PRODUCTS

AMIDOSULFONIC ACID

CAS Number : 5329-14-6
EC Number : 226-218-8
ECHA InfoCard   : 100.023.835
PubChem CID   : 5987
ChemSpider   : 5767
Chemical formula : H3NSO3
Molar mass   : 97.10 g/mol
Appearance   : white crystals
Density   : 2.15 g/cm3
Melting point   : 205 °C

IUPAC name :
-Sulfamic acid

Amidosulfonic Acid , also known as amidosulfonic acid, amidosulfuric acid, aminosulfonic acid, sulphamic acid and sulfamidic acid, is a molecular compound with the formula H3NSO3.
This colourless, water-soluble compound finds many applications.
Amidosulfonic Acid melts at 205 °C before decomposing at higher temperatures to water, sulfur trioxide, sulfur dioxide and nitrogen.
Amidosulfonic Acid (H3NSO3) may be considered an intermediate compound between sulfuric acid (H2SO4), and sulfamide (H4N2SO2), effectively replacing a hydroxyl (–OH) group with an amine (–NH2) group at each step.
This pattern can extend no further in either direction without breaking down the sulfonyl (–SO2–) moiety.
Amidosulfonic Acid are derivatives of sulfamic acid.

Production of Amidosulfonic Acid
Amidosulfonic Acid is produced industrially by treating urea with a mixture of sulfur trioxide and sulfuric acid (or oleum).
The conversion is conducted in two stages, the first being sulfamation:

OC(NH2)2 + SO3 → OC(NH2)(NHSO3H)
OC(NH2)(NHSO3H) + H2SO4 → CO2 + 2 H3NSO3

In this way, approximately 96,000 tonnes were produced in 1995.

Structure and reactivity of Amidosulfonic Acid
Amidosulfonic Acid is well described by the formula H3NSO3, not the tautomer H2NSO2(OH).
The relevant bond distances are 1.44 Å for the S=O and 1.77 Å for the S–N.
The greater length of the S–N is consistent with a single bond.
Furthermore, a neutron diffraction study located the hydrogen atoms, all three of which are 1.03 Å distant from the nitrogen.
In the solid state, the molecule of Amidosulfonic Acid is well described by a zwitterionic form.

Hydrolysis of Amidosulfonic Acid
The crystalline solid is indefinitely stable under ordinary storage conditions, however, aqueous solutions of sulfamic acid slowly hydrolyse to ammonium bisulfate, according to the following reaction:

H3NSO3 + H2O → [NH4]+[HSO4]−

Its behaviour resembles that of urea, (H2N)2CO.
Both feature amino groups linked to electron-withdrawing centres that can participate in delocalised bonding.
Both liberate ammonia upon heating in water, with urea releasing CO2 while sulfamic acid releases sulfuric acid.

Acid–base reactions of Amidosulfonic Acid
Amidosulfonic Acid is a moderately strong acid, Ka = 0.101 (pKa = 0.995).
Because the solid is not hygroscopic, Amidosulfonic Acid is used as a standard in acidimetry (quantitative assays of acid content).

H3NSO3 + NaOH → NaH2NSO3 + H2O
Double deprotonation can be effected in ammonia solution to give the anion HNSO2−3.
H3NSO3 + 2 NH3 → HNSO2−3 + 2 NH+4

Reaction with nitric and nitrous acids of Amidosulfonic Acid
With nitrous acid, Amidosulfonic Acid reacts to give nitrogen:

HNO2 + H3NSO3 → H2SO4 + N2 + H2O
while with nitric acid, it affords nitrous oxide:

HNO3 + H3NSO3 → H2SO4 + N2O + H2O

Reaction with hypochlorite of Amidosulfonic Acid
The reaction of excess hypochlorite ions with Amidosulfonic Acid or a sulfamate salt gives rise reversibly to both N-chlorosulfamate and N,N-dichlorosulfamate ions.

HClO + H2NSO3H → ClNHSO3H + H2O
HClO + ClNHSO3H ⇌ Cl2NSO3H + H2O

Consequently, Amidosulfonic Acid is used as hypochlorite scavenger in the oxidation of aldehydes with chlorite such as the Pinnick oxidation.

Reaction with alcohols of Amidosulfonic Acid
Upon heating Amidosulfonic Acid will react with alcohols to form the corresponding organosulfates.
Amidosulfonic Acid is more expensive than other reagents for doing this, such as chlorosulfonic acid or oleum, but is also significantly milder and will not sulfonate aromatic rings. Products are produced as their ammonium salts.
Such reactions can be catalyzed by the presence of urea.
Without the presence of any catalysts, Amidosulfonic Acid will not react with ethanol at temperatures below 100 °C.

