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Anhydrous dibasic sodium phosphate is required for nerve and muscle functioning.
Anhydrous dibasic sodium phosphate can be used as a dietary supplement and as a nutrient.
Anhydrous dibasic sodium phosphate is used in food and water treatment in conjunction with trisodium phosphate.
CAS Number: 7558-79-4
Molecular Formula: Na2HPO4
Molecular Weight: 141.96
EINECS Number: 231-448-7
Synonyms:7558-79-4, Sodium phosphate dibasic, Disodium hydrogen phosphate, Disodium hydrogenorthophosphate, DISODIUM PHOSPHATE, Sodium phosphate, dibasic, Dibasic sodium phosphate, Acetest, disodium hydrogenphosphate, Disodium acid phosphate, Soda phosphate, Phosphoric acid, disodium salt, Exsiccated sodium phosphate, Disodium orthophosphate, Sodium hydrogenphosphate, Sodium hydrogen phosphate, disodium;hydrogen phosphate, Sodium monohydrogen phosphate, FEMA No. 2398, secondary Sodium phosphate, Disodium acid orthophosphate, sec-Sodium phosphate, Disodium phosphate, anhydrous, Disodium monohydrogen phosphate, Disodium hydrogen phosphate, anhydrous, Na2HPO4, Hydrogen disodium phosphate, SODIUM PHOSPHATE, DIBASIC, ANHYDROUS, Sodium phosphate, dibasic (anhydrous), SODIUM PHOSPHATE, DIBASIC ANHYDROUS, MFCD00003496, Phosphoric acid, sodium salt (1:2), Disodium hydrogen monophosphate, 22ADO53M6F, INS NO.339(II), DSP, CHEBI:34683, INS-339(II), Dibasic sodium phosphate anhydrous, dibasic sodium phosphate, anhydrous, E-339(II), phosphoric acid, disodium salt, anhydrous, Disodium phosphate anhydrous, Phosphate of soda, Caswell No. 778, Disodium hydrophosphate, Disodium phosphoric acid, Sodium phosphate dibasic, anhydrous, FEMA Number 2398, Fleet enema, Natriumphosphat [German], Sodium phosphate (NaHPO4), Sodium phosphate, exsiccated, CCRIS 5931, HSDB 376, Sodium orthophosphate, secondary, Sodium acid phosphate, anhydrous, Sodium Phosphate dibasic anhydrous, EINECS 231-448-7, EPA Pesticide Chemical Code 076403, Sodium monohydrogen phosphate (2:1:1), UNII-22ADO53M6F, Disodium hydrogen orthophosphate, Disodium phospahte, Sodiumphosphatedibasic, Disodiumhydrogenphosphate, sodium hydrogen-phosphate, disodium hydrogen-phosphate, EC 231-448-7, Sorensen's sodium phosphate, di-sodium hydrogen phosphate, di-Sodium hydrogen phosphate anhydrous, USP grade, phosphoric acid disodium salt, sodium hydrogen orthophosphate, Water Supply QC Check Sample: o-Phosphate Nutrients, SODIUM PHOSPHATE [FHFI], DTXSID1026039, DISODIUM PHOSPHATE [HSDB], Sodium phosphate,dibasic,anhydrous, BCP13559, Sodium hydrogen phosphate, anhydrous, Sodium phosphate dibasic, ACS grade, Disodium Hydrogen Phosphate Submicron, AKOS015902440, AKOS015950661, CCG-266159, DB14502, di-Sodium hydrogen phosphate, anhydrous, SODIUM PHOSPHATE, DIBASIC [MI], DISODIUM PHOSPHATE [EP MONOGRAPH], SODIUM PHOSPHATE DIBASIC [WHO-DD], Sodium phosphate dibasic, ACS/HPLC grade, Sodium phosphate dibasic, biochemical grade, NS00082436, Sodium phosphate dibasic, Trace metals grade, Sodium phosphate dibasic, for molecular biology, Q418448, SODIUM PHOSPHATE, DIBASIC, ANHYDROUS [II], SODIUM PHOSPHATE,DIBASIC,ANHYDROUS [VANDF], Disodium hydrogen orthophosphate;Sodium hydrogen phosphate, SODIUM PHOSPHATE, DIBASIC ANHYDROUS [ORANGE BOOK], SODIUM PHOSPHATE, DIBASIC, ANHYDROUS [ORANGE BOOK], VISICOL COMPONENT SODIUM PHOSPHATE, DIBASIC ANHYDROUS, TECHNICAL;SODIUM PHOSPHATE, DIBASIC BIO-REFINED;Sodiumhydrogenphosphate,99+%(ACS);buffer solution from di-sodium hydrogen phosphate;sodium hydrogen phosphate, anhydrous, acs;sodium phosphate dibasic solution;DIBASICSODIUMPHOSPHATE,DRIED,USP;SODIUMPHOSPHATE,DIBASIC,ANHYDROUS,BIOTECHGRADE
Anhydrous dibasic sodium phosphate is highly hygroscopic and water soluble.
