PRODUCTS

ASCORBYL GLUCOSIDE

CAS NUMBER: 129499-78-1

EC NUMBER: 603-337-7

MOLECULAR FORMULA: C12H18O11

MOLECULAR WEIGHT: 338.26

IUPAC NAME: (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2H-furan-5-one

Ascorbyl Glucoside (AA-2G) is an ascorbic acid derivative that contains at least one glycosyl group.
Ascorbyl Glucoside is commonly used in cosmetic products to administer vitamin C topically.
Ascorbyl Glucoside exhibits superior stability and penetration ability compared to ascorbyl phosphate salts, but the rate of its in vivo conversion to ascorbic acid is not known.

Ascorbyl Glucosides such as AA-2G, like many other derivatives of the ascorbic acid, show antiscorbutic effects.
Ascorbyl Glucoside is also sometimes used in skin whitening products.
Ascorbyl Glucoside is synthesized through a glycosylation process catalyzed by glycosyltransferase-class enzymes.

What are the Benefits of Ascorbyl Glucoside for Skin?
-Fights free radicals:
Think of antioxidants, ascorbyl glucoside included, as little Pac-Men working to scavenge up pesky (and skin-damaging) free radicals that are formed when we're exposed to things such as UV rays and pollution.
Antioxidants tend to have a synergistic effect when combined, which is why this ingredient works so well when paired with other commonly used antioxidants such as vitamin E or ferulic acid.

-Promotes brighter skin: Ascorbyl Glucoside ultimately converts into l-ascorbic acid, which is a choice ingredient for both helping to fade existing dark marks and ward off the production of new ones by interfering in the melanin (color) production process in the skin
-Boosts collagen production: More collagen equals stronger, smoother, less-wrinkled skin and once ascorbyl glucoside breaks down into l-ascorbic acid it can do just that, stimulating the production of this essential protein.

Ascorbyl Glucoside at a Glance:
-Stable form of vitamin C combined with starch-derived glucose
-Maintains many of the same benefits as pure vitamin C
-Easily penetrates skin
-Brightening and tone-improving benefits enhanced by niacinamide
-Excellent antioxidant to improve skin’s environmental defenses

Ascorbyl Glucoside is a stable form of vitamin C combined with the sugar glucose.
The glucose is derived from a natural starch source, such as rice, while the vitamin C portion is synthetic.
When properly formulated and absorbed into skin, it breaks down to ascorbic acid, also known as pure vitamin C.
Once absorbed, its breakdown to vitamin C is gradual, creating what’s known as a reservoir effect within skin.
This leads to longer-lasting benefits.

ascorbyl glucoside functions as an antioxidant and works well with other replenishing and antioxidant ingredients to preserve key substances skin needs to look smoother, brighter, and younger.
Research on ascorbyl glucoside’s ability to improve uneven skin tone and hyperpigmentation is encouraging but not as extensive when compared with the decades of research amassed for ascorbic acid; however, ascorbyl glucoside plus the B vitamin niacinamide is a viable combination to consider, and several skin care products pair these ingredients.
Ascorbyl Glucoside is typically used in concentrations of 2-5% when brightening dull skin and fading the look of hyperpigmentation is the goal.
Products with higher concentrations are available, but comparative research with commonly used concentrations is lacking.

Levels of 0.5% and above can provide antioxidant benefits and help neutralize the damage associated with exposure to airborne pollutants and other environmental threats.
Ascorbyl Glucoside’s considered safe as used in cosmetics, both rinse-off and leave-on.
Ascorbyl Glucoside is widely compatible with other cosmetic ingredients.
Unlike the tight pH range ascorbic acid needs to be effective on skin, ascorbyl glucoside works between a pH of 5-8, with the lower end of this spectrum considered better due to being a close match to the normal pH range of skin.

Ascorbyl Glucoside is a form of vitamin C that is used in skincare products.
Unlike L-ascorbic acid, which is the naturally occurring form of vitamin C, ascorbyl glucoside is a stable form of vitamin C when paired with glucose.
L-ascorbic acid is a notoriously unstable form of vitamin C that often breaks down when exposed to air and sunlight.
While L-ascorbic acid can be stabilized with ferulic acid and antioxidants it presents many difficulties with formulating.