ROH + H2NSO3H → ROS(O)2O− + NH+4

An example of this reaction is the production 2-ethylhexyl sulfate, a wetting agent used in the mercerisation of cotton, by combining sulfamic acid with 2-ethylhexanol.

Applications of Amidosulfonic Acid
Amidosulfonic Acid is mainly a precursor to sweet-tasting compounds.
Reaction with cyclohexylamine followed by addition of NaOH gives C6H11NHSO3Na, sodium cyclamate.
Related compounds are also sweeteners, such as acesulfame potassium.

Sulfamates have been used in the design of many types of therapeutic agents such as antibiotics, nucleoside/nucleotide human immunodeficiency virus (HIV) reverse transcriptase inhibitors, HIV protease inhibitors (PIs), anticancer drugs (steroid sulfatase and carbonic anhydrase inhibitors), antiepileptic drugs, and weight loss drugs.

Cleaning agent of Amidosulfonic Acid
Amidosulfonic Acid is used as an acidic cleaning agent and descaling agent sometimes pure or as a component of proprietary mixtures, typically for metals and ceramics.
For cleaning purposes, there are different grades based on application such as GP Grade, SR Grade and TM Grade.
Amidosulfonic Acid is frequently used for removing rust and limescale, replacing the more volatile and irritating hydrochloric acid, which is cheaper.

Amidosulfonic Acid is often a component of household descalant, for example, Lime-A-Way Thick Gel contains up to 8% sulfamic acid and has pH 2.0–2.2,or detergents used for removal of limescale.
When compared to most of the common strong mineral acids, sulfamic acid has desirable water descaling properties, low volatility, and low toxicity.
Amidosulfonic Acid forms water-soluble salts of calcium and ferric iron.

Amidosulfonic Acid is preferable to hydrochloric acid in household use, due to its intrinsic safety.
If inadvertently mixed with hypochlorite based products such as bleach, it does not form chlorine gas, whereas the most common acids would; the reaction (neutralisation) with ammonia, produces a salt, as depicted in the section above.
Amidosulfonic Acid also finds applications in the industrial cleaning of dairy and brewhouse equipment.
Although Amidosulfonic Acid is considered less corrosive than hydrochloric acid, corrosion inhibitors are often added to the commercial cleansers of which it is a component.
Amidosulfonic Acid can be used as a descalant for descaling home coffee and espresso machines and in denture cleaners.

Other uses of Amidosulfonic Acid
-Catalyst for esterification process
-Dye and pigment manufacturing
-Herbicide
-Descalant for scale removal
-Coagulator for urea-formaldehyde resins
-Ingredient in fire extinguishing media. Sulfamic acid is the main raw material for ammonium sulfamate which is a widely used herbicide and fire retardant material for household products.
-Pulp and paper industry as a chloride stabilizer
-Synthesis of nitrous oxide by reaction with nitric acid
-The deprotonated form (sulfamate) is a common counterion for nickel(II) in electroplating.
-Used to separate nitrite ions from mixture of nitrite and nitrate ions( NO3−+ NO2−) during qualitative analysis of nitrate by Brown Ring test.
-Obtaining deep eutectic solvents with urea

Silver polishing of Amidosulfonic Acid
According to the label on the consumer product, the silver cleaning product TarnX contains thiourea, a detergent, and Amidosulfonic Acid.

Amidosulfonic Acid appears as a white crystalline solid.
Density 2.1 g / cm3.
Melting point 205 °C.
Combustible.
Irritates skin, eyes, and mucous membranes.
Low toxicity.
Used to make dyes and other chemicals.

Amidosulfonic Acid is the simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to hydroxy and amino groups and by double bonds to two oxygen atoms.

Use and Manufacturing of Amidosulfonic Acid
Used as a herbicide and chemical reagent; [ChemIDplus] Used as a herbicide (ammonium sulfamate) and to stabilize chlorine for swimming pools, cooling towers, and paper mills; used in electroplating (metal salts) and acid cleaning; [Merck Index] Used in photography (color bleach); [www.ci.tucson.az.us/arthazards/medium.html]

Industry Uses of Amidosulfonic Acid
-Agricultural chemicals (non-pesticidal)
-Bleaching agents
-Corrosion inhibitors and anti-scaling agents
-Finishing agents
-Paint additives and coating additives not described by other categories
-Plating agents and surface treating agents
-Processing aids, not otherwise listed
-Solvents (for cleaning and degreasing)
-Solvents (which become part of product formulation or mixture)
-Surface active agents
-acid cleaner
-chemical distribution

