary supplements and cosmetic products, Alpha-Tocopherol Acetate can be found in the following foods:
-green leafy vegetables, such as broccoli and spinach
-oils, such as sunflower oil, wheat germ oil, and corn oil
-sunflower seeds
-nuts, such as almonds and peanuts
-whole grains
-fruits, such as kiwi and mango
Alpha-Tocopherol Acetate is also added to fortified foods, such as cereals, fruit juices, and many spreads.
Alpha-Tocopherol Acetate is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements
Alpha-Tocopherol Acetate is also known simply as tocopheryl acetate
Alpha-Tocopherol Acetate is a synthetic form of vitamin E found in dietary supplements and skincare products.
Alpha-Tocopherol Acetate is known for its antioxidant properties in which cells are protected from the damaging effects of compounds known as free radicals.
Alpha-Tocopherol Acetate is also considered the most stable and active form of vitamin E and the best option overall for treating vitamin E deficiency.
Alpha-Tocopherol Acetate can be found in thousands of skincare products where it is used as a skin-conditioning agent.
Alpha-Tocopherol Acetate antioxidant effects may help prevent skin damage caused by excessive ultraviolet (UV) radiation from the sun.
Others claim that it can slow skin aging when applied the skin or aging-related eye damage when taken as a supplement.
Alpha-Tocopherol Acetate is also known as:
*Vitamin E acetate
*Tocopherol acetate
*A-tocopherol
*Alpha tocopherol
*D-alpha tocopherol
What Is Alpha-Tocopherol Acetate Used For?
There are many potential benefits that are claimed to be offered by tocopheryl acetate, these include:
-Treating vitamin E deficiency
-Promoting healthy skin (such as moisturizing and preventing wrinkles)
-Helping with wound healing
-Reducing inflammation
-Slowing the progression of age-related macular degeneration (AMD)
-Cancer prevention and cancer treatment symptoms (such as side effects of radiation therapy)
-Treating heart disease
-Improving cognitive decline, such as Alzheimer’s disease
PHYSICAL PROPERTIES:
-Molecular Weight: 472.7
-XLogP3-AA: 10.8
-Exact Mass: 472.39164552
-Monoisotopic Mass: 472.39164552
-Topological Polar Surface Area: 35.5 Ų
-Physical Description: Light yellow liquid
-Color: Lighr Yellow
-Form: Liquid
-Boiling Point: >343 °C
-Melting Point: 82 °F
-Density: 0.9507
-Chemical Classes: Biological Agents -> Vitamins and Derivatives
Alpha-Tocopherol Acetate is a fat-soluble vitamin from a class of organic compounds, many of which are known to have vitamin E activity.
Alpha-Tocopherol Acetate is an antioxidant - naturally occurring chemicals that help prevent cell damage by fighting off highly reactive free radicals.
Alpha-Tocopherol Acetate can be found a variety of places in nature: fruits, vegetables, marine plants, even some seafood.
Alpha-Tocopherol Acetate is used as an alternative to free tocopherol because it is more stable in formulation.
The Alpha-Tocopherol Acetate in our products serves as an antioxidant for the product and for its skin conditioning properties.
CHEMICAL PROPERTIES:
-Hydrogen Bond Donor Count: 0
-Hydrogen Bond Acceptor Count: 3
-Rotatable Bond Count: 14
-Heavy Atom Count: 34
-Formal Charge: 0
-Complexity: 602
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 3
-Undefined Atom Stereocenter Count: 0
-Defined Bond Stereocenter Count: 0
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 1
-Compound Is Canonicalized: Yes
Alpha-Tocopherol Acetate, also known as a-tocopherol acetic acid, belongs to the class of organic compounds known as vitamin e compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
Based on a literature review a significant number of articles have been published on Alpha-Tocopherol Acetate.
Alpha-Tocopherol Acetate belongs to the class of organic compounds known as vitamin e compounds.
These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
Alpha-Tocopherol Acetate is the ester form of α-Tocopherol.
Alpha-Tocopherol Acetate is a series of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring.
Alpha-Tocopherol Acetate is lipid soluble anti-oxidants that protect cell membranes from oxidative damage.
Alpha-Tocopherol Acetate is the form of tocopherol preferentially absorbed by humans.
Alpha-Tocopherol Acetate is the ester of acetic acid and α-tocopherol
Alpha-Tocopherol Acetate is often used in dermatological products such as skin creams.
Alpha-Tocopherol Acetate is a specific form of vitamin E that’s often found in skin care products and dietary supplements.
Alpha-Tocopherol Acetate is known for its antioxidant properties.
Alpha-Tocopherol Acetate is a synthetic form of vitamin E found in dietary supplements and skincare products.
Alpha-Tocopherol Acetate is also considered the most stable and active form of vitamin E and the best option overall for treating vitamin E deficiency.
