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ARBOCEL PWC 500 is a medium sized, off-white, technical crude cellulose fiber with an average fiber length of ~ 500 µm. It acts as a thickener as an absorbent or crack inhibitor in a wide variety of application areas and improves open time and workability. Recommended for use in mineral tile and other mineral building adhesives. ARBOCEL PWC 500 can be used to reduce the separation of light fillers or to increase sag resistance. Also available in low dust.
CAS NO:9004-34-6
EC NO: 232-674-9
SYNONYMS:
Cellulose, microcrystalline
Cellulose gel
SCHEMBL825024
Q80294
cepo;la01;AVIRIN;abicel;avicel;celufi;rexcel;tunicin;MACERAS;arbocel
Cellulose microcrystalline
Lignin Fibers
MCC
β-D-Glucopyranose
(2R,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrol
207-756-2 [EINECS]
492-61-5 [RN]
b-Dextrose
b-D-Glucopyranose
b-D-Glucose
b-Glucose
Dextrose [USP]
D-Glucopyranose [ACD/Index Name] [ACD/IUPAC Name]
D-Glucose [ACD/Index Name] [ACD/IUPAC Name]
Glucose [JP15] [Wiki]
β-D-(+)-Glucose
β-DEXTROSE
β-d-glucopyranose
β-D-Glucopyranose [ACD/Index Name] [ACD/IUPAC Name]
β-D-Glucopyranose [German] [ACD/Index Name] [ACD/IUPAC Name]
β-D-Glucopyranose [French] [ACD/IUPAC Name]
β-d-glucose
β-D-glucose
β-D-Glucose
β-glucose
β-glucose
β-δ-Glucopyranose
ARBOCEL PWC 500
Chemical Properties
white powder
Chemical Properties
ARBOCEL PWC 500 as a white or off-white odorless and tasteless hygroscopic powder containing 5–22% sodium carboxymethylcellulose. It is a water-dispersible organic hydrocolloid.
Chemical Properties
ARBOCEL PWC 500 is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different properties and applications.
Occurrence
The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp.
Uses
High purity cellulose powders for partition chromatography.
Uses
cellulose is a thickener and an emulsifier. It is obtained from plants. cellulose (microcrystalline) is used as an emulsifier in cosmetic creams. It is the chief constituent of plant fiber.
Uses
Wood contains 50–70% cellulose; cotton and other textile fibers of plant origin contain 65–95%; rayon is prepared by dissolving natural cellulose and then precipitating it from solution, with some loss of crystallinity. Cellulose is made into cellophane film and is used to form fibers, resins, coatings and gums.
Uses
Cellulose is a carbohydrate polymer made up of glucose units. It consists of fibrous particles and is used as a fiber source and bulking agent in low-calorie formulations.
Uses
ARBOCEL PWC 500 is a gum that is the non fibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel.
Definition
A natural carbohydrate high polymer (polysaccha- ride) consisting of anhydroglucose units joined by an oxygen linkage to form long molecular chains that are essentially linear. It can be hydrolyzed to glucose. The degree of polymerization is from 1000 for wood pulp to 3500 for cotton fiber, giving a molecular weight from 160,000 to 560,000. Cellulose is a colorless solid, d approximately 1.50, insoluble in water and organic solvents. It will swell in sodium hydroxide solution and is soluble in Schweitzer’s reagent. It is the fundamental con- stituent of all vegetable tissues (wood, grass, cotton, etc.) and the most abundant organic material in the world. Cotton fibers are almost pure cellulose; wood contains approximately 50%. The physical structure of cellulose is unusual in that it is not a single crystal but consists of crystalline areas embedded in amorphous areas. Chemical reagents penetrate the latter more easily than the former. Cel- lulose is virtually odorless and tasteless and is com- bustible, with an ignition point of approximately 450F. In some forms, it is flammable. For example, railroad shipping regulations require a flammable label on such items as burnt fiber, burnt cotton, wet waste paper, and wet textiles. Fires have been known to occur in warehouses in which telephone books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial activity and self-sustaining oxidation.