Useful in conjunction with Sodium Phosphate, Monobasic in the preparation of biological buffers.
Anhydrous dibasic sodium phosphate is commonly used in biological assay buffers.
In foods, it is used to adjust pH.
In water treatment, Anhydrous dibasic sodium phosphate retards calcium scale formation.
Anhydrous dibasic sodium phosphate is also found in some detergents and cleaning agents.
Anhydrous dibasic sodium phosphate is known to be Used in many applications including the purification of antibodies.
Anhydrous dibasic sodium phosphate is used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.
Anhydrous dibasic sodium phosphate, or disodium hydrogen phosphate, or sodium phosphate dibasic, is an inorganic compound with the chemical formula Na2HPO4.
It is one of several sodium phosphates.
The salt is known in anhydrous form as well as hydrates Na2HPO4·nH2O, where n is 2, 7, 8, and 12.
The anhydrous salt is hygroscopic.
Anhydrous dibasic sodium phosphate,NaH2P04·H20, is hygroscopic, transparent, water-soluble crystals.
Anhydrous dibasic sodium phosphate is used as a purgative, reagent,and buffer.
The anhydrous compound is white crystalline powder; hygroscopic; density 1.70 g/cm3; converts to sodium pyrophosphate at 240°C; soluble in water; 874 SODIUM PHOSPHATE, DIBASIC insoluble in alcohol.
The dihydrate is a crystalline powder or granular solid; density 2.066 g/cm3 at 15°C; loses water of crystallization at 92.5°C.
The heptahydrate is a powdered or granular crystalline solid; density 1.679 g/cm3; loses five molecules of water at 48°C.
The dodecahydrate is made up of translucent crystals or granules; density 1.524 g/cm3; readily loses five water molecules on exposure to air at ambient temperature; melts at 35°C when the salt contains all water of crystallization; loses all water at 100°C.
Anhydrous dibasic sodium phosphate is an important component of running buffer of denaturing gel electrophoresis.
Anhydrous dibasic sodium phosphate induces glomerular calcification as well as other nephrotic syndrome in Sprague-Dawley rats.
It can be generated by neutralization of phosphoric acid with sodium hydroxide: H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O
Industrially It is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate: CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4
In the second step, the resulting solution of monosodium phosphate is partially neutralized: NaH2PO4 + NaOH → Na2HPO4 + H2O
Anhydrous dibasic sodium phosphate is known for its alkalinity and is used as a buering agent, protein modier, stabilizer, and emulsifying agent.
Anhydrous dibasic sodium phosphate is commonly used during production of spray dried cheese and nonfat milk powders.
Anhydrous dibasic sodium phosphate protects the milk proteins from heat dehydration allowing the proteins to remain dispersed during the spray drying process, which assists in the solubility of the powders upon reconstitution with water.
Anhydrous dibasic sodium phosphate also stabilizes the emulsion to enhance avor, body, and appearance of the nal product.
Anhydrous dibasic sodium phosphate is a water-soluble, inorganic compound with the chemical formula Na₂HPO₄.
It is a form of sodium phosphate dibasic that does not contain water molecules (anhydrous), unlike its hydrated counterparts such as sodium phosphate dibasic dihydrate (Na₂HPO₄·2H₂O) or heptahydrate (Na₂HPO₄·7H₂O).
Anhydrous dibasic sodium phosphate is an inorganic, water-soluble compound with the chemical formula Na₂HPO₄, which means it consists of two sodium (Na) atoms, one hydrogen (H) atom, one phosphorus (P) atom, and four oxygen (O) atoms.
Unlike its hydrated forms, such as sodium phosphate dibasic dihydrate (Na₂HPO₄·2H₂O) or sodium phosphate dibasic heptahydrate (Na₂HPO₄·7H₂O), the anhydrous version does not contain any water molecules within its crystal structure, making it more concentrated and less prone to decomposition due to moisture.
This compound appears as a white, crystalline powder and is highly soluble in water, forming a slightly alkaline solution with a pH ranging from 8.9 to 9.2 when dissolved in water at standard concentrations.
