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AMINOACETIC ACID

CAS NUMBER: 56-40-6

EC NUMBER: 200-272-2

MOLECULAR FORMULA: C2H5NO2

MOLECULAR WEIGHT: 75.07

IUPAC NAME: 2-aminoacetic acid


Aminoacetic Acid is a non-essential, optically inactive, non-chiral amino acid.
Aminoacetic Acid acts as an inhibitory neurotransmitter, particularly in brain stem and medulla.

Aminoacetic Acid is an amino acid that has a single hydrogen atom as its side chain. 
Aminoacetic Acid is the simplest stable amino acid (carbamic acid is unstable), with the chemical formula NH2‐CH2‐COOH. 

Aminoacetic Acid is one of the proteinogenic amino acids. 
Aminoacetic Acid is encoded by all the codons starting with GG (GGU, GGC, GGA, GGG). 

Aminoacetic Acid is integral to the formation of alpha-helices in secondary protein structure due to its compact form. 
For the same reason, Aminoacetic Acid is the most abundant amino acid in collagen triple-helices. 

Aminoacetic Acid is also an inhibitory neurotransmitter – interference with its release within the spinal cord (such as during a Clostridium tetani infection) can cause spastic paralysis due to uninhibited muscle contraction.
Aminoacetic Acid is the only achiral proteinogenic amino acid. 
Aminoacetic Acid can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom.

Physiological Function:
The principal function of glycine is it acts as a precursor to proteins. 
Most proteins incorporate only small quantities of glycine, a notable exception being collagen, which contains about 35% glycine due to its periodically repeated role in the formation of collagen's helix structure in conjunction with hydroxyproline.
In the genetic code, glycine is coded by all codons starting with GG, namely GGU, GGC, GGA and GGG.

As a biosynthetic intermediate:
In higher eukaryotes, δ-aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from glycine and succinyl-CoA by the enzyme ALA synthase. 
Glycine provides the central C2N subunit of all purines.

As a neurotransmitter:
Aminoacetic Acid is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. 
When Aminoacetic Acid receptors are activated, chloride enters the neuron via ionotropic receptors, causing an inhibitory postsynaptic potential (IPSP). 
Aminoacetic Acid is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. 
Aminoacetic Acid is a required co-agonist along with glutamate for NMDA receptors. 
In contrast to the inhibitory role of Aminoacetic Acid in the spinal cord, this behaviour is facilitated at the (NMDA) glutamatergic receptors which are excitatory.

USES:
Animal and Human Foods:
Aminoacetic Acid is not widely used in foods for its nutritional value, except in infusions. 
Instead Aminoacetic Acid's role in food chemistry is as a flavorant. 
Aminoacetic Acid is mildly sweet, and it counters the aftertaste of saccharine. 
Aminoacetic Acid also has preservative properties, perhaps owing to its complexation to metal ions. 
Aminoacetic Acid is used as supplements for animal feeds.

Chemical Feedstock:
Aminoacetic Acid is an intermediate in the synthesis of a variety of chemical products. 
Aminoacetic Acid is used in the manufacture of the herbicides glyphosate, iprodione, glyphosine, imiprothrin, and eglinazine.
Aminoacetic Acid is used as an intermediate of the medicine such as thiamphenicol.

LaboratoryResearch:
Aminoacetic Acid is a significant component of some solutions used in the SDS-PAGE method of protein analysis. 
Aminoacetic Acid serves as a buffering agent, maintaining pH and preventing sample damage during electrophoresis. 
Aminoacetic Acid is also used to remove protein-labeling antibodies from Western blot membranes to enable the probing of numerous proteins of interest from SDS-PAGE gel. 
This allows more data to be drawn from the same specimen, increasing the reliability of the data, reducing the amount of sample processing, and number of samples required. 
This process is known as stripping.

Aminoacetic Acid is also known as glycine and glycocoll. 
Aminoacetic Acid is present in most of the common proteins, and by chemical analyses1 one fourth of the protein, gelatin, has been shown to be aminoacetic acid.

Aminoacetic Acid is a nonessential amino acid that functions as an inhibitory neurotransmitter in the central nervous system
Aminoacetic Acid is used as a gastric antacid and dietary supplement

Aminoacetic Acid is also used as a bladder irrigation in transurethral prostatectomy.
Aminoacetic Acid is called also aminoacetic acid.

Aminoacetic Acid is a non-essential, non-polar, non-optical, glucogenic amino acid. 
Aminoacetic Acid, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential. 

In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. 
Aminoacetic Acid is an important component and precursor for many macromolecules in the cells.

Aminoacetic Acid is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. 
Aminoacetic Acid has a role as a nutraceutical

Aminoacetic Acid is a hepatoprotective agent
Aminoacetic Acid is an EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor

Aminoacetic Acid is a NMDA receptor agonist, a micronutrient
Aminoacetic Acid is a fundamental metabolite and a neurotransmitter. 

Aminoacetic Acid is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid. 
Aminoacetic Acid is a conjugate base of a glycinium. 

