PRODUCTS

AMINOGUANIDINE BICARBONATE

Aminoguanidine Bicarbonate is used as an intermediate in the synthesis of pharmaceuticals.
Aminoguanidine Bicarbonate serves as a precursor for the production of guanidine derivatives.
Aminoguanidine Bicarbonate is applied in corrosion inhibitors and dyes.

CAS Number: 2582-30-1
EC Number: 219-956-7
MDL number: MFCD00012949
Linear Formula: NH2NHC(=NH)NH2 · H2CO3
Molecular Formula: CH6N4.CH2O3 / C2H8N4O3

SYNONYMS:
aminoguanidinium hydrogen carbonate, Aminoguanidine bicarbonate, 2582-30-1, Aminoguanidine hydrogen carbonate, 2200-97-7, Aminoguanidinium bicarbonate, 2-aminoguanidine;carbonic acid, Aminoguanidine carbonate, Aminoguanidine carbonate (1:1), Aminoguanidium hydrogen carbonate, Aminoguanidinium hydrogen carbonate, N1-Aminoguanidine carbonate (1:1), MFCD00012949, Aminoguanidine hydrogencarbonate, BA 51-090222, NSC7887, N''-aminoguanidine; carbonic acid, amino(diaminomethylidene)azanium;hydrogen carbonate, AMINOGUANIDINE; CARBONIC ACID, 1-Aminoguanidine bicarbonate, AMINOGUANIDINECARBONATE, 2-aminoguanidine,carbonic acid, Hydrazinecarboximidamide carbonate, NSC 7887, EINECS 219-956-7, Amino guanidine bicarbonate, Guanidine, amino-, hydrogen carbonate, Ba 51-090222 (VAN), N(sup 1)-Aminoguanidine carbonate (1:1), AI3-52138, Guanylhydrazine hydrogencarbonate, UNII-X2151435R9, aminoguandine bicarbonate, EC 219-956-7, SCHEMBL40128, CH6N4.H2CO3, 1-aminoguanidine; carbonic acid, DTXSID2062537, Aminoguanidine bicarbonate, 97%, Amino guanidine hydrogen carbonate, 1-aminoguanidine carbonic acid salt, HB0111, AKOS015894487, AKOS015901290, hydrazinecarboximidamide bicarbonate salt, hydrazinecarboximidamide carbonic acid salt, LS-12944, A0307, F87308, Q27293343, [amino(hydrazinyl)methylidene]azanium hydrogen carbonate, F0001-0859, Carbonic acid compound with hydrazinecarboximidamide (1:1), aminoguanidine hydrocarbonate, 2-aminoguanidine;carbonic acid, carbonic acid, compd. with hydrazinecarboximidamide (1:1), guanidine, amino-, hydrogen carbonate, hydrazinecarboximidamide, carbonate (1:1), Aminoguanidine bicarbonate, 2582-30-1, Aminoguanidine hydrogen carbonate, 2200-97-7, Aminoguanidinium bicarbonate, 2-aminoguanidine;carbonic acid, Aminoguanidine carbonate, Aminoguanidine carbonate (1:1), Aminoguanidium hydrogen carbonate, Aminoguanidinium hydrogen carbonate, N1-Aminoguanidine carbonate (1:1), MFCD00012949, Aminoguanidine hydrogencarbonate, BA 51-090222, NSC7887, N''-aminoguanidine; carbonic acid, amino(diaminomethylidene)azanium;hydrogen carbonate, AMINOGUANIDINE; CARBONIC ACID, 1-Aminoguanidine bicarbonate, AMINOGUANIDINECARBONATE, 2-aminoguanidine,carbonic acid, Hydrazinecarboximidamide carbonate, NSC 7887, EINECS 219-956-7, Amino guanidine bicarbonate, Guanidine, amino-, hydrogen carbonate, Ba 51-090222 (VAN), N(sup 1)-Aminoguanidine carbonate (1:1), AI3-52138, Guanylhydrazine hydrogencarbonate, UNII-X2151435R9, aminoguandine bicarbonate, EC 219-956-7, SCHEMBL40128, CH6N4.H2CO3, 1-aminoguanidine; carbonic acid, DTXSID2062537, Aminoguanidine bicarbonate, 97%, Amino guanidine hydrogen carbonate, 1-aminoguanidine carbonic acid salt, HB0111, AKOS015894487, AKOS015901290, hydrazinecarboximidamide bicarbonate salt, hydrazinecarboximidamide carbonic acid salt, LS-12944, A0307, F87308, Q27293343, [amino(hydrazinyl)methylidene]azanium hydrogen carbonate, F0001-0859, Carbonic acid compound with hydrazinecarboximidamide (1:1), 2-Aminoguanidinium hydrogen carbonate, Aminoguanidine hydrocarbonate, Aminoguanidine hydrogencarbonate, Aminoguanidinium hydrogen carbonate, Guanylhydrazine hydrogen carbonate, Aminoguanidine hicarbonate, 1-aminoguanidine carbonate, Aminoguanidine bicarbonate, GUANYLHYDRAZINE BICARBONATE, Aminoguanidine bicarbonate, Aminoguanidine carbonic acid, 1-AMINOGUANIDINE BICARBONATE, Aminoguanidine hydrogen carbonate, 1-AMINOGUANIDINE HYDROGEN CARBONATE, aminoguanidinium hydrogen carbonate, 1-AMINOGUANIDINIUM HYDROGEN CARBONATE, AMINOGUANIDINE BICARBONATE CRYSTALLINE, 1-AMINOGUANIDINIUM HYDROGEN CARBONATE OE, aminoguanidine bicarbonate, aminoguanidine hydrogen carbonate, aminoguanidinium bicarbonate, aminoguanidine hydrocarbonate, aminoguanidine carbonate 1:1, aminoguanidium hydrogen carbonate, n1-aminoguanidine carbonate 1:1, aminoguanidine hydrogencarbonate, aminoguanidinebicarbonate, hydrazinecarboximidamide carbonate, Aminoguanidine monohydrogencarbonate, Aminoguanidine hydrogen carbonate, Guanidine bicarbonate, 1-Aminoguanidine bicarbonate, aminoguanidine bicarbonate, aminoguanidine hydrogen carbonate, aminoguanidinium bicarbonate, aminoguanidine hydrocarbonate, aminoguanidine carbonate 1:1, aminoguanidium hydrogen carbonate, n1-aminoguanidine carbonate 1:1, aminoguanidine hydrogencarbonate, aminoguanidinebicarbonate, hydrazinecarboximidamide carbonate, Hydrazinecarboximidamide bicarbonate

