PRODUCTS

AMINOETHANOIC ACID

Aminoethanoic acid is used as a food additive, feed additive, cosmetic base material, amino acid synthesis, plating chemical, and other uses.
Aminoethanoic acid is used as a food additive and flavor enhancer (sweet taste, masks bitterness).
Aminoethanoic acid is used important structural component in collagen (up to ~35 %).

CAS Number: 56-40-6
6000-43-7 (HCl salt)
EC Number: 200-272-2
227-841-8 (HCl salt)
Abbreviations: Gly, G
E number: E640 (flavour enhancer)
IUPAC name: Glycine
Chemical formula: C2H5NO2
Molar mass: 75.067 g·mol−1

SYNONYMS:
Glycine, Aminoacetic acid, 2-Aminoethanoic acid, Glycocol, Glycic acid, Dicarbamic acid, glycine, 56-40-6, 2-Aminoacetic acid, aminoacetic acid, Aminoethanoic acid, Glycocoll, Glycolixir, Glicoamin, Glycosthene, Aciport, Padil, Hampshire glycine, Amitone, Leimzucker, Acetic acid, amino-, Aminoazijnzuur, Sucre de gelatine, Glicina, GLY (IUPAC abbrev), Glycinum, Glyzin, FEMA No. 3287, Acido aminoacetico, Acide aminoacetique, Acidum aminoaceticum, Glykokoll, Aminoessigsaeure, Hgly, aminoacetate, GLYCINE 1.5% IN PLASTIC CONTAINER, H2N-CH2-COOH, NSC-25936, TE7660XO1C, AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER, DTXSID9020667, NSC25936, DTXCID90667, CHEBI:15428, Acid, Aminoacetic, Copper Salt Glycine, Calcium Salt Glycine, Monosodium Salt Glycine, RefChem:6440, Salt Glycine, Monosodium, Treating Gingivitis Toothpaste, Repair Cracked Teeth Toothpaste, CAREDO Treating Gingivitis Toothpastes, CAREDO Repair Cracked Teeth Toothpastes, CAREDO Treating Gingivitis Toothpastes 100g, CAREDO Repair Cracked Teeth Toothpastes 100g, 200-272-2, 654-407-9, 2-azaniumylacetate, H-Gly-OH, L-Glycine, Glycine, non-medical, Gyn-hydralin, Corilin, Glycine [INN], Glycinum [INN-Latin], Glicina [INN-Spanish], gly, Acide aminoacetique [INN-French], Acido aminoacetico [INN-Spanish], Acidum aminoaceticum [INN-Latin], MFCD00008131, CCRIS 5915, HSDB 495, 25718-94-9, AI3-04085, amino-Acetic acid, NSC 25936, [14C]glycine, CHEMBL773, Glycine iron sulphate (1:1), Athenon, 2-aminoacetate, NCGC00024503-01, Glycine, free base, M03001, CAS-56-40-6, Glycine, labeled with carbon-14, Glycine [USP:INN], EINECS 200-272-2, UNII-TE7660XO1C, Aminoethanoate, 18875-39-3, amino-Acetate, 2-aminoaceticacid, Glycine CRS, Glycine, peptides, [3H]glycine, Glycine USP grade, Glycine (Standard), Glycine - EP, H-Gly, L-Gly, Gly-CO, Gly-OH, [14C]-glycine, Corilin (Salt/Mix), BLOTTING BUFFER, Tocris-0219, Glycine (H-Gly-OH), GLYCINE [VANDF], NH2CH2COOH, GLYCINE [FHFI], GLYCINE [HSDB], Glycine, technical grade, GLYCINE [FCC], GLYCINE [JAN], GLYCINE [II], GLYCINE [MI], GLYCINE [MART.], Glycine (JP18/USP), Glycine, 99%, FCC, GLYCINE [USP-RS], GLYCINE [WHO-DD], Biomol-NT_000195, bmse000089, bmse000977, WLN: Z1VQ, EC 200-272-2, SCHEMBL6163, Gly-253, SCHEMBL62594, GLYCINE [GREEN BOOK], GTPL727, AB-131/40217813, GLYCINE [ORANGE BOOK], SCHEMBL208601, SCHEMBL887085, Glycine, Electrophoresis Grade, GLYCINE [EP MONOGRAPH], BPBio1_001222, GTPL4084, GTPL4635, orb1304737, SCHEMBL1770702, SCHEMBL3928487, SCHEMBL5201284, SCHEMBL9866384, GLYCINE [USP MONOGRAPH], GLYCINE-1-13C-15N, BDBM18133, HY-Y0966R, AZD4282, MSK1408, Glycine, >=99.0% (NT), Glycine, 98.5-101.5%, Pharmakon1600-01300021, Glycine 1000 microg/mL in Water, CS-B1641, EAA89676, HY-Y0966, 1-aminomethyl-2-hydroxymethylbenzene, Glycine, ACS reagent, >=98.5%, Tox21_113575, EBC-00522, Glycine, 99%, natural, FCC, FG, HB0299, NSC760120, s4821, STL194276, Glycine, purum, >=98.5% (NT), Glycine, tested according to Ph.Eur., AKOS000119626, Glycine, for electrophoresis, >=99%, Tox21_113575_1, CCG-266010, DB00145, FG02717, FG71510, NSC-760120, Glycine - Absolute carbon isotope ratio, Glycine, BioUltra, >=99.0% (NT), Glycine, BioXtra, >=99% (titration), SERINE IMPURITY B [EP IMPURITY], Glycine, SAJ special grade, >=99.0%, NCGC00024503-02, NCGC00024503-03, BP-31024, FG175750, Glycine, Vetec(TM) reagent grade, 98%, DB-029870, G0099, G0317, Glycine, ReagentPlus(R), >=99% (HPLC), NS00001575, EN300-19731, C00037, C22407, D00011, D70890, L001246, Q620730, SR-01000597729, C-Terminal [mycofactocin precursor peptide]-glycine, Glycine, certified reference material, TraceCERT(R), SR-01000597729-1, BRD-K72369578-001-04-1, Q27115084, B72BA06C-60E9-4A83-A24A-A2D7F465BB65, F2191-0197, Glycine, European Pharmacopoeia (EP) Reference Standard, Z955123660, Glycine, BioUltra, for molecular biology, >=99.0% (NT), Glycine, from non-animal source, suitable for cell culture, InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5, Glycine, United States Pharmacopeia (USP) Reference Standard, Glycine, Pharmaceutical Secondary Standard, Certified Reference Material, Glycine, analytical standard, for nitrogen determination according to Kjeldahl method, Glycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, >=98.5%, Glycine, meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance), Acetic acid, amino-, Aciport, Aminoacetic acid, Aminoethanoic acid, Glicoamin, Glycocoll, Glycolixir, Glycosthene, Padil, NH2CH2COOH, Amitone, Glycine, non-medical, Hampshire glycine, Athenon, Gly, Glycine, free base, Gyn-hydralin, 2-Aminoacetic acid, NSC 25936, Corilin (Salt/Mix), Aminoacetic acid, Glycine, Amino-acetate, Amino-(carboxy)methyl, Glycocoll, Aminoazijnzuur, Aminoessigsaeure

