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Aminoisobutanol a clear light colored liquid.
Insoluble in water and about the same density as water.
Flash point 172°F.
Aminoisobutanol used to make other chemicals.
CAS Number: 124-68-5
EC Number: 204-709-8
IUPAC Name: 2-Amino-2-methylpropan-1-ol
Chemical Formula: C4H11NO
Other names: Alkyl glycoside, 68515-73-1, (3R,4S,5S,6R)-2-(Decyloxy)-6-(hydroxymethyl)tetrahydro-2H-Pyran-3,4,5-triol, Decyl D-glucopyranoside, Decyl D-glucoside, 54549-25-6, 141464-42-8, D-Glucopyranoside, decyl, (3R,4S,5S,6R)-2-decoxy-6-(hydroxymethyl)oxane-3,4,5-triol, (3R,4S,5S,6R)-2-(Decyloxy)-6-(hydroxymethyl)-tetrahydro-2H-Pyran-3,4,5-triol, MFCD23103077, decyl glucopyranoside, EINECS 259-218-1, C16H32O6, n-decyl-d-glucopyranoside, SCHEMBL43196, DTXSID30893008, JDRSMPFHFNXQRB-IWQYDBTJSA-N, AKOS016004985, DS-3841, A867031, W-111093, W-203522, (3R,4S,5S,6R)-2-(DECYLOXY)-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL, 2-Amino-2-methyl-1-propanol, 124-68-5, 2-Amino-2-methylpropan-1-ol, Aminomethylpropanol, 2-Aminoisobutanol, 1-Propanol, 2-amino-2-methyl-, Isobutanol-2-amine, AMP Regular, 2-AMINO-2-METHYLPROPANOL, Aminomethyl propanol, 2-Methyl-2-aminopropanol, 2-Aminodimethylethanol, Hydroxy-tert-butylamine, Corrguard 75, AMP (thinner), Isobutanolamine, 2-Amino-2,2-dimethylethanol, Amp-95, 2-Methyl-2-aminopropanol-1, 1,1-Dimethyl-2-hydroxyethylamine, 2-Hydroxymethyl-2-propylamine, beta-Aminoisobutanol, AMP 95, Caswell No. 037, 2-Amino-1-hydroxy-2-methylpropane, AMP 75, NSC 441, KV 5088, HSDB 5606, EINECS 204-709-8, EPA Pesticide Chemical Code 005801, 2-Methyl-2-amino-1-propanol, BRN 0505979, DTXSID8027032, AI3-03947, NSC-441, LU49E6626Q, DTXCID407032, NSC441, AMINOMETHYLPROPANOL [II], 2-Amino-2-methyl-1-propanol (90% or less), 2-hydroxy-1,1-dimethylethylamine, EC 204-709-8, 1-PROPANOL,2-AMINO,2-METHYL, 2-AMINO-2-METHYLPROPANOL [HSDB], 2-AMINO-2-METHYL-1-PROPANOL [MI], 2-AMINO-2-METHYL-1-PROPANOL [VANDF], 2-AMINO-2-METHYL-1-PROPANOL [WHO-DD], AMINOMETHYLPROPANOL (II), 2aminoisobutanol, isobutanol amine, Isobutanol2amine, betaAminoisobutanol, Hydroxytertbutylamine, 2Aminodimethylethanol, 2Amino2methylpropanol, 2Methyl2aminopropanol, 2Amino2methylpropan1ol, 2Methyl2aminopropanol1, 2,2-dimethylethanolamine, 2Amino2,2dimethylethanol, 2Hydroxymethyl2propylamine, 1Propanol, 2amino2methyl, 2Amino1hydroxy2methylpropane, AMP95, 1,1Dimethyl2hydroxyethylamine, AMINOMETHYL PROPANOL [INCI], 204-709-8, inchi=1/c4h11no/c1-4(2,5)3-6/h6h,3,5h2,1-2h, 2-Amino-2-methyl-propan-1-ol, .beta.-Aminoisobutanol, beta-Aminoisobutyl alcohol, MFCD00008051, 2-Amino-2-methylpropanol (~95%), CAS-124-68-5, UNII-LU49E6626Q, 2-Amino-2-methyl-1-propanol, 95%, A-Aminoisobutyl alcohol, 2,2-Dimethyl-ethanolamine, Amino-2,2-dimethylethanol, 2-amino 2-methyl propanol, 2-amino-2-methyl propanol, Hydroxymethyl-2-propylamine, 2-Amino-2-methyl-propanol, Amino-2-methyl-1-propanol, H2NC(CH3)2CH2OH, NCIOpen2_009031, 2-amino-2-methyl-1propanol, 2-amino-2-methylpropan-1ol, 2amino-2-methyl-1-propanol, Oprea1_147215, 2-amino-2-methylpropan-l-ol, 2-amino-2-methyl 1-propanol, 2-amino-2-methyl-1 propanol, 2-methyl-2-aminopropan-1-ol, 1-Propanol-2-amino-2-methyl, 2-amino-2,2,dimethyl-ethanol, CHEMBL122588, 2-amino-2 -methyl-1-propanol, 2-amino-2- methylpropan-1-ol, 2-amino-2-methyl-1 -propanol, 2-Amino-2-methyl-propane-1-ol, 1-hydroxy-2-methyl-2-propylamine, 3-hydroxy-2-methyl-2-propylamine, 1-hydroxy-2-methyl-2-aminopropane, propane, 2-amino-2-hydroxymethyl-, STR01693, Tox21_201780, Tox21_303149, BBL023024, STL284638, AKOS000119511, WLN: ZX1 & 1 & 1Q, CS-W013743, FA09404, HY-W013027, SB83772, propane, 2-amino-1-hydroxy-2-methyl-, NCGC00249118-01, NCGC00257048-01, NCGC00259329-01, 1,1-Dimethyl-2-hydroxyethylamine;Pamabron, 2-Amino-2-methyl-1-propanol, 93-97%, DB-041780, A0333, NS00008488, EN300-19785, P20005, Q32703, 2-Amino-2-methyl-1-propanol, BioXtra, >=95%, 2-Amino-2-methyl-1-propanol, purum, >=97.0% (GC), 2-Amino-2-methyl-1-propanol, technical, >=90% (GC), F2190-0372, 2-Amino-2-methyl-1-propanol, BioUltra, >=99.0% (GC), 2-Amino-2-methyl-1-propanol, SAJ first grade, >=98.0%, 2-Amino-2-methyl-1-propanol, ~5% Water, technical grade, 90%, 2-Amino-2-methyl-propan-1-ol; Karl Fischer; Aqualine Electrolyte AD-G
Aminoisobutanol is colorless liquid that is classified as an alkanolamine.