Aminoguanidine Bicarbonate is an inhibitor of NOS (nitric oxide synthase).
Aminoguanidine Bicarbonate is a chemical compound used as precursor for the preparation of aminoguanidine compounds.
Aminoguanidine Bicarbonate has the chemical formula C2H8N4O3.

USES and APPLICATIONS of AMINOGUANIDINE BICARBONATE:
Aminoguanidine Bicarbonate is utilized as an intermediate in the pharmaceutical industry.
Its reactivity makes Aminoguanidine Bicarbonate a valuable precursor in the synthesis of several medicinal compounds.
Applications of Aminoguanidine Bicarbonate: Synthetic raw material of medicine, agricultural chemicals, dyestuff, photograph medicine, and acceptable about Nad.

Aminoguanidine Bicarbonate was used to study the effect of addition of polyamines.
Aminoguanidine Bicarbonate is an organic compound with the molecular formula C2H8N4O3.

Aminoguanidine Bicarbonate has a wide range of applications in the pharmaceutical and specialty chemical industries.
The potential of Aminoguanidine Bicarbonate to shield cells from adenovirus-induced chromosomal damage showcases its prowess in cellular defense mechanisms, promising to bolster the immune response against viral infections.

Acting as an inhibitor of NOS, Aminoguanidine Bicarbonate exerts control over the intricate nitric oxide synthesis process, paving the way for therapeutic interventions in conditions where excess nitric oxide could cause detrimental effects.
Significantly, Aminoguanidine Bicarbonate's role in combating diabetic vascular dysfunction highlights its clinical relevance in managing diabetes.

By mitigating vascular impairments associated with diabetes, Aminoguanidine Bicarbonate contributes to the preservation of cardiovascular health, potentially reducing the risk of severe complications stemming from diabetic-related vascular issues.
Beyond its biological effects, Aminoguanidine Bicarbonate emerges as an indispensable resource in the realm of chemical synthesis.

As a foundational building block for diverse pharmaceuticals, Aminoguanidine Bicarbonate empowers researchers and manufacturers to create innovative drugs targeting a wide range of medical conditions.
Additionally, Aminoguanidine Bicarbonate's application in pesticide production fortifies agricultural practices, ensuring enhanced crop protection and improved yields.