Production Methods
ARBOCEL PWC 500 and carboxymethylcellulose sodium is a spray- or bulk-dried blend of ARBOCEL PWC 500 and sodium carboxymethylcellulose. It is prepared by the chemical depolymerization of highly purified wood pulp. The original crystalline areas of the pulp fibers are combined with sodium carboxymethylcellulose, which serves as a protective colloid and also facilitates dispersion of the product; it is then either spray- or bulk-dried.
Production Methods
ARBOCEL PWC 500 is manufactured by controlled hydrolysis with dilute mineral acid solutions of α-cellulose, obtained as a pulp from fibrous plant materials. Following hydrolysis, the hydrocellulose is purified by filtration and the aqueous slurry is spray dried to form dry, porous particles of a broad size distribution.
General Description
Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composes the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax ARBOCEL PWC 500 and removing pectic acids by extraction with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric acid, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2).
Reactivity Profile
ARBOCEL PWC 500 is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces ARBOCEL PWC 500 nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive.
ARBOCEL PWC 500, NF is an excipient acting as a binder in tablet formation. All Spectrum Chemical NF grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP).
ARBOCEL PWC 500 is a linear polysaccharide of β 1-4 linked glucose residues. The polysaccharide chains are bundled as microfibrils in cell walls and provide the essential structural components within growing plants. Each microfibril exhibits a high degree of three-dimensional internal bonding resulting in a crystalline structure that is insoluble in water, resistant to reagents and very strong.
Appearance (Colour) White to off-white
Appearance (Form) Powder
pH (2% aq. solution) 5.0 - 7.5
Assay min. 98%
Loss on drying max. 6%
ARBOCEL PWC 500 is an important component in the manufacture of pharmaceutical products, cosmetics, foodstuffs and other products. Microcrystalline cellulose is a filler that makes tablets harder.
Excipients can be divided into various broad processing categories for functionality. Bulking agents such as Dibasic Calcium Phosphate, or ARBOCEL PWC 500 are added to make the dosage form enhanced in size, so that it is easier to produce and to accomplish a reasonable tablet weight.
ARBOCEL PWC 500 is used as bulking agent, opacifier, anti-caking agent, extrusion aid and stabilizer for foams and emulsions.
This product can be used in filter aid: anti-caking agent, binder; compatibilizer; fragmentation agent; dispersant; tissue improver; thickener; water treatment agent.
ARBOCEL PWC 500 is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production.[1] The most common form is used in vitamin supplements or tablets. It is also used in plaque assays for counting viruses, as an alternative to carboxymethylcellulose.[2]
A naturally occurring polymer, it is composed of glucose units connected by a 1-4 beta glycosidic bond. These linear cellulose chains are bundled together as microfibril spiralled together in plant cell walls.
Each microfibril exhibits a high degree of three-dimensional internal bonding resulting in a crystalline structure that is insoluble in water and resistant to reagents. There are, however, relatively weak segments of the microfibril with weaker internal bonding. These are called amorphous regions; some argue that they are more accurately called dislocations, because of the single-phase structure of microfibrils. The crystalline region is isolated to produce microcrystalline cellulose.
Uses
Approved within the European Union as a thickener, stabilizer or emulsifier, microcrystalline cellulose was granted the E number E460(i) with basic cellulose given the number E460.[3]
ARBOCEL PWC 500 has use in cosmetics as an abrasive, absorbent, anti-caking agent, aqueous viscosity increasing agent, binder, bulking agent, emulsion stabilizer, slip modifier, and texturizer,[4][5] which can be found in various hair and skin care products as well as makeup.