Aminoethanoic acid is buffer component in the coupled phosphatase-kinase reaction for end labelling of restriction fragments.
Component of Tris-Aminoethanoic acid reservoir buffer used in SDS-polyacrylamide gel electrophoresis in the characterization of in vitro translation products (Molecular Biology Grade).

Aminoethanoic acid has a distinct sweet taste.
Aminoethanoic acid appears as white crystals.
Aminoethanoic acid is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.

Aminoethanoic acid has a role as a nutraceutical, a hepatoprotective agent, an EC 2.1.2.1 (Aminoethanoic acid hydroxymethyltransferase) inhibitor, a NMDA receptor agonist, a micronutrient, a fundamental metabolite and a neurotransmitter.
Aminoethanoic acid is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid.

Aminoethanoic acid is a conjugate base of a glycinium.
It is a tautomer of a Aminoethanoic acid zwitterion.

Aminoethanoic acid is a non-essential amino acid.
Aminoethanoic acid is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient.
Aminoethanoic acid is also a fast inhibitory neurotransmitter.

Aminoethanoic acid is a metabolite found in or produced by Escherichia coli.
Aminoethanoic acid has been reported in Microchloropsis, Pinus densiflora, and other organisms with data available.
Aminoethanoic acid is a non-essential, non-polar, non-optical, glucogenic amino acid.

Aminoethanoic acid, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential.
In contrast, Aminoethanoic acid also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

Aminoethanoic acid is an important component and precursor for many macromolecules in the cells.
Aminoethanoic acid is a small molecule drug with a maximum clinical trial phase of IV (across all indications) and has 12 investigational indications.