Consumer Uses of Amidosulfonic Acid
-Agricultural products (non-pesticidal)
-Building/construction materials not covered elsewhere
-Cleaning and furnishing care products
-Laundry and dishwashing products
-Metal cleaning
-Metal products not covered elsewhere
-Paints and coatings
-Water treatment products
-chemical distribution
-descaling of pipes and manufacturing lines

Household Products of Amidosulfonic Acid
Household & Commercial/Institutional Products
Information on 66 consumer products that contain Sulfamic acid in the following categories is provided:
-Auto Products
-Commercial / Institutional
-Home Maintenance
-Inside the Home

General Manufacturing Information
Industry Processing Sectors
-Acid Cleaning
-All other chemical product and preparation manufacturing
-Fabricated metal product manufacturing
-Food, beverage, and tobacco product manufacturing
-Miscellaneous manufacturing
-Paint and coating manufacturing
-Pharmaceutical and medicine manufacturing
-Plastic material and resin manufacturing
-Primary metal manufacturing
-Soap, cleaning compound, and toilet preparation manufacturing
-Textiles, apparel, and leather manufacturing
-Wholesale and retail trade
-sales and services for the marine industry

Amidosulfonic Acid is an inorganic solid acid formed by replacing the hydroxyl group of sulfuric acid with an amino group.
Amidosulfonic Acid is generally a white, odorless crystalline powder with a relative density of 2.126 and a melting point of 205°C.
Amidosulfonic Acid is easily soluble in water and liquid ammonia.
As long as it is kept dry and not in contact with water, solid Amidosulfonic Acid does not absorb moisture and is relatively stable.

The aqueous solution of Amidosulfonic Acid has the same strong acidity as hydrochloric acid and sulfuric acid, so it is also called solid sulfuric acid.
Amidosulfonic Acid has the characteristics of non-volatile, odorless and low toxicity to human body.
Amidosulfonic Acid is a common chemical raw material, which can be widely used in the synthesis of herbicides, fire retardants, sweeteners, preservatives, metal cleaning agents, etc.

Applications of Amidosulfonic Acid

Cleaning Agent
Amidosulfonic Acid as cleaning agent can be used for cleaning boilers, condensers, heat exchangers, jackets and chemical pipelines.

Textile Industry
Can be used as a remover in the dye industry, a fixing agent for textile dyeing, forming a fireproof layer on textiles, and can also be used to make mesh agents and other additives in the textile industry.

Paper Industry
Amidosulfonic Acid can be used as a bleaching aid to reduce or eliminate the catalytic effect of heavy metal ions in the bleaching liquid, so as to ensure the quality of the bleaching liquid, and at the same time, it can reduce the oxidative degradation of metal ions on fibers and prevent the peeling reaction of fibers. , Improve the strength and whiteness of pulp.

Oil Industry
Amidosulfonic Acid can be used to unblock the oil layer and improve the permeability of the oil layer.
The sulfamic acid solution is injected into the carbonate rock oil-producing layer, because the sulfamic acid is easy to react with the oil layer rock, which can avoid the deposition of salt generated by the reaction.
Although the treatment cost is slightly higher than with hydrochloric acid, the oil production is doubled.

Agricultural
Amidosulfonic Acid and ammonium sulfamate were originally developed as herbicides.

Electroplating Solution
Amidosulfonic Acid for sale is commonly used in gilding or alloying.
The plating solution of gilding, silver and gold-silver alloys is 60 ~ 170g sulfamic acid per liter of water.

Usage areas of Amidosulfonic Acid
Amidosulfonic Acid is a precursor to mainly sweet-tasting compounds.
Reaction with cyclohexylamine followed by addition of NaOH gives C6H11NHSO3Na, sodium cyclamate.
Related compounds are also sweeteners such as acesulfame potassium.

Sulfamates are used in the contents of many drugs such as antibiotics, weight loss drugs, nucleoside / nucleotide human immunodeficiency virus (HIV) reverse transcriptase inhibitors, HIV protease inhibitors (PIs), anticancer drugs (steroid sulfatase and carbonic anhydrase inhibitors), antiepileptic drugs.
Amidosulfonic Acid is used as a catalyst for the esterification process.
Amidosulfonic Acid is used for dye and pigment production.
Urea is used as a coagulator for formaldehyde resins.

