PRODUCTS

AMINOCYCLOHEXANE

CAS Number: 108-91-8
EC Number: 203-629-0
Molecular Formula: C6H13N
Preferred IUPAC name: Cyclohexanamine

DESCRIPTION:

Aminocyclohexane is an organic compound, belonging to the aliphatic amine class.
Aminocyclohexane is a colorless liquid, although, like many amines, samples are often colored due to contaminants.
Aminocyclohexane has a fishy odor and is miscible with water.
Like other amines, Aminocyclohexane is a weak base, compared to strong bases such as NaOH, but Aminocyclohexane is a stronger base than its aromatic analog, aniline.

Aminocyclohexane is a useful intermediate in the production of many other organic compounds (e.g. cyclamate)
Aminocyclohexane appears as a clear colorless to yellow liquid with an odor of ammonia.
Aminocyclohexane has Flash point of 90 °F.
Aminocyclohexane Irritates the eyes and respiratory system.

Skin contact of Aminocyclohexane may cause burns.
Aminocyclohexane is Less dense than water.
Vapors of Aminocyclohexane heavier than air.
Toxic oxides of nitrogen produced during combustion.

Aminocyclohexane is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent.
Aminocyclohexane has a role as a human xenobiotic metabolite and a mouse metabolite.
Aminocyclohexane is a conjugate base of a cyclohexylammonium.
Aminocyclohexane is a natural product found in Zanthoxylum asiaticum with data available.

USAGE OF AMINOCYCLOHEXANE:
•   Raw material for producing desulfurization agent
•   Boiler corrosion inhibitors
•   Boiler water treatment
•   Vulcanization accelerator
•   Emulsifier
•   Antistatic agent
•   Latex coagulant
•   Oil product additives
•   Corrosion resistance agents
•   Fungicides
•   Pesticides

CAS Number: 108-91-8
EC Number: 203-629-0
Molecular Formula: C6H13N
Preferred IUPAC name: Cyclohexanamine

CHEMICAL AND PHYSICAL PROPERTIES OF AMINOCYCLOHEXANE:
Chemical formula:   C6H13N
Molar mass:   99.17
Appearance:   clear to yellowish liquid
Odor:   strong, fishy, amine odor
Density:   0.8647 g/cm3
Melting point:   −17.7 °C (0.1 °F; 255.5 K)
Boiling point:   134.5 °C (274.1 °F; 407.6 K)
Solubility in water:   Miscible
Solubility:
very soluble in ethanol, oil
miscible in ethers, acetone, esters, alcohol, ketones
Vapor pressure:   11 mmHg (20° C)[2]
Acidity (pKa):   10.64[3]
Refractive index (nD):   1.4565
Flash point:   28.6 °C (83.5 °F; 301.8 K)
Autoignition temperature:   293 °C (559 °F; 566 K)
Explosive limits:   1.5–9.4%
Molecular Weight:   99.17
XLogP3   :1.5
Hydrogen Bond Donor Count:   1
Hydrogen Bond Acceptor Count:   1
Rotatable Bond Count:   0
Exact Mass:   99.104799419
Monoisotopic Mass:   99.104799419
Topological Polar Surface Area:   26 Å²
Heavy Atom Count:   7
Formal Charge:   0
Complexity:   46.1
Isotope Atom Count:   0
Defined Atom Stereocenter Count:   0
Undefined Atom Stereocenter Count:   0
Defined Bond Stereocenter Count:   0
Undefined Bond Stereocenter Count:   0
Covalently-Bonded Unit Count:   1
Compound Is Canonicalized:   Yes
AppearanceColourless Oil
Molecular Weight99.17
Storage: 20°C, Inert atmosphere
Solubility: Chloroform (Slightly), Methanol (Slightly)
Category: Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;

Applications:
Cyclohexylamine (Glipizide EP Impurity B) is a building block for pharmaceuticals that has been used for the preparation of paromomycin analogs to be used as aminogycoside antibiotics.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

PREPARATION OF AMINOCYCLOHEXANE:
Aminocyclohexane is produced by two routes, the main one being the complete hydrogenation of aniline using some cobalt- or nickel-based catalysts:
C6H5NH2 + 3 H2 → C6H11NH2
Aminocyclohexane is also prepared by alkylation of ammonia using cyclohexanol.

CAS Number: 108-91-8
EC Number: 203-629-0
Molecular Formula: C6H13N
Preferred IUPAC name: Cyclohexanamine

APPLICATIONS OF AMINOCYCLOHEXANE:
Cyclamate, a derivative of cyclohexylamine, is a popular artificial sweetener.
Cyclohexylamine is used as an intermediate in synthesis of other organic compounds.
Aminocyclohexane is the precursor to sulfenamide-based reagents used as accelerators for vulcanization.

Aminocyclohexane is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators).
The amine itself is an effective corrosion inhibitor.
The herbicide hexazinone and the anesthetic hexylcaine are derived from cyclohexylamine.
Aminocyclohexane has been used as a flushing aid in the printing ink industry.