The ARBOCEL PWC 500 is a valuable additive in pharmaceutical, food, cosmetic and other industries. Different properties of ARBOCEL PWC 500 are measured to qualify its suitability to such utilization, namely particle size, density, compressibility index, angle of repose, powder porosity, hydration swelling capacity, moisture sorption capacity, moisture content, crystallinity index, crystallite size, and mechanical properties such as hardness and tensile strength.
ARBOCEL PWC 500 is pure partially depolymerized cellulose synthesized from α-cellulose precursor.[6] The ARBOCEL PWC 500 can be synthesized by different processes such as reactive extrusion, enzyme mediated, mechanical grinding, ultrasonication, steam explosion and acid hydrolysis. The later process can be done using mineral acids such as H2SO4, HCl and HBr as well as ionic liquids. The role of these reagents is to destroy the amorphous regions leaving the crystalline domains.
The degree of polymerization is typically less than 400. The ARBOCEL PWC 500 particles with size lower than 5 μm must not be more than 10%.
Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) or differential scanning calorimetry (DSC) are also important to predict the thermal behavior of the ARBOCEL PWC 500 upon heat stresses.
ARBOCEL PWC 500 is a pure partially depolymerized cellulose synthesized from α-cellulose precursor (type Iβ), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. The ARBOCEL PWC 500 can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. It is commonly manufactured by spray-drying the neutralized aqueous slurry of hydrolyzed cellulose. The ARBOCEL PWC 500 is a valuable additive in pharmaceutical, food, cosmetic, and other industries. ARBOCEL PWC 500 obtained from different sources will differ considerably in chemical composition, structural organization, and physicochemical properties (crystallinity, moisture content, surface area and porous structure, molecular weight, etc.). The high demand of microcrystalline cellulose used in pharmaceutical industries has led to the utilization of locally and naturally occurring materials in the production of microcrystalline cellulose. Many studies on the physicochemical properties of locally produced ARBOCEL PWC 500 derived from natural sources have been extensively evaluated in the development of a new natural source for ARBOCEL PWC 500 as a substitution of wood, the most abundant one.
ARBOCEL PWC 500 (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.
ARBOCEL PWC 500 is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets USP standards.
It is also found in many processed food products, and may be used as an anti-caking agent, stabilizer, texture modifier, or suspending agent among other uses. According to the Select Committee on GRAS Substances, microcrystalline cellulose is generally regarded as safe when used in normal quantities.
ARBOCEL PWC 500 is a purified, partially depolymerized cellulose prepared by treating alpha-cellulose, obtained as a pulp from fibrous plant material, with mineral acids. The degree of polymerization is typically less than 400. Not more than 10% of the material has a particle size of less than 5 m m.
ARBOCEL PWC 500 E460i, is a non-caloric bulking agent, anti-caking agent, and emulsifier. Cellulose is a compound derived from high quality plant pulp. ARBOCEL PWC 500 is insoluble in water and does not gel like methylcellulose. It also provides natural source of dietary fiber.
ARBOCEL PWC 500 is a polysaccharide consisting of several hundred to over ten thousand glucose units that are β(1→4) linked (for connoisseurs). It is prepared by treating alpha cellulose, obtained as a pulp from fibrous plant material, first with mineral acids and then with hydrochloric acid. Natural cellulose has both amorphous and crystalline regions, and the acids attack the amorphous regions, leaving the crystalline regions for further purification. ARBOCEL PWC 500 is a tasteless, odourless crystalline powder; it is hygroscopic in nature and insoluble in water, but with water it swells and produces a gel.
ARBOCEL PWC 500 is available in different sizes (25-250 µm) that have different properties. It is non-toxic, consisting of 99+% dietary fibre and some salts, and it is biodegradable. One of its main applications is in pharmacy, where it is the most widely used tableting agent. Because of its properties, among which chemical purity and high crystallinity, many more applications start to develop like in sprays, oral suspensions and lotions. Here, it is an alternative to synthetic gels or polymers.
