AMMONIUM LACTATE

CAS: 515-98-0
EC Number: 208-214-8
PubChem: 17397077
MDL number: MFCD00036411
ChEMBL: CHEMBL1200747
LigandBox: D02920
NIKKAJI: J5.211F
IUPAC name: azanium 2-hydroxypropanoate
DRUG CLASS: Alpha-hydroxy acid 
density: 1.054 g/mL at 25 °C
refractive index: n20/D 1.363 

APPLICATIONS

Ammonium lactate is used to treat xerosis (dry or scaly skin) and ichthyosis vulgaris (an inherited dry skin condition) in adults and children. 
Ammonium lactate is in a class of medications called alpha-hydroxy acids. 
Ammonium lactate works by increasing skin hydration.
Ammonium lactate solution has been used in the ammonium lactate fermentation broth for the concentration of organic acid salts by conventional electrodialysis (EDC).
Ammonium lactate is applied topically to the skin.
Ammonium lactate is used as Moistening agent .
Ammonium lactate is used as keratolytic (used for peeling).
Ammonium lactate is used as buffer agent.
Ammonium lactate is used as exfoliant.
ammonium lactate is used for:
-Dry, scaly skin
-Itchy skin
Ammonium lactate treats dry, scaly skin from xerosis or ichthyosis. 
Also Ammonium lactate relieves itching caused by these conditions.
Ammonium lactate is used to treat xerosis (dry or scaly skin) and ichthyosis vulgaris (an inherited dry skin condition) in adults and children. 
Ammonium lactate is in a class of medications called alpha-hydroxy acids. 
Ammonium lactate works by increasing skin hydration.
When ammonium lactate is applied topically, it is found to thicken the viable epidermis while reducing the thickness of the stratum corneum layer. 
Ammonium lactate is a neutralized version of lactic acid.
Ammonium lactate is an organic salt of ammonium with mild anti-bacterial properties. 
Ammonium lactate can be used for the research of xerosis.
Ammonium L-lactate (CAS# 515-98-0) is a useful research chemical compound.
Ammonium Lactate is a compound that can be used in many different ways. 
For example, it’s used as an ingredient in food and cosmetics. 
Ammonium Lactate can be prepared by the neutralization of lactic acid with ammonium hydroxide or ammonia gas at room temperature and pressure, followed by distillation to recover water produced during the reaction. 
Ammonium Lactate is also used for making bread and yogurt. 
Ammonium Lactate is also an aid in the treatment of certain skin conditions.
Ammonium Lactate is also used as a feed additive for livestock.
Ammonium lactate is used in skincare, pharmaceuticals, food preservatives, and feed additives among others.
Cosmetic grade ammonium lactate has a wide range of applications in skin care products. 
Ammonium lactate can be used as an effective skin conditioning agent to improve the appearance and health of the skin, hair, or nails among others. 
The cosmetic grade Ammonium lactate provides cleansing, moisturizing, softening effects on various types of substrates e.g., paper, leather & plastics among others making it suitable for use in pharmaceuticals, food preservatives & feed additives too.
Ammonium lactate is used in skincare products due to its exfoliating properties. 
Ammonium lactate has the ability to remove old and dead cells on the top layer of our skin, which can be useful for those who have hyperpigmentation or uneven skintone issues. 
Ammonium lactate also aids in the regeneration process by triggering new cell formation that results in improving the overall texture and appearance of the skin. Moreover, Ammonium lactate reduces dryness as well as flaking off without causing any side effects associated with harsh chemical peels. 
The other uses include:  
treating various dermatological problems including psoriasis, eczema, etc., prevention of stretch marks during pregnancy, treatment for the delicate skin around or lips because ammonium lactate is not as harsh for these areas.
Ammonium lactate is used in animal feed formulation to increase the rate of milk production and weight gain using less amount of expensive proteins which are very essential for growth, reproduction, and lactation. 
Ammonium Lactate act as a source of energy (increases deamination process) that helps in increasing their appetite without having any negative effect on the health or performance like urea molasses blocks (UMB).
Ammonium Lactate has various pharmaceutical applications where it acts as an active ingredient due to its therapeutic properties while also acting synergistically with other drugs while reducing their side effects. 
Ammonium lactate can be used along with antibiotics such as neomycin, bacitracin, cephalosporins, and polymyxin B to increase the effectiveness of these drugs. 
Ammonium lactate  also improves the penetration abilities of antibiotics in tissues leading to higher plasma concentrations when compared with the individual use of both these substances. 
Ammonium Lactate can be used along with ibuprofen for treating corns on feet caused due to cornification dermatitis or hyperkeratosis. 
This combination is more effective than using either substance alone because Ammonium lactate reduces skin irritation while improving drug absorption after its application over this area where excess keratin has accumulated too much causing pain and discomfort in walking/standing shoes etc.