Aminoethanoic acid is a simple, nonessential amino acid, although experimental animals show reduced growth on low-Aminoethanoic acid diets.
The average adult ingests 3 to 5 grams of Aminoethanoic acid daily.
Aminoethanoic acid is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.

Aminoethanoic acid levels are effectively measured in plasma in both normal patients and those with inborn errors of Aminoethanoic acid metabolism.
Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the Aminoethanoic acid cleavage enzyme system (EC 2.1.1.10).

The Aminoethanoic acid cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins).
Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively.

The Aminoethanoic acid cleavage system catalyses the oxidative conversion of Aminoethanoic acid into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate.
It is the main catabolic pathway for Aminoethanoic acid and it also contributes to one-carbon metabolism.

Patients with a deficiency of this enzyme system have increased Aminoethanoic acid in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma Aminoethanoic acid ratio.
(A3412).

Aminoethanoic acid is also a fast inhibitory neurotransmitter.
Aminoethanoic acid (symbol Gly or G; /ˈɡlaɪsiːn/) is an organic compound with the formula C2H5NO2, and is the simplest stable amino acid, distinguished by having a single hydrogen atom as its side chain.

As one of the 20 proteinogenic amino acids, Aminoethanoic acid is a fundamental building block of proteins in all life and is encoded by all codons starting with GG (GGU, GGC, GGA, and GGG).
Because of its minimal side chain, Aminoethanoic acid is the only common amino acid that is not chiral, meaning it is superimposable on its mirror image.

In the body, Aminoethanoic acid plays several crucial roles.
Its small and flexible structure is vital for the formation of certain protein structures, most notably in collagen, where Aminoethanoic acid makes up about 35% of the amino acid content and enables the tight coiling of the collagen triple helix.

Aminoethanoic acid disrupts the formation of alpha-helices in secondary protein structure, in favor instead of random coils.
Beyond its structural role, Aminoethanoic acid functions as an inhibitory neurotransmitter in the central nervous system, particularly in the spinal cord and brainstem, where it helps regulate motor and sensory signals.

Disruption of Aminoethanoic acid signaling can lead to severe neurological disorders and motor dysfunction; for example, the tetanus toxin causes spastic paralysis by blocking Aminoethanoic acid release.
Aminoethanoic acid also serves as a key precursor for the synthesis of other important biomolecules, including the porphyrins that form heme in blood and the purines used to build DNA and RNA.

Aminoethanoic acid is a white, sweet-tasting crystalline solid, leading to its name from Greek word glykys (Greek: γλυκύς) or "sweet".
While the body can synthesize it, Aminoethanoic acid is also obtained from the diet and produced industrially by chemical synthesis for use as a food additive, a nutritional supplement, and an intermediate in the manufacture of products such as the herbicide glyphosate.

In aqueous solutions, Aminoethanoic acid exists predominantly as a zwitterion (H3N+CH2COO-), a polar molecule with both a positive and negative charge, making it highly soluble in water.
Aminoethanoic acid can also fit into hydrophobic environments due to its minimal side chain.

USES and APPLICATIONS of AMINOETHANOIC ACID:
Industrial & Chemical Uses of Aminoethanoic acid: Intermediate for chemical synthesis, including herbicides like glyphosate.
Aminoethanoic acid is used in metal complexation and as a buffer in biochemical applications.
Biochemical & Nutritional Uses of Aminoethanoic acid: Non‑essential amino acid in human nutrition (the body can produce it).

Aminoethanoic acid is used as a food additive and flavor enhancer (sweet taste, masks bitterness).
Aminoethanoic acid is used important structural component in collagen (up to ~35 %).
Medical & Research uses of Aminoethanoic acid: Precursor in biosynthesis of heme, purines, and other biomolecules.

Aminoethanoic acid functions as an inhibitory neurotransmitter in the central nervous system.
Aminoethanoic acid is used as a food additive, feed additive, cosmetic base material, amino acid synthesis, plating chemical, and other uses.

-Chemical feedstock uses of Aminoethanoic acid:
Aminoethanoic acid is an intermediate in the synthesis of a variety of chemical products.
Aminoethanoic acid is used in the manufacture of the herbicides glyphosate, iprodione, glyphosine, imiprothrin, and eglinazine.
Aminoethanoic acid is used as an intermediate of antibiotics such as thiamphenicol.