Aminoisobutanol is a useful buffer and a precursor to numerous other organic compounds.
Reactivity Profile
Aminoisobutanol is an aminoalcohol.
Amines are chemical bases.
They neutralize acids to form salts plus water.
These acid-base reactions are exothermic.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Aminoisobutanol may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides 2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations.
Aminoisobutanol has phototoxic effect as it can interact and penetrate above the sebum layer.
However, Aminoisobutanol is not carcinogenic.
Uses
Aminoisobutanol is used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.
Aminoisobutanol is also used in ATR-FTIR spectroscopic investigation of the carbon monoxide absorption characteristics of a series of heterocyclic diamines.
Aminoisobutanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells.
Aminoisobutanol is used for the preparation of buffer solutions.
Aminoisobutanol is a component of the drugs ambuphylline and pamabrom.
Aminoisobutanol is also used in cosmetics.
Aminoisobutanol is a precursor to oxazolines via its reaction with acyl chlorides.
Via sulfation of the alcohol, the compound is also a precursor to 2,2-dimethylaziridine.
Aminoisobutanol is used in the synthesis of Fepradinol & G-130.
Aminoisobutanol is also used for Isobucaine, and Radafaxine.
Synthesis
The synthesis of Aminoisobutanol is as follows:
In a 1L three-neck flask with mechanical stirring, first add 200ml of water, add a few drops of dilute sulfuric acid to make Aminoisobutanol slightly acidic (pH=3.5-4), then heat to 40-50, and start adding 99.0 at the same time.
2,2-Dimethylaziridine and 400ml dilute sulfuric acid aqueous solution, keep the temperature and slightly acidic condition, drop 2,2-dimethylaziridine, then continue to react at this temperature 1h, then under reduced pressure distillation to remove 80% of the water, add 500ml ethanol to the obtained system, neutralize with 30% sodium hydroxide to pH=9.5-10, filter and remove the salt, the obtained filtrate is distilled out of ethanol under normal pressure , And then distilled under reduced pressure to obtain crude 2-amino-2-methyl-1-propanol.
This crude product is then rectified to obtain 112.9g Aminoisobutanoll refined product with a yield of about 91.0%, chromatographic purity is about 99.4%.
Aminoisobutanol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Aminoisobutanol is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Aminoisobutanol is used in the following products: washing & cleaning products, coating products, plant protection products, cosmetics and personal care products, lubricants and greases, biocides (e.g. disinfectants, pest control products), fertilisers and perfumes and fragrances.
Other release to the environment of Aminoisobutanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Release to the environment of Aminoisobutanol can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).
Other release to the environment of Aminoisobutanol is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Aminoisobutanol can be found in products with material based on: plastic used for large surface area articles (e.g. construction and building materials for flooring, insulation).
Widespread uses by professional workers
Aminoisobutanol is used in the following products: plant protection products, coating products, fertilisers, adhesives and sealants and inks and toners. Aminoisobutanol is used in the following areas: agriculture, forestry and fishing, health services and scientific research and development. Other release to the environment of Aminoisobutanol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Formulation
Aminoisobutanol is used in the following products: oil and gas exploration or production products, pH regulators and water treatment products, coating products, fillers, putties, plasters, modelling clay, metal working fluids, finger paints, inks and toners, lubricants and greases, paper chemicals and dyes, plant protection products, perfumes and fragrances, washing & cleaning products and cosmetics and personal care products.
Release to the environment of Aminoisobutanol can occur from industrial use: formulation of mixtures.
Uses at industry
Aminoisobutanol is used in the following products: pH regulators and water treatment products, oil and gas exploration or production products, coating products, adhesives and sealants, inks and toners, laboratory chemicals, metal working fluids and pharmaceuticals.
Aminoisobutanol is used in the following areas: mining, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and health services.
Aminoisobutanol is used for the manufacture of: wood and wood products and chemicals.
Release to the environment of Aminoisobutanol can occur from industrial use: in processing aids at industrial sites, in the production of articles and as processing aid.
