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Anionic methacrylate copolymer is typically a white to off-white powder or granule that forms films but does not dissolve in strongly acidic environments.
Anionic methacrylate copolymer can swell or dissolve depending on pH conditions.
Anionic methacrylate copolymer improves controlled-release behavior.
CAS Number: 26936-24-3
Molecular Formula: C13H20O6
Molecular Weight: 272.3
Synonyms: Poly(methyl acrylate, methyl methacrylate, methacrylic acid), 26936-24-3, Eudragit FS 30D, 2-Propenoic acid, 2-methyl-, polymer with methyl 2-methyl-2-propenoate and methyl 2-propenoate;Methyl Acrylate, Methyl Methacrylate and Methacrylic Acid (7:3:1) Copolymer 280000 Dispersion (200 mg);Methyl acrylate, Methyl methacrylate and Methycrylic acid (7:3:1) Copolymer 280000 Dispersion
Anionic methacrylate copolymer is a synthetic polymer composed of methyl acrylate, methyl methacrylate, and methacrylic acid.
Anionic methacrylate copolymer is used primarily as a glazing, film-coating, and release agent in the food and pharmaceutical industries, it acts similarly to shellac to protect ingredients from moisture.
Anionic methacrylate copolymers are a group of polymeric compounds used as food additives.
The E numbers are E1205, E1206, and E1207, depending on whether the substance is basic, neutral, or anionic, respectively.
Anionic methacrylate copolymer is a synthetic polymer made from methacrylic acid and methacrylate ester monomers, where the polymer contains negatively charged (anionic) carboxyl groups (–COO⁻) along its chain.
It is widely used in pharmaceutical coatings, especially for controlled-release and enteric (delayed-release) drug systems, because it is stable in acidic conditions but dissolves at higher pH levels.
Anionic methacrylate copolymer is designed to protect active ingredients from stomach acid and release them in the intestine.
Anionic methacrylate copolymer improves targeted drug delivery and stability.
Anionic methacrylate copolymer is a copolymer of methacrylic acid derivatives, where the ratio of acidic (ionizable) and neutral monomers determines its solubility and pH-response behavior.
The anionic groups become ionized at higher pH, making the polymer soluble.
Anionic methacrylate copolymer improves pH-dependent functionality.
Anionic methacrylate copolymer acts as a film-forming agent, enteric coating material, pH-sensitive polymer, and controlled-release matrix.
Its main feature is pH-triggered solubility, which allows selective drug release.
Anionic methacrylate copolymer improves pharmaceutical targeting and protection.
Anionic methacrylate copolymer is best described as a pH-responsive synthetic polymer used mainly to protect drugs in acidic environments and enable controlled release in the intestine.
Anionic methacrylate copolymer is especially important because it is one of the most widely used pH-responsive functional polymers in modern oral drug delivery systems.
Anionic methacrylate copolymers behavior is mainly controlled by the ionization of carboxylic acid groups along the polymer chain.
This improves predictable, environment-triggered performance.
Anionic methacrylate copolymer’s key feature is its pKa-dependent solubility, meaning it remains insoluble in acidic conditions but becomes soluble when the pH rises above a specific threshold.
This allows precise control over where dissolution occurs in the gastrointestinal tract.
Anionic methacrylate copolymer improves site-selective drug release.
Different commercial grades are designed with different methacrylic acid to ester ratios, which define their dissolution pH (for example, ~5.5, ~6.0, or ~7.0).
Anionic methacrylate copolymer enables targeted delivery to specific intestinal regions such as the duodenum, jejunum, or colon.
This improves therapeutic targeting accuracy.
In enteric film formation, the polymer forms continuous, flexible coatings when applied from aqueous or organic solvent systems.
After drying, it creates a stable barrier against gastric fluid.
This improves protection of acid-sensitive drugs.
In multiparticulate systems, it is often applied to pellets or granules rather than single tablets.
This allows more uniform distribution and reduced risk of dose dumping.
Anionic methacrylate copolymer improves safety and dosing control.
In combination coating systems, it is frequently blended with plasticizers (like triethyl citrate) to prevent brittle films and improve mechanical flexibility.