Due to its hygroscopic nature, it readily absorbs moisture from the air, which means it must be stored in a dry and tightly sealed container to prevent clumping or degradation.
Anhydrous dibasic sodium phosphate is widely used in various industries, including food, pharmaceuticals, water treatment, and laboratory research.
In the food industry, it serves as an emulsifier, buffer, and stabilizer, often found in processed cheeses, dairy products, and baked goods to regulate acidity and improve texture.
In medicine and pharmaceuticals, Anhydrous dibasic sodium phosphate is frequently used as a laxative ingredient, a pH buffer in formulations, and a component of electrolyte replacement solutions.
Additionally, it plays an essential role in biological and chemical research, where it is utilized as a buffering agent to maintain pH stability in various experiments, particularly in biochemistry and molecular biology applications.
Melting point: 243-245 °C
Density: 1.064 g/mL at 20 °C
Bulk density: 880 kg/m³
Vapor density: 4.9 (vs air)
Vapor pressure: 0 Pa at 20℃
FEMA: 2398 | DISODIUM PHOSPHATE
Storage temp.: Store at +5°C to +30°C.
Solubility: H2O: 0.5 M at 20 °C, clear, colorless
Form: powder
Color: White
PH: 8.9-9.2 (25℃, 50g/L in water)
pKa: (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
Odor: odorless
Biological source: synthetic
Water Solubility: >=10 g/100 mL at 20 ºC
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.019, λ: 280 nm Amax: 0.016
Merck: 14,8659
Stability: Stable. Incompatible with strong acids. Hygroscopic.
InChIKey: BNIILDVGGAEEIG-UHFFFAOYSA-L
LogP: -2.15
Anhydrous dibasic sodium phosphate, dibasic appears as a colorless to white crystalline solid.
Soluble in water, the primary hazard is the threat to the environment.
Immediate steps should be taken to limit spread to the environment.
Anhydrous dibasic sodium phosphate is used as a fertilizer, in pharmaceuticals, in food processing, and for many other uses.
Anhydrous dibasic sodium phosphate is a sodium phosphate.
Anhydrous dibasic sodium phosphate is prepared by treating phosphoric acid with a slight excess of sodium carbonate.
The solution is boiled to expel carbon dioxide.
Upon cooling dodecahydrate crystallizes out.
Heating dodecahydrate at 100°C forms the anhydrous salt: H3PO4 + Na2CO3 → Na2HPO4 + CO2 + H2O
Anhydrous dibasic sodium phosphate also is prepared by reacting dibasic calcium phosphate with sodium carbonate.
The product calcium carbonate precipitates leaving dibasic sodium salt in the solution.
The solution on cooling yields crystals of hydrated product: CaHPO4 + Na2CO3 → CaCO3 + Na2HPO4
The anhydrous compound is white crystalline powder; hygroscopic; density 1.70 g/cm3; converts to sodium pyrophosphate at 240°C; soluble in water;insoluble in alcohol.
The dihydrate is a crystalline powder or granular solid; density 2.066 g/cm3 at 15°C; loses water of crystallization at 92.5°C.
The heptahydrate is a powdered or granular crystalline solid; density 1.679 g/cm3; loses five molecules of water at 48°C.
The dodecahydrate is made up of translucent crystals or granules; density 1.524 g/cm3; readily loses five water molecules on exposure to air at ambient temperature; melts at 35°C when the salt contains all water of crystallization; loses all water at 100°C.
All the hydrates are soluble in water and insoluble in alcohol.
Anhydrous dibasic sodium phosphate in combination with sodium phosphate monobasic is used in the preparation of oral sodium phosphate solution (OSPS), which is a purgative used for bowel cleansing before colonoscopy.
Anhydrous dibasic sodium phosphate is a sodium salt of phosphoric acid.
Anhydrous dibasic sodium phosphate is a white powder that is highly hygroscopic and water soluble.
Anhydrous dibasic sodium phosphate has been used for preparing phosphate buer which in turn is utilized in X-gal staining.
Used as a pH buer, stabilizer and emulsier in processed cheese, condensed milk, instant pudding and other food applications.
Anhydrous dibasic sodium phosphate is the inorganic compound with the formula Na2HPO4.
Anhydrous dibasic sodium phosphate is one of several sodium phosphates.
The salt is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates.
All are water-soluble white powders; the anhydrous salt being hygroscopic.
Anhydrous dibasic sodium phosphate is a reagent with very high buering capacity.
Anhydrous dibasic sodium phosphate is widely used in molecular biology, biochemistry and chromatography.