-Laboratory research uses of Aminoethanoic acid:
Aminoethanoic acid is a significant component of some solutions used in the SDS-PAGE method of protein analysis.
Aminoethanoic acid serves as a buffering agent, maintaining pH and preventing sample damage during electrophoresis.

Aminoethanoic acid is also used to remove protein-labeling antibodies from Western blot membranes to enable the probing of numerous proteins of interest from SDS-PAGE gel.
This allows more data to be drawn from the same specimen, increasing the reliability of the data, reducing the amount of sample processing, and number of samples required.
This process is known as stripping.

-Animal and human foods use of Aminoethanoic acid:
Aminoethanoic acid is not widely used in foods for its nutritional value, except in infusions.
Instead, Aminoethanoic acid's role in food chemistry is as a flavorant.

Aminoethanoic acid is mildly sweet, and it counters the aftertaste of saccharine.
Aminoethanoic acid also has preservative properties, perhaps owing to its complexation to metal ions.
Metal glycinate complexes, e.g. copper(II) glycinate are used as supplements for animal feeds.

As of 1971, the U.S. Food and Drug Administration "no longer regards Aminoethanoic acid and its salts as generally recognized as safe for use in human food", and only permits food uses of Aminoethanoic acid under certain conditions.
Aminoethanoic acid has been researched for its potential to extend life.
The proposed mechanisms of this effect are Aminoethanoic acid's ability to clear methionine from the body, and activating autophagy.

HISTORY AND ETYMOLOGY of AMINOETHANOIC ACID:
Aminoethanoic acid was discovered in 1820 by French chemist Henri Braconnot when he hydrolyzed gelatin by boiling it with sulfuric acid.
He originally called Aminoethanoic acid "sugar of gelatin", but French chemist Jean-Baptiste Boussingault showed in 1838 that it contained nitrogen.
In 1847 American scientist Eben Norton Horsford, then a student of the German chemist Justus von Liebig, proposed the name "glycocoll"; however, the Swedish chemist Berzelius suggested the simpler current name a year later.

The name comes from the Greek word γλυκύς "sweet tasting" (which is also related to the prefixes glyco- and gluco-, as in glycoprotein and glucose).
In 1858, the French chemist Auguste Cahours determined that Aminoethanoic acid was an amine of acetic acid.

PRODUCTION of AMINOETHANOIC ACID:
Although Aminoethanoic acid can be isolated from hydrolyzed proteins, this route is not used for industrial production, as it can be manufactured more conveniently by chemical synthesis.
The two main processes are amination of chloroacetic acid with ammonia, giving Aminoethanoic acid and hydrochloric acid, and the Strecker amino acid synthesis, which is the main synthetic method in the United States and Japan.
About 15 thousand tonnes are produced annually in this way.
Aminoethanoic acid is also co-generated as an impurity in the synthesis of EDTA, arising from reactions of the ammonia co-product.

PRESENCE IN SPACE, AMINOETHANOIC ACID:
The presence of Aminoethanoic acid outside the Earth was confirmed in 2009, based on the analysis of samples that had been taken in 2004 by the NASA spacecraft Stardust from comet Wild 2 and subsequently returned to Earth.
Aminoethanoic acid had previously been identified in the Murchison meteorite in 1970.

The discovery of Aminoethanoic acid in outer space bolstered the hypothesis of so-called soft-panspermia, which claims that the "building blocks" of life are widespread throughout the universe.
In 2016, detection of Aminoethanoic acid within Comet 67P/Churyumov–Gerasimenko by the Rosetta spacecraft was announced.
The detection of Aminoethanoic acid outside the Solar System in the interstellar medium has been debated.

EVOLUTION of AMINOETHANOIC ACID:
Aminoethanoic acid is proposed to be defined by early genetic codes.
For example, low complexity regions (in proteins), that may resemble the proto-peptides of the early genetic code are highly enriched in Aminoethanoic acid.

PHYSIOLOGICAL FUNCTION of AMINOETHANOIC ACID:
The principal function of Aminoethanoic acid is it acts as a precursor to proteins.
Most proteins incorporate only small quantities of Aminoethanoic acid, a notable exception being collagen, which contains about 35% Aminoethanoic acid due to its periodically repeated role in the formation of collagen's helix structure in conjunction with hydroxyproline.
In the genetic code, Aminoethanoic acid is coded by all codons starting with GG, namely GGU, GGC, GGA and GGG.