Anionic methacrylate copolymer helps coatings withstand compression and gastrointestinal movement.
This improves coating durability and performance.
In moisture protection, it also acts as a barrier against water vapor, helping protect hygroscopic drugs during storage.
Anionic methacrylate copolymer improves shelf stability and product integrity.
In colonic drug delivery research, modified methacrylate copolymers are being engineered to dissolve only at higher pH values or in response to microbial enzymes.
Anionic methacrylate copolymer enables targeted treatment of diseases such as inflammatory bowel disease.
This improves precision medicine potential.
In taste-masking systems, the polymer prevents drug dissolution in saliva, reducing bitterness until the dosage reaches the stomach or intestine.
Anionic methacrylate copolymer improves patient compliance and acceptability.
In pharmaceutical process engineering, it is compatible with fluid-bed coating, pan coating, and spray-coating technologies, making it highly versatile in industrial production.
Anionic methacrylate copolymer improves manufacturing scalability.
In advanced formulation design, it is often used alongside polymers like HPMC, PEG, or PVP to fine-tune release kinetics and film properties.
Anionic methacrylate copolymer improves formulation flexibility and optimization.
storage temp.: 2–8°C
Major Application: pharmaceutical (small molecule)
LogP: 1.346 (est)
FDA UNII: 99Q3C7L77T
EPA Substance Registry System: 2-Propenoic acid, 2-methyl-, polymer with methyl 2-methyl-2-propenoate and methyl 2-propenoate (26936-24-3)
UNSPSC Code: 41116107
Anionic methacrylate copolymers are part of a larger family of methacrylic acid–based functional polymers, commonly engineered for specific pH thresholds such as pH 5.5, 6.0, or 7.0.
This allows precise control over where a drug is released in the gastrointestinal tract.
Anionic methacrylate copolymer improves site-specific drug delivery.
In enteric coating systems, the polymer remains intact in the stomach (low pH ~1–3) and only dissolves in the higher pH environment of the intestine.
Anionic methacrylate copolymer protects acid-sensitive drugs like enzymes or proton-sensitive APIs.
This improves drug stability and effectiveness.
In modified-release formulations, Anionic methacrylate copolymer is used to slow down or delay drug release over time by controlling water penetration into the dosage form.
Anionic methacrylate copolymer helps maintain steady drug levels in the body.
This improves therapeutic consistency.
In pellet and granule coating technologies, it is applied as a thin film around drug particles to control release behavior.
Anionic methacrylate copolymer allows combination of multiple release profiles in a single dose.
Anionic methacrylate copolymer improves dosage flexibility.
In taste masking applications, Anionic methacrylate copolymer is used to prevent immediate dissolution of bitter drugs in the mouth.
Anionic methacrylate copolymer only dissolves later in the gastrointestinal tract.
Anionic methacrylate copolymer improves patient compliance.
In microencapsulation systems, it can protect sensitive active ingredients from moisture, oxygen, and gastric acid.
Anionic methacrylate copolymer increases shelf life and stability.
This improves product durability.
In biopharmaceutical formulation research, anionic methacrylate copolymers are used to study pH-dependent polymer behavior and drug–polymer interactions.
Anionic methacrylate copolymer helps design more advanced delivery systems.
Anionic methacrylate copolymer improves formulation innovation.
In combination coating systems, it is often blended with plasticizers or other polymers to adjust film flexibility and permeability.
This allows fine-tuning of release profiles.
Anionic methacrylate copolymer improves coating performance control.
Anionic methacrylate copolymer is widely used in tablets, capsules, pellets, and multiparticulate systems for controlled gastrointestinal targeting.
This improves versatility across dosage forms.
Anionic methacrylate copolymer is especially important in pharmaceutical engineering because it functions as a smart polymer system, meaning its behavior changes predictably with environmental pH rather than remaining constant.
This makes it one of the key materials in targeted oral drug delivery design.
Anionic methacrylate copolymer improves precision and controllability in dosage forms.
Anionic methacrylate copolymers performance is strongly influenced by the degree of ionization of carboxylic acid groups, which increases sharply once the surrounding pH exceeds its threshold value.
When ionized, the polymer becomes hydrophilic and dissolves; when non-ionized, it remains hydrophobic and insoluble.