Ascorbyl Glucoside is a highly stable form of vitamin C that may help to improve the appearance of dull or pigmented skin.
Ascorbyl Glucoside is also considered to be gentler and a less potent form of vitamin C so it can be a great alternative if you have sensitive or irritated skin.

Ascorbyl Glucoside is a highly effective antioxidant, improves collagen synthesis and reduces wrinkles.
With its skin-lightening effect, the active ingredient is a popular ingredient for corresponding skin creams and care products.
The active ingredient is an ascorbic acid derivative and is metabolized to vitamin C after penetrating the skin.
Ascorbyl Glucoside repairs and protects against skin damage caused by sun rays.

Ascorbyl Glucoside benefits in Cosmetic:
-water soluble, stable vitamin C derivative
-skin whitening / skin lightening
-excellent antioxidant
-reduces fine lines and wrinkles
-boosts collagen production
-repairs and protects from sun damage
-COSMOS approved
-NATRUE certified

Ascorbyl Glucoside is a water-soluble derivative of Vitamin C.
Ascorbyl Glucoside is much more stable in water but it is less potent than direct L-Ascorbic Acid.
Being more compatible with water allows for a very pleasant serum texture.
Ascorbyl Glucoside is considered a gold standard of Vitamin C derivatives due to its high stability and comfortable use

Once absorbed, its breakdown to vitamin C is gradual, creating what’s known as a reservoir effect within skin.
This leads to longer-lasting benefits.
Sometimes referred to as AA2G, ascorbyl glucoside functions as an antioxidant and works well with other replenishing and antioxidant ingredients to preserve key substances skin needs to look smoother, brighter, and younger.
Research on ascorbyl glucoside’s ability to improve uneven skin tone and hyperpigmentation is encouraging but not as extensive when compared with the decades of research amassed for ascorbic acid; however, ascorbyl glucoside plus the B vitamin niacinamide is a viable combination to consider, and several skin care products pair these ingredients.

Ascorbyl Glucoside is typically used in concentrations of 2–5% when brightening dull skin and fading the look of hyperpigmentation is the goal.
Products with higher concentrations are available, but comparative research with commonly used concentrations is lacking.
Levels of 0.5% and above can provide antioxidant benefits and help neutralize the damage associated with exposure to airborne pollutants and other environmental threats.
Ascorbyl Glucoside’s considered safe as used in cosmetics, both rinse-off and leave-on.

Ascorbyl Glucoside is widely compatible with other cosmetic ingredients.
Unlike the tight pH range ascorbic acid needs to be effective on skin, ascorbyl glucoside works between a pH of 5–8, with the lower end of this spectrum considered better due to being a close match to the normal pH range of skin.
As an antioxidant, ascorbyl glucoside plays nice with many different ingredients, though it works especially well with niacinamide, a type of vitamin B.

When combined, these two ingredients can help address issues such as loss of firmness and elasticity, wrinkles and fine lines, unevenness in the complexion, and large pores.
All antioxidants also work well with sunscreen, offering an added layer of protection.
At the risk of channeling overly complicated, high school chemistry class vibes, ascorbyl glucoside is a water-soluble form of vitamin C that's combined with glucose, a sugar.
In the world of vitamin C and its derivatives, l-ascorbic acid is the most potent, pure version

Ascorbyl Glucoside's so often used in so many beauty products.
As mentioned, it's not as strong as l-ascorbic acid, but it is gentler and more stable.
Unlike l-ascorbic acid, ascorbyl glucoside is water-soluble, meaning it can be formulated into many skincare products that are water-based, such as serums
Ascorbyl Glucoside's much more similar to sodium ascorbyl phosphate, another type of vitamin C; both are water-soluble, stable, and gentler than l-ascorbic acid.

while there's not a lot of data comparing the two, one major difference appears to be that ascorbyl glucoside remains stable at a variety of pHs, whereas sodium ascorbyl phosphate is stable at only about a pH of 7.
And that's yet another reason why the former is so often used in a variety of different product formulations.
Starring a water-soluble derivative of vitamin C, this brightening serum provides antioxidant protection to reduce signs of ageing and even out skin tone.

Ascorbyl Glucoside is used to protect skin from exposure to UV rays.
It is a form of skincare superstar, vitamin C.