Alpha-Tocopherol Acetate is also known as D-alpha tocopherol
Alpha-Tocopherol Acetate is used for reducing inflammation
SYNONYMS:
Vitamin E acetate
alpha-Tocopherol acetate
58-95-7
Tocopherol acetate
D-ALPHA-TOCOPHERYL ACETATE
Alfacol
D-alpha-tocopherol acetate
Econ
Ephynal acetate
Tokoferol acetate
Tocopheryl acetate
(+)-alpha-Tocopherol acetate
Tocopherex
Evipherol
Tocophrin
Erevit
alpha-Tocopheryl acetate
Vitamin Ealpha acetate
DL-alpha-Tocopheryl acetate
Vitamin E acetate, d-
Tinoderm E
(+)-alpha-Tocopheryl acetate
Natur-E granulate
Lutavit E 50
Ephynal
52225-20-4
alpha-Tocopherol acetate, all rac
DL-alpha-Tocopherylacetate
(R,R,R)-alpha-Tocopheryl acetate
D-.alpha.-Tocopherol acetate
Tocopheryl acetate, D-alpha-
Vitamin E Acetate (D-form)
(2R,4'R,8'R)-alpha-Tocopheryl acetate
alpha-Tocopherol acetate, (2R,4'R,8'R)-
D-|A-Tocopherol acetate
D-alpha tocoferil acetate
Tocopherolacetate, alpha-
DL-alpha tocopheryl acetate
.alpha.-Tocopheryl acetate
d-Alpha Tocopheryl Acetate
Tocopherol acetate
RRR-alpha-tocopheryl acetate
(+)-alfa-tocopherol acetate
alpha-tocopheryl acetate, D-
(+-)-alpha-Tocopherol acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, [2R-[2R*(4R*,8R*)]]-
(+)-.alpha.-Tocopherol acetate
(+)-.alpha.-Tocopheryl acetate
.alpha.-Tocopherol acetate
Vitamin E Acetate Oil - Synthetic
5-17-04-00169 (Beilstein Handbook Reference)
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-
6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
d-Vitamin E acetate
(R,R,R)-.alpha.-Tocopheryl acetate
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*)))-
CAS-58-95-7
(+-)-alpha-Tocopherol Acetateacid ester
CAS-52225-20-4
EINECS 257-757-7
O-Acetyl-alpha-tocopherol
(2R,4'R,8'R)-.alpha.-Tocopheryl acetate
DL-alpha-Tocopherol acetate, >=96% (HPLC)
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
DL-alpha-Tocopherylacetate (Vitamin E acetate)
DL-alpha-Tocopherol acetate, analytical standard
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] acetate
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-b- enzopyran-6-ol, acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, 6-acetate, (2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, acetate, (2R)-rel-
D-.alpha.-Tocopheryl acetate
C31H52O3
DL-alpha-Tocopherol acetate, tested according to Ph.Eur.
(+)-alpha-Tocopherol acetate, oil or semi-solid, ~1360 IU/g, semisynthetic
Alpha Tocopheryl Acetate, United States Pharmacopeia (USP) Reference Standard
alpha-Tocopherol acetate, European Pharmacopoeia (EP) Reference Standard
DL-alpha-Tocopherol acetate, certified reference material, TraceCERT(R)
(+)-alpha-Tocopherol acetate, BioReagent, suitable for insect cell culture, ~1360 IU/g
(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate #
Tocopheryl Acetate, a, Pharmaceutical Secondary Standard; Certified Reference Material
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate
[2R-[2R*(4R,8R*)]]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate
Alpha Tocopheryl Acetate
Copherol 12250
d-|ATocopheryl Acetate
O-Acetyl-|A-tocopherol
1406-70-8
alpha-Tocopherylis acetas
vitamin E acetate, (2R-(2R*(4R*,8R*)))-isomer
DL-|A-Tocopheryl acetate
vitamin E acetate, ((2R*(4R*,8R*))-(+-))-isomer
(+)-|A-Tocopherol acetate
(+)-|A-Tocopheryl Acetate
all-rac-|A-Tocopheryl acetate
DL-ALPHA-TOCOPHEROLACETATE
(R,R,R)-|A-Tocopheryl Acetate
(2R*(4R*,8R*))-(1)-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate,(2R*(4R*,8R*))-(+-)-
.ALPHA.-TOCOPHEROL ACETATE, D-
(2R,4'R,8'R)-|A-Tocopherol Acetate
(2R,4'R,8'R)-|A-Tocopheryl Acetate
DL-alpha-Tocopherol acetate
Tocopheryl Acetate, d-Alpha
DL-alpha-Tocopheryl acetate, 98%
TOCOPHERYL ACETATE [WHO-DD]
ALPHA-TOCOPHEROL ACETATE, D-
ALPHA-TOCOPHEROL ACETATE. D-
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate
.ALPHA.-TOCOPHEROL ACETATE. D-
.ALPHA.-TOCOPHEROL ACETATE [MI]
TOCOPHERYL ACETATE, .ALPHA., D-
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol 6-Acetate
[2R*(4R*,8R*)]-()-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
133-80-2
2H-1-benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate,
2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,6-acetate, (2R)-
all-rac-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
D-ALPHA TOCOFERIL ACETATE
RRR-ALPHA-TOCOPHERYL ACETATE
TOCOPHERYL ACETATE,D-ALPHA
Tocopheryl acetate (Vitamin E acetate) solution
DL-alpha-Tocopherylacetate (Vitamin E acetate)
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl acetate
2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,acetate, (2R)-