This improves switch-like release behavior.
In enteric film mechanics, the polymer forms dense, continuous coatings that resist gastric fluid penetration for several hours.
The integrity of this film is critical for protecting acid-sensitive compounds such as enzymes, peptides, and certain antibiotics.
Anionic methacrylate copolymer improves drug protection efficiency.
In drug stability systems, it helps prevent hydrolysis and acid degradation during gastric transit.
By isolating the drug from low pH environments, it significantly extends functional stability.
Anionic methacrylate copolymer improves shelf-life and in-vivo stability.
In pellet coating technology, it allows multiple coating layers with different polymers to be stacked, enabling complex release profiles such as immediate + delayed + sustained release in a single dosage form.
Anionic methacrylate copolymer improves multifunctional dosing strategies.
In colon-targeted delivery research, modified versions of anionic methacrylate copolymers are being developed that respond not only to pH but also to microbial enzymes in the colon.
Anionic methacrylate copolymer enables treatment of localized intestinal diseases with minimal systemic exposure.
Anionic methacrylate copolymer improves targeted therapeutic design.
In drug–polymer interaction science, the polymer can form hydrogen bonding or electrostatic interactions with active pharmaceutical ingredients, stabilizing them in amorphous or dispersed states.
Anionic methacrylate copolymer helps reduce crystallization and improves dissolution behavior.
Anionic methacrylate copolymer improves molecular-level formulation stability.
Uses:
Anionic methacrylate copolymer intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Methyl Acrylate, Methyl Methacrylate and Methacrylic Acid (7 to 3 to 1) Copolymer 280000 Dispersion
Anionic methacrylate copolymer is used as a glazing agent in solid food supplements and in solid foods for special medical purposes (FSMPs).
Anionic methacrylate copolymer is used as a glazing agent in solid food supplements and solid FSMPs.
Anionic methacrylate copolymer, a non-authorised ingredient, was found to be present in some samples.
Anionic methacrylate copolymer is mainly used as a pH-sensitive film-former, enteric coating agent, controlled-release polymer, and protective matrix because it dissolves only at higher pH values.
In enteric-coated tablets and capsules, it is used to prevent drug release in the stomach and enable release in the intestine.
Anionic methacrylate copolymer improves drug protection and targeted delivery.
In controlled-release pharmaceutical systems, it is used to regulate how quickly drugs are released.
Anionic methacrylate copolymer improves dosing consistency and therapeutic effect.
In pellet and granule coatings, it is used to create pH-dependent release profiles.
Anionic methacrylate copolymer improves flexibility in multi-dose formulations.
In taste-masking systems, it is used to prevent immediate dissolution in the mouth.
Anionic methacrylate copolymer improves patient acceptability.
In microencapsulation applications, it is used to protect sensitive active ingredients.
Anionic methacrylate copolymer improves stability and shelf life.
In oral drug delivery systems, it is used to enhance site-specific targeting in the gastrointestinal tract.
Anionic methacrylate copolymer improves treatment precision.
Anionic methacrylate copolymer is mainly used as a pH-sensitive enteric polymer, controlled-release coating agent, film former, and protective matrix because it dissolves only above specific pH thresholds.
In enteric-coated tablets and capsules, it is used to prevent drug release in the stomach and enable release in the intestine.
This improves drug protection and targeted delivery.
In controlled-release formulations, it is used to regulate the rate and location of drug release.
Anionic methacrylate copolymer improves dosing consistency and therapeutic control.
In pellets and multiparticulate systems, it is used to create uniform pH-dependent coatings.
Anionic methacrylate copolymer improves flexibility and safety in dosing.
In taste-masking coatings, it is used to prevent immediate dissolution in the mouth.
Anionic methacrylate copolymer improves patient compliance.
In moisture-protective coatings, it is used to shield hygroscopic drugs from humidity.
Anionic methacrylate copolymer improves stability and shelf life.
In colonic and intestinal targeting systems, it is used to deliver drugs to specific regions of the GI tract.
Anionic methacrylate copolymer improves therapeutic precision.
Anionic methacrylate copolymer is mainly used as a pH-sensitive enteric polymer, controlled-release coating material, protective film former, and drug-release regulator because it dissolves selectively at intestinal pH levels.