Aminoacetic Acid is a conjugate acid of a glycinate. 
Aminoacetic Acid is a tautomer of a glycine zwitterion.
Aminoacetic Acid appears as white crystals.

Aminoacetic Acid is a nonessential amino acid. 
Aminoacetic Acid is the only amino acid that does not form an L or D optical rotation. 
Aminoacetic Acid is the simplest amino acid and is found in the protein of all life forms.


PHYSICAL PROPERTIES: 

-Molecular Weight: 75.07    

-XLogP3: -3.2        

-Exact Mass: 75.032028402    

-Monoisotopic Mass: 75.032028402    

-Topological Polar Surface Area: 63.3 Ų

-Physical Description: White crystalline powder

-Color: White

-Form: Crystals

-Odor: Odorless

-Taste: Sweet

-Melting Point: 290 °C

-Solubility: very soluble in water

-Density: 1.1607

-Vapor Pressure: 0.00000013

-Chemical Classes: Biological Agents -> Amino Acids and Derivatives


Aminoacetic Acid is an organic amino acid also known as Glycine. 
Aminoacetic Acid is used by the body to synthesize proteins.

Aminoacetic Acid is a non-essential, optically inactive, non-chiral amino acid.
Aminoacetic Acid acts as an inhibitory neurotransmitter, particularly in brain stem and medulla.

Aminoacetic Acid is an amino acid that has a single hydrogen atom as its side chain. 
Aminoacetic Acid is the simplest stable amino acid (carbamic acid is unstable), with the chemical formula NH2‐CH2‐COOH. 

Aminoacetic Acid can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom.
Aminoacetic Acid is used in the manufacture of the herbicides glyphosate, iprodione, glyphosine, imiprothrin, and eglinazine.
Aminoacetic Acid is used as an intermediate of the medicine such as thiamphenicol.


CHEMICAL PROPERTIES: 

-Hydrogen Bond Donor Count: 2    

-Hydrogen Bond Acceptor Count: 3    

-Rotatable Bond Count: 1

-Heavy Atom Count: 5    

-Formal Charge: 0    

-Complexity: 42.9    

-Isotope Atom Count: 0    

-Defined Atom Stereocenter Count: 0    

-Undefined Atom Stereocenter Count: 0    

-Defined Bond Stereocenter Count: 0    

-Undefined Bond Stereocenter Count: 0    

-Covalently-Bonded Unit Count: 1    

-Compound Is Canonicalized: Yes


Aminoacetic Acid is present in most of the common proteins, and by chemical analyses1 one fourth of the protein, gelatin, has been shown to be aminoacetic acid.
Aminoacetic Acid is a nonessential amino acid that functions as an inhibitory neurotransmitter in the central nervous system
Aminoacetic Acid is used as a gastric antacid and dietary supplement

Aminoacetic Acid is also used as a bladder irrigation in transurethral prostatectomy.
Aminoacetic Acid is called also aminoacetic acid.

Aminoacetic Acid is a non-essential, non-polar, non-optical, glucogenic amino acid. 
Aminoacetic Acid has a role as a nutraceutical

Aminoacetic Acid is a hepatoprotective agent
Aminoacetic Acid is a fundamental metabolite and a neurotransmitter. 

Aminoacetic Acid is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid. 
Aminoacetic Acid appears as white crystals.

Aminoacetic Acid is a nonessential amino acid. 
Aminoacetic Acid is the only amino acid that does not form an L or D optical rotation. 
Aminoacetic Acid is the simplest amino acid and is found in the protein of all life forms.


SYNONYMS: 

glycine
2-Aminoacetic acid
56-40-6
aminoacetic acid
Glycocoll
Aminoethanoic acid
Glycolixir
H-Gly-OH
Glycosthene
Padil
Aciport
Glicoamin
Hampshire glycine
L-Glycine
Amitone
Leimzucker
Acetic acid, amino-
Aminoazijnzuur
Glycine, non-medical
Gyn-hydralin
Corilin
Glyzin
Acide aminoacetique
Acido aminoacetico
Acidum aminoaceticum
amino-Acetic acid
[14C]glycine
Glycine iron sulphate (1:1)
aminoacetate
Athenon
glycine-13c
polyglycine
Glicina
Acido aminoacetico
Acide aminoacetique
Acidum aminoaceticum
Glykokoll
Aminoessigsaeure
Aminoethanoate
amino-Acetate
2-aminoacetate
[3H]glycine
Glycine 1 M solution
Glycine 1000 microg/mL in Water
2-Aminoacetic acid;Aminoacetic acid
Benzene, diethenyl-, polymer with 2-methyl-1,3-butadiene, hydrogenated
acetic acid, amino-
acide aminoacetique
aciport
amino-acetic acid
amino-aceticacid
aminoacetic acid
2-aminoacetic acid
aminoazijnzuur
aminoessigsaeure
aminoethanoic acid
amitone
corilin
glicoamin
glycine USP
glycoamin
glycocoll
glycolixir
glykokoll
glyzin
gyn-hydralin
hgly
leimzucker
padil
 

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