Recommended Use: 
Ammonium lactate lotion is indicated for the treatment of dry, scaly skin(xerosis) and ichthyosis vulgaris and for temporary relief of itching
associated with these conditions.

Restrictions on Use: 
Ammonium Lactate Lotion is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients

DESCRIPTION

Ammonium lactate is a compound with formula NH4(C2H4(OH)COO). 
Ammonium lactate is the ammonium salt of lactic acid. 
Ammonium lactate appears as white solid or liquid. 
Ammonium lactate Has no odor. 
Ammonium lactate Sinks and mixes with water. 
Ammonium lactate—a derivative of lactic acid—and other AHA are useful as moisturizing agents. 
The use of an occlusive vehicle can also add to the hydration benefits. 
Some formulations have small amounts of petrolatum in the lotions or creams for this reason.
Ammonium lactate has mild anti-bacterial properties.
Ammonium lactate has E number "E328" and is the active ingredient of the skin lotions Amlactin and Lac-Hydrin.
Ammonium lactate is the chemical combination of lactic acid and ammonium hydroxide. 
Ammonium lactate is used as a skin moisturizer lotion to treat dry, scaly, itchy skin. 
Those who are using Ammonium lactate should avoid exposure to sunlight or artificial UV rays, such as sunlamps or tanning beds.
Ammonium lactate makes skin more sensitive to sunlight, and skin is more likely to sunburn.
Ammonium lactate is a combination of lactic acid and ammonium hydroxide. 
Ammonium lactate is a moisturizer.
Moisturizing agent; contains lactic acid neutralized with ammonium hydroxide (i.e., ammonium lactate); 12% cream and lotion are available Rx-only for the treatment of ichthyosis vulgaris and mild to severe xerosis. 
Five-percent strength is an OTC, fragrance-free lotion used to relieve dry skin.
Ammonium lactate is used to treat dry, scaly, itchy skin.
Ammonium lactate may also be used for purposes not listed in this medication guide.
Ammonium lactate appears as white solid or liquid. Has no odor. Sinks and mixes with water.
Ammonium Lactate is an organic salt of ammonium (lactic acid neutralized with ammonium hydroxide), topical moisturizing Ammonium Lactate can be applied as a humectant in ichthyosis vulgaris and xerosis. 
Available as cream or lotion, this agent moisturizes the skin and breaks up the scales. 
Ammonium lactate is an anti-itch topical medication formulated from 12% lactic acid and ammonium hydroxide. 
Ammonium lactate hydrates the outermost skin layer and promotes skin moisturizing for a prolonged time. 
Ammonium lactate also prevents keratinization of epidermal skin layer, which keeps skin smoother and hydrated for a longer time. 
The FDA approved ammonium lactate in April 1985.
Ammonium lactate is an inorganic compound used for the symptomatic treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.
Ammonium lactate is an ammonium salt of lactic acid. 
Ammonium lactate is generally used as a feedstock for ethyl lactate and as a component of moisturizers.
Ammonium lactate is an over-the-counter medication used to treat dry, scaly, and itchy skin. 
Ammonium lactate  might smell bad, and it can cause your skin to sunburn easier.
Ammonium lactate is an alpha-hydroxy acid medication. 
Experts don't know exactly how ammonium lactate treats dry and itchy skin. 
Ammonium lactate's thought to help boost healthy skin renewal through gentle skin exfoliation. 
Ammonium lactate also seems to help the skin keep its natural moisture while drawing extra moisture from the environment.
Ammonium Lactate is a generic skin moisturizer used to treat dry or irritated skin, such as eczema, psoriasis, and diaper rash. 