Ascorbyl Glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.
Ascorbyl Glucoside is a water-soluble derivative of Vitamin C.
Ascorbyl Glucoside is much more stable in water but it is less potent than direct L-Ascorbic Acid. Being more compatible with water allows for a very pleasant serum texture.
Ascorbyl Glucoside is considered a gold standard of Vitamin C derivatives due to its high stability and comfortable use, but it's impossible to achieve extremely high L-Ascorbic Acid potency with this solution.

Ascorbyl Glucoside repairs and protects against skin damage caused by sun rays.
Ascorbyl Glucoside has been shown to offer specific skin brightening benefits.
Ascorbyl Glucoside has no conflicts and plays nicely with other products.
Ascorbyl Glucoside can be applied as a water-based serum (before anhydrous, oils and creams).

Ascorbyl Glucoside is a derivative of ascorbic acid (AA), also known as vitamin C, can be obtained through diet from plants such as citrus fruits and leafy green vegetables.
While ascorbyl glucoside shares many similarities to its precursor form, AA, its structure is less volatile and more favorable to use in skincare formulations.
For this reason, the use of ascorbyl glucoside in skincare is often incorporated into topical products to provide vitamin C-like benefits, which include enhanced skin radiance and increased antioxidant protection.
The use of ascorbyl glucoside for skin radiance allows for a natural, healthy glow. This may be partially due to, ascorbyl glucoside’s potent antioxidant effects.
By providing antioxidant protection, ascorbyl glucoside is able to neutralize free-radicals present in the environment, thus helping to maintain the skin’s overall quality and appearance.

BENEFITS:

Neutralizes skin-damaging free radicals, inhibits the production of pigment to fade and prevent dark spots, boosts collagen production.
At the end of the day, all types of vitamin C are antioxidant powerhouses, though the benefits definitely don't stop there.

-Fights free radicals:
Think of antioxidants, ascorbyl glucoside included, as little Pac-Men working to scavenge up pesky (and skin-damaging) free radicals that are formed when we're exposed to things such as UV rays and pollution.
Antioxidants tend to have a synergistic effect when combined, which is why this ingredient works so well when paired with other commonly used antioxidants such as vitamin E or ferulic acid.

-Promotes brighter skin:

-Ascorbyl Glucoside ultimately converts into l-ascorbic acid, which is a choice ingredient for both helping to fade existing dark marks and ward off the production of new ones by interfering in the melanin (color) production process in the skin.
Because it inhibits melanin production, it can be useful when treating hyperpigmentation, uneven skin tones, and age spots

-Boosts collagen production:
More collagen equals stronger, smoother, less-wrinkled skin and once ascorbyl glucoside breaks down into l-ascorbic acid it can do just that, stimulating the production of this essential protein.

Ascorbyl Glucoside is a kind of vitamin C which contains the stable component of glucose.
When cream and lotion containing this remarkable substance are applied in skin, Ascorbyl Glucoside is hydrolyzed by glucosidase, an enzyme presenting in the membrane of skin cells.
This process releases vitamin C in its natural active form.
When vitamin C enters cells, it results in significant well-documented biological responses.
Ascorbyl Glucoside has been demonstrated to be hydrolyzed over a prolonged period giving its beneficial physiological effects to the cells and tissues in a constant and sustained manner.
Compared with other vitamin C derivatives, ascorbyl glucoside has a better stability and solubility in solution and could essentially inhibit the discolour and degradation of vitamin C in cosmetics while keeping the whole bioactivity.

Ascorbic Acid 2-Glucoside(AA-2G) is natural vitamin C (ascorbic acid) stabilized with glucose.
Ascorbic Acid 2-Glucoside(AA-2G) was originally developed as a quasi-drug cosmetic product in Japan to lighten the overall tone of the skin and reduce the pigmentation in age spots and freckles.
Ascorbic Acid 2-Glucoside (AA2G) is a natural Vitamin C, containing glucose stable ingredients, with excellent formulation stability.
Ascorbyl Glucoside helps inhibit discoloration and degradation, and retains all the biological activity.
Ascorbyl Glucoside is used not only for whitening, but also to brighten the skin, which plays a role in protecting the skin in sunscreen products.

Ascorbic Acid 2-Glucoside(AA2G™) is natural vitamin C (ascorbic acid) stabilized with glucose.
This combination allows the benefits of vitamin C to be conveniently and effectively used in cosmetic products.

