Quick Search
Ascorbyl glucoside is a natural active substance containing Vitamin C structure, but it is stable.
Ascorbyl glucoside can effectively inhibit formation of melanin, dilute the skin color, reduce age spots and freckles pigmentation.
Ascorbyl glucoside was originally developed as a quasi-drug cosmetic product in Japan to lighten the overall tone of the skin and reduce the pigmentation in age spots and freckles.
CAS: 129499-78-1
MF: C12H18O11
MW: 338.26
EINECS: 425-980-0
Synonyms
Ascofresh;L-Ascorbic acid, 2-O-.alpha.-D-glucopyranosyl-;AA-2G;ascorbic acid 2-O-glucoside;ASCORBYL GLUCOSIDE, ASCORBIC ACID-2- GLUCOSIDE;2-O-A-D-GLUCOPYRANOSYL-L-ASCORBIC ACID;L-Ascorbic acid 2-o-alpha-glucoside;Pyrido(1,2-A)indol-6(7H)-one, 8,9-dihydro-7-(hydroxy(5-methyl-1H-imidazol-4-yl)methyl)-10-propyl-, (R*,S*)-
Further research has shown other dramatic benefits and today Ascorbyl glucoside is used all over the world-not only for whitening but also for brightening dull looking skin, reversing the effects of aging, and in sunscreen products for protection.
L-Ascorbic acid-2-glucoside is a glycoside.
Ascorbyl glucoside is a stable form of vitamin C combined with glucose.
When properly formulated and absorbed into skin, Ascorbyl glucoside breaks down to ascorbic acid (pure vitamin C).
Ascorbyl glucoside is a useful cosmetic gel and skin cleanser.
Once absorbed, Ascorbyl glucoside's breakdown to vitamin C is gradual, creating what’s known as a reservoir effect within skin.
This leads to longer-lasting benefits.
2-O-a-D-glucopyranosyl-L-ascorbic acid or ascorbyl glucoside functions as a skin whitener and radical scavenger in cosmetics.
Ascorbyl glucoside is responsible for the bleaching action of bleaching cosmetics.
This compound is activated in a manner identical to that of vitamin C.
The enzyme present in the epidermal basal membrane, ascorbyl phosphatase, slowly converts Ascorbyl glucoside into vitamin C, thereby maintaining a high vitamin C level in skin throughout the day.
Ascorbyl glucoside, with the CAS number 129499-78-1, is a stable derivative of vitamin C (ascorbic acid) that is commonly used in cosmetic and pharmaceutical formulations due to its antioxidant properties.
Ascorbyl glucoside is characterized by its ability to provide the benefits of ascorbic acid while enhancing stability against oxidation, making it suitable for use in products exposed to air and light.
Ascorbyl glucoside is a white to off-white powder that is soluble in water, allowing for easy incorporation into various formulations.
Ascorbyl glucoside is known for its skin-brightening effects, promoting collagen synthesis, and protecting against UV-induced damage.
Additionally, Ascorbyl glucoside can help in reducing hyperpigmentation and improving overall skin texture.
The glucoside moiety contributes to its stability and bioavailability, making Ascorbyl glucoside an attractive ingredient in skincare products aimed at anti-aging and skin rejuvenation.
Overall, Ascorbyl glucoside is valued for its multifunctional properties and safety profile in topical applications.
Ascorbyl glucoside is a potent antioxidant compound found in the human body.
Ascorbyl glucoside is produced by the enzyme tyrosinase from L-ascorbic acid and has been shown to have anti-apoptotic effects on skin cells.
Ascorbyl glucoside has also been shown to enhance mitochondrial membrane potential and increase the proliferation of skin cells in vitro.
Ascorbyl glucoside has been tested for its ability to prevent radiation damage in mice and was found to be more effective than vitamin C at preventing cell death.
Ascorbyl glucoside can be used as a topical treatment for skin conditions, such as acne or wrinkles, by reducing inflammation and stimulating cellular growth.
Ascorbyl glucoside Chemical Properties
Melting point: 158-163℃
Boiling point: 785.6±60.0 °C(Predicted)
density: 1.83±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.38±0.10(Predicted)
form: Powder
color: White to Off-white
Water Solubility: Soluble in water. (879 g/L) at 25°C.