Anhydrous dibasic sodium phosphate is highly hygroscopic and water soluble.
Sodium Phosphate, Dibasic is especially useful in conjunction with Sodium Phosphate, Monobasic (sc-202342, sc-215883 or sc-251042) in the preparation of biological buers.
Anhydrous dibasic sodium phosphate can be used in many applications including the purication of antibodies.
Anhydrous dibasic sodium phosphate, also known as sodium hydrogen phosphate anhydrous, is an inorganic compound with the molecular formula Na₂HPO₄.
It belongs to the sodium phosphate family, which includes various hydrated and anhydrous forms of sodium phosphates, each with distinct physical and chemical properties.
The term "anhydrous" signifies that this compound does not contain water molecules in its structure, unlike its hydrated counterparts such as sodium phosphate dibasic dihydrate (Na₂HPO₄·2H₂O) or sodium phosphate dibasic heptahydrate (Na₂HPO₄·7H₂O).
Because it is free from hydration, the anhydrous form has a higher purity, stability, and concentration, making it more suitable for applications requiring precise chemical formulations.
Anhydrous dibasic sodium phosphate is typically a white, odorless, crystalline powder that is highly soluble in water, forming a clear and colorless solution.
When dissolved, it produces a mildly alkaline solution with a pH ranging from approximately 8.9 to 9.2, depending on the concentration.
Due to its hygroscopic nature, it readily absorbs moisture from the air, which means it must be stored in airtight containers to prevent clumping and degradation.
It has a melting point of approximately 243-245°C, and in aqueous solutions, it can act as a buffer, helping to maintain stable pH levels in various chemical and biological systems.
Uses:
Anhydrous dibasic sodium phosphate is used as an in conjunction with trisodium phosphate in foods and water treatment.
In foods, it is used to adjust pH.
In water treatment, Anhydrous dibasic sodium phosphate retards calcium scale formation.
Anhydrous dibasic sodium phosphate is also found in some detergents and cleaning agents.
Anhydrous dibasic sodium phosphate is used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.
It is used in pH buffer solutions.
Anhydrous dibasic sodium phosphate, Dibasic is used as a laboratory reagent and a buffer in chemical analysis.
Other uses are in manufacturing ceramics, detergents, and enamels; as a mordant in dyeing; for fireproofing paper and wood; for weighting and printing silk; in the treatment of boiler water; as a sequestrant in food; as a dietary supplement; in soldering enamels; and in fertilizers.
It is used therapeutically as a cathartic.
Anhydrous dibasic sodium phosphate is used in conjunction with trisodium phosphate in foods and water softening treatment.
In foods, it is used to adjust pH.
Its presence prevents coagulation in the preparation of condensed milk.
Similarly, it is used as an anti-caking additive in powdered products.
Anhydrous dibasic sodium phosphate is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening.
In water treatment, it retards calcium scale formation.
Anhydrous dibasic sodium phosphate is also found in some detergents and cleaning agents.
Anhydrous dibasic sodium phosphate is used in foods as a sequestrant, emulsier, buering agent, absorbent, pH control agent, protein modier, source of alkalinity, stabiliser and nutrient supplement Disodium hydrogen phosphate (Na2HPO4) is a sodium salt of phosphoric acid.
Anhydrous dibasic sodium phosphate is a white powder that is highly hygroscopic and water soluble.
Anhydrous dibasic sodium phosphate is therefore used commercially as an anti-caking additive in powdered products.
Anhydrous dibasic sodium phosphate is also known as disodium hydrogen orthophosphate, sodium hydrogen phosphate or sodium phosphate dibasic.
Anhydrous dibasic sodium phosphate is commercially available in both the hydrated and anhydrous forms.
Anhydrous dibasic sodium phosphate is used in food and water treatment in conjunction with trisodium phosphate.
Anhydrous dibasic sodium phosphate is used as an emulsier and buer in foods and pharmaceuticals, anti-caking additive in powdered products, dietary supplement, scale inhibitor, reagent and buer in analytical chemistry.
Anhydrous dibasic sodium phosphate nds application in detergents, cleaning agents, textile, leather auxiliary, fertilizers and galvanoplastics.
Further, Anhydrous dibasic sodium phosphate is used as a saline laxative to treat constipation.
Other release to the environment of Anhydrous dibasic sodium phosphate is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. ooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Disodium Phosphate Anhydrous can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), leather (e.g. gloves, shoes, purses, furniture), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), metal (e.g. cutlery, pots, toys, jewellery) and plastic (e.g. food packaging and storage, toys, mobile phones).