Ascorbyl Glucoside is widely compatible with other cosmetic ingredients.
Unlike the tight pH range ascorbic acid needs to be effective on skin, ascorbyl glucoside works between a pH of 5–8, with the lower end of this spectrum considered better due to being a close match to the normal pH range of skin.
As an antioxidant, Ascorbyl Glucoside plays nice with many different ingredients, though it works especially well with niacinamide, a type of vitamin B.

PHYSICAL PROPERTIES OF ASCORBYL GLUCOSIDE:

-Molecular Weight: 338.26

-XLogP3-AA: -3.1

-Monoisotopic Mass: 338.08491139

-Topological Polar Surface Area: 186 Å²

-Melting point: 158-163℃

-Boiling point: 785.6±60.0 °C(Predicted)

-Density : 1.83±0.1 g/cm3(Predicted)

-pka: 3.38±0.10(Predicted)

-Form: Powder

-Color: White to Off-white

-Water Solubility: Soluble in water

-λmax: 260nm(H2O)

-Flash Point: 296.5±26.4 °C

-PSA: 186.37000

-LogP: -2.57

-Vapour Pressure: 0.0±6.2 mmHg

-Index of Refraction: 1.670

-Storage condition: 2-8°C

Ascorbyl Glucoside has no conflicts and plays nicely with other products.
Ascorbyl Glucoside can be applied as a water-based serum (before anhydrous, oils and creams).

Ascorbyl Glucoside is much more stable in water but it is less potent than direct L-Ascorbic Acid. Being more compatible with water allows for a very pleasant serum texture.
Ascorbyl Glucoside is considered a gold standard of Vitamin C derivatives due to its high stability and comfortable use, but it's impossible to achieve extremely high L-Ascorbic Acid potency with this solution.

CHEMICAL PROPERTIES OF ASCORBYL GLUCOSIDE:

-Hydrogen Bond Donor Count: 7

-Hydrogen Bond Acceptor Count: 11

-Rotatable Bond Count: 5

-Heavy Atom Count: 23

-Formal Charge: 0

-Complexity: 478

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 7

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

STORAGE OF ASCORBYL GLUCOSIDE:

Ascorbyl Glucoside Reacts instantaneously with oxidizing agents.
Ascorbyl Glucoside should be stored away from oxidizing agents.
Ascorbyl Glucoside should be stored in a cool environment.

Ascorbyl Glucoside should not be exposed to light.
Ascorbyl Glucoside should be stored in dark containers.
Ascorbyl Glucoside should be kept in a dry place.

Ascorbyl Glucoside should be stored in a moisture-free environment.
Ascorbyl Glucoside should not be exposed to high temperatures.

Ascorbyl Glucoside preferably should be stored in glass bottles.
Ascorbyl Glucoside should be stored in a ventilated and clean environment.
Ascorbyl Glucoside should be stored in an environment where there are no sudden pressure changes.

SYNONYMS:

L-Ascorbic acid 2-glucoside
2-O-alpha-D-Glucopyranosyl-L-ascorbic acid
Ascorbic acid 2-O-glucoside
L-Ascorbic acid-2-glucoside
(2R)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2h-furan-5-one
L-Ascorbic acid 2-O-alpha-glucoside
L-ascorbic acid 2-O-|A-glucoside
2-O-a-D-Glucopyranosyl-L-ascorbic Acid?
2-O-|A-D-Glucopyranosyl-L-ascorbic Acid
2-O-Hexopyranosylhex-1-enofuranos-3-ulose
2-O-a-D-Glucopyranosyl-L-ascorbic Acid, >=98% (HPLC)
Ascorbyl Glucoside, Pharmaceutical Secondary Standard; Certified Reference Material
(R)-5-((S)-1,2-DIHYDROXYETHYL)-4-HYDROXY-3-(((2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL)OXY)FURAN-2(5H)-ONE
Pyrido(1,2-a)indol-6(7H)-one, 8,9-dihydro-7-(hydroxy(5-methyl-1H-imidazol-4-yl)methyl)-10-propyl-, (R*,S*)-
(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2H-furan-5-one
(5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-hydroxy-3-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2(5H)-furanone
2-O-α-D-Glucopyranosyl-L-ascorbic Acid
2-O-alpha-D-Glucopyranosyl-L-ascorbic acid