Ammonium Lactate works by drawing moisture into the skin from surrounding tissues. 
Ammonium lactate is a medication sometimes prescribed to people who are suffering from dry skin conditions such as ichthyosis vulgaris and xerosis.
Ammonium lactate is an ammonium salt of lactic acid. 
Ammonium lactate is generally used as a feedstock for ethyl lactate and as a component of moisturizers.
Ammonium lactate is for external use only. 
Contact with eyes, lips, or mucous membranes should be avoided. 
Ammonium lactate may cause irritation when applied to the face, especially in patients with fair or sensitive skin. 
A mild, transient stinging may occur when ammonium lactate is applied to a skin abrasion or inflamed areas. 
Patients should be cautioned to avoid artificial or natural sunlight to treated areas of skin, including the face, which may be more sensitive to the effects of sunlight (UV) exposure.
The safety and efficacy of ammonium lactate have not been established in neonates, infants, or children less than 2 years old. 
Potential systemic toxicity from percutaneous absorption of lactic acid has not been studied, but may be a potential concern because of the increased surface area to body weight ratio in young children.
Ammonium lactate is classified as FDA pregnancy category B. 
There are no adequate and well-controlled studies in pregnant women. 
Ammonium lactate should be used during pregnancy only if clearly needed.
Although lactic acid is a normal constituent of blood and tissues, it is not known to what extent ammonium lactate affects normal lactic acid levels in human milk. caution should be exercised when the cream or lotion is administered to breast-feeding women. 
Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. 
If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.
Ammonium lactate is a natural moisturizer, this ammonium salt has almost zero ammonia smell. 
Ammonium lactate can be used in many synthetic materials, processing agents, and as a raw chelate material.
Ammonium lactate made from lactic acid and ammonium ions. 
Ammonium lactate can also be used in other raw material and chelate applications. 
Ammonium lactate has almost zero ammonia smell. 
With excellent moisture-retention properties, Ammonium lactate is often used in skin care products.
Ammonium lactate is a colorless to yellow, water-soluble, syrupy liquid, C3H9NO3, used chiefly in electroplating.
Ammonium lactate is A normal intermediate in the fermentation (oxidation, metabolism) of sugar. 
The concentrated form of ammonium lactate is used internally to prevent gastrointestinal fermentation.
General grade ammonium lactate is an organic compound with the formula (CH(NH)COOH). 
Ammonium lactate is commercially available and Ammonium lactate's a major product of acetic acid fermentation. 
Ammonium lactate is a compound with formula(2H4(OH)COO). 
Ammonium lactate is the ammonium salt of lactic acid. 
Ammonium lactate has mild antibacterial properties. 
Ammonium Lactate is considered to be a well-known organic application having wide range of industrial applications. 
Ammonium lactate is a chemical combination of lactic acid and ammonium hydro-oxide. 
Ammonium lactate is used as moisturizer to treat dry skin, flaky skin or various skin issues. 
Ammonium lactate makes skin more sensitive to sunlight.

Chemical & Physical Properties

Density: 1.054 g/mL at 25 °C
Boiling Point: 227.6ºC at 760mmHg
Melting Point: 91-94ºC
Molecular Formula: C3H9NO3
Molecular Weight: 107.10800
Flash Point: 109.9ºC
Exact Mass: 107.05800
PSA: 60.36000

How should I apply ammonium lactate?