Amidosulfonic Acid is the main raw material of ammonium sulfamate, a widely used herbicide and flame retardant material for household products.
Amidosulfonic Acid is used in the pulp and paper industry as a chloride stabilizer.
Amidosulfonic Acid is used for the synthesis of nitrous oxide by reacting with nitric acid.
The deprotonated form (sulfamate) is a common counterion for nickel(II) in electroplating.

Amidosulfonic Acid is used to separate nitrite ions from a mixture of nitrite and nitrate ions (NO3− + NO2−) during the qualitative analysis of nitrate with the Brown Ring test.
Sulfamic acid is used as an acidic cleaning agent, typically for metals and ceramics, sometimes as a component of pure or proprietary blends. It is often used to remove rust and limescale to replace the cheaper, more volatile and irritating hydrochloric acid.
Amidosulfonic Acid can be used as a descaler in domestic coffee and espresso machines and denture cleaners.
Amidosulfonic Acid can also be used for industrial cleaning of dairy and brewery equipment.

Amidosulfonic Acid, the monoamide of sulfuric acid, is a strong inorganic acid.
Amidosulfonic Acid is generally used in chemical cleaning processes like removal of nitrites, carbonate- and phosphate-containing deposits.
Amidosulfonic Acid is used as a raw material for the preparation of a synthetic sweetener i.e, sodium cyclohexylsulfamate.

Application
Amidosulfonic Acid can be used as a catalyst in:
-Friedlander quinoline synthesis.
-Liquid Beckmann rearrangement for the synthesis of amides from ketoximes.
-The preparation of α-aminophosphonates via a three-component reaction between aldehydes, amines, and diethyl phosphite.

Amidosulfonic Acid is widely utilized as a green catalyst for the preparation of amide from ketoxime.
Amidosulfonic Acid finds an application as a titrant in the determination of the burette injection volume and chemical calibration factor.
Amidosulfonic Acid is an efficient catalyst in the synthesis of polyhydroquinoline derivatives by Hantzsch condensation reaction, deazaoxaflavin, fatty acid methyl and ethyl esters and in the isolation of 5-hydroxymethylfurfural (HMF) from bamboo fiber.
Amidosulfonic Acid is involved in the determination of silicates in water samples.
Amidosulfonic Acid acts as a neutralizing agent during the determination of paracetamol by Glynn and Kendal colorimetric method.

Amidosulfonic Acid, Reagent, ACS is a molecular compound with several other names such as aminosulfonic acid.
Amidosulfonic Acid has no color, is soluble in water and has a melting point of 205ºC.
Amidosulfonic Acid has varied uses, such as cleaning agent, herbicide, catalyst in the esterification processes as well as being used in the creation of antibiotics, anti-cancer drugs and weight loss drugs.
As an ACS grade reagent, Spectrum Chemical manufactured compound is used as the quality standard against which other substances are grade and has met the toughest regulatory standards for quality and pureness.

Amidosulfonic Acid is also known as Sulphamic Acid, Amidosulfonic acid, Amidosulfuric acid, Minosulfonic acid, or Sulfamidic acid.
Amidosulfonic Acid is a molecular compound with the formula H3NSO3. It is a dry, non-volatile, non-hygroscopic, stable solid.
Amidosulfonic Acid is soluble in water and forms a strongly acidic aqueous solution that is comparable in acidity to the common strong mineral acids, but it can be safely handled and stored in the dry form.
The CAS Number for Amidosulfonic Acid is 5329-14-6.

The main reason why Amidosulfonic Acid is used in oil and gas drilling is to reduce the pH of used extraction fluids and compounds prior to the disposal of these fluids.
The benefits of using Amidosulfonic Acid is its ease of handling, solubility and low corrosiveness.
Amidosulfonic Acid can also be used as an acidic cleaning agent, sometimes on its own or mixed with other products, typically for metals and ceramics.
Amidosulfonic Acid is frequently used for removing rust and limescale.
Amidosulfonic Acid is produced industrially by treating urea with a mixture of sulfur trioxide and sulfuric acid (or oleum).
Amidosulfonic Acid melts at 205 °C before decomposing at higher temperatures to water, sulfur trioxide, sulfur dioxide and nitrogen.

Amidosulfonic Acid should always be added to water, never add water to sulfamic acid.
At room temperature, diluted aqueous Amidosulfonic Acid is stable for a long period of time but hydrolysis occurs at elevated temperatures.
Concentrated Amidosulfonic Acid can be corrosive and can cause burns on the skin when it is not properly handled.
This chemical is unique because it not only causes chemical burns, but also secondary thermal burns as a result of dehydration.
Amidosulfonic Acid is vital to use proper PPE such as Rubber gloves, full clothing, rubber apron, and eye and face protection when mixing to avoid contact with unprotected skin.
Contaminated clothing should be washed before being used again.