Furthermore, Aminoguanidine Bicarbonate's relevance in the production of dyes and foaming agents underscores its significance in the industrial sector.
Its unique properties make Aminoguanidine Bicarbonate an ideal candidate for creating vibrant and durable dyes, catering to various industries such as textiles, cosmetics, and more.

Simultaneously, Aminoguanidine Bicarbonate's capacity as a foaming agent plays a crucial role in the production of numerous consumer products, ranging from personal care items to industrial materials.

Aminoguanidine Bicarbonate can be used as raw materials for the synthesis of pharmaceuticals, pesticides, dyes, foaming agents and explosives.
Aminoguanidine Bicarbonate can be used as a synthetic raw material for medicine, pesticide, dye, photographic agent, foaming agent and explosive.

PHYSICAL AND CHEMICAL PROPERTIES OF AMINOGUANIDINE BICARBONATE:
Aminoguanidine Bicarbonate is a white fine crystalline powder.
Aminoguanidine Bicarbonate is soft, practically insoluble in water. Insoluble in alcohol and other acids.
Aminoguanidine Bicarbonate is unstable when heated, and gradually decomposes when it exceeds 50 ° C., turns red when it is heated to 100 ° C.
In an oil bath, and decomposes completely when Aminoguanidine Bicarbonate is heated to 171-173 ° C.

PROPERTIES OF AMINOGUANIDINE BICARBONATE:
Molecular Formula: CH6N4·H2CO3
Molecular Weight: 136.11 g/mol
Appearance: White crystalline powder
Density: Approx. 1.8 g/cm³
Melting Point: Decomposes upon heating (not clearly defined)
Solubility: Soluble in water, slightly soluble in alcohol.
pH (aqueous solution): Basic

BENEFITS OF AMINOGUANIDINE BICARBONATE:
*Stability under normal conditions.
*High reactivity due to the presence of guanidine functional groups.

PROPERTIES OF AMINOGUANIDINE BICARBONATE:
*Chemical
Addition of an equimolar amount of freebase aminoguanidine to Aminoguanidine Bicarbonate will yield aminoguanidinium carbonate.

Aminoguanidine Bicarbonate will react with acids to yield their respective salts.
X-ray analysis has shown that solid Aminoguanidine Bicarbonate is actually a zwitterionic molecule, 2-guanidinium-1-aminocarboxylate monohydrate.

*Physical
Aminoguanidine Bicarbonate is a white solid, slightly soluble in water.
Recrystallization from hot water is possible, but some decomposition always occurs and reprecipitation tends to be slow and incomplete.

*Availability
Aminoguanidine Bicarbonate is sold by chemical suppliers.

PREPARATION OF AMINOGUANIDINE BICARBONATE:
Aminoguanidine Bicarbonate can be prepared by reacting calcium cyanamide with hydrazine sulfate.
Aminoguanidine Bicarbonate can also be easily prepared by reducing nitroguanidine with zinc powder.

Diachrynic used this route obtaining a great yield:
41.14 g zinc powder (629 mmol, 3.3 molar eq.) are weighed and put to the side.
Into a reaction flask of at least 500 mL are put 20.00 g nitroguanidine (192 mmol, 1 molar eq.) and 47.62 g of ammonium sulfate (360 mmol, 1.88 molar eq.) in 285 mL of water.

The suspension is stirred and not everything dissolves, this is expected.
The reaction flask is immersed in an ice bath and equipped with magnetic stirring and a thermometer.
Stirring is started.

Once the solution reaches 10 °C the addition of small spatulas of zinc powder at a time is started.
Monitor the exotherm and don't add too much at once, however the reaction is fairly easy to control.
3-4 spatulas of zinc can be added at a time, making the temperature jump up by 5-8 °C.

The reaction was kept between 5-15 °C, leaning to the latter temperature.
The complete addition of zinc took about 1 hour, during which the ice bath was refilled just once.
Afterwards the reaction was left stirring at about 15 °C for a further 30 minutes.

The pH rose to about 8-9.
Using a fritted vacuum filter the zinc oxide sludge was removed, it filtered fairly easily.