Ammonium lactate is usually applied twice a day. 
Use exactly as directed on the label, or as prescribed by your doctor. 
Do not use in larger or smaller amounts or for longer than recommended.
Shake the lotion form of this medication well just before using it.
Wash your hands before and after applying this medication, unless you are using it to treat a hand condition.
Do not apply ammonium lactate to your face unless your doctor has told you to.
The bad smell from ammonium lactate is caused by the ammonia in the medication. 
Ammonia is one of the ingredients used to make this product.

For the treatment of ichthyosis vulgaris:
Topical dosage (12% lotion or cream):
Adults, Adolescents, and Children >= 2 years: 
Apply twice daily to the affected skin areas and rub in thoroughly. 
Clinical improvement may not be evident for several weeks. 
If the skin condition worsens with treatment, the medication should be discontinued promptly.

For the treatment of xerosis:
Topical dosage:
Adults, Adolescents, and Children >= 2 years: 
Apply twice daily to the affected skin areas and rub in thoroughly. 
Clinical improvement may not be evident for several weeks. 
If the skin condition worsens with treatment, the medication should be discontinued promptly.

Pros and cons of ammonium lactate
Pros:
-Ammonium lactate Mildly exfoliates to help remove dry skin, unlike many alternatives.
-Ammonium lactate has Very few side effects for most people.
-Ammonium lactate Can be used for children as young as 2 years old.
-Ammonium lactate is Lower-cost and available over-the-counter.

Cons:
-Ammonium lactate Can have a strong odor.
-Ammonium lactate Does not work for everyone.
-Ammonium lactate Can cause you to sunburn easier.
-Ammonium lactate may Not the best option to use on your face.

MECHANISM OF ACTION OF AMMONIUM LACTATE

Lactic acid is an alpha-hydroxy acid that acts as a keratin-softening agent by increasing the hydration of human skin and reducing epidermal keratinization. 
Lactic acid is reported to be one of the most effective naturally occurring humectants in the skin. 
Glycerin and propylene glycol are also humectants. Humectants draw water into the stratum corneum to hydrate the epidermis, while emollients retain water that is already present. 
Mineral oil and petrolatum are emollients; they act as occlusive agents and moisturizers, helping to relieve pruritus and other symptoms of dry skin. 
Urea is a mild keratolytic. 
Urea also increases water uptake in the stratum corneum and has a direct effect on the stratum corneum elasticity by binding to epidermal protein. 
Cetyl alcohol acts as an emulsion stabilizer and thickening agent.

Preparation method of ammonium lactate solids

The invention belongs to the technical field of pharmaceutical and chemical engineering, and relates to a preparation method of ammonium lactate solids, in particular to a method for changing an ammonium lactate solution into the ammonium lactate solids. 
The preparation method of the ammonium lactate solids mainly comprises steps as follows: 
1) preparation of the ammonium lactate solution : a lactic acid solution reacts with ammonia water to produce the ammonium lactate solution; 
2) preparation of a concentrated ammonium lactate solution : the ammonium lactate solution is extracted with acetonitrile and concentrated, and the concentrated ammonium lactate solution is obtained; 
3) preparation of the ammonium lactate solids: the concentrated ammonium lactate solution is dissolved in ethanol, acetonitrile, acetone or a acetonitrile and acetone mixed solution is added, and the solids are precipitated. 
The ammonium lactate solid products prepared with the preparation method of the ammonium lactate solids are high in purity, good in stability, easy to store and transport and suitable for mass industrial production.

SYNONYMS:
Ammonium lactate
515-98-0
Ammonium (+-)-lactate
Ammonium lactate [USAN]
Lactate (monoAmmonium)
Lactic acid ammonium salt
Ammonium 2-hydroxypropanoate
2-Hydroxypropanoate d'ammonium