The main benefits of ARBOCEL PWC 500 are:
Higher compressibility
Increased flow
Strong binder
Odorless, tasteless
Non-reactive
Low-absorption
ARBOCEL PWC 500 is produced in a controlled environment. The end result is a pure, white powder without any taste or smell, able to add form and hardness to your tablets. ARBOCEL PWC 500 maintains the necessary advantages of a diluent. It is effective as a bulking agent in your tablet or capsule, giving the desirable weight for your customers. Microcrystalline cellulose has minimal bulk density, increasing flow characteristics. Easy flow helps to ensure that each ingredient is consistently spread throughout a mixture. If the mix is consistent, each tablet will have the same quantity of each ingredient at the end of production, creating a quality product.
ARBOCEL PWC 500 really does its job, and also it does it well. It works well with many other popular excipients and is an integral part of many manufacturers' formulas. Binders undoubtedly are a crucial element in the tableting process simply because they ensure “hardness” in a tablet. Additionally, compressibility affects all aspects of the final product, for example, disintegration, dissolution and absorption.ARBOCEL PWC 500 is directly compressible and therefore can be compressed into a tablet without having to granulate or process a mix, making the overall manufacturing process more efficient.
Compressibility and binding are both unquestionable characteristics of ARBOCEL PWC 500. Neither of these characteristics deter its ability to dissolve with ease once in tablet form, a crucial element of any tablet or capsule. ARBOCEL PWC 500 is safe to consume in normal amounts, and broadly used as an excipient for tableting. Additionally it is a natural source of dietary fiber and is also non-caloric. Above all else, ARBOCEL PWC 500 is inert, meaning it will not react to or interfere with other substances.
Overall, this product could possibly be what you are searching for. It is sought-after since it is amongst the top diluents with outstanding binding qualities, and will also preserve these properties for you. Your process of formation will become easier as a result of this ingredient. With its advantages and uses, Microcrystalline Cellulose is your ideal choice for a binding agent. Using ARBOCEL PWC 500 alongside other excipients makes production run smoothly and efficiently.
For formulation development, Pharmacel can be applied in a wide variety of oral solid dosage forms, including tablets, capsules, sachets, pellets and others. ARBOCEL PWC 500 is widely used in diverse pharmaceutical processes, like wet granulation, dry granulation or direct compression. ARBOCEL PWC 500 grades with low moisture-content are especially useful for application with moisture sensitive APIs. Pharmacel has high compactability properties, meaning that strong tablets can be made at low forces. These low forces can increase the life of tooling during tableting steps in production, even when the proportion of active ingredients within a tablet is high. In addition, tablets containing ARBOCEL PWC 500, can be made to disintegrate readily when a superdisintegrant, such as Primojel or Primellose of DFE Pharma, is used, thus maximizing the potential for drug bioavailability. Combined together with various directly compressible lactose (DCL) grades (granulated, anhydrous, spray dried), ARBOCEL PWC 500 exhibits improved functional properties which can be useful for direct compression applications.
ARBOCEL PWC 500 and carboxymethylcellulose sodium is used to produce thixotropic gels suitable as suspending vehicles in pharmaceutical and cosmetic formulations. The sodium carboxymethylcellulose aids dispersion and serves as a protective colloid.
Concentrations of less than 1% solids produce fluid dispersions, while concentrations of more than 1.2% solids produce thixotropic gels. When properly dispersed, it imparts emulsion stability, opacity and suspension in a variety of products, and is used in nasal sprays, topical sprays and lotions, oral suspensions, emulsions, creams and gels.
ARBOCEL PWC 500 is widely used in pharmaceuticals, primarily as a binder/diluent in oral tablet and capsule formulations where it is used in both wet-granulation and direct-compression processes. In addition to its use as a binder/diluent, microcrystalline cellulose also has some lubricant and disintegrant properties that make it useful in tableting.
ARBOCEL PWC 500 is also used in cosmetics and food products.