The yellow colored filtrate is put into a flask with magnetic stirring, and 8.57 g of 25% ammonia solution (126 mmol, 0.66 molar eq.) are added as well as 28.57 g of sodium bicarbonate (340 mmol, 0.94 molar eq.) with stirring, it dissolves after a short while.

The solution is left standing for 12 h during which the Aminoguanidine Bicarbonate slowly precipitates.
Afterwards Aminoguanidine Bicarbonate is vacuum filtered off and air dried.
Yield of Aminoguanidine Bicarbonate: 15.700 g (115 mmol, 60% based on nitroguanidine)

NATURE OF AMINOGUANIDINE BICARBONATE:
Aminoguanidine Bicarbonate is a white fine crystalline powder.
Aminoguanidine Bicarbonate is soft, practically insoluble in water, insoluble in alcohol and other acids.
Heating is not stable, when more than 45 degrees Celsius is gradually decomposed, melting point of 170~172 degrees Celsius.

If Aminoguanidine Bicarbonate is heated slowly, it can be melted.
When Aminoguanidine Bicarbonate is heated to 171~173 ° C in an oil bath, it will be completely decomposed.
The decomposition products of Aminoguanidine Bicarbonate are soluble in water and can be decomposed by other acids, free aminoguanidine is formed and dissolved in water.

PREPARATION METHOD OF AMINOGUANIDINE BICARBONATE:
there are the following process routes.
with lime nitrogen, hydrazine hydrate, ammonium bicarbonate as the main raw material.

The distilled water is added to the lime nitrogen, the temperature is kept at 45~50 ℃ for 6 hours, the waste residue is filtered off to obtain the calcium cyanamide solution, and then dilute sulfuric acid is added to adjust the pH value to 6~7, after cooling to room temperature and filtering, the cyanamide solution is obtained, in which 5% hydrazine hydrate is added, and the temperature is kept at 50 ° C.

For 4 hours, then ammonium bicarbonate is added, and the crystal is precipitated, filter dry is Aminoguanidine Bicarbonate crude.
Then add acetic acid to dissolve the crude product, add oxalic acid, filter off calcium oxalate, adjust the pH value of the solution to 8~9 with ammonia water, and add a small amount of EDTA disodium salt, the filtered filtrate is reacted with the filtered ammonium bicarbonate solution, placed, crystallized, filtered, washed with distilled water and ethanol respectively, and finally dried by filtration to obtain a finished product.

Aminoguanidine Bicarbonate can also be obtained by reacting cyanamide with hydrazine sulfate and then adding an aqueous solution of sodium bicarbonate to the reaction.

BIOCHEM/PHYSIOL ACTIONS OF AMINOGUANIDINE BICARBONATE:
Aminoguanidine Bicarbonatee protects the cells infected with adenovirus from chromosomal damage.
Aminoguanidine is a specific and highly effective inhibitor of diamine oxidase present in fetal calf serum.
Aminoguanidine Bicarbonate is an inhibitor of NOS (nitric oxide synthase).

PHYSICAL and CHEMICAL PROPERTIES of AMINOGUANIDINE BICARBONATE:
Appearance (Color): White to cream to light yellow
Appearance (Form): Crystalline powder
Infrared Spectrum: Conforms
Titration with HClO4: 98.0 to 102.0%
Residue after Ignition: ≤0.3%
IUPAC Name: N''-aminoguanidine; carbonic acid
Molecular Formula: C2H8N4O3
InChI Key: OTXHZHQQWQTQMW-UHFFFAOYSA-N
SMILES: OC(O)=O.NN=C(N)N
Molecular Weight (g/mol): 136.11
Synonym: amino-guanidine; carbonic acid

CAS: 2582-30-1
CAS Number: 2582-30-1
EC Number: 219-956-7
Hill Formula: C₂H₈N₄O₃
Chemical Formula: CH₆N₄ * H₂CO₃
Molar Mass: 136.11 g/mol
HS Code: 2928 00 90
Density: 1.56 g/cm³ (20°C)
Ignition Temperature: 245°C
Melting Point: 172°C (decomposes)
pH Value: 8.9 (5 g/l, H₂O, 20°C)
Bulk Density: 700 kg/m³

Solubility: 3.3 g/l
Molecular Formula / Molecular Weight: CH6N4·H2CO3 = 136.11
Physical State (20°C): Solid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN: 2582-30-1
Reaxys Registry Number: 3569869
PubChem Substance ID: 87561960
SDBS (AIST Spectral DB): 1667
MDL Number: MFCD00012949
Molecular Weight: 136.11 g/mol
Hydrogen Bond Donor Count: 5
Hydrogen Bond Acceptor Count: 5