Anhydrous dibasic sodium phosphate is used in the following products: metal surface treatment products, pH regulators and water treatment products, fertilisers, llers, putties, plasters, modelling clay, water treatment chemicals and laboratory chemicals.
Anhydrous dibasic sodium phosphate is used in the following areas: agriculture, forestry and shing, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and formulation of mixtures and/or re-packaging.
Anhydrous dibasic sodium phosphate is used for the manufacture of: metals, fabricated metal products, mineral products (e.g. plasters, cement), textile, leather or fur, pulp, paper and paper products and chemicals.
Other release to the environment of Anhydrous dibasic sodium phosphate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Anhydrous dibasic sodium phosphate is used in the following products: pH regulators and water treatment products, pharmaceuticals, cosmetics and personal care products, llers, putties, plasters, modelling clay, fertilisers, metal surface treatment products, water treatment chemicals, leather treatment products and metal working uids.
Release to the environment of Anhydrous dibasic sodium phosphate can occur from industrial use: formulation of mixtures, formulation in materials, manufacturing of the substance and in the production of articles.
Other release to the environment of Anhydrous dibasic sodium phosphate is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. ooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Anhydrous dibasic sodium phosphate is used in the following products: pH regulators and water treatment products, metal surface treatment products, water treatment chemicals, fertilisers, leather treatment products and metal working uids.
Anhydrous dibasic sodium phosphate is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and formulation of mixtures and/or re packaging.
Anhydrous dibasic sodium phosphate is used for the manufacture of: chemicals, metals, fabricated metal products, textile, leather or fur, pulp, paper and paper products, plastic products and mineral products (e.g. plasters, cement).
Release to the environment of Anhydrous dibasic sodium phosphate can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, of substances in closed systems with minimal release and as processing aid.
Anhydrous dibasic sodium phosphate ACS Granular can be used as a laboratory reagent.
Product specifications, SDSs and certifications are available under Additional Information.
It serves as a food additive (E339), where it functions as a buffer, emulsifier, and stabilizer in processed foods such as dairy products, baked goods, and meats.
In processed cheese and dairy products, it prevents proteins from coagulating and enhances texture.
Anhydrous dibasic sodium phosphate is used in instant pudding mixes and powdered beverages to regulate acidity and improve solubility.
It can act as a leavening agent in baked goods, helping dough to rise and maintain a uniform texture.
Anhydrous dibasic sodium phosphate is a key ingredient in laxatives and bowel-cleansing solutions, often used before colonoscopies or medical procedures.
It is included in oral rehydration solutions (ORS) and electrolyte replacement therapies to help restore fluid balance in cases of dehydration.
In intravenous (IV) solutions, it helps maintain proper pH levels in the blood and body fluids.
Anhydrous dibasic sodium phosphate is sometimes found in toothpaste formulations, where it aids in plaque removal and enamel remineralization.
Anhydrous dibasic sodium phosphate is a common buffering agent used in laboratories for biological and chemical experiments.
It is a crucial component in phosphate-buffered saline (PBS), a widely used buffer solution in molecular biology, cell culture, and biochemistry.
Anhydrous dibasic sodium phosphate helps maintain pH stability in enzymatic reactions, protein purification, and DNA/RNA studies.
In water treatment facilities, it is used to control pH levels and prevent the formation of scale and corrosion in pipes and boilers.
Anhydrous dibasic sodium phosphate is used in the manufacturing of detergents, where it helps soften water and improve cleaning efficiency.
In textile and paper industries, it is employed as a buffering agent to regulate pH during production processes.
Safety Profile:
While Anhydrous dibasic sodium phosphate (Na₂HPO₄) is widely used in food, pharmaceuticals, and industrial applications, it is important to recognize that improper handling, excessive exposure, or accidental ingestion in large amounts can pose potential health and safety risks.
Though generally considered low in toxicity, this compound can cause irritation to the skin, eyes, and respiratory system and may contribute to electrolyte imbalances if ingested in large doses.
Direct contact with Anhydrous dibasic sodium phosphate in powdered form may cause mild to moderate irritation to the skin and eyes.
Prolonged or repeated exposure can lead to redness, dryness, or inflammation, especially in individuals with sensitive skin or pre-existing conditions such as dermatitis.
If the compound enters the eyes, Anhydrous dibasic sodium phosphate can cause watering, redness, and discomfort, and in severe cases, may lead to temporary blurred vision or corneal irritation.
Immediate rinsing with clean water for at least 15 minutes is recommended if accidental eye contact occurs.