In enteric-coated tablets and capsules, it is used to prevent drug release in the stomach.
Anionic methacrylate copolymer improves acid protection and targeted intestinal delivery.
In controlled-release systems, it is used to regulate timing and location of drug release.
Anionic methacrylate copolymer improves dosing precision and therapeutic consistency.
In pellet and granule coating, it is used to create uniform pH-responsive layers.
This improves flexibility in multi-particulate dosage forms.
In taste-masking applications, it is used to prevent drug dissolution in the mouth.
This improves patient compliance and product acceptability.
In moisture-sensitive formulations, it is used as a protective barrier against humidity.
Anionic methacrylate copolymer improves shelf-life stability.
In intestinal and colonic targeting systems, it is used to deliver drugs to specific regions of the gastrointestinal tract.
Anionic methacrylate copolymer improves site-specific therapy.
Anionic methacrylate copolymer is mainly used as a pH-responsive enteric coating material, controlled-release polymer, film-forming agent, and protective matrix because it remains intact in acidic conditions and dissolves at higher intestinal pH.
In enteric-coated tablets and capsules, it is used to prevent drug release in the stomach and ensure release in the intestine.
Anionic methacrylate copolymer improves acid protection and targeted drug delivery.
In controlled-release dosage forms, it is used to regulate when and where active ingredients are released.
Anionic methacrylate copolymer improves dosing precision and therapeutic consistency.
In pellet and multiparticulate systems, it is used to coat small particles with uniform pH-dependent layers.
This improves flexibility and safety in dose design.
In taste-masking applications, it is used to prevent immediate dissolution of bitter drugs in the mouth.
Anionic methacrylate copolymer improves patient compliance and acceptability.
Anionic methacrylate copolymer is used to reduce water uptake and protect sensitive drugs.
Anionic methacrylate copolymer improves stability and shelf life.
In intestinal and colon-targeted delivery systems, it is used to deliver drugs specifically to lower gastrointestinal regions.
Anionic methacrylate copolymer improves site-specific therapy and reduces side effects.
In multi-layer coating technologies, it is used as part of layered film systems to fine-tune release profiles.
This improves formulation control and versatility.
In industrial pharmaceutical processing, it is used in fluid-bed coating, pan coating, and spray coating methods for large-scale production.
Anionic methacrylate copolymer improves manufacturing efficiency and scalability.
In combination formulations, it is blended with plasticizers or other polymers to adjust flexibility and permeability.
Anionic methacrylate copolymer improves coating durability and performance control.
In advanced drug delivery research, it is used to develop new systems for targeted and controlled oral delivery of sensitive active ingredients.
Anionic methacrylate copolymer improves innovation in pharmaceutical technology.
Safety Profile:
Anionic methacrylate copolymer is generally considered a low-toxicity and low-hazard pharmaceutical polymer, widely used in regulated oral dosage forms.
The primary hazard is dust irritation during handling of the dry powder.
Anionic methacrylate copolymer may cause temporary irritation to the eyes, nose, throat, or respiratory tract.
Anionic methacrylate copolymer improves workplace safety awareness.
Inhalation of airborne particles may lead to mild respiratory discomfort, especially in poorly ventilated environments.
Proper dust control is recommended.
Anionic methacrylate copolymer improves occupational exposure management.
Eye contact with powder can cause mechanical irritation, but it is not corrosive or chemically reactive.
Rinsing with water is sufficient for first aid.
Anionic methacrylate copolymer improves basic handling safety.
Skin contact is generally low risk, and these polymers are widely used in pharmaceutical coatings with good safety profiles.
Anionic methacrylate copolymer improves consumer safety confidence.
From a toxicological perspective, the polymer is considered to have low systemic toxicity, and its use in oral medicines indicates strong regulatory acceptance.
Anionic methacrylate copolymer improves confidence in pharmaceutical safety.
The material is chemically stable under normal storage conditions, but should be protected from moisture and excessive heat.
Anionic methacrylate copolymer improves storage reliability.
From an environmental perspective, it is not readily biodegradable but generally shows low acute environmental toxicity, so proper disposal is recommended.