**As a biosynthetic intermediate
In higher eukaryotes, δ-aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from Aminoethanoic acid and succinyl-CoA by the enzyme ALA synthase.
Aminoethanoic acid provides the central C2N subunit of all purines.

**As a neurotransmitter
Aminoethanoic acid is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina.
When Aminoethanoic acid receptors are activated, chloride enters the neuron via ionotropic receptors, causing an inhibitory postsynaptic potential (IPSP).
Strychnine is a strong antagonist at ionotropic Aminoethanoic acid receptors, whereas bicuculline is a weak one.

Aminoethanoic acid is a required co-agonist along with glutamate for NMDA receptors.
In contrast to the inhibitory role of Aminoethanoic acid in the spinal cord, this behaviour is facilitated at the (NMDA) glutamatergic receptors which are excitatory.

**As a toxin conjugation agent
Aminoethanoic acid conjugation pathway has not been fully investigated.
Aminoethanoic acid is thought to be a hepatic detoxifier of a number endogenous and xenobiotic organic acids.
Bile acids are normally conjugated to Aminoethanoic acid in order to increase their solubility in water.

The human body rapidly clears sodium benzoate by combining it with Aminoethanoic acid to form hippuric acid which is then excreted.
The metabolic pathway for this begins with the conversion of benzoate by butyrate-CoA ligase into an intermediate product, benzoyl-CoA, which is then metabolized by Aminoethanoic acid N-acyltransferase into hippuric acid.

CHEMICAL REACTIONS of AMINOETHANOIC ACID:
Aminoethanoic acid's acid–base properties are most important.
In aqueous solution, Aminoethanoic acid is amphoteric: below pH = 2.4, it converts to the ammonium cation called glycinium.
Above about pH 9.6, it converts to glycinate.

Aminoethanoic acid functions as a bidentate ligand for many metal ions, forming amino acid complexes.
A typical complex is Cu(glycinate)2, i.e. Cu(H2NCH2CO2)2, which exists both in cis and trans isomers.
As a bifunctional molecule, Aminoethanoic acid reacts with many reagents.

These can be classified into N-centered and carboxylate-center reactions.
With acid chlorides, Aminoethanoic acid converts to the amidocarboxylic acid, such as hippuric acid and acetylAminoethanoic acid.
With nitrous acid, one obtains glycolic acid (van Slyke determination).

With methyl iodide, the amine becomes quaternized to give trimethylAminoethanoic acid, a natural product:
H3N+CH2COO− + 3 CH3I → (CH3)3N+CH2COO− + 3 HI
Aminoethanoic acid condenses with itself to give peptides, beginning with the formation of glycylAminoethanoic acid:
2 H3N+CH2COO− → H3N+CH2CONHCH2COO− + H2O

Pyrolysis of Aminoethanoic acid or glycylAminoethanoic acid gives 2,5-diketopiperazine, the cyclic diamide.
Aminoethanoic acid forms esters with alcohols.
They are often isolated as their hydrochloride, such as Aminoethanoic acid methyl ester hydrochloride.
Otherwise, the free ester tends to convert to diketopiperazine.

METABOLISM of AMINOETHANOIC ACID:
BIOSYNTHESIS
Aminoethanoic acid is not strictly essential to the human diet, as it is biosynthesized in the body.
However, Aminoethanoic acid is considered semi-essential in that the amount that can be biosynthesized is insufficient for all metabolic uses.

Aminoethanoic acid can be synthesized from the amino acid serine, which is in turn derived from 3-phosphoglycerate.
In most organisms, the enzyme serine hydroxymethyltransferase catalyses this transformation via the cofactor pyridoxal phosphate:
serine + tetrahydrofolate → Aminoethanoic acid + N5,N10-methylene tetrahydrofolate + H2O

In E. coli, antibiotics that target folate depletes the supply of active tetrahydrofolates, halting Aminoethanoic acid biosynthesis as a consequence.
In the liver of vertebrates, Aminoethanoic acid synthesis is catalyzed by Aminoethanoic acid synthase (also called Aminoethanoic acid cleavage enzyme).

This conversion is readily reversible:
CO2 + NH+4 + N5,N10-methylene tetrahydrofolate + NADH + H+ ⇌ Aminoethanoic acid + tetrahydrofolate + NAD+
In addition to being synthesized from serine, Aminoethanoic acid can also be derived from threonine, choline or hydroxyproline via inter-organ metabolism of the liver and kidneys.

