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CAS Number: 540-69-2
Molecular Weight: 63.06
EC Number: 208-753-9
Beilstein Registry Number: 3625095
Linear Formula: HCO2NH4
IUPAC Name: azanium;formate
APPLICATIONS
Pure ammonium formate decomposes into formamide and water when heated, and this is its primary use in industry.
Formic acid can also be obtained by reacting ammonium formate with a dilute acid, and since ammonium formate is also produced from formic acid, ammonium formate can serve as a way of storing formic acid.
Ammonium formate can also be used in palladium on carbon (Pd/C) reduction of functional groups.
In the presence of Pd/C, ammonium formate decomposes to hydrogen, carbon dioxide, and ammonia.
This hydrogen gas is adsorbed onto the surface of the palladium metal, where it can react with various functional groups.
For example, alkenes can be reduced to alkanes, formaldehyde to methanol, and nitro compounds to amines.
Activated single bonds to heteroatoms can also be replaced by hydrogens (hydrogenolysis).
Ammonium formate can be used as a buffer in high performance liquid chromatography (HPLC), and is suitable for use with liquid chromatography-mass spectrometry.
The pKa values of formic acid and the ammonium ion are 3.8 and 9.2, respectively.
Phenolic benzyl protecting groups are quickly removed by ammonium formate and microencapsulated palladium(0) under microwave irradiation.
Ammonium formate is widely used in various organic reactions like Leuckart reaction which involves the reductive amination of aldehydes and ketones.
Ammonium formate serves as a buffer in high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC/MS).
Ammonium formate finds application in palladium on carbon (Pd/C) reduction of functional groups.
For example, reduction of alkenes to alkanes and formaldehyde to methanol.
Ammonium formate is also used to prepare formic acid insitu as well as used to store formic acid by making it as an ammonium salt.
Ammonium formate solution is 10 M, a buffer component for purification of glycosaminoglycans.
Ammonium formate solution is a buffer solution, buffer component for the separation and purification of glycosaminoglycans from complex systems by affinity chromatography with Polybrene.
Ammonium formate has been used as a constituent in pre-mixed eluents for forming gradient during quantification of diuron by liquid chromatography-mass spectrometry.
Ammonium Formate is an intermediate used to prepare AZD0530 as a highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
Ammonium Formate is also used to synthesize inhibitors of human cyclophilin A.
AMMONIUM FORMATE is used for various purposes in agriculture.
Ammonium formate can be used to study biological buffers.
Ammonium formate has been used in a study to develop an ultrasensitive and selective high performance liquid chromatographic method for one of volatile signaling phytohormones, jasmonic acid (JA).
Ammonium formate has also been used in a study to develop and validate a direct injection liquid chromatography-electrospray ionization-tandem mass spectrometric method (LC-ESI-MS/MS) for the rapid and simple determination of 13 phenylalkylamine derivatives.
Ammonium formate has been used as buffer solution during LC-MS/MS analysis for screening of drugs and exogenous compounds.
Ammonium formate may be used as a catalytic hydrogen transfer agent in reduction of aliphatic and aromatic nitro compounds.
Ammonium formate has been used in the separation of non-steroidal anti-inflammatory drugs and of oligosaccharide mixtures using capillary electrochromatography.
Ammonium formate is also used in the analysis of phosphatidylserines, triacylglycerols and triacylglycerol oxidation products, and oligogalacturonic acids using HPLC and HPLC-MS methods.
Ammonium formate may be employed in the following studies:
-Deprotection of N-benzyl derivatives of amino acids and amines to afford free amino acids and amines.
-Conversion of α, β-unsaturated nitroalkenes to the corresponding oximes.
-Preparation of nitriles.
Ammonium Formate decomposes into formamide and water when heated, and this is its primary use in industry.
Ammonium Formate is used to obtain Formic acid which is done by reacting ammonium formate with a dilute acid.
Ammonium Formate is also produced from formic acid; it can serve as a way of storing formic acid.
Ammonium Formate is used in palladium on carbon (Pd/C) reduction of functional groups.
Ammonium Formate is used for reductive amination of aldehydes and ketones (Leuckart reaction)
Ammonium Formate is used as a buffer in high performance liquid chromatography (HPLC), and is suitable for use with liquid chromatography/mass spectrometry (LC/MS).
Ammonium Formate is used as a Laboratory reagent.
DESCRIPTION
Ammonium formate, NH4HCO2, is the ammonium salt of formic acid.
Ammonium formate is a colorless, hygroscopic, crystalline solid.
Formic acid is the simplest carboxylic acid.
Ammonium formate is an intermediate in normal metabolism.
Ammonium formate is responsible for both metabolic acidosis and disrupting mitochondrial electron transport and energy production by inhibiting cytochrome oxidase activity, the terminal electron acceptor of the electron transport chain.
Cell death from cytochrome oxidase inhibition by formate is believed to result partly from depletion of ATP, reducing energy concentrations so that essential cell functions cannot be maintained.