FIRST AID MEASURES of Amidosulfonic Acid

If Inhaled
If inhaled, move casualty to fresh air.
If not breathing, give artificial respiration and consult a physician.

In Case of Skin Contact
Remove contaminated clothing and shoes.
Wash off with soap and plenty of water.
Take victim immediately to hospital.
Consult a physician.

In Case of Eye Contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If Swallowed
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Do NOT induce vomiting unless advised to do so by a physician or Poison Control Center.
Seek medical attention.

Synonyms :
SULFAMIC ACID
5329-14-6
Amidosulfonic acid
Aminosulfonic acid
Sulphamic acid
Amidosulfuric acid
Imidosulfonic acid
Sulfamidic acid
Sulfaminic acid
Jumbo
Sulphamidic acid
Aminosulfuric acid
Kyselina sulfaminova
Kyselina amidosulfonova
sulfuramidic acid
NSC 1871
UNII-9NFU33906Q
amidohydroxidodioxidosulfur
H2NSO3H
MFCD00011603
CHEMBL68253
CHEBI:9330
[S(NH2)O2(OH)]
9NFU33906Q
DSSTox_CID_14005
DSSTox_RID_79107
DSSTox_GSID_34005
Caswell No. 809
Kyselina sulfaminova [Czech]
CAS-5329-14-6
HSDB 795
Kyselina amidosulfonova [Czech]
EINECS 226-218-8
UN2967
SULFAMIC ACID, ACS
EPA Pesticide Chemical Code 078101
SULFAMIC ACID, REAG
sulfoamine
Sulfamidsaeure
AI3-15024
Sulphamic-acid-
Amidoschwefelsaeure
amidosulphuric acid
Sulfamic acid [UN2967] [Corrosive]
WLN: ZSWQ
NH2SO3H
Sulfamic acid, ACS grade
EC 226-218-8
NCIOpen2_000675
Molybdenum, Quant Test Strips
DTXSID6034005
BDBM26994
NSC1871
Sulfamic acid, p.a., 99.5%
Sulfamic acid, analytical standard
NSC-1871
Sulfamic acid, reagent grade, 98%
Tox21_201905
Tox21_303482
STL282725
7773-06-0 (mono-ammonium salt)
AKOS005287325
Sulfamic acid, ACS reagent, 99.3%
ZINC238809066
UN 2967
NCGC00090927-01
NCGC00090927-02
NCGC00257489-01
NCGC00259454-01
Sulfamic acid [UN2967] [Corrosive]
Sulfamic acid, ReagentPlus(R), >=99%
Sulfamic acid, >=99.5% (alkalimetric)
FT-0688102
Sulfamic acid, 99.999% trace metals basis
Sulfamic acid, SAJ first grade, >=99.0%
Sulfamic acid, JIS special grade, >=99.5%
Q412304
W-105754
Sulfamic acid, analytical standard (for acidimetry), ACS reagent
226-218-8 [EINECS]
5329-14-6 [RN]
Acide sulfamique [French] [ACD/IUPAC Name]
amidosulfonic acid
Amidosulfuric acid
aminosulfonic acid
Imidosulfuric acid [ACD/Index Name]
Kyselina amidosulfonova [Czech]
Kyselina sulfaminova [Czech]
MFCD00011603 [MDL number]
Sulfamic acid [ACD/Index Name] [ACD/IUPAC Name]
sulfamidic acid
Sulfamidsäure [German] [ACD/IUPAC Name]
[5329-14-6] [RN]
7773-06-0 (Mono-ammonium salt)
amidohydroxidodioxidosulfur
Amidoschwefelsaeure
Amidosulfonic acid, Sulphamic acid, Sulfamidic acid
Amidosulfonicacid
Amidosulfuric Acid, Amidosulfonic Acid
Aminosulfuric acid
Dihydroxy-imino-oxo-λ6-sulfane
Imidosulfonic acid
Kyselina amidosulfonova [Czech]
Kyselina sulfaminova [Czech]
SO2 [Formula]
Sulfamic acid [UN2967] [Corrosive]
Sulfamic acid, acs
Sulfamic acid, reag
Sulfamidsaeure
Sulfaminic acid
SULFITE ION
sulfuramidic acid
SULPHAMIC ACID
Sulphamic-acid-
Sulphamidic acid
UN 2967
WLN: ZSWQ
氨基磺酸 [Chinese]