DEGRADATION
Aminoethanoic acid is degraded via three pathways.
The predominant pathway in animals and plants is the reverse of the Aminoethanoic acid synthase pathway mentioned above.
In this context, the enzyme system involved is usually called the Aminoethanoic acid cleavage system:

Aminoethanoic acid + tetrahydrofolate + NAD+ ⇌ CO2 + NH+4 + N5,N10-methylene tetrahydrofolate + NADH + H+
In the second pathway, Aminoethanoic acid is degraded in two steps.

The first step is the reverse of Aminoethanoic acid biosynthesis from serine with serine hydroxymethyl transferase.
Serine is then converted to pyruvate by serine dehydratase.
In the third pathway of its degradation, Aminoethanoic acid is converted to glyoxylate by D-amino acid oxidase.

Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction.
The half-life of Aminoethanoic acid and its elimination from the body varies significantly based on dose.
In one study, the half-life varied between 0.5 and 4.0 hours.

PHYSICAL and CHEMICAL PROPERTIES of AMINOETHANOIC ACID:
Chemical formula: C2H5NO2
Molar mass: 75.067 g·mol−1
Appearance: White solid
Density: 1.1607 g/cm3
Melting point: 233 °C (451 °F; 506 K) (decomposition)
Solubility in water: 249.9 g/L (25 °C)
Solubility: soluble in pyridine
Solubility: sparingly soluble in ethanol
Solubility: insoluble in ether
Acidity (pKa): 2.34 (carboxyl), 9.6 (amino)

Magnetic susceptibility (χ): −40.3·10−6 cm3/mol
CAS Number: 56-40-6
CAS Number: 6000-43-7 (HCl salt)
Abbreviations: Gly, G
EC Number: 200-272-2
EC Number: 227-841-8
E number: E640 (flavour enhancer)
IUPAC name: Glycine
Systematic IUPAC name: Aminoacetic acid
Physical state: Crystalline powder

Color: white
Odor: odourless
Melting point/freezing point: Melting point/ range: 240 °C
Initial boiling point and boiling range: Not applicable
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: > 140 °C not auto-flammable
Decomposition temperature: > 233 °C

pH: 5,9 - 6,4 at 50 g/l at 20 °C
Viscosity: Viscosity, kinematic: No data available
Viscosity: Viscosity, dynamic: No data available
Water solubility: 250 g/l at 25 °C - soluble
Partition coefficient n-octanol/water: log Pow: -3,21 - Bioaccumulation is not expected., (ECHA)
Vapor pressure: No data available
Density: 1,161 g/cm3 at 20 °C
Relative density: No data available
Relative vapour density: No data available

Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available
Molecular Weight: 75.07 g/mol
XLogP3: -3.2
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 1

Exact Mass: 75.032028402 Da
Monoisotopic Mass: 75.032028402 Da
Topological Polar Surface Area: 63.3 Å²
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 42.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CAS Number: 56-40-6
EC Number / EINECS: 200-272-2
PubChem CID: 750
ChemSpider ID: 730
Molecular Formula: C₂H₅NO₂
Molecular Weight: ~75.07 g/mol

Appearance: White crystalline solid (odorless)
Density: ~1.1607 g/cm³
Melting Point: ~233-236 °C (decomposes)
Solubility: Highly soluble in water, sparingly soluble in ethanol, insoluble in ether
pKa Values: ~2.34 (carboxyl) and ~9.6 (amino)
Zwitterionic Behavior: Exists as a zwitterion in solution (both positive and negative charges)
Chemical Properties:
Functional Groups: Amino group (–NH₂) and carboxyl group (–COOH)
Amphoteric: Can act as both an acid and a base
Chirality: Not chiral (only amino acid without optical rotation)

Solution Behavior: In aqueous solution at neutral pH exists mostly as a zwitterion.
Reactivity: Can form peptide bonds (protein linkage), reacting via amine + carboxylic acid functional groups.
CAS Number: 56-40-6
EC Number: 200-272-2
Formula: C₂H₅NO₂
Molecular Weight: ~75.07
Appearance: White crystalline solid
Solubility: Soluble in water
Melting Point: ~233-236 °C
pKa (carboxyl): ~2.34
pKa (amino): ~9.6

FIRST AID MEASURES of AMINOETHANOIC ACID:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of AMINOETHANOIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of AMINOETHANOIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of AMINOETHANOIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of AMINOETHANOIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of AMINOETHANOIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available