Furthermore, inhibition of cytochrome oxidase by formate may also cause cell death by increased production of cytotoxic reactive oxygen species (ROS) secondary to the blockade of the electron transport chain.
Ammonium formate is a white solid with a weak odor of ammonia.
Ammonium formate Sinks and mixes slowly with water.
Ammonium formate is the ammonium salt of formic acid.
Ammonium formate has a role as a buffer.
Ammonium formate derives from a formic acid.
Acidic salts, such as AMMONIUM FORMATE, are generally soluble in water.
Ammonium formate is The ammonium salt of formic acid.
Ammonium formate is readily available, stable and nontoxic in nature.
Ammonium formate can be used in conjugation with palladium on carbon (Pd-C) or Raney-nickel catalysts.
Ammonium formate is White solid with a weak odor of ammonia.
Ammonium formate Sinks and mixes slowly with water.
Ammonium Formate is the ammonium salt of formic acid in solution form.
Ammonium Formate is a colorless, hygroscopic, crystalline solid.
Pure Ammonium Formate decomposes into formamide and water when heated, and this is its primary use in industry.
Formic acid can also be obtained by reacting ammonium formate with a dilute acid, and since Ammonium Formate is also produced from formic acid, Ammonium Formate can serve as a way of storing formic acid.
Ammonium formate, NH4HCO2, is the ammonium salt of formic acid.
Ammonium formate is a colorless, hygroscopic, crystalline solid.
Pure ammonium formate decomposes into formamide and water when heated, and this is its primary use in industry.
Formic acid can also be obtained by reacting ammonium formate with a dilute acid, and since ammonium formate is also produced from formic acid, Ammonium formate can serve as a way of storing formic acid.
Ammonium formate, HCOOK having a chemical formula, 84.12 g / mole of molecular weight, with a characteristic smell, crystal is a material which is solid.
Ammonium formate is an ammonium salt of formic acid.
Ammonium formate is a cheap and promising N-formylating agent for various amines (secondary and aniline).
Ammonium formate's anhydrous form may be employed as a catalyst for the synthesis of various amino derivatives from aliphatic and aromatic compounds.
Ammonium formate can be used as a source to produce ammonia.
Ammonium formate can also be used in the reductive alkylation of amines.
Ammonium formate is the ammonium salt of formic acid.
Ammonium formate is readily available, is stable and nontoxic in nature.
Ammonium formate can be used in conjugation with Palladium on carbon (Pd-C) or Raney-Nickel catalysts.
Ammonium formate is an ammonium salt of formic acid.
Ammonium formate is a cheap and promising N-formylating agent for various amines (secondary and aniline).
Ammonium formate's anhydrous form may be employed as a catalyst for the synthesis of various amino derivatives from aliphatic and aromatic compounds.
Ammonium formate can be used as a source to produce ammonia.
Ammonium formate can also be used in the reductive alkylation of amines.
Reactions
When heated, ammonium formate eliminates water, forming formamide.
Upon further heating, ammonium formate forms hydrogen cyanide (HCN) and water.
A side reaction of ammonium formate is the decomposition of formamide to carbon monoxide (CO) and ammonia.
Physical and chemical properties
Physical state: solid
Form: crystalline
Colour: colourless
Odour: stinging
Melting point/freezing point: 116 °C at 1.013 hPa
Flammability: non-combustible
Density: 1,28 g/cm³ (25 °C)
Preparation
Ammonium formate can be made by bubbling ammonia through formic acid, though this requires lots of ammonia.
An ammonium salt, such as ammonium bicarbonate can be used instead.
Cooling the solution will cause the salt to precipitate.
Excess water can be evaporated by carefully heating the solution, at below 115℃, to prevent Ammonium formate from melting/decomposing.
Filter the resulting precipitate and leave it to dry, either in open air or in a desiccator.
Heating will not dry ammonium formate, instead Ammonium formate will decompose, resulting in a yellow syrup containing water, formamide and ammonium formate.
Ammonium formate should be kept in closed bottles, away from moisture.
Ammonium formate Can be stored in a desiccator.
Ammonia may be added to limit hydrolysis.
Ammonium formate may release formic acid vapors and protection should be worn when handling the compound.
Storage
Ammonium formate can be stored for 3 years at -20°C as powder.
Ammonium formate can be stored for 2 years at -80°C in solvent.
Safety
Ammonium formate Causes skin irritation.
Ammonium formate Causes serious eye irritation.
Ammonium formate May cause respiratory irritation.
SYNONYMS
540-69-2
Formic acid, ammonium salt
Formic acid ammonium salt
azanium;formate
Ammonium tetraformate
Ammoniumformiat
Formic acid ammonium salt
540-69-2
Formic acid, ammonium salt
ammoniumformate
azanium formate
Ammonium tetraformate
BQ6650000
Formiate d'ammonium