Rotatable Bond Count: 0
Exact Mass: 136.05964013 g/mol
Monoisotopic Mass: 136.05964013 g/mol
Topological Polar Surface Area: 148 Å²
Heavy Atom Count: 9
Formal Charge: 0
Complexity: 67.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: Water, 1e+006 mg/L @ 25°C (est)
Physical State: Solid
Solubility: Soluble in water (3.3 mg/ml at 30°C), and water (2.7 mg/ml at 20°C)
Storage: Store at 4°C
Melting Point: 170-172°C (lit.) (dec.)
Boiling Point: 422.4°C at 760 mmHg
Density: 1.60 g/cm³
Refractive Index: n20D ~1.67 (Predicted)

Chemical Formula: C2H8N4O3
Molar Mass: 136.11 g/mol
Appearance: White solid
Odor: Odorless
Density: 1.56 g/cm³ (20°C)
Melting Point: 170–172°C (338–342°F; 443–445 K)
Boiling Point: Decomposes
Solubility in Water: 0.27 g/100 ml (20°C), 0.33 g/100 ml (30°C)
Vapor Pressure: ~0 mmHg

Molecular Formula: C2H8N4O3
Molecular Weight: 136.11
InChI: InChI=1S/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)
InChIKey: OTXHZHQQWQTQMW-UHFFFAOYSA-N
SMILES: N(N)C(=N)N.C(O)(=O)O
CAS: 2582-30-1
Molecular Formula: CH6N4·H2CO3
Molecular Weight: 136.11
Storage Details: Ambient
Harmonised Tariff Code: 29280090 EXP 2928009055 IMP

Melting Point: 164° - 166°C
Fe: 8ppm max
Water Content: <0.5%
Sulfate: 0.007% max
Assay: >99%
Residue on Ignition: 0.07% max
S: 400ppm max
Chloride: 0.01% max
Appearance: White crystalline powder
Insoluble in Acetic Acid: <0.05%

Assay: 97%
InChI Key: OTXHZHQQWQTQMW-UHFFFAOYSA-N
InChI: 1S/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)
Melting Point: 170-172°C (dec.) (lit.)
Quality Level: 100
SMILES String: OC(O)=O.NNC(N)=N
Solubility: H2O: soluble 2.7 g/L at 20°C, H2O: soluble 3.3 g/L at 30°C
CAS: 2582-30-1
EINECS: 219-956-7
InChI: InChI=1/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)/p-2
InChIKey: OTXHZHQQWQTQMW-UHFFFAOYSA-N

Molecular Formula: C2H8N4O3
Molar Mass: 136.11
Density: 1.6 g/cm³
Melting Point: 170-172°C (dec.) (lit.)
Boiling Point: 422.4°C at 760 mmHg
Flash Point: 209.3°C
Water Solubility: <5 g/L (20°C)
Solubility: H2O: soluble 2.7 g/L at 20°C
Vapor Pressure: 2.56E-08 mmHg at 25°C
Appearance: Crystalline Powder
Color: White to off-white

BRN: 3569869
pKa: 6.19 [at 20°C]
pH: 8.9 (5g/l, H2O, 20°C)
Storage Condition: Store below +30°C
Chemical Name or Material: Aminoguanidine Bicarbonate
Melting Point: 162°C
Molecular Formula: C2H8N4O3
Quantity: 500 g
InChI Key: OTXHZHQQWQTQMW-UHFFFAOYSA-N

IUPAC Name: 2-aminoguanidine;carbonic acid
PubChem CID: 164944
Percent Purity: ≥99.0% (T)
CAS: 2582-30-1
Color: White
MDL Number: MFCD00012949
SMILES: C(=NN)(N)N.C(=O)(O)O
Molecular Weight (g/mol): 136.111
Formula Weight: 136.11

FIRST AID MEASURES of AMINOGUANIDINE BICARBONATE:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of AMINOGUANIDINE BICARBONATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of AMINOGUANIDINE BICARBONATE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system

EXPOSURE CONTROLS/PERSONAL PROTECTION of AMINOGUANIDINE BICARBONATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of AMINOGUANIDINE BICARBONATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of AMINOGUANIDINE BICARBONATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available