SAFETY INFORMATION ABOUT AMINOCYCLOHEXANE:

FIRST AID MEASURES
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area.

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.

In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Take victim immediately to hospital.
Consult a physician.

In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Most important symptoms and effects, both acute and delayed:
The most important known symptoms and effects are described in the labelling

FIREFIGHTING MEASURES:
Extinguishing media
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Further information:
Use water spray to cool unopened containers.

ACCIDENTAL RELEASE MEASURES:
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection.
Avoid breathing vapours, mist or gas.
Ensure adequate ventilation.

Remove all sources of ignition.
Evacuate personnel to safe areas.
Beware of vapours accumulating to form explosive concentrations.
Vapours can accumulate in low areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations

HANDLING AND STORAGE:
Precautions for safe handling:
Avoid contact with skin and eyes.
Avoid inhalation of vapour or mist.

Keep away from sources of ignition - No smoking.
Take measures to prevent the build up of electrostatic charge.
Conditions for safe storage, including any incompatibilities:

Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Handle under inert gas.
Protect from moisture.
Air sensitive.

EXPOSURE CONTROLS/PERSONAL PROTECTION
Exposure controls:
Appropriate engineering controls:
Avoid contact with skin, eyes and clothing.
Wash hands before breaks and immediately after handling the product.
Personal protective equipment:

Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject (KCL 890 / Aldrich Z677698, Size M)
Splash contact:

Material: Nature latex/chloroprene
Minimum layer thickness: 0.6 mm
Break through time: 31 min
Material tested:Lapren (KCL 706 / Aldrich Z677558, Size M)
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves.
This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers.
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing.,
The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:

Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure:

Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

STABILITY AND REACTIVITY
Chemical stability:
Stable under recommended storage conditions.
Possibility of hazardous reactions
Vapours may form explosive mixture with air.

Conditions to avoid:
Heat, flames and sparks.
Incompatible materials:

Strong oxidizing agents, Carbon dioxide (CO2), sodium hypochlorite, Organic acids, Mineral acids, Peroxides
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)

DISPOSAL CONSIDERATIONS
Waste treatment methods:
Product:
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable.

Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

CAS Number: 108-91-8
EC Number: 203-629-0
Molecular Formula: C6H13N
Preferred IUPAC name: Cyclohexanamine

SYNONYMS OF AMINOCYCLOHEXANE:
MeSH Entry Terms:
Cyclohexylamine
Cyclohexylamines
Aminocyclohexane
Aminohexahydrobenzene
Hexahydroaniline
Depositor-Supplied Synonyms:
CYCLOHEXYLAMINE
Cyclohexanamine
108-91-8
Aminocyclohexane
Hexahydroaniline
Hexahydrobenzenamine
Aminohexahydrobenzene
Cyclohexyl amine
1-Cyclohexylamine
1-Aminocyclohexane
Aniline, hexahydro-
Benzenamine, hexahydro-
Aminocylcohexane
Cyclohexylamines
cyclohexyl-amine
1-AMINO-CYCLOHEXANE
CCRIS 3645
HSDB 918
cyclohexaneamine
UNII-I6GH4W7AEG
Cyclohexylamine.HCl
I6GH4W7AEG
157973-60-9
CHEBI:15773
MFCD00001486
Cyclohexylamine [UN2357] [Corrosive]
DSSTox_CID_3996
DSSTox_RID_77250
DSSTox_GSID_23996
CAS-108-91-8
HAI
EINECS 203-629-0
UN2357
BRN 0471175
cylohexylamine
cyclohexylarnine
cyclo-hexylamine
AI3-15323
cyclohexane-amine
n-cyclohexylamine
cyclohexanyl amine
Hexahydro-Aniline
monocyclohexylamine
4-Cyclohexylamine
Cyclohexylamine,(S)
Hexahydro-Benzenamine
Cyclohexanamine, 9CI
CyNH2
Cyclohexylamine [UN2357] [Corrosive]
Cyclohexylamine, 99.5%
bmse000451
EC 203-629-0
4-12-00-00008 (Beilstein Handbook Reference)
BIDD:ER0290
GTPL5507
CHEMBL1794762
DTXSID1023996
BDBM81970
BCP30928
Tox21_202380
Tox21_300038
STK387114
ZINC12358775
AKOS000119083
Cyclohexylamine, ReagentPlus(R), 99%
UN 2357
VS-0326
Aminocyclohexane pound>>Hexahydroaniline
NCGC00247889-01
NCGC00247889-02
NCGC00253922-01
NCGC00259929-01
AM802905
BP-21278
CAS_108-91-8
NCI60_004907
Cyclohexylamine 1000 microg/mL in Methanol
Cyclohexylamine, ReagentPlus(R), >=99.9%
FT-0624217
C00571
J-002206
J-520164
Q1147539
F2190-0381