λmax: 260nm(H2O)(lit.)
Cosmetics Ingredients Functions: ANTIOXIDANT
Cosmetic Ingredient Review (CIR): Ascorbyl glucoside (129499-78-1)
InChI: 1S/C12H18O11/c13-1-3(15)9-8(19)10(11(20)22-9)23-12-7(18)6(17)5(16)4(2-14)21-12/h3-7,9,12-19H,1-2H2/t3-,4+,5+,6-,7+,9+,12+/m0/s1
InChIKey: MLSJBGYKDYSOAE-DCWMUDTNSA-N
LogP: -2 at 20℃
Surface tension: 71mN/m at 1g/L and 20℃
Uses
According to the manufacturer, ascorbyl glucoside functions as a time-release version of vitamin C (ascorbic acid), and therefore is more stable than traditional ascorbic acid.
Ascorbyl glucoside is considered to have skin-lightening and anti-hyperpigmentation properties, thanks to an ability to suppress melanin production.
Ascorbyl glucoside's skinbrightening capacities are attributed to an apparent ability to reduce pre-existing melanin levels (as in the case of freckles or age spots).
Ascorbyl glucosidecould also help promote collagen synthesis and help reduce skin inflammation.
Ascorbyl glucoside is found in antiaging, anti-wrinkle, and sun care products.
Ascorbyl glucoside reduce the free radicals that result from UV irradiation of the skin, and significantly reduce cell damage and photo-aging.
Ascorbyl glucoside also promotes collagen synthesis.
Ascorbyl glucoside can function as an antioxidant.
Ascorbyl glucoside is mainly used in advanced cosmetics as skin lightening and whitening agents.
Ascorbyl glucoside is one of the whitening additives announced and approved by the Department of Health, and Ascorbyl glucoside is recognized as the most stable vitamin C derivative.
At the same time, Ascorbyl glucoside is also the most commonly used whitening ingredient in major brands.
Ascorbyl glucoside not only has a good whitening effect, but also has stable chemical properties and is non-irritating to the skin.
The content of melanin in human skin determines the color of the skin.
Ascorbyl glucoside is the main raw material for producing melanin.
Ascorbyl glucoside is the rate-limiting enzyme in the synthesis pathway of tyrosine.
Ascorbyl glucoside mainly affects the conversion of tyrosine into polysaccharides.
Ascorbyl glucoside, and the oxidation of dopa to dopaquinone affects melanin production.
Benefits
Ascorbyl glucoside is a whitening agent widely used in cosmetic formulations.
Studies have shown that Ascorbyl glucoside has a depigmenting effect on UVB pigmentation as a tyrosinase inhibitor or after being converted into free ascorbic acid by intrinsic epidermal glucosidase.
Ascorbyl glucoside has the following benefits for the skin:
Whitening effect: brightens skin tone, lightens pigmentation and improves solar vitiligo.
Antioxidant effect: neutralizes free radicals and prevents skin damage.
High safety and low irritation: According to the review results of the Cosmetic Ingredient Safety Expert Group, ascorbyl glucoside and its sodium salt are safe in cosmetics.
Slows down aging
Side effects
While pure vitamin C can sting and cause mild irritation, there aren't any side effects we know of with Ascorbyl glucoside, says Nussbaum.
Still, Ascorbyl glucoside is an active ingredient for sure, so you can always test out a small amount elsewhere on your skin to make sure you can tolerate it.
Synthesis
A method for producing ascorbyl glucoside, characterized in that it comprises the following steps:
Step 1: the ascorbyl glucoside reaction solution is separated by nanofiltration to remove the residual VC in the reaction solution to obtain a nanofiltration concentrate;
Step 2: the nanofiltration concentrate is separated by a continuous fluid separation device to remove glucose from the VC glucoside reaction solution;
Step 3: the VC glucoside solution from the continuous fluid separation device is first adjusted by a cation resin to adjust the pH, and then concentrated by a nanofiltration membrane to remove inorganic salts in the reaction solution to obtain the VC glucoside concentrate;
Step 4: The VC glucoside concentrate is concentrated by distillation under reduced pressure to further increase the concentration of VC glucoside, and then crystallized to obtain VC glucoside.
